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Study of EGFR mutations in head and neck squamous cell carcinomas.

Autops Case Rep 2021 Apr 15;11:e2021251. Epub 2021 Apr 15.

INHS ASVINI, Department of Pathology, Colaba, Mumbai, India.

Introduction: Squamous carcinoma is the commonest malignancy of the head and neck region. It is associated with high morbidity and mortality. Epidermal growth factor receptor (EGFR) regulates downstream signaling pathways through its tyrosine kinase (TK) domains that play a role in cell proliferation and survival. Read More

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Tele Otology in India: Last 10 Years-A Scopic Review.

Indian J Otolaryngol Head Neck Surg 2021 May 1:1-13. Epub 2021 May 1.

Department of General Medicine, All India Institute of Medical Sciences, Deoghar, India.

Hearing loss is the commonest sensory deficit among humans, affecting 466 million people worldwide. Early detection is the key to hearing rehabilitation, as speech and language develops early in the childhood. Scarcity of human resources and infrastructure in developing countries like India leads to difficulty in implementation of hearing screening programmes. Read More

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Clinico-Epidemiological Profile of Childhood Alopecia Areata Along with Dermoscopic Correlation: A Cross-Section, Observational Study.

Indian Dermatol Online J 2021 Mar-Apr;12(2):250-257. Epub 2021 Mar 2.

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Childhood alopecia areata (AA) is a common cause of dermatologic consultation; however, data is scarce in the present set-up.

Objectives: To evaluate the clinico-epidemiological profile of childhood AA along with dermoscopic correlation.

Methods: We conducted a cross-sectional study including 50 new cases of childhood AA for 1 year. Read More

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ACR Appropriateness Criteria® Radiologic Management of Lower Gastrointestinal Tract Bleeding: 2021 Update.

J Am Coll Radiol 2021 May;18(5S):S139-S152

Specialty Chair, University of Chicago Hospital, Chicago, Illinois.

Diverticulosis remains the commonest cause for acute lower gastrointestinal tract bleeding (GIB). Conservative management is initially sufficient for most patients, followed by elective diagnostic tests. However, if acute lower GIB persists, it can be investigated with colonoscopy, CT angiography (CTA), or red blood cell (RBC) scan. Read More

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Pleomorphic adenoma of hard palate: a case report.

Pan Afr Med J 2021 9;38:146. Epub 2021 Feb 9.

Département d´Odontologie Chirurgicale, Faculté de Médecine Dentaire de Rabat, Université Mohammed V, Rabat, Maroc.

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. Read More

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Pemphigus Vulgaris and Bullous Pemphigoid of the Upper Aerodigestive Tract: A Review Article and Novel Approaches to Management.

ORL J Otorhinolaryngol Relat Spec 2021 Apr 26:1-9. Epub 2021 Apr 26.

Department of Otolaryngology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Background: Autoimmune bullous diseases are rare conditions characterized by blistering of the skin and mucous membranes. The 2 commonest forms are pemphigus vulgaris and bullous pemphigoid. The oral cavity or oropharynx may be the initial site of presentation or often the only site involved. Read More

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Chondroblastoma of the patella with secondary aneurysmal bone cyst, an easily misdiagnosed bone tumor:a case report with literature review.

BMC Musculoskelet Disord 2021 Apr 23;22(1):381. Epub 2021 Apr 23.

Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, 750004, People's Republic of China.

Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that commonly affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. The patella is an infrequent site. Read More

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Clinico-Pathologic Profile and Treatment Outcomes of Patients with Diffuse Large B Cell Lymphoma Based on Cell of Origin Classification.

Indian J Hematol Blood Transfus 2021 Apr 27;37(2):226-231. Epub 2020 Jul 27.

Department of Medical Oncology, JIPMER, Puducherry, India.

Diffuse large B cell lymphoma (DLBCLs) constitute 40% of all non-Hodgkin lymphoma and it represent a heterogeneous group of neoplasms rather than a single clinicopathological entity. We analysed the outcomes and clinical features based on the cell of origin in a series of patients with DLBCL from our institute. Medical case records of all newly diagnosed DLBCL treated in our institute from January 2015 to July 2017 were analysed for this study. Read More

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A review of computed tomography patterns of metastatic breast cancer patients undergoing treatment at a private oncology centre in Ghana.

Pan Afr Med J 2021 18;38:50. Epub 2021 Jan 18.

