165 results match your criteria compared gmi

Real-world Performance of the MiniMed™ 780G System: First Report of Outcomes from 4'120 Users.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

Medtronic International Trading Sàrl, Toluchenaz, Tolochenaz, Switzerland, 46733;

Background: The MiniMed™ 780G system includes an Advanced Hybrid Closed Loop (AHCL) algorithm which provides for both automated basal and correction bolus insulin delivery. The preliminary performance of the system in real-world settings was evaluated.

Methods: Data uploaded from August 2020 to March 2021 by individuals living in Belgium, Finland, Italy, the Netherlands, Qatar, South Africa, Sweden, Switzerland and the United Kingdom were aggregated and retrospectively analyzed to determine the mean Glucose Management Indicator (GMI), percentage of time spent within (TIR), below (TBR) and above (TAR) glycemic ranges, system use and insulin consumption in users having ≥10 days of sensor glucose (SG) data after initiating AHCL. Read More

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September 2021

Glucose control in home-isolated adults with type 1 diabetes affected by COVID-19 using continuous glucose monitoring.

J Endocrinol Invest 2021 Sep 5. Epub 2021 Sep 5.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Luigi Miraglia 2, 80138, Naples, Italy.

Purpose: This study is aimed at evaluating changes in metrics of glucose control in home-isolated patients with type 1 diabetes and COVID-19 using a continuous glucose monitoring (CGM) system.

Methods: We included adults aged 18-45 years with type 1 diabetes, using CGM, followed by telemedicine at a Southern Italian University Hospital. Thirty-two home-quarantined subjects with SARS-CoV-2 positive swab constituted the COVID-19 group. Read More

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September 2021

Transcutaneous auricular vagus nerve stimulation influences gastric motility: A randomized, double-blind trial in healthy individuals.

Brain Stimul 2021 Jun 27;14(5):1126-1132. Epub 2021 Jun 27.

Epilepsy Center Hessen and Department of Neurology, Philipps-University Marburg, Marburg, Germany; Center for Mind, Brain and Behavior, CMBB, Philipps-University Marburg, Marburg, Germany; Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Germany. Electronic address:

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) has been investigated regarding its therapeutic properties in several several conditions such as epilepsy, migraine and major depressive disorder and was shown to access similar neural pathways as invasive vagus nerve stimulation. While the vagus nerve's role in gut motility is physiologically established, the effect of taVNS has scarcely been investigated in humans and yielded conflicting results. Real-time gastric magnetic resonance imaging (rtMRI) is an established reproducible method to investigate gastric motility non-invasively. Read More

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Improved individual and population-level HbA1c estimation using CGM data and patient characteristics.

J Diabetes Complications 2021 08 17;35(8):107950. Epub 2021 May 17.

Department of Management Science and Engineering, Stanford School of Engineering, Stanford, CA, USA; Division of Pediatric Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Lucile Packard Children's Hospital, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Clinical Excellence Research Center, Stanford School of Medicine, Stanford, CA, USA. Electronic address:

Machine learning and linear regression models using CGM and participant data reduced HbA1c estimation error by up to 26% compared to the GMI formula, and exhibit superior performance in estimating the median of HbA1c at the cohort level, potentially of value for remote clinical trials interrupted by COVID-19. Read More

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An Examination of the Glucose Management Indicator in Young Children with Type 1 Diabetes.

J Diabetes Sci Technol 2021 Jun 7:19322968211023171. Epub 2021 Jun 7.

Children's Mercy Hospital, Endocrine/Diabetes Clinical Research, Kansas City, MO, USA.

Background: Previous studies utilizing glucose data from continuous glucose monitors (CGM) to estimate the Glucose Management Indicator (GMI) have not included young children or determined appropriate GMI formulas for young children with type 1 diabetes (T1D).

Methods: We extracted CGM data for 215 children with T1D (0-6 years) from a repository. We defined sampling periods ranging from the 3-27 days prior to an HbA1c measurement and compared a previously established GMI formula to a young child-specific GMI equation based on the sample's CGM data. Read More

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Extreme Lake-Effect Snow from a GPM Microwave Imager Perspective: Observational Analysis and Precipitation Retrieval Evaluation.

