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Effects of Tourniquet Application on Faster Recovery after Surgery and Ischemia-Reperfusion Post-Total Knee Arthroplasty, Cementation through Closure versus Full-Course and Nontourniquet Group.

J Knee Surg 2021 May 15. Epub 2021 May 15.

Department of Orthopaedic Surgery, Jinling Hospital, Nanjing, China.

Pneumatic tourniquets are used in total knee arthroplasty (TKA) for surgical field visualization and improved cementation; however, their use is controversial. This study aimed to assess the effects of tourniquet application on faster recovery post-TKA. Our hypothesis was that inflammation and limb function would be similar with different tourniquet applications. Read More

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Early predictive factors of visual loss at 1-year in neovascular age-related macular degeneration under anti-VEGF in the GEFAL study.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Université Lyon 1, Lyon, France; UMR-CNRS 5510 Matéis, Villeurbane, France.

Purpose: To evaluate early predictive factors of visual loss in patients treated with anti-vascular endothelial growth factor (VEGF) injections under as-needed regimen for neovascular age-related macular degeneration (AMD).

Design: Post-hoc analysis from the randomized controlled trial GEFAL, comparing ranibizumab versus bevacizumab for neovascular AMD.

Participants: 393 patients aged ≥50 years with neovascular AMD. Read More

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Neurophysiological tracking of speech-structure learning in typical and dyslexic readers.

Neuropsychologia 2021 May 12:107889. Epub 2021 May 12.

Maastricht Brain Imaging Center, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.

Statistical learning, or the ability to extract statistical regularities from the sensory environment, plays a critical role in language acquisition and reading development. Here we employed electroencephalography (EEG) with frequency-tagging measures to track the temporal evolution of speech-structure learning in individuals with reading difficulties due to developmental dyslexia and in typical readers. We measured EEG while participants listened to (a) a structured stream of repeated tri-syllabic pseudowords, (b) a random stream of the same isochronous syllables, and (c) a series of tri-syllabic real Dutch words. Read More

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Sex Differences Among Patients With High Risk Receiving Ticagrelor With or Without Aspirin After Percutaneous Coronary Intervention: A Subgroup Analysis of the TWILIGHT Randomized Clinical Trial.

JAMA Cardiol 2021 May 15. Epub 2021 May 15.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Importance: Shortened dual antiplatelet therapy followed by potent P2Y12 receptor inhibitor monotherapy reduces bleeding without increasing ischemic events after percutaneous coronary intervention (PCI).

Objective: To explore sex differences and evaluate the association of sex with outcomes among patients treated with ticagrelor monotherapy vs ticagrelor plus aspirin.

Design, Setting, And Participants: This was a prespecified secondary analysis of TWILIGHT, an investigator-initiated, placebo-controlled randomized clinical trial conducted at 187 sites across 11 countries. Read More

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Prognostic value of non-smoking, non-alcohol drinking status in oral cavity cancer.

Clin Oral Investig 2021 May 15. Epub 2021 May 15.

Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China.

Objectives: To compare the treatment response and prognosis of oral cavity cancer between non-smoking and non-alcohol-drinking (NSND) patients and smoking and alcohol-drinking (SD) patients.

Methods: A total of 313 consecutively treated patients from 2000 to 2019 were included. Demographic, clinicopathologic, treatment, and prognosis information were obtained. Read More

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The impact of delayed time to first CT head on functional outcomes after blunt head trauma with moderately depressed GCS.

Eur J Trauma Emerg Surg 2021 May 14. Epub 2021 May 14.

Division of Trauma and Surgical Critical Care, LAC + USC Medical Center, University of Southern California, 2051 Marengo Street, Inpatient Tower, C5L100, Los Angeles, CA, 90033, USA.

Purpose: Recent work suggests patients with moderately depressed Glasgow Coma Scale (GCS) score in the Emergency Department (ED) who do not undergo immediate head CT (CTH) have delayed neurosurgical intervention and longer ED stay. The present study objective was to determine the impact of time to first CTH on functional neurologic outcomes in this patient population.

Methods: Blunt trauma patients presenting to our Level I trauma center (11/2015-10/2019) with first ED GCS 9-12 were retrospectively identified and included. Read More

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A randomized clinical trial evaluating the short-term results of ureteral stent encrustation in urolithiasis patients undergoing ureteroscopy: micro-computed tomography evaluation.

