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The age-standardized incidence, mortality, and case fatality rates of COVID-19 among 79 countries: cross-sectional comparison and their correlation with associated factors.

Epidemiol Health 2021 Sep 8:e2021061. Epub 2021 Sep 8.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objectives: During the coronavirus disease 2019 (COVID-19) pandemic, crude incidence and mortality rates have been widely reported; however, age-standardized rates are more suitable for comparison. In this study, we estimated and compared the age-standardized incidence, mortality, and case fatality rates among countries and investigated the relationship between these rates and factors associated with healthcare resources: gross domestic product per capita, number of hospital beds per population, and number of doctors per population.

Methods: The incidence, mortality, and case fatality rates of 79 countries were age-standardized using the WHO standard population. Read More

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September 2021

Social competence, leisure time activities, and smoking trajectories among adolescent boys: Data from The Korean Children & Youth Panel Survey.

Epidemiol Health 2021 Sep 9:e2021066. Epub 2021 Sep 9.

Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Objectives: To identify trajectories and potential predictors of tobacco use patterns among adolescents in Korea and to develop appropriate strategies for the implementation of primary prevention of tobacco use.

Methods: Tobacco trajectory and associated predictors were analyzed for 1,169 children from sixth (age 11) to tenth (age 15) grades in The Korean Children & Youth Panel Survey from 2012 to 2016.

Results: The three trajectory of smoking experience was identified: non-smokers (T1; 82. Read More

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September 2021

Clinical analysis of uterine intravenous leiomyomatosis: A retrospective study of 260 cases.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Methods: We collected the clinical data of 260 patients admitted to the hospital from April 2003 to September 2019 with pathologically confirmed intravenous leiomyomatosis (IVL) and followed up with these patients regularly. Univariate and multivariate logistic regression analyses were carried out on the relevant recurrence factors.

Results: A total of 166 patients were regularly followed up, the median follow-up time was 36 (range 2-168) months, 14 (5. Read More

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September 2021

[Automatic detection of epileptiform potentials and seizures in the EEG].

Fortschr Neurol Psychiatr 2021 Sep 15;89(9):445-458. Epub 2021 Sep 15.

Automatic computer-based algorithms for the detection of epileptiform potentials and seizure patterns on EEG facilitate a time-saving, objective method of quantitative EEG interpretation which is available 7/24. For the automatic detection of interictal epileptiform potentials sensitivities range from 65 to 99% with false positive detections of 0,09 to 13,4 per minute. Recent studies documented equal or even better performance of automatic spike detection programs compared with experienced human EEG readers. Read More

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September 2021

Anxiety and Depression Impact on Inhospital Complications and Outcomes After Total Knee and Hip Arthroplasty: A Propensity Score-Weighted Retrospective Analysis.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Department of Orthopeadic Surgery and Sports Medicine, Detroit Medical Center, Detorit, MI (Zalikha and El-Othmani), and the Department of Biomedical Sciences, Oakland University William Beaumont School of Medicine, Auburn Hills, MI (Karabon and Hajj Hussein).

Introduction: The purpose of this study was to assess the impact of anxiety and depression on immediate inhospital outcomes and complications after total joint arthroplasty of the hip (total hip arthroplasty [THA]) and knee (total knee arthroplasty [TKA]) using a large national registry.

Methods: Data from the National Inpatient Sample was used to identify all patients undergoing TKA and THA between 2006 and 2015. Patients were divided in four groups based on a concomitant diagnosis of depression, anxiety, depression plus anxiety, and neither depression nor anxiety (control group). Read More

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November 2020

The Implementation of Lean Six Sigma Principles to Improve the Value of Care Delivery for Total Joint Arthroplasty Patients: The Perioperative Institute of Surgical Excellence Experience.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Department of Orthopaedic Surgery, Detroit Medical Center, Detroit, MI (El-Othmani and Sayeed), the Central Michigan University School of Medicine, Mt Pleasant, MI (Crespi), the Sinai-Grace Hospital, Detroit Medical Center (Pallekonda), and the John D. Dingell VA Medical Center (Saleh), Detroit, MI.

Background: With the projected increase in the volume of total joint arthroplasty (TJA), minimizing variations in surgery times, hospital length of stay (LOS), discharge dispositions, and inhospital complication rates would help reduce costs and improve the quality of care. As the move toward bundle payment models gains further traction, providers will be reimbursed based on the quality and cost associated with the surgical episode. As such, it remains critical to design and implement high-quality cost-effective perioperative delivery care models. Read More

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November 2020

Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

Respiration 2021 Sep 15:1-11. Epub 2021 Sep 15.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.

Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Read More

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September 2021

High performance and low power consumption resistive random access memory with Ag/Fe2O3/Pt structure.