J Atmos Ocean Technol 2021 Feb 12;38(2):293-311. Epub 2021 Feb 12.

National Aeronautics and Space Administration, Washington, D.C.

This study focuses on the ability of the Global Precipitation Measurement (GPM) passive microwave sensors to detect and provide quantitative precipitation estimates (QPE) for extreme lake-effect snowfall events over the U.S. lower Great Lakes region. Read More

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February 2021

The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation.

Nat Commun 2021 05 11;12(1):2683. Epub 2021 May 11.

CNRS, Université Clermont Auvergne, Inserm, Institut Génétique Reproduction et Développement (iGReD), Clermont-Ferrand, France.

In flowering plants, heterochromatin is demarcated by the histone variant H2A.W, elevated levels of the linker histone H1, and specific epigenetic modifications, such as high levels of DNA methylation at both CG and non-CG sites. How H2A. Read More

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Role of pre-transplant chest high-resolution computed tomography and serum galactomannan index in predicting post-transplant invasive pulmonary aspergillosis in allogeneic hematopoietic cell transplant recipients.

Transpl Infect Dis 2021 Aug 22;23(4):e13632. Epub 2021 May 22.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: The role of pre-HCT chest high-resolution computed tomography (HRCT) and serum galactomannan index (GMI) in predicting the post-allogeneic hematopoietic cell transplant (HCT) invasive pulmonary aspergillosis (IPA) is debatable.

Methods: This was a single-center, prospective study from 2014 to 2019. The primary objective was to study if pre-HCT chest HRCT and serum GMI predicted IPA post-HCT. Read More

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Real-world performance of the MiniMed™ 670G system in Europe.

Diabetes Obes Metab 2021 08 27;23(8):1942-1949. Epub 2021 May 27.

Medtronic International Trading Sàrl, Tolochenaz, Switzerland.

Aim: To evaluate the real-world performance of the MiniMed 670G system in Europe, in individuals with diabetes.

Materials And Methods: Data uploaded from October 2018 to July 2020 by individuals living in Europe were aggregated and retrospectively analysed. The mean glucose management indicator (GMI), percentage of time spent within (TIR), below (TBR) and above (TAR) glycaemic ranges, system use and insulin consumed in users with 10 or more days of sensor glucose data after initial Auto Mode start were determined. Read More

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Accurate prediction of HbA1c by continuous glucose monitoring using a kinetic model with patient-specific parameters for red blood cell lifespan and glucose uptake.

Diab Vasc Dis Res 2021 May-Jun;18(3):14791641211013734

Abbott Diabetes Care, Alameda, CA, USA.

Background: A recent kinetic model proposed a new individualized glycaemic marker, calculated HbA1c (cHbA1c), based on kinetic parameters and glucose levels that are specific to each person. The aims of the current work were to validate the accuracy of this glucose metric for clinical use and evaluate data requirements for the estimation of personal kinetic factors.

Methods: We retrieved HbA1c and glucose data from a group of 51 Japanese T1D patients under sensor-augmented pump (SAP) therapy. Read More

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Boosting the Tunable Microwave Scattering Signature of Sensing Array Platforms Consisting of Amorphous Ferromagnetic FeCoSiB Microwires and Its Amplification by Intercalating Cu Microwires.

Nanomaterials (Basel) 2021 Apr 4;11(4). Epub 2021 Apr 4.

Instituto de Magnetismo Aplicado, UCM-ADIF, 28230 Las Rozas, Spain.

The following work addresses new configurations of sensing array platforms that are composed of Co-based amorphous ferromagnetic microwires (MWs) to obtain an enhanced modulation of the microwave scattering effects through the application of low strength DC or AC magnetic fields. An amorphous MW is an ultrasoft ferromagnetic material (coercivity ~0.2 Oe) with a circumferential magnetic anisotropy that provides a high surface sensitivity when it is subjected to an external magnetic field. Read More

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Teleassistance for Patients With Type 1 Diabetes During the COVID-19 Pandemic: Results of a Pilot Study.

J Med Internet Res 2021 04 6;23(4):e24552. Epub 2021 Apr 6.

