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The contribution of deleterious rare alleles in ENPP1 and osteomalacia causative genes to atypical femoral fracture.

J Clin Endocrinol Metab 2022 Jan 17. Epub 2022 Jan 17.

Department of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1Takeoka, Kiyose, 204-8585 Japan.

Background: Atypical femoral fractures (AFFs) are very rare atraumatic or mild-trauma fractures in the subtrochanteric region or femoral shaft. Some unique genetic variants in Asian populations might confer susceptibility to AFF, since the incident of AFFs is higher in Asian. Because rare variants have been found to be causative in some diseases and the roles of osteomalacia causative genes were not reported, we investigated rare variants in genes causing abnormal mineralization. Read More

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January 2022

Susceptibility-Weighted MRI and Microbleeds in Mild Traumatic Brain Injury: Prediction of Posttraumatic Complaints?

Eur Neurol 2022 Jan 17:1-9. Epub 2022 Jan 17.

Department of Neurology, Medical Spectrum Twente, Hospital Enschede, Enschede, The Netherlands.

Background: Only in 7-15% of patients with mild traumatic brain injury (mTBI), traumatic CT-abnormalities are found. Nevertheless, 40% of mTBI patients suffer from posttraumatic complaints not resolving after 6 months. We discuss the ability of susceptibility-weighted imaging (SWI), sensitive for microbleeds, to detect more subtle brain abnormalities. Read More

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January 2022

Clinical characteristics, cytokine profiles and plasma IgE in adults with asthma.

Mol Immunol 2022 Jan 14;143:50-57. Epub 2022 Jan 14.

Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Asthma is a disease with complicated network of inflammatory responses of cytokines and ImmunoglobulinE (IgE). The aim of this study was to explore the clinical characteristics, cytokine profile and plasma IgE in the Malaysian population. This is a cross-sectional study involving physician-diagnosed asthma patients (n = 287) recruited from the Chest Clinic, University of Malaya Medical Centre (UMMC). Read More

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January 2022

Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2.

Pharmacol Biochem Behav 2022 Jan 14:173338. Epub 2022 Jan 14.

Department of Pharmaceutical Sciences, School of Pharmacy, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, United States.

Nicotine-induced rewarding and mood altering effects contribute to the continued use of nicotine and the subsequent development of nicotine dependence. The goal of this study was to assess the role of two specific regulators of G-protein signaling (RGS) proteins namely RGS2 and RGS4 in the above described effects of nicotine. Male and female mice lacking either RGS2 (RGS2 KO) or RGS4 (RGS4 KO), and their respective wildtype (WT) littermates were used in this study. Read More

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January 2022

Original ArticleThe Weiss ring, a major confounding factor for measurements of peripapillary retinal nerve fiber layer thickness: The impact of the Weiss ring on RNFL thickness measurements.

Am J Ophthalmol 2022 Jan 13. Epub 2022 Jan 13.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea. Electronic address:

Purpose: To identify how the Weiss ring affects the measurement of mean and sectoral peripapillary retinal nerve fiber layer (pRNFL) thicknesses.

Design: Retrospective cross-sectional study.

Methods: Subjects were divided into two groups: controls (control group) and subjects in which a Weiss ring was visible on optical coherence tomography fundus images (WR group). Read More

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January 2022

Pragmatic Trial of Personalized Music for Agitation and Antipsychotic Use in Nursing Home Residents With Dementia.

J Am Med Dir Assoc 2022 Jan 14. Epub 2022 Jan 14.

Center for Gerontology & Healthcare Research, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA; Center for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA; US Department of Veterans Affairs Medical Center, Providence, RI, USA.

Objective: To test the effect of a personalized music intervention on agitated behaviors and medication use among long-stay nursing home residents with dementia.

Design: Pragmatic, cluster-randomized controlled trial of a personalized music intervention. Staff in intervention facilities identified residents' early music preferences and offered music at early signs of agitation or when disruptive behaviors typically occur. Read More

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January 2022

Sonography in male infertility: a useful yet underutilized diagnostic tool.