Nanotechnology 2021 Sep 15. Epub 2021 Sep 15.

Shanghai Jiao Tong University, Shanghai, CHINA.

Due to magnetic field tunability and the abundance of iron in the earth's crust, iron oxide-based resistive random access memory (RRAM) is considered to be low cost and potential for multi-level storage. However, the relatively high operation voltage (›1V) and small storage window (‹100) limit its application. In this work, the devices with simple Ag/Fe2O3/Pt structure exhibit typical bipolar resistive switching with ultralow set voltage (Vset) of 0. Read More

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September 2021

Utility of a Postural Stability/Perceptual Inhibition Dual Task for Identifying Concussion in Adolescents.

J Sport Rehabil 2021 Sep 15:1-6. Epub 2021 Sep 15.

Context: Research in the area of dual-task paradigms to assess sport-related concussion (SRC) status is growing, but additional assessment of this paradigm in adolescents is warranted.

Design: This case-control study compared 49 adolescent athletes aged 12-20 years with diagnosed SRC to 49 age- and sex-matched controls on visual-spatial discrimination and perceptual inhibition (PIT) reaction time tasks performed while balancing on floor/foam pad conditions.

Methods: The SRC group completed measures at a single time point between 1 and 10 days postinjury. Read More

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September 2021

Muscle Activation in the Shoulder Girdle and Lumbopelvic-Hip Complex During Common Therapeutic Exercises.

J Sport Rehabil 2021 Sep 15:1-7. Epub 2021 Sep 15.

Context: Lumbopelvic-hip complex (LPHC) exercises are used to increase stabilization within the human body. Torso-elevated side support (TESS), foot-elevated side support (FESS), prone bridge plank (PBP), and V-sit are common LPHC exercises.

Objective: To evaluate muscle activation in the shoulder girdle and LPHC during 4 LPHC exercises and evaluate the reasoning for termination. Read More

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September 2021

Predicting length of stay and mortality among hospitalized patients with type 2 diabetes mellitus and hypertension.

Int J Med Inform 2021 Sep 4;154:104569. Epub 2021 Sep 4.

International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Type 2 diabetes mellitus (T2DM) and hypertension (HTN), both non-communicable diseases, are leading causes of death globally, with more imbalances in lower middle-income countries. Furthermore, poor treatment and management are known to lead to intensified healthcare utilization and increased medical care costs and impose a significant societal burden, in these countries, including Indonesia. Predicting future clinical outcomes can determine the line of treatment and value of healthcare costs, while ensuring effective patient care. Read More

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September 2021

Ultrasound and heat treatment effects on Staphylococcus aureus cell viability in orange juice.

Ultrason Sonochem 2021 Sep 7;78:105743. Epub 2021 Sep 7.

Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal. Electronic address:

Ultrasounds are being considered an excellent alternative technology in juice preservation. Yet, when combined with heat treatment, the process seems to be further intensified. This work aimed to evaluate and compare the impact of ultrasounds and heat treatments, when applied alone or in combination, on Staphylococcus aureus survival in orange juice. Read More

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September 2021

Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study.

J Neurol Sci 2021 Sep 4;430:118069. Epub 2021 Sep 4.

Department of Neurology, Saarland University Medical Center, Homburg, Germany.

Background: To assess the validity of neurosonological parameters (transorbital sonography (TOS)) for detection and monitoring of patients with idiopathic intracranial hypertension (IIH).

Methods: Prospective, single-center, case-controlled study in 25 patients with IIH and 19 controls. Visual parameters of papilledema, visual acuity, computerized static threshold perimetry, fundus examination, and neurosonological parameters of papilledema/optic disc elevation (ODE), optic nerve sheath diameter (ONSD) and optic nerve diameter (OND) were recorded at baseline and only for patients with IIH again within 6 months. Read More

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September 2021

Coastal armouring affects intertidal biodiversity across the Alboran Sea (Western Mediterranean Sea).

Mar Environ Res 2021 Sep 8;171:105475. Epub 2021 Sep 8.

Laboratorio de Biología Marina, Departamento de Zoología, Facultad de Biología. Universidad de Sevilla. Avda. de la Reina Mercedes, 6. 41012, Sevilla, Spain. Electronic address:

Intertidal ecosystems are key habitats that are being replaced by artificial hard substrates due to the increment of human activities in coastal areas. These new substrates host generally less biodiversity mainly due to differences in complexity and composition. This is a global phenomenon and has led to the development of strategies in the framework of eco-engineering. Read More

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September 2021

Applying interpretable deep learning models to identify chronic cough patients using EHR data.

