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Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis.

Sci Rep 2021 Sep 17;11(1):18578. Epub 2021 Sep 17.

School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.

Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. Read More

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September 2021

Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest.

J Biophotonics 2021 Sep 17:e202100216. Epub 2021 Sep 17.

Histology, Cytology and Embryology Department, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

The impairments of cerebral blood flow microcirculation brought on by cardiac and respiratory arrest were assessed with multi-modal diagnostic facilities, utilising laser speckle contrast imaging, fluorescence spectroscopy and diffuse reflectance spectroscopy. The results of laser speckle contrast imaging show a notable reduction of cerebral blood flow in small and medium size vessels during a few minutes of respiratory arrest, while the same effect was observed in large sinuses and their branches during the circulatory cessation. Concurrently, the redox ratio assessed with fluorescence spectroscopy indicates progressing hypoxia, NADH accumulation and increase of FAD consumption. Read More

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September 2021

Ultrafast Control of Magnetic Anisotropy by Resonant Excitation of 4f Electrons and Phonons in Sm_{0.7}Er_{0.3}FeO_{3}.

Phys Rev Lett 2021 Sep;127(10):107401

Department of Physics and Center for Applied Photonics, University of Konstanz, D-78457 Konstanz, Germany.

We compare the ultrafast dynamics of the spin reorientation transition in the orthoferrite Sm_{0.7}Er_{0.3}FeO_{3} following two different pumping mechanisms. Read More

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September 2021

Diagnosis of Hirschsprung disease by hydrocolonic sonography in children.

Eur Radiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Ultrasound, Capital Institute of Pediatrics, No. 2 Yabao Rd, Chaoyang District, Beijing, 100020, China.

Objectives: To compare hydrocolonic sonography with histopathology for diagnosing children with symptoms highly suggestive of Hirschsprung disease (HD).

Methods: In this prospective study, patients presenting refractory constipation highly suggestive of HD underwent hydrocolonic sonography with retrograde infusion of saline into the colon. The dilated segments, narrowed segments, luminal diameter ratio, transition zone (TZ), thickening, and blood perfusion of the upstream bowel were evaluated. Read More

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September 2021

A Contrast Augmentation Approach to Improve Multi-Scanner Generalization in MRI.

Front Neurosci 2021 31;15:708196. Epub 2021 Aug 31.

Icometrix, Leuven, Belgium.

Most data-driven methods are very susceptible to data variability. This problem is particularly apparent when applying Deep Learning (DL) to brain Magnetic Resonance Imaging (MRI), where intensities and contrasts vary due to acquisition protocol, scanner- and center-specific factors. Most publicly available brain MRI datasets originate from the same center and are homogeneous in terms of scanner and used protocol. Read More

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Limited benefit of additional contrast-enhanced CT to end-of-treatment PET/CT evaluation in patients with follicular lymphoma.

Sci Rep 2021 Sep 16;11(1):18496. Epub 2021 Sep 16.

Clinic for Nuclear Medicine and Molecular Imaging, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Despite follicular lymphoma (FL) is frequently characterized by a moderate increase of glucose metabolism, PET/CT examinations provides valuable information for staging and response assessment of the disease. The aim of the study was to assess and compare the diagnostic performance of PET/ldCT and PET/ceCT, respectively, in evaluating FL patients at the end of treatment. Fifty FL consecutive patients who underwent end-of-therapy PET/CT with both ldCT and ceCT were analyzed. Read More

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September 2021

Selection, optimization and compensation strategies and their relationship with well-being and impulsivity in early, middle and late adulthood in a Polish sample.

BMC Psychol 2021 Sep 16;9(1):144. Epub 2021 Sep 16.

Faculty of Psychology, Kazimierz Wielki University, ul. Staffa 1, 85-867, Bydgoszcz, Poland.

Background: The model of selection, optimization, and compensation (SOC model) characterises the life management strategies that contribute to successful development. Although the SOC model is an important developmental theory, until now there has been no Polish version of a measurement tool for SOC strategies. The studies conducted so far have consistently indicated a relationship between the use of these strategies and well-being. Read More

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September 2021

Comparison of weight per volume and protein nitrogen units in non-standardized allergen extracts: implications for prescribing subcutaneous immunotherapy.

Allergy Asthma Clin Immunol 2021 Sep 16;17(1):92. Epub 2021 Sep 16.

Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Allergen extracts used in subcutaneous immunotherapy can be standardized or non-standardized. Standardized extracts are available in specific biological potencies, presumably making their biological activity more consistent. The majority of allergen extracts are non-standardized and may have less consistent potencies. Read More

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September 2021

[Clinical significance of the deep learning algorithm based on contrast-enhanced CT in the differential diagnosis of gastric gastrointestinal stromal tumors with a diameter ≤ 5 cm].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Sep;24(9):796-803

Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Contrast-enhanced CT is an important method of preoperative diagnosis and evaluation for the malignant potential of gastric submucosal tumor (SMT). It has a high diagnostic accuracy rate in differentiating gastric gastrointestinal stromal tumor (GIST) with a diameter greater than 5 cm from gastric benign SMT. This study aimed to use deep learning algorithms to establish a diagnosis model (GISTNet) based on contrast-enhanced CT and evaluate its diagnostic value in distinguishing gastric GIST with a diameter ≤ 5 cm and other gastric SMT before surgery. Read More

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September 2021

Brain-wide inferiority and equivalence tests in fMRI group analyses: Selected applications.

Hum Brain Mapp 2021 Sep 16. Epub 2021 Sep 16.

Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Null hypothesis significance testing is the major statistical procedure in fMRI, but provides only a rather limited picture of the effects in a data set. When sample size and power is low relying only on strict significance testing may lead to a host of false negative findings. In contrast, with very large data sets virtually every voxel might become significant. Read More

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September 2021

BLADE turbo gradient- and spin-echo in the assessment of sinonasal lesions: a comprehensive comparison of image quality in readout-segmented echo-planar imaging.

Acta Radiol 2021 Sep 16:2841851211041820. Epub 2021 Sep 16.

Department of Radiology, 159395Eye & ENT Hospital, 12478Fudan University, Shanghai Medical College, Shanghai, PR China.

Background: A two-dimensional turbo gradient-echo and spin-echo diffusion-weighted pulse sequence with a non-Cartesian BLADE trajectory (TGSE BLADE) can eliminate image artifacts and distortion with clinically acceptable scan times. This process has the potential to overcome the shortcomings of current diffusion-weighted imaging (DWI) techniques, especially in the sinonasal region.

Purpose: To investigate the feasibility of TGSE BLADE in the assessment of sinonasal lesions and compare the quality of TGSE BLADE with RESOLVE images both qualitatively and quantitatively. Read More

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September 2021

Subjective and objective clinical outcomes of a new trifocal toric intraocular lens and effect of femtosecond laser cataract surgery.

Eur J Ophthalmol 2021 Sep 16:11206721211046496. Epub 2021 Sep 16.

Bayindir Hospital, Ankara, Turkey.

Purpose: To evaluate the clinical outcomes and quality of life following implantation of PanOptix toric intraocular lens (IOL) and to compare the outcomes following femtosecond laser assisted cataract surgery (FLACS) and standard cataract surgery (SCS).

Methods: This comparative retrospective study included 79 eyes of 55 patients underwent cataract or refractive lens exchange surgery between April 2017 and January 2020 in Bayindir Hospital and Kaskaloglu Eye Hospital. Corneal (CA) and refractive astigmatism (RA), uncorrected visual acuities for distant, intermediate, and near (UDVA, UIVA, and UNVA), low contrast distance visual acuity, rotational stability, defocus curves, photopic and mesopic contrast sensitivity (CS), visual function-14 (VF-14) test, presence of dysphotopsia, and need for spectacles were evaluated at postoperative third month. Read More

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September 2021

A comparison of carotid atherosclerosis in symptomatic patients between 2002-2005 and 2012-2015 cohorts using multi-contrast magnetic resonance vessel wall imaging.

J Geriatr Cardiol 2021 Aug;18(8):623-630

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China.

Objective: To compare the morphological and compositional characteristics of carotid plaques in two cohorts (2002-2005 and 2012-2015) of Chinese patients using magnetic resonance vessel wall imaging.

Methods: Symptomatic patients with carotid atherosclerotic plaques who underwent carotid vessel wall magnetic resonance imaging between 2002-2005 and 2012-2015 were retrospectively recruited. Plaque morphology [including mean wall area, wall thickness, and maximum normalized wall index (NWI)] and composition [including calcification, intraplaque hemorrhage, and lipid-rich necrotic core (LRNC)] in symptomatic carotid arteries were evaluated and compared between patients in these two time periods. Read More

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Perioperative Two-Dimensional Left Ventricular Global Longitudinal Strain in Coronary Artery Bypass Surgery: A Prospective Observational Pilot Study.

