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T-cell immune response after mRNA SARS-CoV-2 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignancies.

Br J Haematol 2021 Oct 14. Epub 2021 Oct 14.

School of Medicine, University of Milano, Italy.

Patients affected by lymphoid malignancies (LM) are frequently immune-compromised, suffering increased mortality from COVID-19. This prospective study evaluated serological and T-cell responses after complete mRNA vaccination in 263 patients affected by chronic lymphocytic leukaemia, B- and T-cell lymphomas and multiple myeloma. Results were compared with those of 167 healthy subjects matched for age and sex. Read More

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October 2021

EEG Spatiotemporal Patterns Underlying Self-other Voice Discrimination.

Cereb Cortex 2021 Oct 15. Epub 2021 Oct 15.

Functional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, 1202, Switzerland.

There is growing evidence showing that the representation of the human "self" recruits special systems across different functions and modalities. Compared to self-face and self-body representations, few studies have investigated neural underpinnings specific to self-voice. Moreover, self-voice stimuli in those studies were consistently presented through air and lacking bone conduction, rendering the sound of self-voice stimuli different to the self-voice heard during natural speech. Read More

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October 2021

Volume Reduction of the Dorsal Lateral Prefrontal Cortex Prior to the Onset of Frank Psychosis in Individuals with an At-Risk Mental State.

Cereb Cortex 2021 Oct 15. Epub 2021 Oct 15.

Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 9300194, Japan.

Although some individuals with at-risk mental states (ARMS) develop overt psychosis, surrogate markers which can reliably predict a future onset of psychosis are not well established. The dorsal lateral prefrontal cortex (DLPFC) is thought to be involved in psychotic disorders such as schizophrenia. In this study, 73 ARMS patients and 74 healthy controls underwent 1. Read More

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October 2021

Functional Abnormality of the Executive Control Network in Individuals With Obesity During Delay Discounting.

Cereb Cortex 2021 Oct 14. Epub 2021 Oct 14.

Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.

Individuals with obesity (OB) prefer immediate rewards of food intake over the delayed reward of healthy well-being achieved through diet management and physical activity, compared with normal-weight controls (NW). This may reflect heightened impulsivity, an important factor contributing to the development and maintenance of obesity. However, the neural mechanisms underlying the greater impulsivity in OB remain unclear. Read More

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October 2021

Twelve Months of Time-restricted Eating and Resistance Training Improve Inflammatory Markers and Cardiometabolic Risk Factors.

Med Sci Sports Exerc 2021 Jul 7. Epub 2021 Jul 7.

Department of Biomedical Sciences, University of Padova, Padova, Italy Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Introduction: Recently, a modified intermittent fasting protocol was demonstrated to be able to maintain muscle mass and strength, decrease fat mass and improve some inflammation and cardiovascular risk factors in healthy resistance-trained males after 2 months. The present study sought to investigate the long-term effects on these parameters.

Methods: The experiment is a single-blind randomized study. Read More

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Qualitative Components of Dyspnea during Incremental Exercise across the COPD Continuum.

Med Sci Sports Exerc 2021 Jul 7. Epub 2021 Jul 7.

Respiratory Investigation Unit, Department of Medicine, Queen's University and Kingston Health Sciences Centre Kingston General Hospital Campus, Kingston, Ontario, Canada Department of Chest Diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt Centre for Heart Lung Innovation, Providence Health Care Research Institute, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada Kingston General Health Research Institute, Kingston, Ontario, Canada.

Introduction: Evaluation of the intensity and quality of activity-related dyspnea is potentially useful in people with chronic obstructive pulmonary disease (COPD). The present study sought to examine associations between qualitative dyspnea descriptors, dyspnea intensity ratings, dynamic respiratory mechanics, and exercise capacity during cardiopulmonary exercise testing (CPET) in COPD and healthy controls.

Methods: In this cross-sectional study, 261 patients with mild-to-very severe COPD (forced expiratory volume in 1 second [FEV1] 62 ± 25 %pred) and 94 age-matched controls (FEV1 114 ± 14 %pred) completed an incremental cycle CPET to determine peak oxygen uptake (V[Combining Dot Above]O2peak). Read More

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Changes in 6DOF knee kinematics during gait with decreasing gait speed.

