117,076 results match your criteria compared described


Social and Educational Outcomes in Patients with Biliary Atresia: A Systematic Review.

J Pediatr Gastroenterol Nutr 2021 Sep 22. Epub 2021 Sep 22.

Paediatric Liver, GI and Nutrition Centre and Mowatlabs, Kings College Hospital, London, UK William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK University College London Medical School, University College London, London, UK Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.

Objectives: To systematically review the social outcomes of patients with biliary atresia (BA), including educational, employment and family outcomes.

Methods: We conducted a systematic review of Medline, EMBASE, Global Health, Maternity and Infant Care Database, supplemented by reference searching. NHLBI scoring was conducted for quality assessment. Read More

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September 2021

Bases for pesticide dose expression and adjustment in 3D crops and comparison of decision support systems.

Sci Total Environ 2021 Sep 16;806(Pt 1):150357. Epub 2021 Sep 16.

Research Group on AgroICT & Precision Agriculture, Department of Agricultural and Forest Engineering, University of Lleida - Agrotecnio CERCA Center, Rovira Roure 191, 25198 Lleida, Spain.

Authorities around the world have committed to limiting the use of chemical pesticides by reducing doses, among other strategies. Nevertheless, different dose expression models and decision support systems (DSSs) for dose adjustment coexist for high growing crops (3D crops). Among them, leaf wall area (LWA) and tree row volume (TRV) models have recently been proposed by the European and Mediterranean Plant Protection Organization (EPPO) for pre-registration trials. Read More

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September 2021

Toxic effects of cyanotoxins in teleost fish: A comprehensive review.

Aquat Toxicol 2021 Sep 17;240:105971. Epub 2021 Sep 17.

Integrative Biology Research Unit, Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, India. Electronic address:

The phenomenon of eutrophication leads to the global occurrence of algal blooms. Cyanotoxins as produced by many cyanobacterial species can lead to detrimental effects to the biome due to their stability and potential biomagnification along food webs. Therefore, understanding of the potential risks these toxins pose to the most susceptible organisms is an important prerequisite for ecological risks assessment of cyanobacteria blooms. Read More

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September 2021

The transcriptional characteristics of mast cells derived from skin tissue in type 2 diabetes patients at the single-cell level.

Acta Histochem 2021 Sep 21;123(7):151789. Epub 2021 Sep 21.

Wound Treatment Department, TCM-Integrated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China. Electronic address:

Objectives: The mechanisms underlying the role of mast cells in wound healing have not been thoroughly studied, and even fewer data are available on studies related to mast cells in the skin of patients with type 2 diabetes mellitus (T2DM). Therefore, this study aims to explore the transcriptional characteristics of mast cells at the single-cell level in patients with T2DM and provide experimental data for studying mast cell behaviors under abnormal glucose metabolism.

Methods: Two patients with T2DM and one trauma patient without diabetes were enrolled. Read More

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September 2021

Anterolateral proximal tibial opening wedge osteotomy for biplanar correction in genu valgum recurvatum using patient specific instrumentation (PSI). A technical note.

Knee 2021 Sep 21;33:58-64. Epub 2021 Sep 21.

Department of Orthopedic Surgery, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, the Netherlands.

Background: Biplanar anterolateral proximal tibial opening wedge osteotomy has been described as successful for patients with combined recurvatum and valgus alignment. As it is a correction in two planes, it is a technically demanding procedure. We report the use of a novel technique with patient specific instrumentation (PSI) guides for different steps, aiming to reduce the complexity of this procedure. Read More

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September 2021

Clinical Features in Russian Patients with COVID-Associated Parosmia/Phanthosmia.

