74 results match your criteria compared amygdalin


Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling.

Chin J Integr Med 2021 Nov 24. Epub 2021 Nov 24.

Institute of Liver Diseases, Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective: To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model, and the underlying mechanisms were partly dissected in vivo and in vitro.

Methods: Thirty-two male mice were randomly divided into 4 groups, including control, model, low- and high-dose amygdalin-treated groups, 8 mice in each group. Except the control group, mice in the other groups were injected intraperitoneally with 10% carbon tetrachloride (CCl)-olive oil solution 3 times a week for 6 weeks to induce liver fibrosis. Read More

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November 2021

Active Components Formulation Developed from Fuzheng Huayu Recipe () for Anti-Liver Fibrosis.

Chin J Integr Med 2021 Sep 28. Epub 2021 Sep 28.

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Objective: To screen the active components from Fuzheng Huayu Recipe (, FZHY) and redesign a new recipe composed of the active components, and validate the effect of active components formulation from FZHY against liver fibrosis.

Methods: Thirty-two components from FZHY were evaluated for their activities against liver fibrosis respectively, with 6 kinds of cell models in vitro, including oxidative stressed hepatocyte in L-02, hypoxia injured/proliferative hepatic sinusoidal endothelial cells in SK-HEP-1 and human hepatic sinusoidal endothelial cells (HHSEC), and activated hepatic stellate cell in LX-2. The comprehensive activity of each component against liver fibrosis was scored according to the role of original herbs in FZHY and cell functions in fibrogenesis. Read More

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September 2021

In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.

Life Sci 2021 Nov 15;285:119961. Epub 2021 Sep 15.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Faculty of Pharmacy, BUC, Cairo, Egypt.

Aim: Hepatocellular carcinoma (HCC) is a potentially life-threatening cancer. In the current study, anti-HCC efficacy of amygdalin, or metformin alone or in combination in comparison to doxorubicin was studied.

Main Methods: Both in-vitro and in-vivo based models. Read More

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November 2021

Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes.

Bioorg Med Chem Lett 2021 10 14;49:128326. Epub 2021 Aug 14.

College of Korean Medicine, Gachon University, Seongnam 13120, South Korea. Electronic address:

Flowers of Prunus persica (L.) Batsch (Rosaceae), known as peach blossoms, have been reported to exert anti-obesity effects by improving hepatic lipid metabolism in obese mice. However, little is known regarding the anti-adipogenic effects of the phenolic compounds isolated from P. Read More

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October 2021

Insight into phenotypic and genotypic differences between vaginal BC5 and BC12 to unravel nutritional and stress factors influencing their metabolic activity.

Microb Genom 2021 06;7(6)

Department of Pharmacy and Biotechnology (FaBit), University of Bologna, Bologna, Italy.

The vaginal microbiota, normally characterized by lactobacilli presence, is crucial for vaginal health. Members belonging to and species exert crucial protective functions against pathogens, although a total comprehension of factors that influence their dominance in healthy women is still lacking. Here we investigated the complete genome sequence and comprehensive phenotypic profile of strain BC5 and strain BC12, two vaginal strains featured by anti-bacterial and anti-viral activities. Read More

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Amygdalin and Benzoic Acid on the Influences of the Soil Environment and Growth of Rehd. Seedlings.

ACS Omega 2021 May 6;6(19):12522-12529. Epub 2021 May 6.

State Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong 271018, China.

Crop rotation in fruit trees is an effective approach for addressing some of the problems of continuous cropping. To determine whether aged peach orchard soil is suitable for planting apple trees, we studied the effects of two substances abundant in aged peach orchard soil-amygdalin and benzoic acid-on the soil microbial community structure, soil enzyme activity, and the growth of Rehd. seedlings. Read More

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Role of Amygdalin in Blocking DNA Replication in Breast Cancer In Vitro.

Curr Pharm Biotechnol 2021 ;22(12):1612-1627

Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Background: Amygdalin has anticancer benefits because of its active component, hydrocyanic acid. However, the underlying molecular mechanism is unclear.

