107,586 results match your criteria compared alternative


MIDeepSeg: Minimally interactive segmentation of unseen objects from medical images using deep learning.

Med Image Anal 2021 May 18;72:102102. Epub 2021 May 18.

School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, China; SenseTime Research, Shanghai, China.

Segmentation of organs or lesions from medical images plays an essential role in many clinical applications such as diagnosis and treatment planning. Though Convolutional Neural Networks (CNN) have achieved the state-of-the-art performance for automatic segmentation, they are often limited by the lack of clinically acceptable accuracy and robustness in complex cases. Therefore, interactive segmentation is a practical alternative to these methods. Read More

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Biofortification quality in bananas monitored by energy-dispersive X-ray fluorescence and chemometrics.

Food Chem 2021 Jun 2;362:130172. Epub 2021 Jun 2.

São Paulo State University (UNESP), Institute of Chemistry, Group of Alternative Analytical Approaches (GAAA), Bioenergy Research Institute (IPBEN), Av. Prof. Francisco Degni, 55 - Jardim Quitandinha, Araraquara, São Paulo CEP: 14.800-060, Brazil; National Institute of Alternative Technologies for Detection Toxicological Assessment and Removal of Micropollutants and Radioactive Substances (INCT-DATREM), São Paulo State University (UNESP), Institute of Chemistry, Av. Prof. Francisco Degni, 55 - Jardim Quitandinha, Araraquara, São Paulo, CEP: 14.800-060, Brazil. Electronic address:

Biofortification is a nutritional strategy used to enhance nutrients in a variety of staple foods. As bananas and plantains (Musa spp.) are considered staple food in many developing countries, monitoring zinc (Zn) content in biofortified bananas is crucial to ensure this mineral intake. Read More

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Periodontal condition of mandibular incisors treated with modified Kazanjian vestibuloplasty compared to untreated sites: A prospective study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Periodontology, Medical University of Warsaw, Poland.

Background: A shallow vestibule, insufficient keratinized tissue width and pulling of marginal gingiva may be associated with gingival recession, plaque accumulation and gingivitis. Conventional techniques for treatment of gingival recession use autogenous or allogenic grafts. However, these methods result in soreness at the donor site and pose an economic burden, which may cause patients to withdraw from treatment. Read More

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Analysis and comparison of autologous platelet-rich plasma preparation systems used in the treatment of enthesopathies: A preliminary study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Trauma and Hand Surgery, Wroclaw Medical University, Poland.

Background: Autologous platelet-rich plasma (PRP) injection is an alternative but widely accepted method for the treatment of degenerative changes in tendon attachments known as enthesopathies. The PRP is considered a safe source for high concentrations of the growth factors involved in the healing process. Despite initial promising outcomes, many recent studies report conflicting results for this treatment. Read More

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An evaluation of alternative biodegradable and reusable drinking straws as alternatives to single-use plastic.

J Food Sci 2021 Jun 12. Epub 2021 Jun 12.

Department of Food Science, Cornell University, Ithaca, New York, USA.

The manufacture of single-use plastic items uses fossil fuels, and releases greenhouse gases. Plastic waste is also harmful to humans and wildlife. Recent attention towards the regulation or elimination of plastic straws has led to the development of many alternatives to single-use plastic straws, some intended to be disposed of immediately after use, and others to be cleaned and reused. Read More

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Performance of nanoScan PET/CT and PET/MR for quantitative imaging of F and Zr as compared with ex vivo biodistribution in tumor-bearing mice.

EJNMMI Res 2021 Jun 12;11(1):57. Epub 2021 Jun 12.

Amsterdam UMC, Vrije Universiteit Amsterdam, Radiology & Nuclear Medicine, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands.

Introduction: The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninvasive longitudinal evaluation of tracer distribution in the same animals, but systemic comparison with ex vivo biodistribution is lacking. Our aim was to evaluate the potential of preclinical PET imaging for accurate tracer quantification, especially in tumor models. Read More

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Metabolic responses to polychromatic LED and OLED light at night.

Sci Rep 2021 Jun 11;11(1):12402. Epub 2021 Jun 11.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.

Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the effects of polychromatic white light using conventional light-emitting diodes (LED) and an alternative light source, organic light-emitting diodes (OLED), producing reduced spectral content in the short wavelength of blue light (455 nm). Ten male participants were exposed to either LED, OLED (1000 lx), or dim (< 10 lx) light for 4 h before sleep in a metabolic chamber. Read More

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NPWT Resource Use Compared With Conventional Wound Treatment in Subcutaneous Abdominal Wounds With Healing Impairment After Surgery: SAWHI Randomized Clinical Trial Results.

Ann Surg 2021 Jun 10. Epub 2021 Jun 10.

Institute for Research in Operative Medicine, University of Witten/Herdecke, Cologne, Germany.

Objective: To compare resource utilization of NPWT and CWT for SAWHI after surgery.

Summary Of Background Data: NPWT is widely used in the management of complex wounds but high-level evidence of its resource use remains sparse.

Methods: The multicenter, multinational, randomized clinical SAWHI study enrolled a total of 539 consecutive, compliant adult patients with SAWHI after surgery without fascial dehiscence between August 2, 2011, and January 31, 2018. Read More

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A Comparative Study of Autologous and Acellular Dermal Matrix Static Cheek Slings in Corrective Surgery for Facial Palsy.

Ann Plast Surg 2021 Jun 10. Epub 2021 Jun 10.

From the Department of Plastic Surgery, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; and Department of Plastic Surgery and Burns Unit, Cruces University Hospital, Baracaldo, Spain Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA Department of Plastic Surgery, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.

Background: Facial palsy causes devastating disability due to loss of facial function as well as social and psychological impairment. Cheek slings are a secondary technique that provide static support to the midface. This study aimed to describe our technique and compare a traditional sling material (tensor fascia lata) with a porcine-derived acellular dermal matrix alternative (Strattice). Read More

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Novel selection paradigms for endovascular stroke treatment in the extended time window.

J Neurol Neurosurg Psychiatry 2021 Jun 11. Epub 2021 Jun 11.

Neurology, Emory University, Atlanta, Georgia, USA

Background And Purpose: The optimal selection methodology for stroke thrombectomy beyond 6 hours remains to be established.

Methods: Review of a prospectively collected database of thrombectomy patients with anterior circulation strokes, adequate CT perfusion (CTP) maps, National Institute of Health Stroke Scale (NIHSS)≥10 and presenting beyond 6 hours from January 2014 to October 2018. Patients were categorised according to five selection paradigms: DAWN clinical-core mismatch (DAWN-CCM): between age-adjusted NIHSS and CTP core, DEFUSE 3 perfusion imaging mismatch (DEFUSE-3-PIM): between CTP-derived perfusion defect (Tmax >6 s lesion) and ischaemic core volumes and three non-contrast CT Alberta Stroke Program Early CT Score (ASPECTS)-based criteria: age-adjusted clinical-ASPECTS mismatch (aCAM): between age-adjusted NIHSS and ASPECTS, eloquence-adjusted clinical ASPECTS mismatch (eCAM): ASPECTS 6-10 and non-involvement of the right M6 and left M4 areas and standard clinical ASPECTS mismatch (sCAM): ASPECTS 6-10. Read More

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Can Assessment of the Tongue on Brain MRI Aid Differentiation of Seizure from Alternative Causes of Transient Loss of Consciousness?

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Wake Forest School of Medicine, Winston Salem, North Carolina

Background And Purpose: Transient loss of consciousness is commonly evaluated in the emergency department. Although typically caused by epileptic seizure, syncope, or psychogenic nonepileptic seizure, the underlying etiology is frequently misdiagnosed. Lateral tongue bites are reportedly a specific clinical finding of seizure. Read More

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Combined stoma reversal and liver resection for rectal metastatic cancer: A single center retrospective analysis.

J Visc Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France.

Goal Of The Study: Concomitant liver metastases are discovered at the time of diagnosis in 25% of patients with colorectal cancers. The appropriate time to restore digestive continuity after stoma creation during rectal surgery has not yet been established. The objective of this study is to assess the morbidity of stoma reversal during the secondary hepatectomy procedure. Read More

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Whole-cell biocatalyst for cadaverine production using stable, constitutive and high expression of lysine decarboxylase in recombinant Escherichia coli W3110.

Enzyme Microb Technol 2021 Aug 3;148:109811. Epub 2021 May 3.

Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Microbial production of industrial chemicals is a sustainable approach to reduce the dependence on petroleum-based chemicals such as acids, alcohols, and amines, in which the cadaverine is a natural diamide and serves as one of the key monomers for biopolymer production. In this study, the constitutive promoter J23100 driven lysine decarboxylase (CadA) for cadaverine production was established and compared in different Escherichia coli strains. The best chassis designed as JW, expressed the highest amount of CadA by using J23100 promoter, showing stable and high copy numbers (i. Read More

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Suprascapular nerve block is a clinically attractive alternative to interscalene nerve block during arthroscopic shoulder surgery: a meta-analysis of randomized controlled trials.

J Orthop Surg Res 2021 Jun 11;16(1):376. Epub 2021 Jun 11.

Department of Orthopedic, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Dongxiaokou Town, Changping District, Beijing, 102218, China.

Background: The interscalene brachial plexus block (ISB) is a commonly used nerve block technique for postoperative analgesia in patients undergoing shoulder arthroscopy surgery; however, it is associated with potentially serious complications. The use of suprascapular nerve block (SSNB) has been described as an alternative strategy with fewer reported side effects for shoulder arthroscopy. This review aimed to compare the impact of SSNB and ISB during shoulder arthroscopy surgery. Read More

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Retrosigmoid transhorizontal fissure approach to lateral pontine cavernous malformation: comparison to transpetrosal presigmoid retrolabyrinthine approach.

J Neurosurg 2021 Jun 11:1-10. Epub 2021 Jun 11.

Objective: The retrosigmoid (RS) approach is a classic route used to access deep-seated brainstem cavernous malformation (CM). The angle of access is limited, so alternatives such as the transpetrosal presigmoid retrolabyrinthine (TPPR) approach have been used to overcome this limitation. Here, the authors evaluated a modification to the RS approach, horizontal fissure dissection by using the RS transhorizontal (RSTH) approach. Read More

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Use of available crop by-products as alternative bedding materials to wheat straw for rearing broilers.

Animal 2021 Jun 8;15(7):100260. Epub 2021 Jun 8.

Poultry Production Department, Agriculture College, Damietta University, Damietta 34517, Egypt.

The provision of suitable bedding for rearing broilers is an ongoing challenge for poultry producers. The aim of the present study was to evaluate the effect of using different types of crop residues as alternative bedding materials to wheat straw on growth performance, carcass traits, health, and welfare of broilers; moreover, the effects on the bedding and air quality were analyzed. We randomly assigned 180 1-day-old chickens (Cobb 500) across six bedding groups (three replicates of 10 birds each). Read More

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Energy balance of torrefied microalgal biomass with production upscale approached by life cycle assessment.

J Environ Manage 2021 Jun 8;294:112992. Epub 2021 Jun 8.

Mechanical Engineering Department, De La Salle University, 2401 Taft Avenue, 0922, Manila, Philippines; Center for Engineering and Sustainable Development Research, De La Salle University, Manila, 0922, Philippines.

Torrefaction is a thermochemical process used to convert the biomass into solid fuel. In this study, torrefaction increased the raw microalgal biomass' energy content from 20.22 MJ⋅kg to 27. Read More

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Nanopriming with phytosynthesized zinc oxide nanoparticles for promoting germination and starch metabolism in rice seeds.

J Biotechnol 2021 Jun 8. Epub 2021 Jun 8.

Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India. Electronic address:

The application of zinc oxide nanoparticles (ZnO NPs) in agricultural field is emerging and relatively new. In this work, a simple, cost-efficient, non-toxic and eco-friendly method for the green synthesis of ZnO NPs by Cassia occidentalis leaf extract has been described. Techniques used to characterize nanoparticles (NPs) were X-ray diffractometer (XRD), UV visible spectroscopy, Particle size analyzer (PSA), Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). Read More

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Larvicidal potential of cell wall degrading enzymes from Trichoderma asperellum against Aedes aegypti (Diptera: Culicidae).

Biotechnol Prog 2021 Jun 11. Epub 2021 Jun 11.