Department of Health Science, University Magna Graecia Catanzaro, Catanzaro, Italy.

Background: Telemedicine use in chronic disease management has markedly increased during health emergencies due to COVID-19. Diabetes and technologies supporting diabetes care, including glucose monitoring devices, software analyzing glucose data, and insulin delivering systems, would facilitate remote and structured disease management. Indeed, most of the currently available technologies to store and transfer web-based data to be shared with health care providers. Read More

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Multiscale porosity in a 3D printed gellan-gelatin composite for bone tissue engineering.

Biomed Mater 2021 04 16;16(3). Epub 2021 Apr 16.

Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

The aim of this work was to develop a complex-shaped gelatin-gellan composite scaffold with multiscale porosity using a combination of cryogenic 3D printing and lyophilization for bone tissue engineering. Cryogenic 3D printing was used to fabricate a low-concentration composite of complex-shaped macroporous gelatin-gellan structures with a pore size of 919 ± 89 µm. This was followed by lyophilization to introduce micropores of size 20-250 µm and nanometre-level surface functionalities, thus achieving a hierarchical porous structure. Read More

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Modifications in fMRI Representation of Mental Rotation Following a 6 Week Graded Motor Imagery Training in Chronic CRPS Patients.

J Pain 2021 Jun 6;22(6):680-691. Epub 2021 Jan 6.

Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Germany. Electronic address:

Complex regional pain syndrome (CRPS) is a neuropathic pain condition that is difficult to treat. For behavioral interventions, graded motor imagery (GMI) showed relevant effects, but underlying neural substrates in patient groups have not been investigated yet. A previous study investigating differences in the representation of a left/right hand judgment task demonstrated less recruitment of subcortical structures, such as the putamen, in CRPS patients than in healthy controls. Read More

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Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy.

J Transl Med 2021 01 6;19(1). Epub 2021 Jan 6.

Cancer Research Institute, Seoul National University, Seoul, Korea.

Background: Metastatic breast cancer (mBC) is a complex and life-threatening disease and although it is difficult to cure, patients can benefit from sequential anticancer treatment, including endocrine therapy, targeted therapy and cytotoxic chemotherapy. The patient-derived xenograft (PDX) model is suggested as a practical tool to predict the clinical outcome of this disease as well as to screen novel drugs. This study aimed to establish PDX models in Korean patients and analyze their genomic profiles and utility for translational research. Read More

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January 2021

Personal Glycation Factors and Calculated Hemoglobin A1c for Diabetes Management: Real-World Data from the Diabetes Prospective Follow-up (DPV) Registry.

Diabetes Technol Ther 2021 Jun 26;23(6):452-459. Epub 2021 May 26.

Clinical and Computational Research, Abbott Diabetes Care, Alameda, California, USA.

Glycated hemoglobin A1c (HbA1c) is a key biomarker in the glycemic management of individuals with diabetes, but the relationship with glucose levels can be variable. A recent kinetic model has described a calculated HbA1c (cHbA1c) that is individual specific. Our aim was to validate the routine clinical use of this glucose metric in younger individuals with diabetes under real-life settings. Read More

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Gene expression data support the hypothesis that Isoetes rootlets are true roots and not modified leaves.

Sci Rep 2020 12 9;10(1):21547. Epub 2020 Dec 9.

Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK.

Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are true roots, like roots in other lycopsids. Read More

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December 2020

Effect of water immersion restraint stress on gastric mucosa in rats with removed salivary glands.

Int J Clin Exp Pathol 2020 1;13(11):2853-2859. Epub 2020 Nov 1.

Department of General Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong Province, China.

Objective: To explore the effect of salivary gland removal on water immersion restraint stress (WIRS)-induced gastric mucosal injury (GMI) in rats.

Methods: Eighty male WISTAR rats were allocated into sham operation (sham) group, sham + WIRS group, salivary gland removal group, and salivary gland removal + WIRS group, with 20 rats in each group. In the sham group, skin and subcutaneous tissues were cut to expose glands. Read More

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November 2020

Glycemic Metrics Derived From Intermittently Scanned Continuous Glucose Monitoring.