Objective: This study aimed to investigate the molecular mechanism by which amygdalin exerts antiproliferative effects in the human Michigan Cancer Foundation-7 (MCF-7) breast cancer cell line. Read More

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September 2021

Amygdalin promotes the activity of T cells to suppress the progression of HBV-related hepatocellular carcinoma via the JAK2/STAT3 signaling pathway.

BMC Infect Dis 2021 Jan 12;21(1):56. Epub 2021 Jan 12.

Department of Hepatology, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, Hunan, China.

Background: Hepatitis B virus (HBV) infection is a high-risk factor of hepatocellular carcinoma (HCC). Cellular immune responses are essential for HCC development, and the CD4+ and CD8+ T subtypes are identified as the primary anti-tumor immune cells. In the study, we investigated the effect and mechanism of amygdalin in the cellular immune response in HBV-related HCC and HCC progression. Read More

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January 2021

The antiinflammatory effects of Xuefu Zhuyu decoction on C3H/HeJ mice with alopecia areata.

Phytomedicine 2021 Jan 22;81:153423. Epub 2020 Nov 22.

Department of dermatology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu 610071, China. Electronic address:

Background: As a traditional and typical prescription of prominently activating blood circulation to remove blood stasis, Xuefu Zhuyu decoction (XZD) consists of 15 kinds of herbal medicine. Clinical investigations have showed that XZD could significantly promote the new hair generation of alopecia areata (AA) patients characterized by Qi stagnation and blood stasis.

Purpose: The purpose of this study was executed to determine whether the mechanisms by which XZD stimulated newborn hair were related to its anti-inflammatory effects. Read More

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January 2021

Colony-Level Effects of Amygdalin on Honeybees and Their Microbes.

Insects 2020 Nov 11;11(11). Epub 2020 Nov 11.

Bee Research Laboratory, Beltsville Agricultural Research Center, US Department of Agriculture, Beltsville, MD 20705, USA.

Amygdalin, a cyanogenic glycoside, is found in the nectar and pollen of almond trees, as well as in a variety of other crops, such as cherries, nectarines, apples and others. It is inevitable that western honeybees () consistently consume amygdalin during almond pollination season because almond crops are almost exclusively pollinated by honeybees. This study tests the effects of a field-relevant concentration of amygdalin on honeybee microbes and the activities of key honeybee genes. Read More

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November 2020

Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products.

Sci Rep 2020 08 17;10(1):13903. Epub 2020 Aug 17.

Laboratory for Preservation Technology and Enzyme Inhibition Studies, Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. In the present study, we designed a library of amygdalin derivatives, and two most active derivatives selected on the basis of various parameters viz. dock score, binding energy, and ADMET data using molecular docking software (Schrodinger's Maestro). Read More

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Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines.

Curr Mol Pharmacol 2021 10;14(4):667-675

Department of Medical Biotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Cell adhesion, as dynamic interactions between cell-cell and cell-matrix, has an essential role in cancer cell migration. Integrins as cell membrane receptors are involved in cell adhesion and signal transduction. Aberrant expression of integrins is associated with the cancer cell adhesion. Read More

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October 2021

Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice.

PeerJ 2020 21;8:e9232. Epub 2020 May 21.

Department of Biotechnology, Faculty of Science, Taif University, Taif, Makkah, Kingdom of Saudi Arabia.

Background: Little is known regarding the toxic and therapeutic doses of amygdalin. Treatment regimens and schedules can vary between humans and animal models, and there have been reports of cyanide toxicity due to amygdalin use.

Objective: The aim of this study was to evaluate the effect of different doses of amygdalin on antioxidant gene expression and suppression of oxidative damage in mice. Read More

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Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma-induced liver toxicity.

Environ Sci Pollut Res Int 2020 Mar 8;27(9):9236-9246. Epub 2020 Jan 8.

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.

