17,488 results match your criteria comorbidity type


Impact of Socioeconomic Factors and Gender on Refill Adherence and Persistence to Lipid-Lowering Therapy in Type 1 Diabetes.

Diabetes Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Introduction: Lipid-lowering therapy (LLT) reduces the risk of cardiovascular disease (CVD) in patients with type 1 diabetes (T1D). However, socioeconomic factors and gender may have an impact on the adherence to and non-persistence with LLT.

Methods: This was a nationwide register-based cohort study that included 6192 individuals with T1D aged ≥ 18 years who were registered in the Swedish National Diabetes Register and had initiated novel use of LLT. Read More

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The Analysis of Hospital Readmission Rates After the Implementation of Hospital Readmissions Reduction Program.

J Patient Saf 2021 Jul 21. Epub 2021 Jul 21.

From the Eastern Connecticut State University, Willimantic, Connecticut Department of Industrial and Systems Engineering, Rochester Institute of Technology, Rochester, New York.

Objectives: This study aims to analyze the impact of Hospital Readmissions Reduction Program (HRRP) on the nationwide optimization efforts of length of stay (LOS) and readmissions in the United States.

Methods: We use the Nationwide Readmission Database between 2010 and 2016 provided in the Healthcare Cost and Utilization Project by the Agency for Healthcare Research and Quality. The study focuses on acute myocardial infarction, chronic obstructive pulmonary disease, congestive heart failure (CHF), pneumonia monitored by the HRRP and 2 conditions, septicemia, and mood disorders that were not monitored by the HRRP but had among the highest readmissions. Read More

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Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP.

J Inflamm Res 2021 15;14:3335-3348. Epub 2021 Jul 15.

Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, People's Republic of China.

Background: Chronic obstructive pulmonary disease (COPD) often coexists with multiple comorbidities which may have a significant impact on acute exacerbations of patients. At present, what kind of comorbidities affects acute exacerbations and how comorbidities lead to poor prognosis are still controversial. The purpose of our study is to determine the impact of comorbidities on COPD exacerbation and establish an acute exacerbation risk assessment system related to comorbidities. Read More

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Single-neuron correlate of epilepsy-related cognitive deficits in visual recognition memory in right mesial temporal lobe.

Epilepsia 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Objective: Impaired memory is a common comorbidity of refractory temporal lobe epilepsy (TLE) and often perceived by patients as more problematic than the seizures themselves. The objective of this study is to understand what the relationship of these behavioral impairments is to the underlying pathophysiology, as there are currently no treatments for these deficits, and it remains unknown what circuits are affected.

Methods: We recorded single neurons in the medial temporal lobes (MTLs) of 62 patients (37 with refractory TLE) who performed a visual recognition memory task to characterize the relationship between behavior, tuning, and anatomical location of memory selective and visually selective neurons. Read More

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Risk Factors for Mortality in Melioidosis: A Single-Centre, 10-Year Retrospective Cohort Study.

ScientificWorldJournal 2021 5;2021:8154810. Epub 2021 Jul 5.

Department of Microbiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Melioidosis is a tropical infectious disease with diverse clinical presentations. We aimed to investigate the characteristics and mortality risk factors of patients diagnosed with melioidosis in the past 10 years. This was a retrospective cohort study conducted at a quaternary care centre in South India. Read More

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Anhedonia and Substance Use Disorders by Type, Severity, and With Mental Health Disorders.

J Addict Med 2021 Jul 16. Epub 2021 Jul 16.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA (SWS, STL); Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD (SWS, JWB, DHE); The University of Illinois at Chicago, Center for Dissemination and Implementation Science, Chicago, IL (BCB); The Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, PA (STL).

Objectives: Anhedonia can accompany substance use disorders (SUDs); its severity may vary by substance type, severity of SUD symptoms, or psychiatric comorbidity. The goal of this study was to clarify the contribution of each.

Methods: Data were from participants aged 18 to 65 years in the National Epidemiologic Survey on Alcohol and Related Conditions III (n = 30,999; 51% women), a cross-sectional, nationally representative sample reporting lifetime DSM-5 symptoms and lifetime anhedonia. Read More

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Real-World Clinical Outcomes of Bamlanivimab and Casirivimab-Imdevimab among High-Risk Patients with Mild to Moderate Coronavirus Disease 2019.

J Infect Dis 2021 Jul 19. Epub 2021 Jul 19.

Mayo Clinic, Rochester, Minnesota, USA.

Background: Bamlanivimab and casirivimab-imdevimab are authorized for treatment of high-risk patients with mild to moderate coronavirus disease-2019 (COVID-19). We compared the outcomes of patients who received these therapies to identify factors associated with hospitalization and other clinical outcomes.