J Diabetes Sci Technol 2020 Dec 3:1932296820975822. Epub 2020 Dec 3.

Department of Public Health, Section for Biostatistics, Aarhus University, Denmark.

Background: Glucose data from intermittently scanned continuous glucose monitoring (isCGM) is a combination of scanned and imported glucose values. The present knowledge of glycemic metrics originate mostly from glucose data from real-time CGM sampled every five minutes with a lack of information derived from isCGM.

Methods: Glucose data obtained with isCGM and hemoglobin A1c (HbA1c) were obtained from 169 patients with type 1 diabetes. Read More

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December 2020

Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis.

Cancers (Basel) 2020 Nov 4;12(11). Epub 2020 Nov 4.

Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Randomized controlled basket trials investigating drugs targeting a rare molecular alteration are challenging. Using patients as their own control overcomes some of these challenges. Growth modulation index (GMI) is the ratio of progression-free survival (PFS) on the current therapy to time to progression (TTP) on the last prior line of therapy; GMI ≥ 1. Read More

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November 2020

Liquid biopsy for invasive mold infections in hematopoietic cell transplant recipients with pneumonia through next-generation sequencing of microbial cell-free DNA in plasma.

Clin Infect Dis 2020 Oct 29. Epub 2020 Oct 29.

Fred Hutchinson Cancer Research Center, Seattle, WA.

Background: Non-invasive diagnostic options are limited for invasive mold infections (IMI). We evaluated the performance of a plasma microbial cell-free DNA sequencing (mcfDNA-Seq) test for diagnosing pulmonary IMI after hematopoietic cell transplant (HCT).

Methods: We retrospectively assessed the diagnostic performance of plasma mcfDNA-Seq NGS in 114 HCT recipients with pneumonia after HCT who had stored plasma obtained within 14 days of diagnosis of Proven/Probable Aspergillus IMI (n=51), Proven/Probable non-Aspergillus IMI (n=24), Possible IMI (n=20), and non-IMI controls (n=19). Read More

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October 2020

Evaluation of NASA's high-resolution global composition simulations: Understanding a pollution event in the Chesapeake Bay during the summer 2017 OWLETS campaign.

Atmos Environ (1994) 2020 Feb 16;222. Epub 2019 Nov 16.

Science Systems and Applications Inc. (SSAI), Lanham, MD, 20706, USA.

Recirculation of pollutants due to a bay breeze effect is a key meteorological mechanism impacting air quality near urban coastal areas, but regional and global chemical transport models have historically struggled to capture this phenomenon. We present a case study of a high ozone (O) episode observed over the Chesapeake Bay during the NASA Ozone Water-Land Environmental Transition Study (OWLETS) in summer 2017. OWLETS included a complementary suite of ground-based and airborne observations, with which we characterize the meteorological and chemical context of this event and develop a framework to evaluate model performance. Read More

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February 2020

Type 1 diabetes and COVID-19: The "lockdown effect".

Diabetes Res Clin Pract 2020 Dec 25;170:108468. Epub 2020 Sep 25.

Section of Metabolic Diseases & Diabetes, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy; Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address:

Aims: The aim of this study was to evaluate the effect the lockdown imposed during COVID-19 outbreak on the glycemic control of people with Type 1 diabetes (T1D) using Continuous (CGM) or Flash Glucose Monitoring (FGM).

Materials And Methods: We retrospectively analyzed glucose reading obtained by FGM or CGM in T1D subjects. Sensor data from 2 weeks before the lockdown (Period 0, P), 2 weeks immediately after the lockdown (period 1, P), in mid-lockdown (Period 2, P) and immediately after end of lockdown (Period 3, P) were analyzed. Read More

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December 2020

Comparing immunogenicity of the Escherichia coli-produced bivalent human papillomavirus vaccine in females of different ages.

Vaccine 2020 09 24;38(39):6096-6102. Epub 2020 Jul 24.

The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China.

Background: The safety and efficacy of a recently licensed Escherichia coli (E. coli)-produced bivalent HPV vaccine have been shown. Specific antibody levels are important indicators to evaluate the efficacy of vaccination. Read More

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September 2020

Function-Based Tractography of the Language Network Correlates with Aphasia in Patients with Language-Eloquent Glioblastoma.