Gait Posture 2021 Oct 8;91:52-58. Epub 2021 Oct 8.

Department of Orthopaedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, China; School of Medicine, South China University of Technology, Guangzhou, 510006, China. Electronic address:

Background: Gait speed is recognized to correlate to knee kinematic alterations. Clinically, patients with knee diseases tend to walk slowly compared to healthy controls. Hence, gait speed may serve as a confounding factor in the kinematic characteristics of patients during gait compared to healthy controls. Read More

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October 2021

Radiofrequency ablation turbinoplasty improves the sense of smell in pediatric patients: A prospective study.

Int J Pediatr Otorhinolaryngol 2021 Oct 5;150:110935. Epub 2021 Oct 5.

Service of Otolaryngology, Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.

Introduction: The olfactory sense is of paramount importance for the adequate development of a child. Olfactory loss in children might have different origins. One of the most common is conductive, when nasal obstruction prevents odorants from reaching the olfactory epithelium. Read More

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October 2021

Cutibacterium acnes phylogenetic type IC and II isolated from patients with non-acne diseases exhibit high-level biofilm formation.

Int J Med Microbiol 2021 Oct 9;311(7):151538. Epub 2021 Oct 9.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

Cutibacterium (formerly Propionibacterium) acnes is an important for not only exacerbating factor of acne vulgaris but also pathogen of surgical site infections (SSIs) in orthopedics and plastic surgery. Although biofilm-forming (BF) C. acnes are associated with intractable SSI, characteristics of these strains were still unknown. Read More

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October 2021

The enteroinsular axis during hospitalization in newborn foals.

Domest Anim Endocrinol 2021 Sep 16;78:106686. Epub 2021 Sep 16.

College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

The enteroinsular axis (EIA) is an energy regulatory system that modulates insulin secretion through the release of enteroendocrine factors (incretins). Despite the importance of energy homeostasis in the equine neonate, information on the EIA in hospitalized foals is lacking. The goals of this study were to measure serum insulin and plasma incretin (glucose-dependent insulinotropic polypeptide [GIP], glucagon-like peptide-1 [GLP-1] and glucagon-like peptide-2 [GLP-2]) concentrations, to determine the insulin and incretin association, as well as their link to disease severity and outcome in hospitalized foals. Read More

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September 2021

Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study.

Parkinsonism Relat Disord 2021 Sep 21;91:167-172. Epub 2021 Sep 21.

University Hospital of Burgos, Department of Neurology, Spain. Electronic address:

Background And Purpose: Given the overlapping clinical manifestations and pathology, the differentiation between essential tremor (ET) and Parkinson's disease (PD) is difficult. Our aims were to examine the plasma metabolomics profiling and their association with motor and non-motor symptoms (NMS) in patients with PD, and to determine differences between de novo PD compared to moderate-advanced PD vs. controls and patients with ET. Read More

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September 2021

Increased functional connectivity in a population at risk of developing Parkinson's disease.

Parkinsonism Relat Disord 2021 Oct 6;92:1-6. Epub 2021 Oct 6.

Center for Neurology and Hertie-Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Tübingen, Germany; Department of Neurology, Christian-Albrechts-University, Kiel, Germany.

Background: While the concept of prodromal Parkinson's disease (PD) is well established, reliable markers for the diagnosis of this disease stage are still lacking. We investigated the functional connectivity of the putamina in a resting-state functional MRI analysis in persons with at least two prodromal factors for PD, which is considered a high risk for PD (HRPD) group, in comparison to PD patients and controls.

Methods: We included 16 PD patients, 20 healthy controls and 20 HRPD subjects. Read More

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October 2021

Face processing of social cognition in patients with first episode psychosis: Its deficits and association with the right subcallosal anterior cingulate cortex.