J Ultrasound 2022 Jan 17. Epub 2022 Jan 17.

Department of Radio-Diagnosis, University College of Medical Sciences and GTB Hospital, New Delhi, India.

Purpose: To assess the utility of comprehensive sonographic examination including scrotal sonography, Testicular Doppler and Transrectal Ultrasound (TRUS) to evaluate the male reproductive system and differentiate between obstructive (OG) and non-obstructive (NOG) causes of azoospermia.

Methods: 30 infertile men with azoospermia and 30 control subjects with normospermia underwent sonographic evaluation. FNAC/biopsy findings were used for assigning a final diagnosis of obstructive or non-obstructive azoospermia. Read More

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January 2022

Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile.

Cell Mol Neurobiol 2022 Jan 17. Epub 2022 Jan 17.

Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong, 510515, People's Republic of China.

Amyotrophic lateral sclerosis, a fatal neurodegeneration disease affecting motor neurons in the brain and spinal cord, is difficult to diagnose and treat. The objective of this study is to identify novel candidate genes related to ALS. Transcriptome-wide association study of ALS was conducted by integrating the genome-wide association study summary data (including 1234 ALS patients and 2850 controls) and pre-computed gene expression weights of different tissues. Read More

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January 2022

Risk and Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Corneal Transplantation: A Case-Control Study.

Cornea 2022 Feb;41(2):224-231

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; and.

Purpose: The purpose of this study was to evaluate the risk of symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after corneal transplantation surgery, with cataract surgeries as controls, and the impact of the novel coronavirus disease pandemic in the clinical and surgical complications of corneal transplantation and cataract surgeries.

Methods: A retrospective matched case-control study of 480 consecutive individuals who underwent surgery at the Bascom Palmer Eye Institute between May 2020 and November 2020. A total of 240 patients who underwent corneal transplantation with tissue obtained from the Florida Lions Eye Bank were age, race, ethnicity, and sex matched with 240 patients who underwent cataract surgery during the same day and by the same surgical team. Read More

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February 2022

Impact of Acanthamoeba Keratitis on the Vision-Related Quality of Life of Contact Lens Wearers.

Cornea 2022 Feb;41(2):206-210

School of Optometry and Vision Science, Kensington UNSW, Sydney, Australia.

Purpose: The aim of this study was to determine the impact of Acanthamoeba keratitis (AK) caused by contact lens (CL) use on vision-related quality of life (VRQOL) and the sociodemographic factors and disease outcome associated with VRQOL.

Methods: Sixty-one CL-associated AK cases and 59 asymptomatic CL wearers (mean age ±SD 39.4 ± 16. Read More

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February 2022

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma.

Neoplasma 2022 Jan 18. Epub 2022 Jan 18.

Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Growing evidences have revealed that exosomal miRNAs, lncRNAs, and circRNAs play a pleiotropic role in tumor biology. Cell-cell communication mediated by exosomes has been considered to be a key factor in the malignant progression of colorectal cancer. However, the importance of exosome-derived circRNAs in the biological function and clinical significance of colorectal adenoma remains elusive. Read More

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January 2022

Altered Cholinergic Innervation in De Novo Parkinson's Disease with and without Cognitive Impairment.

Mov Disord 2022 Jan 17. Epub 2022 Jan 17.

Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Altered cholinergic innervation plays a putative role in cognitive impairment in Parkinson's disease (PD) at least in advanced stages. Identification of the relationship between cognitive impairment and cholinergic innervation early in the disease will provide better insight into disease prognosis and possible early intervention.

Objective: The aim was to assess regional cholinergic innervation status in de novo patients with PD, with and without cognitive impairment. Read More

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January 2022

BCG and BCGΔBCG1419c transiently protect hypersusceptible I/St mice and induce different influx of macrophages and neutrophils during pulmonary tuberculosis.