J Cardiothorac Vasc Anesth 2021 Aug 25. Epub 2021 Aug 25.

Department of Cardiac Anesthesiology, Heart Center Dresden, University Hospital, Dresden, Germany. Electronic address:

Objectives: There are limited data on perioperative left ventricular strain. The authors aimed to describe the entire perioperative course of two-dimensional left ventricular global longitudinal strain in patients undergoing coronary artery bypass graft (CABG) surgery and compare to common parameters of LV function assessment.

Design: Prospective observational study. Read More

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Insights from and Identical Location (IL) Techniques on the Activation of Electrocatalysts for the Conversion of CO₂: A Mini-Review.

Chimia (Aarau) 2021 Sep;75(9):733-743

University of Bern, Department of Chemistry, Biochemistry and Pharmaceu- tical Sciences;, Email:

In this mini-review we compare two prototypical metal foam electrocatalysts applied to the transformation of CO₂ into value-added products ( alcohols on Cu foams and formate on Bi foams). A substantial improvement in the catalyst performance is typically achieved through thermal annealing of the as-deposited foam materials, followed by the electro-reduction of the pre-formed oxidic precursors prior or during the actual CO₂ electrolysis. Utilizing highly insightful and sensitive complementary analytical techniques (XAS, XRD, and Raman spectroscopy) we demonstrate that this catalyst pre-activation process is entirely accomplished in case of the oxidized Cu foams prior to the formation of hydrocarbons and alcohols from the CO₂. Read More

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September 2021

Towards cross-Canada monitoring of the unregulated street drug supply.

BMC Public Health 2021 Sep 15;21(1):1678. Epub 2021 Sep 15.

British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada.

Background: The well-being of people who use drugs (PWUD) continues to be threatened by substances of unknown type or quantity in the unregulated street drug supply. Current efforts to monitor the drug supply are limited in population reach and comparability. This restricts capacity to identify and develop measures that safeguard the health of PWUD. Read More

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September 2021

Spinal versus general anesthesia for patients undergoing outpatient total knee arthroplasty: a national propensity matched analysis of early postoperative outcomes.

BMC Anesthesiol 2021 Sep 15;21(1):226. Epub 2021 Sep 15.

Department of Anesthesiology, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Davol #129, Providence, RI, 02903, USA.

Background: A comparison of different anesthetic techniques to evaluate short term outcomes has yet to be performed for patients undergoing outpatient knee replacements. The aim of this investigation was to compare short term outcomes of spinal (SA) versus general anesthesia (GA) in patients undergoing outpatient total knee replacements.

Methods: The ACS NSQIP datasets were queried to extract patients who underwent primary, elective, unilateral total knee arthroplasty (TKA) between 2005 and 2018 performed as an outpatient procedure. Read More

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September 2021

Influence of Moxonidine and Bisoprolol on Morphofunctional Condition of Arterial Wall and Telomerase Activity in Postmenopausal Women with Arterial Hypertension and Osteopenia. The Results from a Moscow Randomized Study.

Cardiovasc Drugs Ther 2021 Sep 15. Epub 2021 Sep 15.

Pirogov Russian National Research Medical University, Moscow, Russia.

Purpose: To compare the effect of 12 months of treatment with moxonidine or bisoprolol on telomerase activity (TA) and parameters characterizing the arterial wall state in postmenopausal women with arterial hypertension (AH) and osteopenia.

Methods: An open-label randomized study with 114 postmenopausal women with hypertension and osteopenia; pulse wave velocity (PWV), intima-media thickness (IMT), and TA were analyzed initially and after 12 months of therapy with moxonidine (n = 57) or bisoprolol (n = 57).

Results: Both medications effectively lowered blood pressure (BP) in both groups. Read More

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September 2021

Comparison of indocyanine green fluorescence lymphangiography and magnetic resonance lymphangiography to investigate lymphedema of the extremities.

Ann Ital Chir 2021 ;92:452-459

Purpose: The aim of this study is to compare two dynamic imaging modalities employed to study peripheral lymphatic system, Magnetic Resonance Lymphangiography (MRL) and Indocyanine Green Lymphangiography (ICGL), evaluating their role for planning lymphaticovenular anastomosis (LVA) or other surgical-nonsurgical treatments in patients with lymphedema of the extremities.