Vitamin B17 (VB17), also known as amygdalin and laetrile, is a type of carbohydrate occurring naturally in many plants, such as apricot kernels which have obtained a great interest in cancer therapy. This study aimed to investigate the hepatic protective potential of VB17 against Ehrlich ascites carcinoma (EAC)-bearing mice-induced liver injury, DNA damage, apoptotic P53, and PCNA alterations. A total of 100 female mice were divided into 5 groups (1st group, control group; 2nd group, VB17 group; 3rd group, EAC group; 4th group, pre-treated EAC with VB17; 5th group, co-treated EAC with VB17). Read More

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[Evaluation of key production processes of Chan Taoren formula granules based on characteristic chromatogram and D-amygdalin transfer rate].

Zhongguo Zhong Yao Za Zhi 2019 Nov;44(21):4641-4647

College of Pharmaceutical Sciences,Zhejiang University of Technology Hangzhou 310014,China.

This study aimed to establish characteristic chromatogram and content determination method for Chan Taoren formula granules,evaluate the production processes of Chan Taoren formula granules based on the correlation of characteristic chromatogram and the transfer rate of D-amygdalin,and clarify the key control points. The optimized analytical method was carried out on a Waters CORTECS C18 column(4. 6 mm×150 mm,2. Read More

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November 2019

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice.

Environ Toxicol 2020 Apr 10;35(4):528-537. Epub 2019 Dec 10.

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.

Cancer is the major cause of death and many factors that lead to its occurrences, such as environmental pollution and pesticides and other factors. Ehrlich carcinoma development depends on many things associated with the environment, nutrition, personal habits, and family history. The present study aimed to evaluate the potential protective effects of vitamin B17 (VB17) against Ehrlich ascites carcinoma (EAC) that induced kidney toxicity in female mice. Read More

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Apoptosis Induction of Armeniacae Semen Extractin Human Acute Leukemia (NALM-6 and KG-1) Cells.

Int J Hematol Oncol Stem Cell Res 2019 Jul;13(3):116-121

Department of Pharmacognosy and Medicinal Plants Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Prunusarmeniaca is a member of the Rosacea family. The most important ingredient of this family is amygdalin that is believed to have anti-tumor and analgesic properties. The aim of this study was to evaluate the anti-proliferative effects of Armeniacae semen extract on the acute leukemia, NALM-6, and KG-1 cell lines, and investigate the effect of the extract on apoptosis of these cell lines and caspase-3 gene expression. Read More

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Modulation of Hematological Indices of Normal and Alloxan-Induced Diabetic Rabbits by Aqueous Extract of Pleurotus tuberregium Sclerotia.

Endocr Metab Immune Disord Drug Targets 2020 ;20(3):380-387

Department of Biochemistry, Faculty of Science, University of Port Harcourt, Port Harcourt, Nigeria.

Objective: The ability of an aqueous extract of the sclerotia of Pleurotus tuberregium to modulate hematological parameters was investigated in normal and alloxan treated rabbits.

Methods: The extract was subjected to atomic absorption spectrophotometric and flame ionization detector-coupled-gas chromatographic (GC-FID) analysis. Diabetes mellitus was induced by a 120 mg/kg body weight intravenous injection of alloxan. Read More

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January 2021

Changes of amygdalin and volatile components of apricot kernels during the ultrasonically-accelerated debitterizing.

Ultrason Sonochem 2019 Nov 28;58:104614. Epub 2019 May 28.

Institute of Food & Physical Field Processing, School of Food Engineering and Nutrition Sciences, Shaanxi Normal University, Xi'an 710062, Shaanxi Province, PR China.