J Med Microbiol 2022 Jan;71(1)

Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C., Guadalajara, Jalisco, Mexico.

Host genetic factors influence both susceptibility to infection and immune responses generated by vaccination. Genetically susceptible mice help to study mechanisms of immune protection which may differ from those operating in more resistant models. In this work, we compared the efficacy of protection conferred by subcutaneous vaccination of hypersusceptible I/St mice with BCG and the first-generation, hygromycin resistant version of the vaccine candidate BCGΔBCG1419c, against tuberculosis (TB), measured as survival, weight loss and replication in lungs. Read More

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January 2022

Cavovarus With a Twist: Midfoot Coronal and Axial Plane Rotational Deformity in Charcot-Marie-Tooth Disease.

Foot Ankle Int 2022 Jan 15:10711007211064600. Epub 2022 Jan 15.

Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background: The cavovarus deformity of Charcot-Marie-Tooth (CMT) disease is often characterized by a paradoxical relationship of hindfoot varus and forefoot valgus. The configuration of the midfoot, which links these deformities, is poorly understood. Accurate assessment of 3-dimensional alignment under physiologic loadbearing conditions is possible using weightbearing computed tomography (WBCT). Read More

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January 2022

Effects of curved path walking compared to straight path walking in older adults with cognitive deficits: A systematic review and network meta-analysis.

Physiother Res Int 2022 Jan 17:e1935. Epub 2022 Jan 17.

Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas, USA.

Objective: To determine whether the existing literature provides evidence that curved path walking time can be a reliable marker of cognitive impairment among older adults using a network meta-analysis (NMA).

Data Sources: PubMed, Web of Science, ScienceDirect, Scopus, and Korean Studies Information Service System (KSISS) electronic databases were searched in December 2019.

Study Selection: Studies that included the following variables were selected: (P): patients with cognitive impairment, (I): straight path versus curved path walking, (C): control group without cognitive impairment, (O): walking time, and (S): cross-sectional or longitudinal study design. Read More

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January 2022

Driving performance of euthymic outpatients with bipolar disorder undergoing real-world pharmacotherapy.

Psychiatry Clin Neurosci 2022 Jan 17. Epub 2022 Jan 17.

Department of Psychiatry, Nagoya University, Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan.

Objective: Medications for the treatment of bipolar disorder (BD) could affect patients' cognitive function. Patients with BD present with neurocognitive impairment even in a remission state. Little research is available on the daily functioning, especially driving performance, of stable outpatients with BD under pharmacological treatment. Read More

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January 2022

Regulation of gingival fibroblast phenotype by periodontal ligament cells in vitro.

J Periodontal Res 2022 Jan 17. Epub 2022 Jan 17.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

Objectives: Stem cell transplantation has shown modest effects on periodontal tissue regeneration, and it is still unclear how regenerative effects utilizing this modality are mediated. A greater understanding of the basic interactions between implanted and host cells is needed to improve future strategies. The aims of this study were to investigate the effects of periodontal ligament (PDL) cells on expression of periodontal markers and alkaline phosphatase (ALP) activity of gingival fibroblasts (GF). Read More

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January 2022

Development of a high-throughput differential mobility separation-tandem mass spectrometry (DMS-MS/MS) method for clinical urine drug testing.

J Mass Spectrom Adv Clin Lab 2022 Jan 3;23:50-57. Epub 2022 Jan 3.

Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States.

Introduction: Differential mobility separation (DMS) is an analytical technique used for rapid separation of ions and isomers based on gas phase mobility prior to entering a mass spectrometer for analysis. The entire DMS process is accomplished in fewer than 20 ms and can be used as a rapid alternative to chromatographic separation.

Objective: The primary objective was to evaluate the utility of DMS-tandem mass spectrometry (DMS-MS/MS) as a replacement for immunoassay-based clinical toxicology testing. Read More

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January 2022

Quarantine and testing strategies to ameliorate transmission due to travel during the COVID-19 pandemic: a modelling study.