Materials And Methods: We conducted a retrospective study of 32 patients (26 women) with a mean age of 38 years (range 18-73) enrolled from January 2014 to December 2018; 20 out of 32 were affected by lower limb lymphedema with 6 cases of primary lymphedema; all of them had stage II disease. All the patient underwent ICGL and MRL within a month of one another, by injecting different contrast medium into interdigital web spaces. Read More

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September 2021

Recent Academic Research on Clinically Relevant Digital Measures: Systematic Review.

J Med Internet Res 2021 Sep 15;23(9):e29875. Epub 2021 Sep 15.

Department of Biomedical Engineering, Duke University, Durham, NC, United States.

Background: Digital clinical measures collected via various digital sensing technologies such as smartphones, smartwatches, wearables, ingestibles, and implantables are increasingly used by individuals and clinicians to capture health outcomes or behavioral and physiological characteristics of individuals. Although academia is taking an active role in evaluating digital sensing products, academic contributions to advancing the safe, effective, ethical, and equitable use of digital clinical measures are poorly characterized.

Objective: We performed a systematic review to characterize the nature of academic research on digital clinical measures and to compare and contrast the types of sensors used and the sources of funding support for specific subareas of this research. Read More

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September 2021

Method for determining slice sensitivity profile of iterative reconstruction CT images using low-contrast sphere phantom.

Radiol Phys Technol 2021 Sep 14. Epub 2021 Sep 14.

Department of Clinical Support, Niigata University Medical and Dental Hospital, 754, Ichibancho, Asahimachidori, Chuo-ku, Niigata-shi, Niigata, Japan.

A novel method for measuring the slice sensitivity profile (SSP) of computed tomography (CT) images reconstructed using an iterative reconstruction (IR) algorithm is proposed herein. A phantom that included a low-contrast spherical object was scanned and consecutive cross-sectional images were reconstructed. The mean CT values in a region including the sphere were measured for all images and plotted as a function of slice position along the longitudinal [Formula: see text] direction to yield a mean CT value profile [Formula: see text]. Read More

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September 2021

Curled cation structures accelerate the dynamics of ionic liquids.

Phys Chem Chem Phys 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Saarland University, Campus B2.2, 66123, Saarbrücken, Germany.

Ionic liquids are modern liquid materials with potential and actual implementation in many advanced technologies. They combine many favourable and modifiable properties but have a major inherent drawback compared to molecular liquids - slower dynamics. In previous studies we found that the dynamics of ionic liquids are significantly accelerated by the introduction of multiple ether side chains into the cations. Read More

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September 2021

Direct measurement of neuronal ensemble activity using photoacoustic imaging in the stimulated Fos-LacZ transgenic rat brain: A proof-of-principle study.

Photoacoustics 2021 Dec 30;24:100297. Epub 2021 Aug 30.

The Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, USA.

Measuring neuroactivity underlying complex behaviors facilitates understanding the microcircuitry that supports these behaviors. We have developed a functional and molecular photoacoustic tomography (F/M-PAT) system which allows direct imaging of Fos-expressing neuronal ensembles in Fos-LacZ transgenic rats with a large field-of-view and high spatial resolution. F/M-PAT measures the beta-galactosidase catalyzed enzymatic product of exogenous chromophore X-gal within ensemble neurons. Read More

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December 2021

Formulary Substitution of Proton Pump Inhibitors Based on Acquisition Price: Changes in Usage and Costs of Acid-Suppressant Therapies.

P T 2006 Dec;31(12):716-734

Associate Professor at the University of Colorado School of Pharmacy and Health Sciences Center in Denver, Colorado.

Objective: In addition to indications for proton pump inhibitors (PPIs) outside the intensive-care unit (ICU), these medications are frequently used to manage nonvariceal upper gastrointestinal (GI) hemorrhage and to prevent stress-related mucosal bleeding in ICU patients. In September 2004, the P&T committee at the University of Colorado Health Sciences Center substituted three PPIs for one less expensive, preferred PPI product; all dosage forms were included. Our goal was to determine whether switching these PPIs to the least expensive agent would alter their usage and associated costs in the ICU (48 beds) and in non-ICU sites (325 beds). Read More

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December 2006

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data.

Nat Commun 2021 Sep 14;12(1):5420. Epub 2021 Sep 14.