Schizophr Res 2021 Oct 11;238:99-107. Epub 2021 Oct 11.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States of America; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address:

The clinical importance of social cognition is well acknowledged in patients with psychosis, in particular those with first episode psychosis (FEP). Nevertheless, its brain substrates and circuitries remain elusive, lacking precise analysis between multimodal brain characteristics and behavioral sub-dimensions within social cognition. In the present study, we examined face processing of social cognition in 71 FEP patients and 77 healthy controls (HCs). Read More

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October 2021

Investigating the diagnostic utility of speech patterns in schizophrenia and their symptom associations.

Schizophr Res 2021 Oct 11;238:91-98. Epub 2021 Oct 11.

Centre for Mental Health, Swinburne University of Technology, Melbourne, Australia; Department of Psychiatry, St. Vincent's Hospital, Melbourne, Australia.

Background: Speech disturbances are a recognised aspect of schizophrenia that may have potential utility as a diagnostic indicator. Recent advances in quantitative speech assessment methods have led to more reproducible and precise metrics making this possible. The current study sought firstly to characterise the speech profile of schizophrenia patients using quantitative speech measures, then examine the diagnostic utility of these measures and explore their relationship to symptoms. Read More

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October 2021

Mnemnonic Discrimination Deficits in First Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to NMDA-Receptor Hypofunction.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Oct 11. Epub 2021 Oct 11.

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham. Electronic address:

Background: Converging evidence from neuroimaging and post-mortem studies suggests that hippocampal subfields are differentially affected in schizophrenia. Recent studies report dentate gyrus dysfunction in chronic schizophrenia, but the underlying mechanisms remain to be elucidated. Here we sought examine if this deficit is already present in first episode psychosis, and if N-methyl-d-aspartate (NMDA) receptor hypofunction, a putative central pathophysiological mechanism in schizophrenia, experimentally induced by ketamine, would result in a similar abnormality. Read More

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October 2021

Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease.

Neurobiol Aging 2021 Sep 6;109:31-42. Epub 2021 Sep 6.

Department of Neurology, Goethe University, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University, Frankfurt am Main, Germany. Electronic address:

Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an "Alzheimer's disease (AD)-like" pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. Read More

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September 2021

Retinal Microvascular and Perfusional Disruption in Paediatric COVID-19: A Case-Control Optical Coherence Tomography Angiography Study.

Photodiagnosis Photodyn Ther 2021 Oct 11:102577. Epub 2021 Oct 11.

İzmir Katip Çelebi University Atatürk Educating and Research Hospital, Department of Ophthalmology, 35200, İzmir, Turkey. Electronic address:

Purpose: To investigate the short-term effect of coronavirus 2019 (COVID-19) on the retinal capillary network and choroid in children.

Materials And Methods: This prospective, cross-sectional, case-control study included 19 recovered COVID-19 paediatric patients and 20 healthy children. Macular thickness, choroidal thickness, vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) values were obtained. Read More

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October 2021

Modulating medial prefrontal cortex activity using real-time fMRI neurofeedback: Effects on reality monitoring performance and associated functional connectivity.

Neuroimage 2021 Oct 11:118640. Epub 2021 Oct 11.

Department of Psychology, University of Roehampton, Grove House, Roehampton Lane, London, SW15 5PJ, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK; Department of Psychiatry, Icahn Medical Institute, Mount Sinai Hospital, 1 Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.

Neuroimaging studies have found 'reality monitoring', our ability to distinguish internally generated experiences from those derived from the external world, to be associated with activity in the medial prefrontal cortex (mPFC) of the brain. Here we probe the functional underpinning of this ability using real-time fMRI neurofeedback to investigate the involvement of mPFC in recollection of the source of self-generated information. Thirty-nine healthy individuals underwent neurofeedback training in a between groups study receiving either Active feedback derived from the paracingulate region of the mPFC (21 subjects) or Sham feedback based on a similar level of randomised signal (18 subjects). Read More

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October 2021

Quantitative Romberg using a Force Plate: An Objective Measure for Cervical Myelopathy.

Spine J 2021 Oct 11. Epub 2021 Oct 11.