Psychiatr Danub 2021 Sep;33(Suppl 9):130-136

Department of Neurology, Neurosurgery and Neurorehabilitation, Kirov State Medical University, 112 Karl Marx Street, Kirov 610027, Russia,

Background: Olfactory dysfunction is a typical symptom of COVID-19 infection. While COVID-associated anosmia is well-described, knowledge of parosmia (olfactory distortions) and phanthosmia (olfactory hallucinations) is relatively lacking. We undertook a clinical study of the parosmia/phanthosmia phenotype, aiming to support improved prediction and management of these symptoms. Read More

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September 2021

Long-Term Survival After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: A 16-Year Experience.

J Invasive Cardiol 2021 Sep 23. Epub 2021 Sep 23.

Division of Cardiology, Department of Medicine, Medical University of South Carolina, 114 Doughty Street, MSC 592, Charleston, SC 29464 USA.

Background: Alcohol septal ablation (ASA) is an accepted treatment for medically refractory hypertrophic obstructive cardiomyopathy (HOCM). The procedural and medium-term outcomes have been reassuring. The iatrogenic targeted septal infarction has raised theoretical concerns about risk of arrhythmia and long-term survival. Read More

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September 2021

Experimental nerve transfer model in the neonatal rat.

Neural Regen Res 2022 May;17(5):1088-1095

Christian Doppler Laboratory for the Restoration of Extremity Function; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Surgery; Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Vienna, Austria.

Clinically, peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth injuries. Most surgical concepts, however, have investigated nerve reconstructions in adult animal models. The immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of reliable experimental models. Read More

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Self-organised pattern formation increases local diversity in metacommunities.

Ecol Lett 2021 Sep 23. Epub 2021 Sep 23.

Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.

Self-organised formation of spatial patterns is known from a variety of different ecosystems, yet little is known about how these patterns affect the diversity of communities. Here, we use a food chain model in which autotroph diversity is described by a continuous distribution of a trait that affects both growth and defence against heterotrophs. On isolated patches, diversity is always lost over time due to stabilising selection, and the local communities settle on one of two alternative stable community states that are characterised by a dominance of either defended or undefended species. Read More

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September 2021

Pediatric obstructive sleep-disordered breathing is associated with arterial stiffness.

Eur J Pediatr 2021 Sep 23. Epub 2021 Sep 23.

Post-Graduate Program in Health Sciences, Faculdade Ciências Médicas de Minas Gerais - FCM-MG, MG, Belo Horizonte, Brazil.

The association between obstructive sleep-disordered breathing (oSDB) and arterial stiffness, an independent predictor of cardiovascular outcomes, is not well established in children. This study compared cardiovascular parameters between healthy and oSDB children and aimed to identify predictors of arterial stiffness indices in children with oSDB. Cross-sectional study realized in a tertiary hospital from June 2018 to January 2020. Read More

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September 2021

Association of Female Genital Schistosomiasis With the Cervicovaginal Microbiota and Sexually Transmitted Infections in Zambian Women.

Open Forum Infect Dis 2021 Sep 22;8(9):ofab438. Epub 2021 Aug 22.

Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.

Background: The cervicovaginal microbiota, including sexually transmitted infections (STIs), have not been well described in female genital schistosomiasis (FGS).

Methods: Women (aged 18-31, sexually active, nonpregnant) were invited to participate at the final follow-up of the HPTN 071 (PopART) Population Cohort in January-August 2018. We measured key species of the cervicovaginal microbiota (, , , , and ) and STIs (, , , and ) using quantitative PCR (qPCR). Read More

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September 2021

Evaluation of activity of ceftaroline on methicillin resistant blood isolates from Iran.

Iran J Microbiol 2021 Aug;13(4):442-448

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: Ceftaroline (CPT) is a novel cephalosporin with potent activity against methicillin-resistant (MRSA). Despite its recent introduction, CPT resistance in MRSA has been described worldwide. We aimed in the current study to evaluate the activity of CPT against 91 clinical MRSA and 3 MSSA isolates. Read More

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The Effects of Intensive Neurorehabilitation on Sequence Effect in Parkinson's Disease Patients With and Without Freezing of Gait.

Front Neurol 2021 7;12:723468. Epub 2021 Sep 7.