Comput Methods Programs Biomed 2021 Sep 4;210:106395. Epub 2021 Sep 4.

Indiana University School of Medicine, 340W 10th St #6200, Indianapolis, IN 46202, United States; Regenstrief Institute, 1101W 10th Street, Indianapolis, IN, 46202, United States. Electronic address:

Background And Objective: Chronic cough (CC) affects approximately 10% of adults. Many disease states are associated with chronic cough, such as asthma, upper airway cough syndrome, bronchitis, and gastroesophageal reflux disease. The lack of an ICD code specific for chronic cough makes it challenging to identify such patients from electronic health records (EHRs). Read More

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September 2021

A deep learning approach for synthetic MRI based on two routine sequences and training with synthetic data.

Comput Methods Programs Biomed 2021 Aug 31;210:106371. Epub 2021 Aug 31.

Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain.

Background And Objective: Synthetic magnetic resonance imaging (MRI) is a low cost procedure that serves as a bridge between qualitative and quantitative MRI. However, the proposed methods require very specific sequences or private protocols which have scarcely found integration in clinical scanners. We propose a learning-based approach to compute T1, T2, and PD parametric maps from only a pair of T1- and T2-weighted images customarily acquired in the clinical routine. Read More

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Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Biochim Biophys Acta Gen Subj 2021 Sep 12:130010. Epub 2021 Sep 12.

The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Road, Changchun, Jilin 130021, China. Electronic address:

Background: Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).

Methods: A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Read More

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September 2021

In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.

Bioorg Chem 2021 Aug 24;116:105300. Epub 2021 Aug 24.

Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, 11884, Egypt. Electronic address:

Based on the biological importance of the thiazole nucleus, we decided to prepare and evaluate the biological activity of some new isatin derivatives containing thiazole moiety. The 5-(piperidin-1-ylsulfonyl)indoline-2,3-dione (1) was prepared and used as a starting material in the synthesis of many isatin derivatives for anticonvulsant evaluation. All the newly synthesized thiazlidino/thiosemicarbazide-indolin-2-one derivatives screened in vivo for their anticonvulsant activity against pentylenetetrazole-induced convulsions in mice. Read More

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Primate neuronal connections are sparse in cortex as compared to mouse.

Cell Rep 2021 Sep;36(11):109709

Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA; Argonne National Laboratory, Lemont, IL 60439, USA. Electronic address:

Detailing how primate and mouse neurons differ is critical for creating generalized models of how neurons process information. We reconstruct 15,748 synapses in adult Rhesus macaques and mice and ask how connectivity differs on identified cell types in layer 2/3 of primary visual cortex. Primate excitatory and inhibitory neurons receive 2-5 times fewer excitatory and inhibitory synapses than similar mouse neurons. Read More

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September 2021

Conscious processing of narrative stimuli synchronizes heart rate between individuals.

Cell Rep 2021 Sep;36(11):109692

Paris Brain Institute, ICM, 75013 Paris, France; Inserm U 1127, 75013 Paris, France; CNRS UMR 7225, 75013 Paris, France. Electronic address:

Heart rate has natural fluctuations that are typically ascribed to autonomic function. Recent evidence suggests that conscious processing can affect the timing of the heartbeat. We hypothesized that heart rate is modulated by conscious processing and therefore dependent on attentional focus. Read More

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September 2021

Artificial intelligence in nutrition research: perspectives on current and future applications.

Appl Physiol Nutr Metab 2021 Sep 15. Epub 2021 Sep 15.

Université Laval, INAF, Pavillon des services, 2440 Hochelaga, Québec, Quebec, Canada, G1V 0A6;

Artificial intelligence (AI) is a rapidly evolving area that offers unparalleled opportunities of progress and applications in many healthcare fields. In this review, we provide an overview of the main and latest applications of AI in nutrition research and identify gaps to address to potentialize this emerging field. AI algorithms may help better understand and predict the complex and non-linear interactions between nutrition-related data and health outcomes, particularly when large amounts of data need to be structured and integrated, such as in metabolomics. Read More

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September 2021

Comparing Different Techniques in Children With or Without a Simultaneous Fundoplication: Does the Gastrostomy Technique Matter?

J Laparoendosc Adv Surg Tech A 2021 Sep 12;31(9):1067-1072. Epub 2021 Jul 12.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ondokuz Mayıs University Medical School, Samsun, Turkey.

To evaluate the results of different gastrostomy techniques and the impact of simultaneous fundoplication. The patients who underwent a gastrostomy procedure between 2009 and 2019 in a single tertiary center were evaluated retrospectively. The patients are divided into groups depending on the gastrostomy techniques as open gastrostomy (OG), laparoscopic gastrostomy (LG), percutaneous endoscopic gastrostomy (PEG), and laparoscopy-assisted PEG (LAPEG). Read More

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September 2021

Personality in Children With Vocal Fold Nodules: A Multitrait Analysis.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

Pediatric Otolaryngology Clinic, Primary Children's Medical Center, Salt Lake City, UT.