Norton Leatherman Spine Center, 210 East Gray Street, Suite #900, Louisville, KY 40202. Electronic address:

Background Context: Surgical decision making for Cervical Spondylotic Myelopathy (CSM) relies on evaluation of symptoms and physical examination. The Romberg test is a clinical exam used to identify balance issues with CSM. However, the Romberg test has a subjective interpretation and has a binary (positive or negative) result. Read More

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October 2021

Leptin, ghrelin, & insulin levels and food intake in premenstrual syndrome: A case-control study.

Appetite 2021 Oct 11:105750. Epub 2021 Oct 11.

Postgraduate Program in Health Sciences: Gynaecology and Obstetrics (PPGGO), Menopause Research Group. Department of Gynaecology and Obstetrics, Clinical Hospital of Porto Alegre (HCPA), School of Medicine (FAMED), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Objectives: The objective of this study was to evaluate the relationship between food intake and serum levels of leptin and ghrelin in the luteal (LP) and follicular (FP) phases of the MC (menstrual cycle) in participants with and without PMS (premenstrual syndrome).

Methods: This was a case-control study with healthy participants aged 20-45 years with regular menstrual cycles (24-35 days) with and without PMS. After the Daily Record of Severity of Problems (DRSP) was filled out for two months (PMS diagnosis), a nutritional assessment was carried out based on twelve food intake records (for two menstrual cycles) to quantify food intake. Read More

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October 2021

MiR-186-5p dysregulation leads to depression-like behavior by de-repressing SERPINF1 in hippocampus.

Neuroscience 2021 Oct 11. Epub 2021 Oct 11.

Department of Women Health Care, Wuxi Matemal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province 214002, PR China. Electronic address:

Diagnosis of major depressive disorder (MDD) is perplexing due to its multifactorial etiologies. Here, we isolated exosomes from the peripheral blood of MDD patients (n=10) and healthy control subjects (n=10) for mass spectrometry-based label-free quantitative proteomics. We identified that SERPINF1 is significantly diminished in the peripheral blood-derived exosomes of MDD patients compared to the healthy control subjects. Read More

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October 2021

ELUCIDATING THE ASSOCIATION BETWEEN DEPRESSION, ANXIETY, AND COGNITION IN MIDDLE-AGED ADULTS: APPLICATION OF DIMENSIONAL AND CATEGORICAL APPROACHES.

J Affect Disord 2021 Oct 11. Epub 2021 Oct 11.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Level 6, 18 Innovation Walk, Clayton, Victoria, Australia. Electronic address:

Background: In older adults, depressive and anxiety symptoms are associated with dementia risk, and represent a manifestation of the dementia prodrome. Understanding how these symptoms are related to cognition in midlife may inform risk models of dementia.

Methods: This study examined the relationship between depressive and anxiety symptoms, and cognition, in a sample (n = 2,657) of participants enrolled in the Healthy Brain Project. Read More

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October 2021

Reliability of Aqueous Flare Measurements During Uveitis by a Spot Fluorometer.

J Ocul Pharmacol Ther 2021 Oct 13. Epub 2021 Oct 13.

School of Optometry, Indiana University, Bloomington, Indiana, USA.

To evaluate the reliability of intensity of light scatter (ILS) for diagnosing mild-to-moderate uveitis, which is difficult to score by the subjective standardized uveitis nomenclature (SUN) grading. ILS (in millivolts) was measured in healthy subjects and uveitis patients by a custom-made Spot fluorometer. The reliability was assessed by noise analysis of the instrument using turbid samples and intra- and interobserver variabilities. Read More

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October 2021

Intrapulmonary Pharmacokinetic Modeling and Simulation of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Pneumonia Patients and Healthy Subjects.

J Clin Pharmacol 2021 Oct 14. Epub 2021 Oct 14.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, 06102, USA.

Cefiderocol is a siderophore cephalosporin for the treatment of infections caused by Gram-negative bacteria including carbapenem-resistant strains. The aim of this study was to develop an intrapulmonary pharmacokinetic model of cefiderocol and assess pharmacokinetic profile in lungs. An intrapulmonary pharmacokinetic model of cefiderocol was developed using the concentration data in plasma and epithelial lining fluid (ELF) from 7 pneumonia patients requiring mechanical ventilation and 20 healthy subjects. Read More

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October 2021

Assessment of the physical performance in children with asymptomatic pre-excitation.