Sci Rep 2021 May 14;11(1):10337. Epub 2021 May 14.

Department of Urology and Andrology, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, 573-1152, Japan.

Although many ureteral stents are commercially available, the actuality of encrustation is yet to be elucidated in humans. This study compared the Tria Ureteral Stent with PercuShield and the Polaris Ultra Ureteral Stent with HydroPlus Coating for short-term encrustation formation. Eighty-four patients, who required ureteral stent placement after ureteroscopy, were randomized into two stent groups. Read More

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Predictive SNPs for β-thalassemia/HbE disease severity.

Sci Rep 2021 May 14;11(1):10352. Epub 2021 May 14.

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.

β-Thalassemia/HbE disease has a wide spectrum of clinical phenotypes ranging from asymptomatic to dependent on regular blood transfusions. Ability to predict disease severity is helpful for clinical management and treatment decision making. A thalassemia severity score has been developed from Mediterranean β-thalassemia patients. Read More

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Influence of Minimally Invasive Resection Technique on Sphincter Preservation and Short-term Outcome in Low Rectal Cancer in the Netherlands.

Dis Colon Rectum 2021 May 13. Epub 2021 May 13.

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, Netherlands Department of Surgery, Amphia, Breda, Netherlands Department of Surgery, Reinier de Graaf Hospital, Delft, the Netherlands. Department of Surgery, Amsterdam University Medical Centers, Free University Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands Department of Surgery, Gelderse Vallei Hospital, Ede, the Netherlands.

Background: Transanal and robotic-assisted total mesorectal excision are techniques that can potentially overcome challenges encountered with a pure laparoscopic approach in patients with rectal cancer.

Objective: The aim of this study was to evaluate the proportion and predictive factors of restorative procedures and subsequent short-term outcomes of three minimally invasive techniques to treat low rectal cancer.

Design: This is a nationwide observational comparative registry study. Read More

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Does Adding the Dialectical Behavior Therapy Prolonged Exposure (DBT PE) Protocol for PTSD to DBT Improve Outcomes in Public Mental Health Settings? A Pilot Nonrandomized Effectiveness Trial With Benchmarking.

Behav Ther 2021 May 1;52(3):639-655. Epub 2020 Sep 1.

West Chester University.

The Dialectical Behavior Therapy Prolonged Exposure (DBT PE) protocol improves DBT's effects on PTSD in research settings, but its effectiveness in community settings is largely unknown. This pilot nonrandomized controlled trial examined DBT with and without DBT PE in four public mental health agencies. Patients (N = 35, 12-56 years old, 80. Read More

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Feasibility and Efficacy of Delivering Cognitive Behaviour Therapy through Online Psychotherapy Tool (OPTT) for Depression: Protocol.

JMIR Res Protoc 2021 May 12. Epub 2021 May 12.

Department of Psychiatry, Queen's University, Hotel Dieu Hospital166 Brock Street, Kingston, CA.

Background: Major Depressive Disorder (MDD) is a prevalent and debilitating mental health disorder. Among different therapeutic approaches (e.g. Read More

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Postoperative pain control after arthroscopic rotator cuff repair: Arthroscopy-guided continuous suprascapular nerve block versus ultrasound-guided continuous inter-scalene block.

Arthroscopy 2021 May 11. Epub 2021 May 11.

Department of Orthopaedic Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. Electronic address:

Purpose: We aimed to compare the clinical efficacy and safety of arthroscopy-guided continuous suprascapular nerve block (AS-SSNB) and ultrasound-guided continuous interscalene block (US-ISB) in postoperative analgesia in patients undergoing arthroscopic rotator cuff repair (ARCR).

Methods: A prospective study was performed between March and November 2020. In total, 76 patients were enrolled and divided into two groups: in 38 patients of group 1 (AS-SSNB), an indwelling catheter was introduced via the Neviaser portal under arthroscopic view before closing the portal at the end of the surgery; and in 38 patients of group 2 (US-ISB), an indwelling catheter was inserted directing towards the interscalene brachial plexus prior to the surgery under ultrasound-guidance. Read More

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Breaking potentially bad news of cancer workup to well-informed patients by telephone versus in-person: A randomised controlled trial on psychosocial consequences.

