3,403 results match your criteria compared crs

Increased Detection of Mycobacterium tuberculosis Disease Using a Tissue-Based Laboratory-Developed Polymerase Chain Reaction Assay Compared to Standard Diagnostics.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut.

Standard diagnostics for Mycobacterium tuberculosis (MTB) including acid-fast bacilli (AFB) smear and culture, and Xpert™ MTB/RIF real-time Polymerase Chain Reaction (RT-PCR; Xpert) have variable sensitivity and/or long turnaround times. We describe the clinical performance of a laboratory-developed tissue-based MTB PCR compared with AFB culture and Xpert using a composite reference standard (CRS). Over an 8-year period, MTB PCR was performed on pulmonary, pleural, or lymph node specimens for 36 patients. Read More

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September 2021

Reproductive performance of indigenous Lao pigs reared by small-scale farmers in northern provinces of Laos.

Arch Anim Breed 2021 9;64(2):365-373. Epub 2021 Sep 9.

Doctoral School of Animal Husbandry, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.

Indigenous pigs are essential domestic animals for rural life and meat supply in Laos, especially for ethnic people in remote areas. Northern provinces have the most numerous indigenous pig populations, i.e. Read More

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September 2021

Long-acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study.

Int Forum Allergy Rhinol 2021 Sep 17. Epub 2021 Sep 17.

Lyra Therapeutics, Inc, Watertown, MA.

Background: Topical steroids are first-line treatment for chronic rhinosinusitis (CRS), but fail to provide adequate symptom control for all patients. Designed for medical treatment failures, LYR-210 is an implantable matrix that locally elutes mometasone furoate to inflamed sinonasal tissue for up to 24 weeks in CRS patients. In an open-label phase 1 study, LYR-210 demonstrated clinically relevant improvement in the 22-item Sino-Nasal Outcome Test (SNOT-22). Read More

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September 2021

Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis.

Front Immunol 2021 31;12:733019. Epub 2021 Aug 31.

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

The mechanisms that lead to disease onset and propagation in patients with chronic rhinosinusitis (CRS) are not fully elucidated. Maresins (MaR) are a family of essential fatty acid-derived lipid mediators that play a central role in the regulation of inflammation with several studies demonstrating that these mediators display protective activities in airway inflammation. Therefore, in the present studies we evaluated whether concentrations of these mediators were altered in both peripheral blood and nasal secretions from CRS patients. Read More

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Update on Minimalist Running Shoes.

J Spec Oper Med 2021 ;21(3):107-110

This article provides updated information comparing minimalist running shoes (MRS) to conventional running shoes (CRS). Our previous review found that, compared with running in CRS, transitioning to MRS resulted in lower energy cost and less ground contact occurring at the forefoot, resulting in lower impact forces. There was some increased risk of injury with MRS, although data were conflicting. Read More

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September 2021

Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.

FASEB J 2021 Oct;35(10):e21907

Department of Cardiovascular Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.

This study investigated the effect of apela on renal function and anti-inflammatory effect on whole body and kidney tissue in mice with type I cardiorenal syndrome (CRS). The murine type I CRS model was established and apela was subcutaneously infused for two weeks. Cardiac and renal functions were evaluated by echocardiography and blood biochemistry, respectively. Read More

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October 2021

Association of Quality of Life Measures and Otolaryngologic Care in Cystic Fibrosis Patients.

Ann Otol Rhinol Laryngol 2021 Sep 11:34894211045636. Epub 2021 Sep 11.

Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Objectives: Appropriate management of chronic rhinosinusitis (CRS) among patients with cystic fibrosis (CF) is important in improving quality of life. Otolaryngologists play a critical role in reducing CRS symptom burden. This study seeks to evaluate the role of patient-reported quality-of-life measures in guiding interventions for CF-related sinus disease. Read More

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September 2021

Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.

PLoS One 2021 10;16(9):e0257220. Epub 2021 Sep 10.

Department of Thoracic Surgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Zhejiang Chinese Medicine and Western Medicine Integrated Hospital, Hangzhou, Zhejiang, China.

Objective: The purpose of this study was to evaluate the diagnostic efficacy of Xpert MTB/RIF for tuberculous pericarditis (TBP).

Methods: We searched relevant databases for Xpert MTB/RIF for TBP diagnosis until April 2021 and screened eligible studies for study inclusion. We evaluated the effectiveness of Xpert MTB/RIF when the composite reference standard (CRS) and mycobacterial culture were the gold standards, respectively. Read More

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September 2021

Prognosis of poorly cohesive gastric cancer after complete cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (CYTO-CHIP study).

Br J Surg 2021 Sep 9. Epub 2021 Sep 9.

Department of Surgical Oncology, CHU Lyon Sud, Hospices Civils de Lyon, Lyon, France.