Lancet Reg Health Eur 2022 Jan 10:100304. Epub 2022 Jan 10.

Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, 06525, USA.

Background: Numerous countries have imposed strict travel restrictions during the COVID-19 pandemic, contributing to a large socioeconomic burden. The long quarantines that have been applied to contacts of cases may be excessive for travel policy.

Methods: We developed an approach to evaluate imminent countrywide COVID-19 infections after 0-14-day quarantine and testing. Read More

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January 2022

Evidence for an Inherited Contribution to Sepsis Susceptibility Among a Cohort of U.S. Veterans.

Crit Care Explor 2022 Jan 11;4(1):e0603. Epub 2022 Jan 11.

Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.

Analyze a unique clinical and genealogical resource for evidence of familial clustering of sepsis to test for an inherited contribution to sepsis predisposition.

Design: Observational study.

Setting: Veteran's Health Affairs (VHA) Genealogy/Phenotype resource, a U. Read More

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January 2022

Cannabis Vapor Exposure Alters Neural Circuit Oscillatory Activity in a Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents.

Schizophr Bull Open 2022 Jan 20;3(1):sgab052. Epub 2021 Nov 20.

Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada.

Cannabis use is highly prevalent in patients with schizophrenia and worsens the course of the disorder. To understand how exposure to cannabis changes schizophrenia-related oscillatory disruptions, we investigated the impact of administering cannabis vapor containing either Δ9-tetrahydrocannabinol (THC) or balanced THC/cannabidiol (CBD) on oscillatory activity in the neonatal ventral hippocampal lesion (NVHL) rat model of schizophrenia. Male Sprague Dawley rats underwent lesion or sham surgeries on postnatal day 7. Read More

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January 2022

In vitro evaluation of Sensi-IP®: A soluble and mineralizing sensitivity solution.

Heliyon 2022 Jan 25;8(1):e08672. Epub 2021 Dec 25.

Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, B3H 4R2, Canada.

Objectives: Sensi-IP®OG (SIP-OG) and Sensi-IP®FF (SIP-FF) are soluble bioactive glasses developed to treat dentin hypersensitivity and promote remineralization. Evaluation of their therapeutic potential to reduce dentin hypersensitivity and recover enamel strength was evaluated using standardized in vitro assessments based on simulated use.

Methods: To assess dentin occlusion a visual occlusion methodology was employed. Read More

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January 2022

Differences in Shoulder Internal Rotation Strength Between Baseball Players With Ulnar Collateral Ligament Reconstruction and Healthy Controls.

Orthop J Sports Med 2022 Jan 7;10(1):23259671211065025. Epub 2022 Jan 7.

Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois, USA.

Background: Studies have indicated decreased shoulder internal rotation (IR) and external rotation (ER) strength in the throwing limb of baseball players after ulnar collateral ligament injury. There is limited evidence on the recovery of shoulder rotation strength after primary ulnar collateral ligament reconstruction (UCLR).

Hypothesis: At the time of return to throwing, baseball players who underwent UCLR would demonstrate decreased IR and ER shoulder strength in the throwing arm as compared with healthy baseball players. Read More

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January 2022

Neutrophil Extracellular Traps Facilitate A549 Cell Invasion and Migration in a Macrophage-Maintained Inflammatory Microenvironment.

Biomed Res Int 2022 6;2022:8316525. Epub 2022 Jan 6.

Thoracic Medicine Department 1, Hunan Cancer Hospital, Changsha, Hunan Province 410013, China.

Introduction: The biological functions of neutrophil extracellular traps (NETs) in tumorigenesis have drawn an increasing amount of attention. This study explored the relationship between NETs and the inflammatory microenvironment in lung cancer cell invasion and metastasis.

Methods: NETs were quantified using myeloperoxidase (MPO-DNA) and immunofluorescence staining. Read More

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January 2022

Nutritional Status and Body Composition in Wilson Disease: A Cross-Sectional Study From China.