Institute for Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.

Estimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. Read More

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September 2021

Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects.

Acta Biomater 2021 Sep 11. Epub 2021 Sep 11.

INSERM, UMR1238, PHY-OS, Faculty of Medicine, 1 Rue Gaston Veil, 44035, University of Nantes, Nantes, France. Electronic address:

In contrast to sintered calcium phosphates (CaPs) commonly employed as scaffolds to deliver mesenchymal stromal cells (MSCs) targeting bone repair, low temperature setting conditions of calcium deficient hydroxyapatite (CDHA) yield biomimetic topology with high specific surface area. In this study, the healing capacity of CDHA administering MSCs to bone defects is evaluated for the first time and compared with sintered beta-tricalcium phosphate (β-TCP) constructs sharing the same interconnected macroporosity. Xeno-free expanded human bone marrow MSCs attached to the surface of the hydrophobic β-TCP constructs, while infiltrating the pores of the hydrophilic CDHA. Read More

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September 2021

Comparison of phosphonate, hydroxypropyl and carboxylate pendants in Fe(III) macrocyclic complexes as MRI contrast agents.

J Inorg Biochem 2021 Aug 28;225:111594. Epub 2021 Aug 28.

Department of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States of America. Electronic address:

Fe(III) macrocyclic complexes containing a macrocycle and three pendant groups including phosphonate (NOTP =1,4,7-triazacyclononane-1,4,7-triyl-tris(methylenephosphonic acid), carboxylate (NOTA = 1,4,7 - triazacyclononane - N,N',N″ - triacetate) or hydroxypropyl (NOHP =(2S,2'S,2"S)-1,1',1″-(1,4,7-triazonane-1,4,7-triyl)tris(propan-2-ol)) were studied in order to compare the effect of these donor groups on solution chemistry and water proton relaxivity. All three complexes, Fe(NOTP), Fe(NOHP) and Fe(NOTA), display a large degree of kinetic inertness to dissociation in the presence of phosphate and carbonate, under acidic conditions of 100 mM HCl or 1 M HCl or to trans-metalation with Zn(II). The r proton relaxivity of the complexes at 1. Read More

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Size-specific dose estimates of adult, chest computed tomography examinations: Comparison of Chinese and updated 2017 American College of Radiology diagnostic reference levels based on the water-equivalent diameter.

PLoS One 2021 13;16(9):e0257294. Epub 2021 Sep 13.

Department of Radiology, Chengdu First People's Hospital, Chengdu, Sichuan Province, China.

Rationale And Objectives: This study aimed to compare the volume computed tomography dose index (CTDIvol), dose length product (DLP), and size-specific dose estimate (SSDE), with the China and updated 2017 American College of Radiology (ACR) diagnostic reference levels (DRLs) in chest CT examinations of adults based on the water-equivalent diameter (Dw).

Materials And Methods: All chest CT examinations conducted without contrast administration from January 2020 to July 2020 were retrospectively included in this study. The Dw and SSDE of all examinations were calculated automatically by "teamplay". Read More

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September 2021

Selective adaptation in speech: Measuring the effects of visual and lexical contexts.

J Exp Psychol Hum Percept Perform 2021 Aug;47(8):1023-1042

Department of Psychology, University of California, Riverside.

Speech selective adaptation is a phenomenon in which repeated presentation of a speech stimulus alters subsequent phonetic categorization. Prior work has reported that lexical, but not multisensory, context influences selective adaptation. This dissociation suggests that lexical and multisensory contexts influence speech perception through separate and independent processes (see Samuel & Lieblich, 2014). Read More

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Impact of Type II LRRK2 inhibitors on signalling and mitophagy.

Biochem J 2021 Sep 13. Epub 2021 Sep 13.

University of Dundee, DUNDEE, United Kingdom.

Much effort has been devoted to the development of selective inhibitors of the LRRK2 as a potential treatment for LRRK2 driven Parkinson's disease. In this study we first compare the properties of Type I (GSK3357679A and MLi-2) and Type II (GZD-824, Rebastinib and Ponatinib) kinase inhibitors that bind to the closed or open conformations of the LRRK2 kinase domain, respectively. We show that Type I and Type II inhibitors suppress phosphorylation of Rab10 and Rab12, key physiological substrates of LRRK2 and also promote mitophagy, a process suppressed by LRRK2. Read More

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September 2021