Background: The incidence of gastric poorly cohesive carcinoma (PCC) is increasing. The prognosis for patients with peritoneal metastases remains poor and the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is controversial. The aim was to clarify the impact of gastric PCC with peritoneal metastases treated by CRS with or without HIPEC. Read More

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September 2021

Rational design and evaluation of the recombinant multiepitope protein for serodiagnosis of rubella.

Curr Pharm Biotechnol 2021 Sep 7. Epub 2021 Sep 7.

Laboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-Rei, campus Centro-Oeste Dona Lindu, 35501-296, Divinópolis, MG. Brazil.

Background: Rubella is an infection caused by rubella virus (RV) and is generally regarded as a mild childhood disease. The disease continues to be of public health importance mainly because when the infection is acquired during early pregnancy it often results in fetal abnormalities, which are classified as congenital rubella syndrome (CRS). An accurate diagnosis for rubella is thus of pivotal importance for proper treatment. Read More

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September 2021

Effect of Xinyi Biyan Pill in Adjuvant Treatment of Patients with Chronic Rhinosinusitis and Its Influence on Serum Inflammatory Factors and Immune Function.

Evid Based Complement Alternat Med 2021 27;2021:2228803. Epub 2021 Aug 27.

Department of ENT & HN Surgery, Shao Yifu Hospital Affiliated to Medical College of Zhejiang University, Hangzhou, Zhejiang 310000, China.

Objective: To explore the effect of Xinyi Biyan Pill in adjuvant treatment of patients with chronic rhinosinusitis (CRS) and its influence on serum inflammatory factors and immune function.

Methods: From January 2017 to April 2020, 112 CRS patients admitted to this hospital were randomly divided into the control group ( = 52) and the study group ( = 60). The control group was treated with endoscopic sinus surgery (ESS), after the operation, levofloxacin capsules were taken orally, budesonide nasal spray was given, and the nasal cavity was flushed with normal saline; on the basis of that mentioned above, the study group was treated with Xinyi Biyan Pill orally after the surgery. Read More

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Peripheral inflammatory markers in patients with prolonged disorder of consciousness after severe traumatic brain injury.

Ann Palliat Med 2021 Aug;10(8):9114-9121

Department of Rehabilitation Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Inflammatory processes are known to be the key secondary effects of severe traumatic brain injury (sTBI). The aim of the present study was to assess the value of peripheral inflammatory markers in the chronic unconscious phase after sTBI.

Methods: This was a prospective cohort study. Read More

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Interaction Between Serum/Glucocorticoid-Regulated Kinase 1 and Interleukin-6 in Chronic Rhinosinusitis.

Allergy Asthma Immunol Res 2021 Sep;13(5):776-790

Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital, Fudan University, Shanghai, China.

Purpose: Serum/glucocorticoid-regulated kinase 1 (SGK1) has recently emerged as a critical regulator of inflammatory diseases. In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS).

Methods: Immunohistochemistry, western blotting, Bio-Plex assay, enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction were performed to assess protein and gene expression levels. Read More

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September 2021

TP-CNN: A Detection Method for atrial fibrillation based on transposed projection signals with compressed sensed ECG.

Comput Methods Programs Biomed 2021 Aug 26;210:106358. Epub 2021 Aug 26.

Cooperative Innovation Center of Internet Healthcare, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address:

Background And Objective: Atrial fibrillation (AF) is the most prevalent arrhythmia, which increases the mortality of several complications. The use of wearable devices to detect atrial fibrillation is currently attracting a great deal of attention. Patients use wearable devices to continuously collect individual ECG signals and transmit them to the cloud for diagnosis. Read More

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Prevalence and risk of residual viremia after ART in low- and middle-income countries: A cross-sectional study.

Medicine (Baltimore) 2021 Sep;100(35):e26817

Chulalongkorn University, Bangkok, Thailand.

Abstract: In order to design effective strategies to eradicate the HIV, an understanding of persistent viral reservoirs is needed. Many studies have demonstrated HIV residual viremia prevalence in high income countries, data from low- and middle-income countries (LMIC) are limited. We assessed the prevalence, and factors associated with residual viremia in people with HIV (PWH), who were virally-suppressed on antiretroviral therapy (ART) in LMIC. Read More

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September 2021

Investigating the association between allergic diseases and COVID-19 in 400 Iranian patients.

Allergol Immunopathol (Madr) 2021 1;49(5):9-15. Epub 2021 Sep 1.

Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran;

Introduction: Allergic diseases could play a role of a predisposing factor for coronavirus disease 2019 (COVID-19). The aim of this study was to investigate allergic comorbidity and its association in COVID-19 patients.

Methods: Demographic data, clinical manifestations, laboratory reports, and radiologic findings, together with underlying comorbidity of patients, were studies. Read More

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September 2021

Predicting Olfactory Loss In Chronic Rhinosinusitis Using Machine Learning.