Laboratório de Química de Polímeros (LQP) - ICB2 - Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: Aedes aegypti is a mosquito vector of arboviruses such as Dengue, Chikungunya, Zika and Yellow Fever that cause important public health diseases. The incidence and gravity of these diseases justifies the search for effective measures to reduce the presence of this vector in the environment. Bioinsecticides are an effective alternative method for insect control, with added ecological benefits such as biodegradability. Read More

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Relationship between diarrhoea risk and the combinations of drinking water sources in the Kathmandu Valley, Nepal.

Int Health 2021 Jun 11. Epub 2021 Jun 11.

Interdisciplinary Centre for River Basin Environment, University of Yamanashi, 4-3-11 Takeda, Kofu, Yamanashi 400-8511, Japan.

In Nepal, the number of diarrhoea hospitalizations in all ages is seriously high. According to the World Health Organization, diarrheal diseases can be substantially prevented through safe drinking water sources. In the Kathmandu Valley, because of the shortage of piped water, local residents use alternative water sources, such as groundwater, jars and tanker water. Read More

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Evaluation of diagnostic ultrasound use in a breast cancer detection strategy in Northern Peru.

PLoS One 2021 11;16(6):e0252902. Epub 2021 Jun 11.

Department of Radiology, University of Washington, Seattle, Washington, United States of America.

To evaluate the diagnostic impact of point-of-care breast ultrasound by trained primary care physicians (PCPs) as part of a breast cancer detection program using clinical breast exam in an underserved region of Peru. Medical records and breast ultrasound images of symptomatic women presenting to the Breast Cancer Detection Model (BCDM) in Trujillo, Peru were collected from 2017-2018. Performance was measured against final outcomes derived from regional cancer center medical records, fine needle aspiration results, patient follow-up (sensitivity, specificity, positive, and negative predictive values), and by percent agreement with the retrospective, blinded interpretation of images by a fellowship-trained breast radiologist, and a Peruvian breast surgeon. Read More

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Inclusion of maintenance energy improves the intracellular flux predictions of CHO.

PLoS Comput Biol 2021 Jun 11;17(6):e1009022. Epub 2021 Jun 11.

Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal.

Chinese hamster ovary (CHO) cells are the leading platform for the production of biopharmaceuticals with human-like glycosylation. The standard practice for cell line generation relies on trial and error approaches such as adaptive evolution and high-throughput screening, which typically take several months. Metabolic modeling could aid in designing better producer cell lines and thus shorten development times. Read More

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Removal of Disperse Blue 56 from synthetic textile effluent using ionic flocculation.

Water Sci Technol 2021 Jun;83(11):2714-2723

Centro de Tecnologia - Departamento de Engenharia Química, Programa de Pós-Graduação em Engenharia Química, Universidade Federal do Rio Grande do Norte, Campus Universitário, Av. Senador Salgado Filho 3000, Natal-RN, 59072-970, Brazil.

The textile industry is one of the main generators of industrial effluent due to the large volumes of water containing a wide variety of pollutants, including dyes. Thus, the present study aimed to remove the Disperse Blue 56 dye present in synthetic textile effluent using ionic flocculation through surfactant flocs produced from animal/vegetable fat, assessing the system at different surfactant concentrations and temperatures. The process kinetics, adsorption mechanism and equilibrium were evaluated. Read More

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Novel serotonin 5-HT receptor antagonists derived from 4-phenylcyclohexane-5-spiro-and 5-methyl-5-phenyl-hydantoin, for use as potential antiplatelet agents.

Pharmacol Rep 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.

Background: Antiplatelet drugs have been used in the treatment of acute coronary syndromes and for the prevention of recurrent events. Unfortunately, many patients remain resistant to the available antiplatelet treatment. Therefore, there is a clinical need to synthesize novel antiplatelet agents, which would be associated with different pathways of platelet aggregation, to develop an alternative or additional treatment for resistant patients. Read More

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Methenamine hippurate compared with trimethoprim for the prevention of recurrent urinary tract infections: a randomized clinical trial.

Int Urogynecol J 2021 Jun 11. Epub 2021 Jun 11.

University of Texas Health Science Center San Antonio, San Antonio, TX, USA.

Introduction And Hypothesis: The objective was to find an alternative treatment to a low-dose antibiotic for the prevention of recurrent urinary tract infections (UTI) and to evaluate the difference in rates of reinfection within 1 year when treated with methenamine hippurate for prophylaxis compared with trimethoprim.