Movement Analysis Research Unit, IRCCS Mondino Foundation, Pavia, Italy.

The sequence effect (SE), defined as a reduction in amplitude of repetitive movements, is a common clinical feature of Parkinson's disease (PD) and is supposed to be a major contributor to freezing of gait (FOG). During walking, SE manifests as a step-by-step reduction in step length when approaching a turning point or gait destination, resulting in the so-called destination sequence effect (dSE). Previous studies explored the therapeutic effects of several strategies on SE, but none of them evaluated the role of an intensive rehabilitative program. Read More

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September 2021

Carbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions.

Onco Targets Ther 2021 16;14:4749-4760. Epub 2021 Sep 16.

Breast Center, Dokkyo Medical University Hospital, Tochigi, 321-0293, Japan.

Purpose: The study investigated the molecular mechanisms that killed pancreatic cancer cells, including cancer stem cells (CSCs), by carbon ion beam irradiation alone or in combination with miRNA-200c under in vitro and in vivo conditions.

Methods: Human pancreatic cancer (PC) cells, PANC1 and PK45, were treated with carbon-ion beam irradiation alone or in combination with microRNA-200c (miR-200c) mimic. Cell viability assay, colony and spheroid formation assay, quantitative real-time PCR analysis of apoptosis-, autophagy-, and angiogenesis-related gene expression, xenograft tumor control and histopathological analyses were performed. Read More

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September 2021

The complete genome of 2,6-dichlorobenzamide (BAM) degrader Aminobacter sp. MSH1 suggests a polyploid chromosome, phylogenetic reassignment, and functions of plasmids.

Sci Rep 2021 Sep 23;11(1):18943. Epub 2021 Sep 23.

Section for Microbiology and Biotechnology, Department of Plant and Environmental Sciences, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg, Copenhagen, Denmark.

Aminobacter sp. MSH1 (CIP 110285) can use the pesticide dichlobenil and its recalcitrant transformation product, 2,6-dichlorobenzamide (BAM), as sole source of carbon, nitrogen, and energy. The concentration of BAM in groundwater often exceeds the threshold limit for drinking water, requiring additional treatment in drinking water treatment plants or closure of the affected abstraction wells. Read More

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September 2021

Global and regional burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2019: results from the Global Burden of Disease study 2019.

Thorax 2021 Sep 23. Epub 2021 Sep 23.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China

Background: Interstitial lung disease (ILD) and pulmonary sarcoidosis are common respiratory diseases with a heterogeneous distribution worldwide. The global burden and temporal trends of ILD and sarcoidosis are rarely explored.

Methods: Using the classification 'ILD and pulmonary sarcoidosis' from the Global Burden of Disease 2019 dataset, we described the age-standardised rates of incidence, mortality, disability-adjusted life-years (DALYs), and their average annual percentage change from 1990 to 2019 by sex, Sociodemographic Index (SDI) and region. Read More

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September 2021

Reconstruction of the Thumb Metacarpophalangeal Ulnar Collateral Ligament With an Adductor Pollicis Slip: An Anatomic Evaluation.

J Hand Surg Am 2021 Sep 21. Epub 2021 Sep 21.

Indiana Hand to Shoulder Center, Indianapolis, IN.

Purpose: Reconstruction of the ulnar collateral ligament (UCL) of the thumb metacarpophalangeal joint is commonly performed for chronic injuries. This study evaluates the anatomic feasibility of using a part of the adductor pollicis tendon to reconstruct UCL.

Methods: Ten cadaveric arms were dissected to evaluate the relationship between the insertions of UCL and the adductor pollicis. Read More

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September 2021

A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging.

J Biomech 2021 Sep 13;129:110750. Epub 2021 Sep 13.