Regional Institute of Population Studies, University of Ghana, Legon, Accra, Ghana.

Introduction: breast cancer is the commonest malignant disease in Ghanaian women and accounts for 17% of cancer-related deaths in the country. It has been classified into molecular subtypes depending on the presence or absence of hormone receptors and the human epidermal growth factor receptor 2. Computed tomography is often the preferred modality for monitoring metastatic disease due to its ability to determine the extent of local and metastatic disease. Read More

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Ribonucleic acid (RNA) COVID-19 vaccine associated cutaneous adverse drug events: a case series of two patients.

Clin Exp Dermatol 2021 Apr 9. Epub 2021 Apr 9.

Jephson Dermatology Centre, South Warwickshire NHS Foundation Trust, Warwick, CV34 5BW, United Kingdom.

Vaccines are biological preparations that enable their recipients to acquire immunity to a specific infectious disease. All vaccines can associate with cutaneous adverse drug events. Ribonucleic acid (RNA) vaccine was first tested in humans in COVID-19 prevention trials in 2020. Read More

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Foreign body aspiration in a tertiary Syrian centre: A 7-year retrospective study.

Heliyon 2021 Mar 17;7(3):e06537. Epub 2021 Mar 17.

Department of Surgery Division of Otorhinolaryngology, Faculty of Medicine, Syrian Private University, Damascus, Syria.

Background: Paediatric foreign body aspiration constitutes significant lethal sequela worldwide. This is the first descriptive Syrian study that aims to describe the epidemiology of foreign body aspiration in a tertiary centre in Syria.

Methods: This is a retrospective cohort study conducted at the Children's University Hospital, Damascus, from 2011 to 2018 during the Syrian crisis. Read More

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Inflammatory Pseudotumor: A 20-Year Single Institutional Experience.

Adv Biomed Res 2020 28;9:68. Epub 2020 Nov 28.

Department of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.

Background: Inflammatory pseudotumor (IPT) is a relatively rare benign disease. The aim of the study was to demonstrate the demographic distribution, clinical presentation, and histomorphological characteristics of IPT while highlighting its associated diagnostic challenges.

Materials And Methods: A retrospective cross-sectional review of all the IPT diagnosed in our institution between January 1999 and December 2018 was conducted. Read More

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November 2020

Early clinical and metabolic response to tazemetostat in advanced relapsed INI1 negative epithelioid sarcoma.

Future Sci OA 2021 Jan 12;7(4):FSO675. Epub 2021 Jan 12.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Epithelioid sarcoma (ES) is a rare soft tissue sarcoma with an incidence of 0.05 per 100,000 population in the USA. It is characterized by multiple local recurrences and regional lymph nodes form the commonest site of metastases. Read More

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January 2021

Factors Affecting Prognosis and Survival in Extremity Osteosarcoma.

Indian J Surg Oncol 2021 Mar 6;12(1):199-206. Epub 2021 Jan 6.

Department of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.

Background: Osteosarcoma is a malignant bone tumor affecting mainly children and young adults and commonly involves extremities. The aim of this study was to assess the patient-related, tumor-related, and treatment-related factors affecting the overall survival in patients with non-metastatic extremity osteosarcoma.

Methodology: A retrospective, single institutional study of 100 patients with non-metastatic extremity osteosarcoma was done between 2014 and 2019. Read More

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Clinical Profile of Non-neutropenic Patients with Invasive Candidiasis: A Retrospective Study in a Tertiary Care Center.

Indian J Crit Care Med 2021 Mar;25(3):267-272

Department of Infectious Disease, Apollo Hospitals, Chennai, Tamil Nadu, India.

Invasive candidiasis (IC) is a major cause of morbidity and mortality in critically ill patients in the intensive care unit (ICU). In this study, we aim to analyze the clinical profile, species distribution, and susceptibility pattern of patients with IC. Case records of non-neutropenic patients ≥18 years of age with IC between January 2016 and June 2019 at a tertiary care referral hospital were analyzed. Read More

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Current Oncologic Standards for Surgery of Small Bowel Cancers.

J Gastrointest Cancer 2021 Mar 31. Epub 2021 Mar 31.

Department of Surgical Gastroenterology, Max Super Speciality Hospital, Saket, New Delhi, India.