Methods: Adult patients who received monoclonal antibody from November 19, 2020 to February 11, 2021 were selected and divided into those who received bamlanivimab (n=2747) and casirivimab-imdevimab (n=849). Read More

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Investigating Pleiotropy Between Depression and Autoimmune Diseases Using the UK Biobank.

Biol Psychiatry Glob Open Sci 2021 Jun;1(1):48-58

Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Background: Epidemiological studies report increased comorbidity between depression and autoimmune diseases. The role of shared genetic influences in the observed comorbidity is unclear. We investigated the evidence for pleiotropy between these traits in the UK Biobank (UKB). Read More

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Intensive multidisciplinary treatment strategies and patient resilience to challenge long-term survival in metastatic colorectal cancer: a case report in real life and clinical practice.

Ann Transl Med 2021 Jun;9(12):1027

Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L'Aquila, L'Aquila, Italy.

In fit metastatic colorectal cancer (MCRC), multidisciplinary treatment strategy integrating intensive FIr-B/FOx triplet chemotherapy associated to bevacizumab and secondary metastasectomies significantly improved clinical outcomes up to progression-free survival (PFS) 17 months and overall survival (OS) 44 months. A non-elderly woman affected by rectal cancer, lymph nodes involvement, synchronous unresectable liver metastases, was treated with first-line FIr-B/FOx integrated with two-stage liver resections, short course radiotherapy, anterior rectal resection, with a PFS 9 months and progression-free interval (PFI) 4 months off-treatment. After progression characterized by single liver and lymph node inferior mesenteric axis metastases, FIr-B/FOx was re-introduced, liver and lymph node resections were performed, with a PFS 8 months and PFI 3 months. Read More

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Impacts of diabetes mellitus on clinical and para-clinical parameters among COVID-19 patients.

J Diabetes Metab Disord 2021 Jul 14:1-9. Epub 2021 Jul 14.

Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Diabetes has several adverse effects on patients with coronavirus disease 2019 (COVID-19); however, the determinants of this effect are still poorly understood. It is tried in current study to evaluate impacts of type 2 diabetes, with and without other comorbidities, on the clinical, para-clinical, and outcome parameters among COVID-19 patients.

Methods: A case series was applied, which involved 406 COVID-19 patients admitted in the city of Shiraz, south-central Iran, from February 20 to April 29, 2020. Read More

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Types of Glaucoma and Associated Comorbidities Among Patients at King Abdulaziz Medical City, Jeddah.

Cureus 2021 Jun 10;13(6):e15574. Epub 2021 Jun 10.

Medical Education, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.

Aim To identify the types of glaucoma and associated comorbidities among patients attending the ophthalmology clinic at King Abdulaziz Medical City (KAMC) in Jeddah. Methods A cross-sectional study that included all glaucoma patients at KAMC in Jeddah between June 1st, 2016 and November 30th, 2020. Data were collected through retrospective chart review from the electronic medical record system (BestCare) and utilized a structured data collection sheet. Read More

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Immune-checkpoint inhibitor-associated diabetes compared to other diabetes types - a prospective, matched control study.

J Diabetes 2021 Jul 18. Epub 2021 Jul 18.

Institute for Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany.

Background: To describe Checkpoint inhibitor-induced diabetes mellitus (CPI-DM) and to compare with regular type 1 (T1DM), type 2 (T2DM), and medication-induced diabetes mellitus (MI-DM).

Methods: We included 88 177 adult patients from the Diabetes Patient Follow-Up (DPV) registry with diabetes manifestation between 2011 and 2020. Inclusion criteria were T1DM, T2DM, MI-DM, or CPI-DM. Read More

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Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States.

Diabetes Ther 2021 Jul 18. Epub 2021 Jul 18.

OptumLabs at UnitedHealth Group, Minneapolis, MN, USA.

Introduction: Diabetes has been identified as a high-risk comorbidity for COVID-19 hospitalization. We evaluated additional risk factors for COVID-19 hospitalization and in-hospital mortality in a nationwide US database.

Methods: This retrospective study utilized the UnitedHealth Group Clinical Discovery Database (January 1, 2019-July 15, 2020) containing de-identified nationwide administrative claims, SARS-CoV-2 laboratory test results, and COVID-19 inpatient admissions data. Read More

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Trends in treatment for patients with depression in general practice in Norway, 2009-2015: nationwide registry-based cohort study (The Norwegian GP-DEP Study).

BMC Health Serv Res 2021 Jul 15;21(1):697. Epub 2021 Jul 15.

Research Unit for General Practice, NORCE Norwegian Research Centre, Årstadveien 17, N-5009, Bergen, Norway.

Background: Depression is highly prevalent, but knowledge is scarce as to whether increased public awareness and strengthened government focus on mental health have changed how general practitioners (GPs) help their depressed patients. This study aimed to examine national time trends in GP depression care and whether trends varied regarding patient gender, age, and comorbidity.