Europace 2021 Oct 14. Epub 2021 Oct 14.

Department of Paediatric Cardiology and General Paediatrics, Medical University of Warsaw, 63A Zwirki i Wigury Street, 02-091 Warsaw, Poland.

Aims: Pre-excitation syndrome can lead to recurrent supraventricular tachycardias (SVTs) and carries a risk of sudden cardiac death (SCD). However, an underestimated consequence of antegrade conduction through an accessory pathway is fusion of intrinsic and accessory conduction that causes asynchronous activation and myocardial contraction that could be a cause for cardiac dysfunction and dilation. It is not known to what extent pre-excitation affects myocardial and physical performance in those patients. Read More

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October 2021

Plasma electrophoresis profiles of Blanding's turtles (Emydoidea blandingii) and influences of month, age, sex, health status, and location.

PLoS One 2021 14;16(10):e0258397. Epub 2021 Oct 14.

Wildlife Epidemiology Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, IL, United States of America.

Baseline plasma electrophoresis profiles (EPH) are important components of overall health and may aid in the conservation and captive management of species. The aim of this study was to establish plasma protein fractions for free-ranging Blanding's turtles (Emydoidea blandingii) and evaluate differences due to age class (adult vs. sub-adult vs. Read More

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October 2021

Effect of axial length on peripapillary microvasculature: An optical coherence tomography angiography study.

PLoS One 2021 14;16(10):e0258479. Epub 2021 Oct 14.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

Objective: To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA).

Methods: Retrospective observational study. A total of 111 eyes from 111 normal healthy subjects were examined. Read More

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October 2021

Leptomeningeal collateral flow in patients with middle cerebral artery occlusion assessed by transcranial Doppler.

J Neuroimaging 2021 Oct 14. Epub 2021 Oct 14.

Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, P. R. China.

Background And Purpose: To explore the application value and clinical significance of transcranial Doppler(TCD)in assessing leptomeningeal collateral flow (LMF) status in patients with unilateral middle cerebral artery (MCA) occlusion.

Methods: Medical records of patients with unilateral MCA occlusion confirmed by digital subtraction angiography (DSA) were analyzed retrospectively. The patients were divided into three groups according to LMF status, and the laboratory and imaging results were collected. Read More

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October 2021

Cardiac involvement in patients recovered from COVID-19 identified using left ventricular longitudinal strain.

J Echocardiogr 2021 Oct 14. Epub 2021 Oct 14.

Division of Echocardiography, Cardioimagem Clínica Cardiológica, SHIS QI7 conjunto 1 casa 11, Brasilia, DF, 71615-210, Brazil.

Introduction: Coronavirus disease-19 (COVID-19) has been associated with subclinical myocardial dysfunction during its acute phase and a recurring pattern of reduced basal left ventricular longitudinal strain on speckle-tracking echocardiography (STE) in hospitalized patients. But a question still remains unanswered: speckle-tracking echocardiography might also be suitable to detect residual myocardial involvement after acute stage of COVID-19?

Methods And Results: We studied 100 patients recovered from COVID-19 with STE to evaluate global (GLS) and segmentar longitudinal strain (LS) and compared with a control group of 100 healthy individuals. STE was performed at a median of 130. Read More

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October 2021

Frequency of hand movements as a possible diagnostic tool for parkinsonian bradykinesia. Proposal of a simple bedside test.

Neurol Sci 2021 Oct 14. Epub 2021 Oct 14.

Department of Neurology, Kaplan Medical Center, Pasternak Street 1, 76100, Rehovot, Israel.

Background: Bradykinesia, dysrhythmia, and decrement in hand movements (HM) are core symptoms of Parkinson's disease (PD). The maximal rate of repetitive rhythm-preserving HM can be a diagnostic tool for PD bradykinesia.

Objectives: To improve the clinical diagnosis of bradykinesia by identifying the frequencies at which rhythmic HM become irregular in PD patients compared to healthy age-matched controls. Read More

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October 2021