Purpose: The last 2 decades has witnessed efforts towards standardization of surgery for small bowel cancers. The proposed recent guidelines/recommendations pertaining to choice of procedure and extent of lymphadenectomy are based on analysis of data from high volume centres of excellence. We evaluated whether these recently proposed oncologic recommendations can be replicated in the setting of single centre/team. Read More

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and Cytology: A Retrospective Analysis of 110 Cases from an Endemic Area.

J Cytol 2020 Oct-Dec;37(4):182-188. Epub 2020 Sep 16.

Dr. Prasoon's Diagnostic Centre, Munger, Bihar, India.

Background: Wuchereriasis is a significant cause of chronic morbidity. It can affect any organ/tissue in the body. Fine-needle aspiration cytology (FNAC) is an easy method for its detection. Read More

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September 2020

Frequency Of Double Expressor Lymphoma In A Tertiary Care Hospital.

J Ayub Med Coll Abbottabad 2021 Jan-Mar;33(1):44-48

Rehman Medical Institute, Peshawar, Pakistan.

Background: Accounting for 30% cases of all lymphoid neoplasms, Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma worldwide. It occurs over a wide age range and has diverse morphology, immunophenotype and clinical outcome. Objectives of the study were to determine the frequency of Double expressor lymphoma (DEL) in a tertiary care hospital. Read More

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A Clinicopathological Study of Skin Tumors from a Tertiary Care Centre in North India.

Indian Dermatol Online J 2021 Jan-Feb;12(1):66-71. Epub 2021 Jan 16.

Department of Pathology, DMCH, Ludhiana, Punjab, India.

Background: There is a huge spectrum of skin tumors which can be confused clinically with malignancies, particularly when they are pigmented or inflamed, and histopathological examination of a biopsy specimen is required to establish a definitive diagnosis and to facilitate appropriate intervention and follow up.

Aim: To evaluate all skin tumors and categorize them according to their origin.

Methods: The present study was conducted over a period of 4 years (July 1, 2013 to June 31, 2017) comprising of 1. Read More

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January 2021

Single dose high-dose-rate brachytherapy with focal dose escalation for prostate cancer: Mature results of a phase 2 clinical trial.

Radiother Oncol 2021 Mar 23;159:67-74. Epub 2021 Mar 23.

Mount Vernon Cancer Centre, Northwood, UK.

Aim: The dominant intraprostatic lesion (DIL) is the commonest site of relapse after single dose high-dose-rate brachytherapy (HDR-BT) for localised prostate cancer. This study investigated toxicity and clinical outcomes of focal dose escalation to the DIL with dose de-escalation to the remaining prostate.

Materials/methods: Between November 2012 and July 2016, 50 patients with localised prostate adenocarcinoma received single fraction HDR-BT. Read More

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Work-related musculoskeletal injuries among obstetricians and gynaecologists: A cross-sectional survey of Fellows of Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG).

Aust N Z J Obstet Gynaecol 2021 Mar 25. Epub 2021 Mar 25.

University of Queensland, Brisbane, Queensland, Australia.

Background: Obstetricians and gynaecologists (O&Gs) are at a risk of work-related musculoskeletal injuries (WRMI) on a daily basis.

Aims: To describe the prevalence of WRMI among O&Gs in Australia and New Zealand, explore risk factors for such injuries, and evaluate their impact.

Methods: An online survey of Fellows of Royal Australian and New Zealand College of Obstetricians and Gynaecologists was conducted in July 2016. Read More

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Real-World Data on Characteristics and Management of Community Patients Receiving Anticoagulation Therapy Who Presented with Acute Bleeding to the Emergency Department at a Regional Australian Hospital: A Prospective Observational Study.

Mediterr J Hematol Infect Dis 2021 1;13(1):e2021017. Epub 2021 Mar 1.

Faculty of Health Sciences, Launceston, University of Tasmania, Tasmania, 7249, Australia.

Objective: To study patients receiving anticoagulants with or without antiplatelet therapy presenting at a regional Australian hospital with bleeding. The main aims are to explore: (1) patients' characteristics and management provided; (2) association between the type of anticoagulant and antiplatelet agent used and the requirement of reversal; (3) and the length of hospital stay (LoS) in conjunction with bleeding episode and management.

Methods: A prospective cross-sectional review of medical records of all patients who presented at a tertiary referral centre with bleeding while receiving anticoagulation therapy between January 2016 and June 2018. Read More

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Management of Rhabdomyosarcoma in Pediatric Patients.

