60,876 results match your criteria common medication


Multiple sclerosis is associated with higher comorbidity and healthcare resource use: a population-based, case-control study in a western Mediterranean region.

Eur J Neurol 2021 Jul 22. Epub 2021 Jul 22.

Servei de Neurología-Neuroimmunología, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Hospital Universitari, Barcelona, Spain.

Background: Comorbidities are common in multiple sclerosis (MS), and have been associated with worse outcomes and increased healthcare resource usage. We studied the frequency of comorbidities and adverse health behaviors (AHB) in MS patients in the Mediterranean region of Catalonia.

Methods: Population-based, case-control study using primary healthcare information covering 80% of Catalonia's population. Read More

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Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.

PLoS One 2021 22;16(7):e0253742. Epub 2021 Jul 22.

Department of Public Health, New York Medical College, Valhalla, New York, United States of America.

Background: Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the prevalence and predictors of HTN among PLWH in care in Cameroon. Read More

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Netupitant/Palonosetron: A Review in Chemotherapy-Induced Nausea and Vomiting.

Authors:
Matt Shirley

Drugs 2021 Jul 22. Epub 2021 Jul 22.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Netupitant/palonosetron (NEPA; Akynzeo), available in oral and intravenous (IV) formulations, is a fixed-dose combination of the neurokinin 1 (NK1) receptor antagonist netupitant (or the prodrug, fosnetupitant, in the IV formulation) and the second-generation serotonin 3 (5-HT) receptor antagonist palonosetron. Administered as a single dose, (fos)netupitant/palonosetron (in combination with dexamethasone) is indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) in adults. In clinical trials, (fos)netupitant/palonosetron plus dexamethasone was associated with high complete response rates (no emesis and no rescue medication) in the acute, delayed and overall phases in patients receiving highly or moderately emetogenic chemotherapy, with efficacy maintained over multiple cycles. Read More

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Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients.

Rev Endocr Metab Disord 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, School of Medicine, University of California, CA, Irvine, Orange, USA.

Hyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-transplant hyperkalemia in recipients with a well-functioning graft. Read More

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Real-world data and treatment patterns of patients with lower urinary tract symptoms due to benign prostatic hyperplasia in Germany: an observational study using health insurance claims data.

World J Urol 2021 Jul 22. Epub 2021 Jul 22.

Faculty of Medicine, Department of Urology, Medical Centre - University of Freiburg, Freiburg, Germany.

Purpose: Benign prostatic hyperplasia (BPH) is associated with lower urinary tract symptoms (LUTS), representing one of the most common urological conditions. However, insights into the actual healthcare of this patient cohort in Germany are scarce. We aimed to retrospectively analyse management patterns of patients with LUTS in Germany using health insurance claims databases. Read More

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Restrictive cardiomyopathy caused by diffuse calcification of the left ventricle after 20 years of haemodialysis.

Cardiovasc J Afr 2021 Jul 5;32:1-3. Epub 2021 Jul 5.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Centre, Taipei, Taiwan. Email:

Valvular and vascular calcifications are common among patients with end-stage renal disease, but diffuse calcification of the left ventricle is rarely reported. We report on a rare case of restrictive cardiomyopathy resulting from severe myocardial calcification and review the literature. A 77-year-old man was diagnosed with end-stage renal disease after having received regular haemodialysis for 20 years. Read More

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Interventions for the management of abdominal pain in ulcerative colitis.

Cochrane Database Syst Rev 2021 Jul 22;7:CD013589. Epub 2021 Jul 22.

Pediatric Gastroenterology, Sidra Medicine, Doha, Qatar.

Background: Ulcerative colitis (UC) is a chronic inflammation of the colon characterised by periods of relapse and remission. It starts in the rectum and can extend throughout the colon. UC and Crohn's disease (CD) are the most common inflammatory bowel diseases (IBDs). Read More

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An Unusual Timing of Amoxicillin-Induced IgA Vasculitis in an Elderly Patient.

Cureus 2021 Jun 19;13(6):e15757. Epub 2021 Jun 19.

Infectious Disease, Veterans Affairs Medical Center, Fargo, USA.

Immunoglobulin A vasculitis is a small vessel vasculitis which is usually common in the pediatric group. It is rare in adult population but more severe than in children. Proposed triggers include infections, malignancy and medications. Read More

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Diabetic Retinopathy in the Aging Population: A Perspective of Pathogenesis and Treatment.

Clin Interv Aging 2021 15;16:1367-1378. Epub 2021 Jul 15.

Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.

The elderly population in the United States is projected to almost double by the year 2050. In addition, the numbers of diabetics are rising, along with its most common complication, diabetic retinopathy (DR). To effectively treat DR within the elderly population, it is essential first to consider the retinal changes that occur due to aging, such as decreased blood flow, retinal thinning, and microglial changes, and understand that these changes can render the retina more vulnerable to oxidative and ischemic damage. Read More

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Characteristics of Hospitalizations and Emergency Department Visits due to Generalized Pustular Psoriasis in the United States.

Curr Med Res Opin 2021 Jul 22. Epub 2021 Jul 22.

Dermatology Research and Education Foundation, Irvine, CA, USA.

Objectives: Generalized pustular psoriasis (GPP) is a rare and severe, inflammatory skin disease. GPP is characterized by recurrent flares that consist of disseminated erythematous skin rash with sterile neutrophil-filled pustules that can result in an emergency department (ED) visit or hospital stay due to systemic complications. This study characterizes hospitalizations, ED visits, and inpatient treatment due to GPP in the United States (US). Read More

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Risk messages relating to fertility and pregnancy: a media content analysis.