Program in Physical Therapy, Washington University School of Medicine in St. Louis, United States. Electronic address:

Diagnostic imaging modalities, like computed tomography (CT) and magnetic resonance imaging (MRI), can be used to assess in vivo muscle quality. Quantitative assessment using these techniques is time-intensive and costly due in part to extensive post-processing needs. The purpose of this study was to identify whether a subset of slices on CT and MRI would yield comparable results to the full number of slices for a measure of muscle quality (muscle deterioration ratio = fat volume/muscle volume) in the foot intrinsic muscles of people with diabetes and peripheral neuropathy. Read More

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September 2021

Histidine phosphorylation in metalloprotein binding sites.

J Inorg Biochem 2021 Sep 15;225:111606. Epub 2021 Sep 15.

Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, United States. Electronic address:

Post-translational modifications (PTMs) are invaluable regulatory tools for the control of catalytic functionality, protein-protein interactions, and signaling pathways. Historically, the study of phosphorylation as a PTM has been focused on serine, threonine, and tyrosine residues. In contrast, the significance of mammalian histidine phosphorylation remains largely unexplored. Read More

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September 2021

Protonation of the oxo-bridged heme/copper assemblies: Modeling the oxidized state of the cytochrome c oxidase active site.

J Inorg Biochem 2021 Aug 27;225:111593. Epub 2021 Aug 27.

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, USA. Electronic address:

In this study on model compounds for the resting oxidized state of the iron‑copper binuclear center in cytochrome c oxidase (CcO), we describe the synthesis of a new μ-oxo-heme/Cu complex, [(TPP)Fe-O-Cu(tmpa)][B(CF)] (2) {TPP: tetraphenyl porphyrinate(2-); TMPA: tris(2-pyridylmethylamine)}, as well as two protonation events for three μ-oxo-heme/Cu complexes with varying peripheral substituents on the heme site. The addition of increasing amounts of strong acid to these μ-oxo-heme/Cu systems successively led to the generation of the corresponding μ-hydroxo, μ-aquo, and the dissociated complexes. The heme/Cu assemblies bridged through a water ligand are reported here for the first time and the H NMR and F NMR spectral properties are consistent with antiferromagnetically coupled high-spin iron(III) and copper(II) centers. Read More

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Comparison of the predictive value of ten risk scores for outcomes of atrial fibrillation patients undergoing radiofrequency pulmonary vein isolation.

Int J Cardiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands. Electronic address:

Background: A significant number of patients experience recurrent atrial fibrillation (AF) after ablation. Various risk scores have been described that may predict outcomes after AF ablation. In this study, we aimed to compare ten previously described risk scores with regard to their predictive value for post-ablation AF recurrence and procedural complications. Read More

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September 2021

30-Year Trends in Graft Survival After Heart Transplant: Modeled Analyses of a Transplant Registry.

Ann Thorac Surg 2021 Sep 21. Epub 2021 Sep 21.

Rutgers Robert Wood Johnson Medical School, Department of Medicine, 125 Paterson St, New Brunswick, NJ; Robert Wood Johnson University Hospital, 1 Robert Wood Johnson Place, New Brunswick, NJ; Institute for Health, Health Care Policy and Aging Research, 112 Paterson St, New Brunswick, NJ. Electronic address:

Background: Heart failure is an epidemic in the United States, and transplantation remains the most definitive therapy. We describe multi-decade trends in post-transplant graft survival, adjusted for concurrent changes in the population, over the 30 years antecedent to the most recent heart allocation policy change.

Methods: Scientific Registry of Transplant Recipients data were used to identify all primary adult heart recipients 1989 through 2017. Read More

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September 2021

Effect of food source availability in the salivary gland transcriptome of the unique burying beetle Nicrophorus pustulatus (Coleoptera: Silphidae).

PLoS One 2021 23;16(9):e0255660. Epub 2021 Sep 23.

Department of Animal and Food Science, Oklahoma State University, Stillwater, Oklahoma, United States of America.