Surg Oncol Clin N Am 2021 Apr 27;30(2):339-353. Epub 2021 Jan 27.

Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

Rhabdomyosarcoma is the commonest soft tissue sarcoma in children. Clinicians need vigilance to recognize the different signs and symptoms this tumor can present with because of variable sites of origin. Diagnosis requires a safe biopsy that obtains sufficient tissue for pathologic, genetic, and biological characterization of the tumor. Read More

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Diagnosis of solid tumors in infants by fine-needle aspiration cytology: 5 years retrospective study from a tertiary care oncology center in South India.

Diagn Cytopathol 2021 Mar 11. Epub 2021 Mar 11.

Department of Radiodiagnosis, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Introduction: Neuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost-effective for solid tumor diagnosis. Read More

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Common general surgical never events: analysis of NHS England never event data.

Int J Qual Health Care 2021 Mar;33(1)

Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, South Tyneside and Sunderland NHS Trust, Kayll Rd, Sunderland SR4 7TP, UK.

Background: There is little available data on common general surgical never events (NEs). Lack of this information may have affected our attempts to reduce the incidence of these potentially serious clinical incidents.

Objectives: The purpose of this study was to identify common general surgical NEs from the data held by the National Health Service (NHS) England. Read More

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Prevalence of acne vulgaris and its clinico-epidemiological pattern in adult patients: Results of a prospective, observational study.

J Cosmet Dermatol 2021 Mar 2. Epub 2021 Mar 2.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Background: Acne is a common disorder in adolescents. The prevalence of acne in adults is also increasing. There are only a few Indian studies on the prevalence and clinical features of adult acne. Read More

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Epidemiology and Retrospective Analysis in Extrapulmonary Neuroendocrine Carcinoma.

Cureus 2021 Jan 17;13(1):e12748. Epub 2021 Jan 17.

Hematology and Medical Oncology, Allegheny Health Network, Pittsburgh, USA.

Objectives: We conducted a retrospective analysis of patients with extrapulmonary neuroendocrine carcinomas (EPNECs) to explore the distribution and overall outcomes by different regimens and their primary sites.

Setting: We reviewed the outcomes of one of the largest data sets of patients with extrapulmonary small cell carcinomas (EPSCCs) identified at Allegheny General Hospital located in Pittsburgh, Pennsylvania, USA.

Participants: Patients diagnosed with grade 3 EPNECs were retrospectively identified. Read More

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January 2021

HISTOMORPHOLOGICAL PATTERN OF UROLOGIC MALIGNANCIES IN ILE-IFE, SOUTH-WESTERN NIGERIA.

Ann Ib Postgrad Med 2020 Jun;18(1):60-64

Urology Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

Introduction: The last decade witnessed a remarkable rise in the prevalence of several malignant diseases in Nigeria. Whether Urologic malignancies (UM) have followed the same trend remains to be studied. The pattern of UM diagnosed in a Nigerian tertiary hospital is hereby presented. Read More

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PERIOPERATIVE MORBIDITY AND MORTALITY AFTER EMERGENCY AND ELECTIVE COLON AND PROXIMAL RECTAL SURGERY IN IBADAN.

Ann Ib Postgrad Med 2020 Jun;18(1):24-30

Department of Surgery, College of Medicine, University of Ibadan, Nigeria.

Objective: While the epidemiology of benign colonic pathologies has not significantly changed in our region, colorectal cancer has steadily increased with a majority of patients presenting with late stage disease particularly large bowel obstruction. This study reviews the outcome of emergency and elective colon and proximal rectal cases with regards to perioperative morbidity and mortality.

Setting: All patients who had surgery for symptoms of lower gastrointestinal tract disease (caecum and proximal rectum) between January 2008 and January 2018 at University College Hospital, Ibadan were included. Read More

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Exploratory pilot study of exogenous sustained-release melatonin on nocturia in Parkinson's disease.

Eur J Neurol 2021 Feb 11. Epub 2021 Feb 11.

Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, London, UK.

Introduction: Nocturia is one of the commonest non-motor symptoms in Parkinson's disease (PD). Nocturia has evolved from being understood as a symptom of urological disorders or neurogenic bladder dysfunction to being considered as a form of circadian dysregulation. Exogenous melatonin is known to help circadian function and can be an effective strategy for nocturia in PD. Read More

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February 2021