Ultrasound has been regarded as an efficient novel technique for debitterizing of the apricot kernels, but its influence is severely concerned on the possible epimerization of d-amygdalin to the l-amygdalin, a more potentially toxigenic compound. Considering this, the experiments were conducted to investigate the epimerization of d-amygdalin and the volatile components in the debitterizing water, which were separated and identified by the high performance liquid chromatography (HPLC) and gas chromatography with a mass spectrometer (GC-MS), respectively. The results indicate that the ultrasonically-debitterizing did not cause the epimerization of d-amygdalin to the l-amygdalin, while the procedure can be greatly accelerated due to the rapid mass transfer and degradation of d-amygdalin induced by ultrasound irradiation. Read More

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November 2019

Expression and characterization of a recombinant stevioside hydrolyzing β-glycosidase from Enterococcus casseliflavus.

Protein Expr Purif 2019 11 9;163:105449. Epub 2019 Jul 9.

Department of Biochemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, 10400, Thailand. Electronic address:

The demand for steviol glycosides, non-caloric sweet components of Stevia rebaudiana Bertoni (stevia) leaves, has increased considerably as a benefit to enhance human health. However, the supply has remained challenging due to limited production, with the lack of a specific steviol glycoside hydrolyzing enzyme. In this study, a novel β-glucosidase (EcBgl) from Enterococcus casseliflavus was cloned and expressed in Escherichia coli. Read More

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November 2019

Amygdalin (Vitamin B17) pretreatment attenuates experimentally induced acute autoimmune hepatitis through reduction of CD4+ cell infiltration.

Authors:
Wael M Elsaed

Ann Anat 2019 Jul 15;224:124-132. Epub 2019 May 15.

Department of Anatomy, Taibah University, Almadinah Almounawrah, Saudi Arabia; Anatomy and Embryology Department, Faculty of Medicine, Mansoura University, Egypt. Electronic address:

Background: Autoimmune hepatitis (AIH) is an immune-mediated inflammation of the liver characterized by disorganized hepatic parenchyma and inflammatory cell infiltration. Although the increased incidence of AIH, the development of novel therapeutic strategies are impeded by the poor understanding of the accompanied detailed immunopathogenic changes. CD4+ T cells are key mediators of inflammatory cell infiltration in initial phases of liver injuries like AIH. Read More

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The anti-cancer effect of amygdalin on human cancer cell lines.

Mol Biol Rep 2019 Apr 5;46(2):2059-2066. Epub 2019 Feb 5.

Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

Derived from rosaceous plant seed, amygdalin belongs to aromatic cyanogenic glycoside group, and its anticancer effects have been supported by mounting evidence. In this study, we objected to investigate amygdalin effect on two antiapoptotic genes (Survivin, XIAP) and two lncRNAs (GAS5, MALAT1) in human cancer cells (A549, MCF7, AGS). Employing RT-qPCR analysis, we compared the mRNA levels of the genes related to apoptosis in A549, MCF7, and AGS cancer cells between amygdalin-treated (24, 48 and 72 h) and un-treated groups. Read More

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Protective effect of amygdalin on epithelial-mesenchymal transformation in experimental chronic obstructive pulmonary disease mice.

Phytother Res 2019 Mar 30;33(3):808-817. Epub 2019 Jan 30.

Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory pulmonary disease characterized by continuous, progressive limitation of airflow. Airway remodelling, which is correlated with epithelial-mesenchymal transitions (EMTs), is a typical pathophysiological change of COPD. Amygdalin, an active ingredient in the traditional Chinese medicine bitter almond with extensive pharmacological effects, was shown to inhibit tissue fibrosis in recent studies. Read More

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Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice.

Nutrients 2018 Nov 12;10(11). Epub 2018 Nov 12.

Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology, Jinju 52725, Korea.

Berries of (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expressions of PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer binding protein α), SREBP1c (sterol regulatory element binding protein 1c), FAS (fatty acid synthase), and aP2 (adipocyte fatty-acid⁻binding protein). Read More

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November 2018

Evaluation of the influence of mirabilite on the absorption and pharmacokinetics of the ingredients in Dahuang-mudan decoction by a validated UPLC/QTOF-MS/MS method.

Biomed Chromatogr 2019 Mar 21;33(3):e4423. Epub 2018 Dec 21.

School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.