Purpose Vocal fold nodules (VNs) are bilateral, symmetrical, callous-like lesions secondary to phonotrauma and possibly related to specific personality traits. This case-control study examined the relation between personality and VNs in children within the context of the Trait Theory of VNs. Method Parents of children with VNs ( = 39, = 7. Read More

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September 2021

Bimodal Fitting and Bilateral Cochlear Implants in Children With Significant Residual Hearing: The Impact of Asymmetry in Spatial Release of Masking on Localization.

J Speech Lang Hear Res 2021 Sep 15:1-14. Epub 2021 Sep 15.

Department of Otorhinolaryngology-Head and Neck Surgery, Hearing and Implants, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.

Purpose This study aimed to gain more insight into the primary auditory abilities of children with significant residual hearing in order to improve decision making when choosing between bimodal fitting or sequential bilateral cochlear implantation. Method Sound localization abilities, spatial release of masking, and fundamental frequency perception were tested. Nine children with bimodal fitting and seven children with sequential bilateral cochlear implants were included in the study. Read More

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September 2021

Individual Differences in Phonetic Plasticity Across Native and Nonnative Contexts.

J Speech Lang Hear Res 2021 Sep 15:1-14. Epub 2021 Sep 15.

Department of Speech, Language, and Hearing Sciences, University of Connecticut, Storrs.

Purpose Individuals vary in their ability to learn the sound categories of nonnative languages (nonnative phonetic learning) and to adapt to systematic differences, such as accent or talker differences, in the sounds of their native language (native phonetic learning). Difficulties with both native and nonnative learning are well attested in people with speech and language disorders relative to healthy controls, but substantial variability in these skills is also present in the typical population. This study examines whether this individual variability can be organized around a common ability that we label "phonetic plasticity. Read More

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September 2021

Age-Related Functional Reserve Decline Is Not Seen in Pharyngeal Swallowing Pressures.

J Speech Lang Hear Res 2021 Sep 15:1-8. Epub 2021 Sep 15.

Department of Neurology, Dell Medical School, The University of Texas at Austin.

Purpose Functional reserve represents the difference between an individual's ability to produce a maximum output function and the ability to perform a functional task. Several studies have documented an age-related decrease in functional reserve with oral tongue pressure generation. Whether this pattern is seen in pharyngeal swallowing pressures is unknown. Read More

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September 2021

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel.

N Engl J Med 2021 Sep 15. Epub 2021 Sep 15.

From the Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot (Y.M.B.-O., R.M.), Technion-Israel Institute of Technology, Haifa (Y.G.), Hebrew University of Jerusalem (M.M.) and Israel Ministry of Health (O.B., S.A.-P., N.A.), Jerusalem, the Biostatistical and Biomathematical Unit, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat Gan (L.F., A.H.), KI Research Institute, Kfar Malal (N.K., B.M.), and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (A.H.) - all in Israel.

Background: On July 30, 2021, the administration of a third (booster) dose of the BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) was approved in Israel for persons who were 60 years of age or older and who had received a second dose of vaccine at least 5 months earlier. Data are needed regarding the effect of the booster dose on the rate of confirmed coronavirus 2019 disease (Covid-19) and the rate of severe illness.

Methods: We extracted data for the period from July 30 through August 31, 2021, from the Israeli Ministry of Health database regarding 1,137,804 persons who were 60 years of age or older and had been fully vaccinated (i. Read More

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September 2021

Does serum TSH level act as a surrogate marker for psychological stress and cardio-metabolic risk among adolescent and young people?

Horm Mol Biol Clin Investig 2021 Sep 16. Epub 2021 Sep 16.

Department of Biochemisty, All India Institute of Medical Sciences, Nagpur, India.

Objectives: The incidence of metabolic syndrome is increasing even at younger ages. Metabolic syndrome constitutes a group of cardiovascular risk factors that include high cholesterol, triacylglycerol, hyperglycemia, central obesity, etc., which increases the risk of cardiovascular disease, diabetes mellitus, may be even cancer. Read More

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September 2021

CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid-derived suppressor cells.

Immun Inflamm Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.

Introduction: The development of pancreatic ductal adenocarcinoma (PDAC) is closely tied with the immune system. C-C motif chemokine ligands (CCL) were proved to lead to immune recruitment and training. Thus, we reckoned CCL2 to be the kernel of immune suppression in PDAC tissues. Read More

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September 2021