Eur J Cancer Care (Engl) 2021 May 14:e13435. Epub 2021 May 14.

The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen K, Denmark.

Background: The use of telephone in delivering cancer care increases, but not in cancer workup. Current protocols for breaking bad news assume a single in-person meeting. Cancer workup involves multiple opportunities for patient information. Read More

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Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients.

Cardiovasc Drugs Ther 2021 May 14. Epub 2021 May 14.

Division of Cardiology, "Bolognini" Hospital, ASST Bergamo Est, Seriate, BG, Italy.

Purpose: The clinical course of COVID-19 may be complicated by acute respiratory distress syndrome (ARDS) and thromboembolic events, which are associated with high risk of mortality. Although previous studies reported a lower rate of death in patients treated with heparin, the potential benefit of chronic oral anticoagulation therapy (OAT) remains unknown. We aimed to investigate the association between OAT with the risk of ARDS and mortality in hospitalized patients with COVID-19. Read More

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Optimizing conditioning regimen with low-dose irradiation or busulfan enables the outcome of transplantation from a 6-7/8 HLA-matched donor comparable to that from an 8/8 HLA-matched unrelated donor in severe aplastic anemia patients under 40 years.

Ann Hematol 2021 May 14. Epub 2021 May 14.

Department of Hematology and Oncology, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai, 200127, China.

With the dramatic improvements in outcomes following alternative donor hematopoietic stem cell transplantation (HSCT), interest in the use of alternative donors in severe aplastic anemia (SAA) is increasing. We conducted a multicenter prospective study to explore the efficiency and safety of upfront HSCT from a 6-8/8 HLA-matched unrelated donor (MUD) or 6-7/8 HLA-matched related donor (MRD) in acquired SAA patients under 40 years. Between August 2014 and July 2017, 115 patients were enrolled, including 48 (41. Read More

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Cost-effectiveness of Public Caseload Midwifery Compared to Standard Care in an Australian Setting: a Pragmatic Analysis to Inform Service Delivery.

Int J Qual Health Care 2021 May 14. Epub 2021 May 14.

Transforming Maternity Care Collaborative, Australia.

Background: Decision-makers need quantifiable data on costs and outcomes to determine the optimal mix of antenatal models of care to offer. This study aimed to examine the cost-utility of a publicly funded Midwifery Group Practice (MGP) caseload model of care compared to other models of care, and demonstrate the feasibility of conducting such an analysis to inform service decision-making.

Methods: Incremental costs and incremental utility (health gains measured in quality adjusted life years) of public MGP caseload was compared to other models of care currently offered at a large tertiary hospital in Australia. Read More

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Synthesis and Evaluation of PPARδ Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis.

J Med Chem 2021 May 14. Epub 2021 May 14.

Center for Drug Design and Development, Department of Medicinal and Biological Chemistry, University of Toledo College of Pharmacy and Pharmaceutical Sciences, 3000 Arlington Avenue, Toledo, Ohio 43614, United States.

We synthesized a directed library of compounds to explore the structure-activity relationships of peroxisome proliferator-activated receptor δ (PPARδ) activation relative to mesenchymal stem cell (MSC) osteogenesis. Our scaffold used para-substituted cinnamic acids as a polar headgroup, a heteroatom and heterocycle core connecting units, and substituted phenyl groups for the lipophilic tail. Compounds were screened for their ability to increase osteogenesis in MSCs, and the most promising were examined for subunit specificity using a quantitative PPAR transactivation assay. Read More

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The evaluation of physical properties of a polyurethane expandable endodontic sealer: a preliminary study.

Aust Endod J 2021 May 14. Epub 2021 May 14.

Abdolmaleki Consulting Group, British Columbia, BC, Canada.

Endodontic sealers play a vital role in providing 3-dimensional (3D) filling of complex root canal system (RCS). This study intended to compare the physical properties of a Polyurethane Expandable Sealer (PES), AH Plus and EndoSequence. Three properties including setting time, radiopacity and flow (rheology) were evaluated based on ISO 6876 standard. Read More

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EXPRESS: Stent Retriever Alone vs. Aspiration and Stent-Retriever Combination in Large Vessel Occlusion Stroke: A Matched Analysis.