Nicrophorus is a genus of beetles that bury and transform small vertebrate carcasses into a brood ball coated with their oral and anal secretions to prevent decay and that will serve as a food source for their young. Nicrophorus pustulatus is an unusual species with the ability to overtake brood of other burying beetles and whose secretions, unlike other Nicrophorus species, has been reported not to exhibit antimicrobial properties. This work aims to better understand how the presence or absence of a food source influences the expression of genes involved in the feeding process of N. Read More

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September 2021

Investigation of the short-term effects of a transdermal formulation of atenolol in healthy cats.

Am J Vet Res 2021 Oct;82(10):811-817

Objective: To investigate associations between short-term treatment with a previously described compounded transdermal formulation of atenolol and heart rate in cats.

Animals: 11 healthy adult cats.

Procedures: Cats received the atenolol gel formulation (gradually increased from 12. Read More

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October 2021

Utilization and Expenditures of Vertebral Augmentation Continue to Decline: An Analysis in Fee-For-Service (FFS) Recipients from 2009 to 2018.

Pain Physician 2021 Sep;24(6):401-415

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background: Despite the high prevalence of vertebral compression fractures (VCFs) associated with refractory pain, deformity, or progressive neurological symptoms, minimally invasive vertebral augmentation procedures, including vertebroplasty and kyphoplasty, have been declining in their relative utilization, along with expenditures.

Objectives: This investigation was undertaken to assess utilization and expenditures for vertebral augmentation procedures, including vertebroplasty and kyphoplasty, in the fee-for-service (FFS) Medicare population from 2009 to 2018.

Study Design: The present study was designed to assess utilization and expenditures in all settings, for all providers in the FFS Medicare population from 2009 to 2018 in the United States. Read More

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September 2021

Differences in the sperm metabolomes of smoking and nonsmoking men.

Biol Reprod 2021 Sep 23. Epub 2021 Sep 23.

Training Center of the European Academy of Andrology (EAA), Dermatology, Venerology and Allergology Clinic, University Hospital Leipzig, Leipzig, Germany.

Currently, spermiogram analysis is the most relevant method used to clarify the potential infertility of a couple. However, in some cases, the reasons for infertility remain obscure. Smoking is among the factors that have been described to adversely affect male fertility. Read More

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September 2021

Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer.

JAMA Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Human Oncology, University of Wisconsin, Madison.

Importance: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.

Objectives: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate differences in survival, particularly after treatment with androgen-signaling inhibitors (ASIs). Read More

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September 2021

Clinical comparison of tear film breakup time measurements in normal dogs using three different methods of fluorescein solution administration.

Vet Ophthalmol 2021 Sep 23. Epub 2021 Sep 23.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.

Objective: To evaluate whether the method of fluorescein administration affects the results of tear film breakup time (TFBUT) measurement in normal dogs.

Animals Studied: Thirty-seven client and hospital staff owned dogs over 1 year of age with no known comorbidities or administration of systemic or topical ophthalmic medications.

Procedures: A prospective randomized three-way crossover study was conducted. Read More

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September 2021

Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study.

Brain 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurology, St. Elisabeth-TweeSteden Hospital, 5022 GC, Tilburg, The Netherlands.

In the wake of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number of patients with neurological disorders, including Guillain-Barré syndrome (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports or small regional retrospective cohort studies. The International GBS Outcome Study is an ongoing prospective observational cohort study enrolling patients with GBS within 2 weeks from onset of weakness. Read More

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September 2021

Comparison of Design Approaches for Low-Cost Sampling Mechanisms in Open-Source Chemical Instrumentation.

HardwareX 2021 Oct 10;10. Epub 2021 Aug 10.

Department of Chemistry & Biochemistry, Rowan University, Glassboro, NJ.

Robotic positioning systems are used in a variety of chemical instruments, primarily for liquid handling purposes, such as autosamplers from vials or well plates. Here, two approaches to the design of open-source autosampler positioning systems for use with 96-well plates are described and compared. The first system, a 3-axis design similar to many low-cost 3D printers that are available on the market, is constructed using an aluminum design and stepper motors. Read More

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October 2021