Methods: Nationwide registry-based cohort study, Norway. Read More

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A closer look to the high burden of the psychiatric disorders among health care workers (HCWs) in Egypt during COVID-19 outbreak: A meta-analysis of 3137 HCWs.

Epidemiol Health 2021 Jul 13:e2021045. Epub 2021 Jul 13.

Faculty of Medicine, Mansoura University, Mansoura, Egypt, Mansoura, Egypt.

Objectives: To study the prevalence of psychiatric disorders among Egyptian health care workers (HCWs) during the Coronavirus Disease 2019 (COVID-19) outbreak.

Method: We searched six databases for relevant papers. The quality of the included articles was measured by The National Institute of Health quality assessment tool. Read More

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Clinically significant depressive symptoms and high diabetes distress in adults with type 1 and type 2 diabetes in Appalachian Ohio.

J Osteopath Med 2021 Jul 15. Epub 2021 Jul 15.

Department of Medicine, Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA.

Context: In rural southeastern Ohio, the prevalence of diabetes is 19.9%, nearly double the national average of 10.5%. Read More

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Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care.

Explor Med 2021 30;2:110-121. Epub 2021 Apr 30.

Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA.

Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cognitive screening variables, which allow for more nuanced examination of patient performance, may predict lengthier hospital stay and greater cost of hospital care. This issue is particularly relevant for older adults undergoing transcatheter aortic valve replacement (TAVR), as this surgical procedure is chosen for intermediate-risk older adults needing aortic replacement. This proof of concept research explored if specific latency and graphomotor variables indicative of planning from digitally-acquired command and copy clock drawing would predict post-TAVR duration and cost of hospitalization, over and above age, education, American Society of Anesthesiologists (ASA) physical status classification score, and frailty. Read More

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Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.

BMJ 2021 07 14;374:n1537. Epub 2021 Jul 14.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

Objective: To assess the associations between statins and adverse events in primary prevention of cardiovascular disease and to examine how the associations vary by type and dosage of statins.

Design: Systematic review and meta-analysis.

Data Sources: Studies were identified from previous systematic reviews and searched in Medline, Embase, and the Cochrane Central Register of Controlled Trials, up to August 2020. Read More

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Digital Health Intervention in Acute Myocardial Infarction.

Circ Cardiovasc Qual Outcomes 2021 Jul 15;14(7):e007741. Epub 2021 Jul 15.

Digital Health Innovation Laboratory, Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (F.A.M., E.M.S., J.D., J.W., H.X., L.M.S., D.W., V.V., D.N.L., R.S., P.P.H., S.W., S.S.M.).

Background: Thirty-day readmissions among patients with acute myocardial infarction (AMI) contribute to the US health care burden of preventable complications and costs. Digital health interventions (DHIs) may improve patient health care self-management and outcomes. We aimed to determine if patients with AMI using a DHI have lower 30-day unplanned all-cause readmissions than a historical control. Read More

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Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis.

Brief Bioinform 2021 Jul 15. Epub 2021 Jul 15.

Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania CT, Italy.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the newly discovered coronavirus, SARS-CoV-2. Increased severity of COVID-19 has been observed in patients with diabetes mellitus (DM). This study aimed to identify common transcriptional signatures, regulators and pathways between COVID-19 and DM. Read More

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Impact of insurance type on outcomes in cardiac arrest patients from 2004 to 2015: A nation-wide population-based study.

PLoS One 2021 14;16(7):e0254622. Epub 2021 Jul 14.

Department of Emergency Medicine, College of Medicine, Korea University Hospital, Seoul, South Korea.

Objectives: There do not appear to be many studies which have examined the socio-economic burden and medical factors influencing the mortality and hospital costs incurred by patients with cardiac arrest in South Korea. We analyzed the differences in characteristics, medical factors, mortality, and costs between patients with national health insurance and those on a medical aid program.

Methods: We selected patients (≥20 years old) who experienced their first episode of cardiac arrest from 2004 to 2015 using data from the National Health Insurance Service database. Read More

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Self-efficacy remains a vital factor in reducing the risk of dialysis in type 2 diabetes care.

Medicine (Baltimore) 2021 Jul;100(28):e26644

Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan, R.O.C.

Abstract: Studies have provided promising outcomes of the pay-for-performance (P4P) program or with good continuity of care levels in diabetes control.We investigate the different exposures in continuity of care (COC) with their providers and those who participate in the P4P program and its effects on the risk of diabetes diabetic nephropathy in the future.We obtained COC and P4P information from the annual database, to which we applied a hierarchical linear modeling (HLM) in 3 levels adjusted to account for other covariates as well as the effects of hospital clustering and accumulating time. Read More

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Health inequalities and income for people with spinal cord injury. A comparison between and within countries.

SSM Popul Health 2021 Sep 26;15:100854. Epub 2021 Jun 26.