Chem Senses 2021 Sep 2. Epub 2021 Sep 2.

Department of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, OR.

Objective: Compare machine learning (ML) based predictive analytics methods to traditional logistic regression in classification of olfactory dysfunction in chronic rhinosinusitis (CRS-OD), and identify predictors within a large multi-institutional cohort of refractory CRS patients.

Methods: Adult CRS patients enrolled in a prospective, multi-institutional, observational cohort study were assessed for baseline CRS-OD using a smell identification test (SIT) or brief SIT (bSIT). Four different ML methods were compared to traditional logistic regression for classification of CRS normosmics versus CRS-OD. Read More

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September 2021

Pharmacokinetics, Safety, and Tolerability of the α -Adrenoreceptor Antagonist BAY 1193397 in Healthy Male Subjects.

Clin Pharmacol Drug Dev 2021 Aug 31. Epub 2021 Aug 31.

Clinical Experimentation Cardiovascular, BAYER AG, Wuppertal, Germany.

The α -adrenoreceptor antagonist BAY 1193397 is in development for the oral treatment of diabetic foot ulcers. Safety, tolerability, and pharmacokinetics of BAY 1193397 were investigated in 3 randomized, single-center phase 1 studies in healthy male subjects: a first-in-human study (single oral doses of 0.5-50 mg), a relative bioavailability and food effect study (single doses of 1 and 10 mg), and a multiple-dose escalation study (using 2 and 5 mg twice daily and 10 and 20 mg once daily for 9 consecutive days). Read More

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Critical parameters for accurate monitoring of caffeine penetration in porcine skin using confocal Raman spectroscopy.

Int J Pharm 2021 Sep 28;607:121055. Epub 2021 Aug 28.

Department of Pharmaceutical Technology, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany. Electronic address:

In this research, we addressed a challenge while measuring the penetration performance of caffeine (CAF) using confocal Raman spectroscopy (CRS). Normally in the process of CRS analysis, skin sample was moved from an incubation setup to a specified CRS-measuring sample holder. Accurate data collection may be questioned due to the variation of the environment the skin placed in. Read More

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September 2021

[Analysis of local reactions and efficacy of CD19 chimeric antigen receptor-modified T cells therapy in recurrent/refractory B-cell lymphoma with >7.5 cm lesions].

Zhonghua Xue Ye Xue Za Zhi 2021 Jul;42(7):570-576

Department of Hematology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.

To observe the local reactions and efficacy of CD19 CAR-T therapy in recurrence/refractory B-cell non-Hodgkin's lymphoma (R/R NHL) patients with >7.5 cm lesions. 32 R/R NHL patients with >7. Read More

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Incidence, Risk Factors, and Outcomes from Conversion of Low-Grade to High-Grade Appendiceal Neoplasms for Patients Undergoing Multiple Cytoreductive Surgeries with Hyperthermic Intraperitoneal Chemotherapy.

Ann Surg Oncol 2021 Aug 28. Epub 2021 Aug 28.

Division of Surgical Oncology, Wake Forest Baptist Health Medical Center, Winston-Salem, NC, USA.

Introduction: Conversion from low-grade to high-grade disease is known to occur following repeat cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC); however, the incidence rate, risk factors, and outcomes have not been studied.

Methods: We conducted a retrospective review of multiple CRS/HIPEC cases for patients originally diagnosed with low-grade appendiceal neoplasms, and compared converted cases with non-converters. Primary outcomes were the incidence rate and risk factors for conversion, while secondary outcomes were effect on cytoreduction, overall survival (OS), and disease-free survival (DFS). Read More

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Misdiagnosis of appendiceal neoplasms as ovarian tumors: Impact of prior gynecologic surgery on definitive cytoreduction and HIPEC.

Eur J Surg Oncol 2021 Aug 24. Epub 2021 Aug 24.

Colon and Rectal Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital, NY, 10021, USA. Electronic address:

Background: Female patients with pelvic/adnexal masses often undergo gynecologic operations due to presumed ovarian origin. The diagnosis of an appendiceal tumor is often only made postoperatively after suboptimal cytoreduction has been performed. We hypothesized that an index gynecological procedure increases the morbidity of definitive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) in patients with appendiceal mucinous tumors. Read More

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In vitro evaluation of a novel oxygen-generating biomaterial for chronic rhinosinusitis therapy.

Int Forum Allergy Rhinol 2021 Aug 26. Epub 2021 Aug 26.

Department of Otolaryngology-Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Hypoxia due to closure at the ostiomeatal complex is widely considered one of the major pathogenic mechanisms leading to chronic inflammation in chronic rhinosinusitis (CRS). The objective of this study was to develop and characterize an oxygen-generating biomaterial (OGB) as an innovative treatment strategy for CRS.