Methods: We present a non-blinded randomized trial comparing methenamine hippurate with trimethoprim for the prevention of recurrent UTI at 12 months after starting treatment. Women over 18 who had at least two culture-positive UTI in the prior 6 months or three in the prior year were included. Read More

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Rehabilitation of Atrophic Posterior Maxilla with Pterygoid Implants: A 3D Finite Element Analysis.

Int J Oral Maxillofac Implants 2021 May-Jun;36(3):e51-e62

Purpose: Clinical cases have shown that pterygoid implants are a successful alternative solution for the rehabilitation of atrophic posterior maxillae; however, little research on the biomechanical behavior has been produced. This study created 3D models of pterygoid implant-supported prostheses and compared the stress and strain distributions in the pterygoid implants and surrounding bone using finite element analysis.

Materials And Methods: Three-dimensional models of a standardized human skull, pterygoid implants, and conventional dental implants were created using Simpleware, based on microcomputed tomography (micro-CT) and CBCT images. Read More

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Impact Of Chronic Kidney Disease On The Pharmacodynamic And Pharmacokinetic Effects Of Ticagrelor In Patients With Diabetes Mellitus And Coronary Artery Disease.

Eur Heart J Cardiovasc Pharmacother 2021 Jun 11. Epub 2021 Jun 11.

University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.

Aims: Patients with diabetes mellitus (DM) and chronic kidney disease (CKD) are at increased risk of atherothrombotic events. Ticagrelor reduces ischaemic events compared to clopidogrel, with the greatest risk reduction in patients with both DM and CKD. How CKD status affects the pharmacodynamic (PD) and pharmacokinetic (PK) profiles of different ticagrelor maintenance dose regimens in patients with DM is unknown. Read More

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Could the Valsalva manoeuvre be an alternative to the tenaculum for intrauterine device insertion?

Eur J Contracept Reprod Health Care 2021 Jun 11:1-4. Epub 2021 Jun 11.

Department of Obstetrics and Gynaecology, Alanya Education and Research Hospital, Alanya, Turkey.

Objectives: This study investigated whether the Valsalva manoeuvre (VM) could be an alternative to use of the tenaculum for intrauterine device (IUD) insertion. The aims were to establish whether VM could provide good patient comfort and enable the insertion to be performed successfully with adequate pain control in cases where the cervix could not be passed spontaneously.

Methods: Women who attended the outpatient clinic of Alanya Education and Research Hospital between November 2017 and December 2020 for IUD insertion were randomly assigned to the VM ( = 52) or tenaculum ( = 55) group. Read More

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Efficacy of glycine powder air-polishing in supportive periodontal therapy: a systematic review and meta-analysis.

J Periodontal Implant Sci 2021 Jun;51(3):147-162

College of Stomatology, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.

Purpose: This systematic review and meta-analysis was conducted to assess the effects of glycine powder air-polishing (GPAP) in patients during supportive periodontal therapy (SPT) compared to hand instrumentation and ultrasonic scaling.

Methods: The authors searched for randomized clinical trials in 8 electronic databases for relevant studies through November 15, 2019. The eligibility criteria were as follows: population, patients with chronic periodontitis undergoing SPT; intervention and comparison, patients treated by GPAP with a standard/nozzle type jet or mechanical instrumentation; and outcomes, bleeding on probing (BOP), patient discomfort/pain (assessed by a visual analogue scale [VAS]), probing depth (PD), gingival recession (Rec), plaque index (PI), clinical attachment level (CAL), gingival epithelium score, and subgingival bacteria count. Read More

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Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography.

Brain Topogr 2021 Jun 11. Epub 2021 Jun 11.

Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, UCSF Biomagnetic Imaging Center, 513 Parnassus Avenue, San Francisco, CA, 94143, USA.

Magnetoencephalography (MEG) is a robust method for non-invasive functional brain mapping of sensory cortices due to its exceptional spatial and temporal resolution. The clinical standard for MEG source localization of functional landmarks from sensory evoked responses is the equivalent current dipole (ECD) localization algorithm, known to be sensitive to initialization, noise, and manual choice of the number of dipoles. Recently many automated and robust algorithms have been developed, including the Champagne algorithm, an empirical Bayesian algorithm, with powerful abilities for MEG source reconstruction and time course estimation (Wipf et al. Read More

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