Int J Stroke 2021 May 14:17474930211019204. Epub 2021 May 14.

Emory University School of Medicine, Atlanta, Georgia, United States.

Background Three randomized clinical trials have reported similar safety and efficacy for contact aspiration (CA) and Stent-retriever (SR) thrombectomy. AimWe aimed to determine whether the Combined Technique (SR+CA) was superior to SR alone as first-line thrombectomy strategy in a patient cohort where balloon-guide catheter was universally used. MethodsA prospectively maintained mechanical thrombectomy database from January 2018-December 2019 was reviewed. Read More

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Endoscopic and surgical treatment of T1N0M0 colorectal neuroendocrine tumors: a population-based comparative study.

Surg Endosc 2021 May 13. Epub 2021 May 13.

Medical Centre for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.

Background: With the rapid advances in endoscopic technology, endoscopic therapy (ET) is increasingly applied to the treatment of small (≤ 20 mm) colorectal neuroendocrine tumors (NETs). However, long-term data comparing ET and surgery for management of T1N0M0 colorectal NETs are lacking. The purpose of this work was to compare overall survival (OS) and cancer-specific survival (CSS) of such patients with ET or surgery. Read More

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Effects of radish powder concentration and incubation time on the physicochemical characteristics of alternatively cured pork products.

J Anim Sci Technol 2020 Nov 30;62(6):922-932. Epub 2020 Nov 30.

School of Food Biotechnology & Nutrition, Kyungsung University, Busan 48434, Korea.

Previous research has indicated that radish powder could be a suitable replacement for chemical nitrite sources in alternatively cured meat products. However, the effects of radish powder level on the physicochemical properties of cured meat have not been systematically studied. In this study, we aimed to investigate the effects of varying concentrations of radish powder and incubation time on the physicochemical properties and cured meat pigments of alternatively cured meat products. Read More

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November 2020

Efficacy and safety of vinorelbine and cisplatin regimen of different doses and intensities for neoadjuvant chemotherapy in patients with locally advanced esophageal carcinoma.

Ann Transl Med 2021 Apr;9(8):660

Department of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.

Background: There are few studies focused on comparing the toxicity, postoperative complication rate, and survival among patients with locally advanced esophageal squamous cell cancer receiving a different dose and intensity of vinorelbine plus cisplatin for neoadjuvant chemoradiotherapy (nCRT) followed by surgery.

Methods: In total, 78 patients diagnosed with locally advanced esophageal squamous cell cancer that had received a vinorelbine and cisplatin (VP)1 or VP2 regimen for nCRT followed by surgery in Taizhou Hospital of Zhejiang Province between June 2008 and December 2016 were retrospectively analyzed. The VP1 regimen involved cisplatin 75 mg/m on day 1, and vinorelbine 25 mg/m on days 1 and 8, for two cycles. Read More

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Does splenectomy significantly improve the prognosis of hepatocellular carcinoma patients with hypersplenism? A systematic review and meta-analysis.

Ann Transl Med 2021 Apr;9(8):641

Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Background: Whether hepatocellular carcinoma (HCC) patients with hypersplenism can benefit from splenectomy is unclear. This study aimed at exploring the efficacy and safety of concurrent splenectomy for HCC patients with hypersplenism.

Methods: PubMed, EMBASE and Web of Science databases were systematically searched to compare data on the combination of hepatectomy or transhepatic arterial infusion (TAI) with splenectomy (the splenectomy group) with data on hepatectomy or TAI alone (the non-splenectomy group) for the treatment of HCC with hypersplenism. Read More

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Premature ovarian insufficiency patients with viable embryos derived from autologous oocytes through repeated oocyte retrievals could obtain reasonable cumulative pregnancy outcomes following frozen-embryo transfer.

Ann Transl Med 2021 Apr;9(7):539

Department of Assisted Reproductive Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Women with premature ovarian insufficiency (POI) are often discouraged from using autologous oocytes; however, some patients have a strong desire to be genetically linked to their offspring. In the present study, we aimed to estimate cumulative pregnancy outcomes following frozen-embryo transfer (FET) in POI patients who could obtain viable embryos with their eggs during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments.