Methods: An OGB was fabricated by coating hydrophobic beeswax (BW, 15mg or 30mg) on the surface of calcium peroxide - catalase complex (CPO-CA, 30mg) and characterized using scanning electron microscopy (SEM). Read More

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The CellBox-2 Mission to the International Space Station: Thyroid Cancer Cells in Space.

Int J Mol Sci 2021 Aug 16;22(16). Epub 2021 Aug 16.

Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.

A spaceflight to the International Space Station (ISS) is a dream of many researchers. We had the chance to investigate the effect of real microgravity (CellBox-2 Space mission) on the transcriptome and proteome of FTC-133 human follicular thyroid cancer cells (TCC). The cells had been sent to the ISS by a Falcon 9 rocket of SpaceX CRS-13 from Cape Canaveral (United States) and cultured in six automated hardware units on the ISS before they were fixed and returned to Earth. Read More

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Tuning enzymatic properties by protein engineering toward catalytic tetrad of carbonyl reductase.

Biotechnol Bioeng 2021 Aug 26. Epub 2021 Aug 26.

Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.

Enzyme engineering toward catalytic-tetrad residues usually results in activity loss. Unexpectedly, we found that a directed evolution campaign yielded a beneficial residue A100 in KmCR (a carbonyl reductase from Kluyveromyces marxianus ZJB14056), which is a residue of catalytic tetrad and conserved according to multiple sequence alignment. Inspired by this finding, we performed saturation mutagenesis on all the four residues of catalytic tetrad of KmCR. Read More

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Impact of Insurance Status on Oncologic and Perioperative Outcomes After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy.

Ann Surg Oncol 2021 Aug 25. Epub 2021 Aug 25.

Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: A growing body of research has shown that underinsured patients are at increased risk of worse health outcomes compared with insured patients. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is largely performed at highly specialized cancer centers and may pose challenges for the underinsured. This study investigates surgical outcomes following CRS-HIPEC for insured and underinsured patients with peritoneal carcinomatosis. Read More

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Deep Learning-Based Algorithm for the Detection and Characterization of MRI Safety of Cardiac Implantable Electronic Devices on Chest Radiographs.

Korean J Radiol 2021 Aug 19. Epub 2021 Aug 19.

Department of Radiology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Objective: With the recent development of various MRI-conditional cardiac implantable electronic devices (CIEDs), the accurate identification and characterization of CIEDs have become critical when performing MRI in patients with CIEDs. We aimed to develop and evaluate a deep learning-based algorithm (DLA) that performs the detection and characterization of parameters, including MRI safety, of CIEDs on chest radiograph (CR) in a single step and compare its performance with other related algorithms that were recently developed.

Materials And Methods: We developed a DLA (X-ray CIED identification [XCID]) using 9912 CRs of 958 patients with 968 CIEDs comprising 26 model groups from 4 manufacturers obtained between 2014 and 2019 from one hospital. Read More

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Optimal level of positive end-expiratory pressure during nasal continuous airway pressure for severe bronchiolitis: a prospective study.

Transl Pediatr 2021 Jul;10(7):1843-1850

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Background: Nasal continuous positive airway pressure (nCPAP) has been increasingly applied in the pediatric setting. However, there is no uniform standard for setting and titrating positive end-expiratory pressure (PEEP) level, which is paramount to the effectiveness of the treatment. This study aimed to investigate the optimal parameters for nCPAP in the treatment of severe bronchiolitis based on clinical efficacy and pulmonary function parameters. Read More

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COVID-19 vaccine strategies for Aotearoa New Zealand: a mathematical modelling study.

Lancet Reg Health West Pac 2021 Oct 19;15:100256. Epub 2021 Aug 19.

School of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.

COVID-19 elimination measures, including border closures have been applied in New Zealand. We have modelled the potential effect of vaccination programmes for opening borders. We used a deterministic age-stratified Susceptible, Exposed, Infectious, Recovered (SEIR) model. Read More

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October 2021

Nonmyeloablative, HLA-Mismatched Unrelated Peripheral Blood Transplantation with High-Dose Post-Transplantation Cyclophosphamide.

Transplant Cell Ther 2021 Aug 20. Epub 2021 Aug 20.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital University School of Medicine, Baltimore, Maryland. Electronic address:

High-dose post-transplantation cyclophosphamide (PTCy) is an effective platform for prevention of severe graft-versus-host disease (GVHD) after allogeneic bone marrow (BM) transplantation with mismatched unrelated donors (mMUDs). Previous studies evaluating PTCy with mMUDs favored BM allografts over peripheral blood stem cell transplantation (PBSCT) due to concerns that PBSCT may be associated with an increased risk of acute and chronic GVHD. In addition, haploidentical PBSCT is associated with high rates of cytokine release syndrome (CRS), which is another concern with mMUD PBSCT. Read More

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