Brain Sci 2020 Jul 1;10(7). Epub 2020 Jul 1.

Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany.

To date, the structural characteristics that distinguish language-involved from non-involved cortical areas are largely unclear. Particularly in patients suffering from language-eloquent brain tumors, reliable mapping of the cortico-subcortical language network is of high clinical importance to prepare and guide safe tumor resection. To investigate differences in structural characteristics between language-positive and language-negative areas, 20 patients (mean age: 63. Read More

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Caudate nuclei volume alterations and cognition and mood dysfunctions in adolescents with single ventricle heart disease.

J Neurosci Res 2020 10 12;98(10):1877-1888. Epub 2020 Jun 12.

Department of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.

Adolescents with single ventricle heart disease (SVHD) exhibit mood and cognitive deficits, which may result from injury to the basal ganglia structures, including the caudate nuclei. However, the integrity of the caudate in SVHD adolescents is unclear. Our aim was to examine the global and regional caudate volumes, and evaluate the relationships between caudate volumes and cognitive and mood scores in SVHD and healthy adolescents. Read More

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October 2020

The purchase of the Diabetic Healthy Food Basket in Cyprus results in cost savings: is it affordable among the low-income population?

Public Health Nutr 2020 12 29;23(18):3409-3416. Epub 2020 May 29.

School of Sciences, European University of Cyprus, 2404Nicosia, Cyprus.

Objective: The main objective was to assess the cost, acceptability and affordability of the Cypriot Diabetic Healthy Food Basket (DHFB).

Design: The development of DHFB was based on the Cypriot HFB with adjustments based on the nutritional guidelines for diabetes as developed by the American Diabetes Association (ADA) and information retrieved through the questionnaires. Two DHFB were constructed for adult women and adult men (±40 years) diagnosed with diabetes. Read More

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December 2020

The Relationship Between CGM-Derived Metrics, A1C, and Risk of Hypoglycemia in Older Adults With Type 1 Diabetes.

Diabetes Care 2020 10 27;43(10):2349-2354. Epub 2020 May 27.

Joslin Diabetes Center, Boston, MA.

Objective: Continuous glucose monitoring (CGM) is now commonly used in the management of type 1 diabetes (T1D). The CGM-derived coefficient of variation (CV) measures glucose variability, and the glucose management indicator (GMI) measures mean glycemia (previously called estimated A1C). However, their relationship with laboratory-measured A1C and the risk of hypoglycemia in older adults with T1D is not well studied. Read More

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October 2020

Effects of Clear-Sky Assimilation of GPM Microwave Imager on the Analysis and Forecast of Typhoon "Chan-Hom".

Sensors (Basel) 2020 May 8;20(9). Epub 2020 May 8.

Key Laboratory of Meteorological Disaster, Ministry of Education (KLME)/Joint International Research Laboratory of Climate and Environment Change (ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, China.

The module of assimilating a new GMI (GPM Microwave Imager) satellite detector was built in the framework of the Weather Research and Forecasting Model (WRF) and its three-dimensional variational (3DVar) data assimilation system (WRFDA). Typhoon "Chan-Hom" in the 2015 Pacific typhoon season was selected to verify the effectivity of the GMI clear-sky assimilation. The results show that, after assimilating the GMI radiance data, the background information in the model is modified positively when compared with the experiment without any assimilation and the one with assimilation of the conventional data. Read More

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A Combination of a Vibrational Electromagnetic Energy Harvester and a Giant Magnetoimpedance (GMI) Sensor.

Sensors (Basel) 2020 Mar 27;20(7). Epub 2020 Mar 27.

Departamento de Ciencias, Universidad Pública de Navarra, 31006 Pamplona, Spain.

An energy harvesting device combined with a giant magnetoimpedance (GMI) sensor is presented to analyze low frequency vibrating systems. An electromagnetic harvester based on magnetic levitation is proposed for the electric power generation. The device is composed of two fixed permanent magnets at both ends of a cylindrical frame, a levitating magnet acting as inertial mass and a pick-up coil to collect the induced electromotive force. Read More

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