Methods: In this matched-retrospective cohort study, only patients undergoing IVF/ICSI treatments with a freeze-all strategy were screened, and 103 POI patients were matched with 515 normal controls in terms of the same number of viable embryos obtained at the same age. Read More

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MRI-Based Radiomics to Differentiate between Benign and Malignant Parotid Tumors With External Validation.

Front Oncol 2021 27;11:656918. Epub 2021 Apr 27.

Radiology and Diagnostic Imaging Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Background: The differentiation between benign and malignant parotid lesions is crucial to defining the treatment plan, which highly depends on the tumor histology. We aimed to evaluate the role of MRI-based radiomics using both T2-weighted (T2-w) images and Apparent Diffusion Coefficient (ADC) maps in the differentiation of parotid lesions, in order to develop predictive models with an external validation cohort.

Materials And Methods: A sample of 69 untreated parotid lesions was evaluated retrospectively, including 37 benign (of which 13 were Warthin's tumors) and 32 malignant tumors. Read More

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Beneficial effects of an intergenerational exercise intervention on health-related physical and psychosocial outcomes in Swiss preschool children and residential seniors: a clinical trial.

PeerJ 2021 27;9:e11292. Epub 2021 Apr 27.

Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.

Background: Intergenerational exercise possesses the potential to becoming an innovative strategy for promoting physical activity in seniors and children. Although this approach has gained attraction within the last decade, controlled trials on physical and psychosocial effects have not been performed yet.

Methods: Sixty-eight healthy preschool children (age: 4. Read More

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Intact tactile anisotropy despite altered hand perception in complex regional pain syndrome: rethinking the role of the primary sensory cortex in tactile and perceptual dysfunction.

PeerJ 2021 3;9:e11156. Epub 2021 May 3.

Neuroscience Research Australia, NEURA, University of New South Wales, Sydney, New South Wales, Australia.

Complex Regional Pain Syndrome (CRPS) is characterised by pain, autonomic, sensory and motor abnormalities. It is associated with changes in the primary somatosensory cortex (S1 representation), reductions in tactile sensitivity (tested by two-point discrimination), and alterations in perceived hand size or shape (hand perception). The frequent co-occurrence of these three phenomena has led to the assumption that S1 changes underlie tactile sensitivity and perceptual disturbances. Read More

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Skeletal microenvironment system utilising bovine bone scaffold co-cultured with human osteoblasts and osteoclast-like cells.

Exp Ther Med 2021 Jul 25;22(1):680. Epub 2021 Apr 25.

Department of Pharmacology, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Wilayah Persekutuan Kuala Lumpur 56000, Malaysia.

A three-dimensional bone cell culture system mimicking the skeletal system is useful for bone tissue engineering and as drug discovery platforms. The present study aimed to establish a three-dimensional skeletal culture system using native bovine bone scaffolds and human bone cells. Bovine bone scaffolds were cultured with human foetal osteoblasts 1. Read More

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Detection of Plasmodium falciparum in laboratory-reared and naturally infected wild mosquitoes using near-infrared spectroscopy.

Sci Rep 2021 May 13;11(1):10289. Epub 2021 May 13.

MRC Centre for Global Infectious Disease Analysis, Infectious Disease Epidemiology, Imperial College London, London, W2 1PG, UK.

There is an urgent need for high throughput, affordable methods of detecting pathogens inside insect vectors to facilitate surveillance. Near-infrared spectroscopy (NIRS) has shown promise to detect arbovirus and malaria in the laboratory but has not been evaluated in field conditions. Here we investigate the ability of NIRS to identify Plasmodium falciparum in Anopheles coluzzii mosquitoes. Read More

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Daytime Variation of Clinical Outcome in Cardiac Surgery: A Propensity-Matched Cohort Study.

J Cardiothorac Vasc Anesth 2021 Apr 3. Epub 2021 Apr 3.

Faculty of medicine, University of Montreal, Canada; Department of Cardiac Surgery, CHUM, Université de Montréal, Montréal, Canada.

Objective: The purpose of the present study was to investigate the hypothesis of a nychthemeral variation in the tolerance to ischemia and reperfusion injury in adult cardiac surgeries.

Design: Retrospective cohort study.

Setting: A single academic center. Read More

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