Front Nutr 2021 31;8:790520. Epub 2021 Dec 31.

Laboratory of Sports and Nutrition Information Technology, Institute of Intelligent Machine, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, China.

Abnormal nutritional status is frequently seen in patients with chronic diseases. To date, no study has investigated the detailed characteristics of abnormal nutritional status among Wilson's disease (WD) patients in the Chinese cohort. This study aimed to describe the nutritional status of WD patients, with a particular focus on the differences between patients with different phenotypes. Read More

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December 2021

Sealing Ability of Various Types of Root Canal Sealers at Different Levels of Remaining Gutta Percha After Post Space Preparation at Two Time Intervals.

J Int Soc Prev Community Dent 2021 Nov-Dec;11(6):721-728. Epub 2021 Nov 30.

Department of Conservative Dentistry, College of Dentistry, Mosul University, Mosul, Iraq.

Objective: This study evaluated the apical sealing ability of various types of sealers (Sure-Seal Root, AH Plus, and GuttaFlow2) at different levels of remaining gutta percha after post space preparation at two time intervals (1 day and 1 week after obturation).

Materials And Methods: One hundred and two single canal mandibular premolars were decoronated at the cement-enamel junction and biomechanically prepared. Twelve samples served as negative and positive controls ( = 6). Read More

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November 2021

Circulating Vimentin Over-Expression in Patients with Oral Sub Mucosal Fibrosis and Oral Squamous Cell Carcinoma.

Indian J Otolaryngol Head Neck Surg 2022 Jan 11:1-6. Epub 2022 Jan 11.

Department of Biotechnology and Otorhinolaryngology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029 India.

Oral squamous cell carcinoma (OSCC) is one of the most common (90%) types of oral carcinomas in the world. It is the 2nd most common and 3rd deadliest cancer in India. The lack of early detection marker is one of the major causes of worst prognosis. Read More

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January 2022

Severity of coronavirus disease 19: Profile of inflammatory markers and (rs4646994) and (rs2285666) gene polymorphisms in Iraqi patients.

Meta Gene 2022 Jan 10:101014. Epub 2022 Jan 10.

Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq.

Susceptibility to coronavirus disease 2019 (COVID-19) and disease severity has recently been associated with inflammatory markers and genetic polymorphisms of (angiotensin-converting enzyme) and genes, but the evidence has been inconclusive. This case-control study (99 COVID-19 patients and 96 controls) sought to assess the significance of age, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and SARS-CoV-2 RT-PCR cycle threshold (Ct) in severity of COVID-19. Besides, two variants of and genes (rs4646994 and rs2285666, respectively) were analyzed to determine their role in COVID-19 susceptibility and/or disease severity. Read More

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January 2022

Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats.

PeerJ 2022 4;10:e12738. Epub 2022 Jan 4.

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.

Polybrominated diphenyl ethers (PBDEs) are legacy compounds with continued widespread human exposure. Despite this, developmental toxicity studies of DE-71, a mixture of PBDEs, are scarce and its potential for endocrine disrupting effects in vivo is not well covered. To address this knowledge gap, we carried out a developmental exposure study with DE-71. Read More

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January 2022

Structural and functional markers of optic nerve damage in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis.

Mult Scler J Exp Transl Clin 2021 Oct 21;7(4):20552173211063126. Epub 2021 Dec 21.

Department of Neurology, Concord Repatriation General Hospital, Sydney, Australia.

Background: Optic neuritis (ON) occurs in immune-mediated disorders including multiple sclerosis (MS), aquaporin-4 antibody-positive (AQP4) neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination (MOGAD). Accurate determination of aetiology is critical for appropriate treatment and prognostication.

Objective: To evaluate demyelination and axonal loss in MOG-ON to facilitate differentiation from MS-ON and AQP4-ON. Read More

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October 2021