Dahuang-mudan decoction (DMD) has been widely used for disease treatment in China for 1700 years. The formula consists of Rhubarb, moutan bark, Prunus persica, wax gourd kernel and mirabilite, which have been well studied by multidisciplinary approaches. However, the role of the mineral mirabilite in DMD is unclear. Read More

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Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats.

Phytomedicine 2018 Sep 17;48:141-151. Epub 2018 Apr 17.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Background: Primary dysmenorrhea (PDM) is one of the most common gynaecological disorders among women, which seriously affects women's life quality due to its high incidence rate. Guizhi Fuling capsule (GZFLC), a well-known traditional Chinese medical prescription, has been widely used to treat gynecological blood stasis syndromes such as PDM. However, its mechanisms of action and combination were still unknown. Read More

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September 2018

Effect of detoxification on biological quality of wild apricot (Prunus armeniaca L.) kernel.

J Sci Food Agric 2019 Jan 13;99(2):517-528. Epub 2018 Aug 13.

Department of Dairy Chemistry, Mansinhbhai Institute of Dairy and Food Technology, Mehsana, Gujarat, India.

Background: Despite rich source of protein and oil, wild (bitter) apricot (Prunus armeniaca L.) kernel is rarely exploited by food industries due to high amount of antinutrients and potentially toxic amygdalin. This study was aimed to assess the effect of detoxification on the biological quality of the wild apricot kernel (WAK)-supplemented diet in male Wistar albino rats. Read More

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January 2019

Mahuang decoction mitigates airway inflammation and regulates IL-21/STAT3 signaling pathway in rat asthma model.

J Ethnopharmacol 2018 Oct 12;224:373-380. Epub 2018 Jun 12.

Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address:

Ethnopharmacological Relevance: Nowadays, bronchial asthma is still a severe disease threatening human health, and it is incumbent upon us to seek effective therapeutic drugs. Mahuang decoction (MHD), a classic famous Chinese prescription, has been used for thousands of years to prevent phlegm from forming, stop coughing and relieve asthma, but the relevant mechanism has not been thoroughly clarified. This study aims to investigate the anti-airway inflammation effect of MHD and the possible molecular mechanism underlying IL21/STAT3 signaling pathway, so as to provide guidance for the treatment of MHD on bronchial asthma. Read More

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October 2018

Influence of amygdalin on PDG, IGF and PDGFR expression in HSC-T6 cells.

Exp Ther Med 2018 Apr 22;15(4):3693-3698. Epub 2018 Feb 22.

Department of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.

The aim of the present study was to elucidate the mechanism of amygdalin treatment on reducing liver fibrosis by investigating its role in regulating the expression level of platelet-derived growth factor (PDGF), insulin-like growth factor (IGF) and PDGF receptor (PDGFR) in the hepatic stellate cell (HSC)-T6 line. HSC-T6 cells were used as an model and randomly assigned into four groups: control, high-dose amygdalin, mid-dose amygdalin and low-dose amygdalin. Following amygdalin treatment, compared with the control, a high dose of amygdalin significantly suppressed the mRNA expression of PDGF and IGF (each P<0. Read More

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Amygdalin ameliorates the progression of atherosclerosis in LDL receptor‑deficient mice.

Mol Med Rep 2017 Dec 25;16(6):8171-8179. Epub 2017 Sep 25.

Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China.

Previous studies have demonstrated that regulatory T cells (Tregs) are pivotal in the regulation of T cell‑mediated immune responses in atherosclerosis, a chronic autoimmune‑like disease. In the authors' previous studies, it was demonstrated that amygdalin ameliorated atherosclerosis by the regulation of Tregs in apolipoprotein E‑deficient (ApoE‑/‑) mice. Therefore, the aim of the present study was to investigate the therapeutic effect of amygdalin on low‑density lipoprotein (LDL) receptor deficient (LDLR‑/‑) mice, and to examine its immune regulatory function by the stimulation of Tregs. Read More

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December 2017