Swiss Paraplegic Research, Guido A. Zäch Institute, Nottwil, Switzerland.

Income and health are related in a bi-directional manner, whereby level of income affects health and vice versa. People in poorer households tend to experience worse health status and higher mortality rates than people in wealthier households, and, at the same time, having poor health could restrict workability leading to less income. This gap exists in almost every country, and it is more pronounced in more unequal countries and in vulnerable populations, such as people experiencing disability. Read More

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September 2021

Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study.

Age Ageing 2021 Jul 10. Epub 2021 Jul 10.

Department of Primary Care and Population Health, University College London, London, UK.

Introduction: cardiovascular disease (CVD) and chronic inflammation are implicated in the development of frailty. Longitudinal analyses of inflammatory markers, biomarkers of cardiac dysfunction and incidence of frailty are limited.

Methods: in the British Regional Heart Study, 1,225 robust or pre-frail men aged 71-92 years underwent a baseline examination, with questionnaire-based frailty assessment after 3 years. Read More

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Comorbidity, lifestyle factors, and sexual satisfaction among Chinese cancer survivors.

Cancer Med 2021 Jul 13. Epub 2021 Jul 13.

Key Lab of Health Technology Assessment of National Health Commission and Key Lab of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China.

Objectives: This study aims to explore the prevalence of sexual satisfaction among Chinese cancer survivors, and explore the association of sexual satisfaction with comorbidity and lifestyle factors.

Methods: A cross-sectional study was performed among 3996 Chinese cancer survivors recruited at Shanghai Cancer Rehabilitation Club from March to April 2017. Data were collected through self-reported questionnaires. Read More

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National trends in the prevalence of glycemic control among patients with type 2 diabetes receiving continuous care in Thailand from 2011 to 2018.

Sci Rep 2021 Jul 12;11(1):14260. Epub 2021 Jul 12.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.

Diabetes is one of the largest global health problems and exhibits a constantly increasing trend. A series of nationwide hospital-based cross-sectional surveys of clinical outcomes was performed annually from 2011 to 2015 and 2018 among patients with type 2 diabetes aged ≥ 20 years receiving medical care for at least 12 months. A two-stage stratified cluster that was proportional to the size sampling technique was used to select a nationally and provincially representative sample of patients with type 2 diabetes in Thailand. Read More

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Comparison of anesthesia management in transcatheter aortic valve implantation: a retrospective cohort study.

Braz J Anesthesiol 2021 Jul 9. Epub 2021 Jul 9.

Health Sciences University, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Trabzon, Turkey.

Background And Objectives: We aimed to investigate the effects of two different anesthetic techniques in our patients who underwent transcatheter aortic valve implantation (TAVI).

Methods: In this study, 303 patients who underwent TAVI procedure with a diagnosis of severe aortic stenosis between January 1, 2012 and December 31, 2018 were retrospectively evaluated. The patients were divided according to the type of anesthesia given during each procedure as; general anesthesia (GA), local anesthesia (LA). Read More

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Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord.

Neuropharmacology 2021 Jul 10;196:108704. Epub 2021 Jul 10.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Clinically, posttraumatic stress disorder (PTSD) and chronic pain are highly comorbid conditions, but the underlying mechanisms of and therapeutic strategies against PTSD-related pain remain unclear. Our previous studies suggested that dysregulation of neuroinflammation contributes to the development of stress-induced hyperalgesia. Recent studies reported that angiotensin II was a 'stress-related hormone', and could induce glial activation by stimulating the type 1 receptor (AT1R). Read More

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Patient Factors Associated with Pharmaceutical Interventions for Inpatients at a Brazilian Teaching Hospital.

Can J Hosp Pharm 2021 1;74(3):211-218. Epub 2021 Jul 1.

, BPharm, MSc, is a PhD student with the Department of Clinical and Experimental Oncology, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.

Background: Pharmaceutical interventions aim to correct or prevent a drug-related problem (DRP) that might lead to negative clinical consequences and increase health care costs.

Objective: To identify variables associated with the provision of pharmaceutical interventions by clinical pharmacists during hospitalization.

Methods: In this retrospective cohort study, adult inpatients of the medical ward of the University Hospital of the University of São Paulo in São Paulo, Brazil, were followed from admission to discharge. Read More

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Is Bariatric Surgery Effective for Chinese Patients with Type 2 Diabetes Mellitus and Body Mass Index < 35 kg/m? A Systematic Review and Meta-analysis.

Obes Surg 2021 Jul 10. Epub 2021 Jul 10.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.

Background: Bariatric surgery has been applied for weight loss and comorbidity control in China since 2000. Recent studies have shown positive results for bariatric surgery in patients with a body mass index (BMI) of less than 35 kg/m. However, the effect of surgery on Chinese patients with type II diabetes mellitus (T2DM) has not yet been systematically investigated. Read More

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