Wellcome Open Res 2021 14;6:114. Epub 2021 May 14.

School of Healthcare Sciences, Cardiff University, Cardiff, CF14 4XN, UK.

The UK print and online media is an important channel by which scientific research is communicated to the public. Media risk messages relating to pregnancy or fertility contribute to the context of reproductive decision making, but their fidelity to the underlying science has been questioned. We measured the volume, distribution and content of science-based risk headlines relating to pregnancy or fertility in the UK media over four months. Read More

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Abdominal Pain Caused by Occlusion of the Celiac Trunk and Superior Mesenteric Artery in Addition to Irritable Bowel Syndrome: Case Series and Literature Review.

Cureus 2021 Jun 17;13(6):e15729. Epub 2021 Jun 17.

Medicine, Qatar University, Doha, QAT.

Irritable bowel syndrome (IBS) is a benign condition of the gastrointestinal tract causing abdominal pain, bloating, diarrhea, and/or constipation. Symptoms of IBS usually improve on passing flatus and defecation. There is no known identifiable underlying pathology; however, several risk factors are known to contribute to the development of IBS, which include a stressful lifestyle and certain foods such as bread, coffee, alcohol, pasta, and chocolates. Read More

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[Achilles tendinopathy in a hemodialysis patient complicated by rupture of the Achilles tendon due to self-medication with ciprofloxacin: about a case].

Pan Afr Med J 2021 29;38:312. Epub 2021 Mar 29.

Service de Traumatologie-Orthopédie B4, Centre Hospitalier Universitaire Hassan II, Fès, Maroc.

This study aims to remind clinicians of fluoroquinolone-related tendinopathies. They are rare side effects, but which can result in functional disability. We report the case of a 79-year-old woman with a 11-year history of haemodialysis who had sudden left ankle pain and functional impairment in the ipsilateral member on day 5 after self-medication with ciprofloxacin. Read More

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Exploring polypharmacy with artificial intelligence: data analysis protocol.

BMC Med Inform Decis Mak 2021 Jul 20;21(1):219. Epub 2021 Jul 20.

Quebec National Institute of Public Health, Quebec, QC, Canada.

Background: Polypharmacy is common among older adults and it represents a public health concern, due to the negative health impacts potentially associated with the use of several medications. However, the large number of medication combinations and sequences of use makes it complicated for traditional statistical methods to predict which therapy is genuinely associated with health outcomes. The project aims to use artificial intelligence (AI) to determine the quality of polypharmacy among older adults with chronic diseases in the province of Québec, Canada. Read More

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Application of failure mode and effects analysis (FMEA) to improve medication safety in the dispensing process - a study at a teaching hospital, Sri Lanka.

BMC Public Health 2021 Jul 20;21(1):1430. Epub 2021 Jul 20.

Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.

Background: Failure mode and effects analysis (FMEA) is a prospective, team based, structured process used to identify system failures of high risk processes before they occur. Medication dispensing is a risky process that should be analysed for its inherent risks using FMEA. The objective of this study was to identify possible failure modes, their effects, and causes in the dispensing process of a selected tertiary care hospital using FMEA. Read More

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Associated mood changes with naloxegol therapy for opioid-induced constipation in a patient with psychiatric disease.

Pain Manag 2021 Jul 21. Epub 2021 Jul 21.

Department of Anesthesiology, University of Texas Health Science Center at Houston, 6431 Fannin St, MSB 5.170, Houston, TX 77030, USA.

The objective of this clinical case report is to highlight unusual adverse effects brought on by Naloxegol therapy in a patient with underlying psychiatric illness. The patient is a 68-year-old female, with a psychiatric history of bipolar disorder, who presented for chronic pain management and opioid-induced constipation. After failing other therapies, she was trialed on Naloxegol on three separate occasions. Read More

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miR-92b-3p Regulates Cell Cycle and Apoptosis by Targeting , Thereby Affecting the Sensitivity of Colorectal Cancer Cells to Chemotherapeutic Drugs.

Cancers (Basel) 2021 Jul 2;13(13). Epub 2021 Jul 2.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

Colorectal cancer (CRC) is the third most common malignant tumor in the world and the second leading cause of cancer death. Multidrug resistance (MDR) has become a major obstacle in the clinical treatment of CRC. The clear molecular mechanism of MDR is complex, and miRNAs play an important role in drug resistance. Read More

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Predicting Antituberculosis Drug-Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study.

JMIR Med Inform 2021 Jul 20;9(7):e29226. Epub 2021 Jul 20.

Department of Tuberculosis Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.

Background: Tuberculosis (TB) is a pandemic, being one of the top 10 causes of death and the main cause of death from a single source of infection. Drug-induced liver injury (DILI) is the most common and serious side effect during the treatment of TB.

Objective: We aim to predict the status of liver injury in patients with TB at the clinical treatment stage. Read More

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Clinico-laboratory characteristics and outcome of patients with eucalyptus oil-induced/provoked seizures: A case series and systematic review of the published patients.

Trop Doct 2021 Jul 20:494755211032095. Epub 2021 Jul 20.

Assistant Professor, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India.

Seizures triggered by skin application, inhalation or ingestion of over-the-counter medications containing eucalyptus oil are known. We report five children who suffered likewise. We made a systematic search for all reported cases and performed a pooled analysis to provide a comprehensive estimate of the type of seizures, their management and outcome. Read More

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Association Between Potentially Inappropriate Medications and 30-Day Post-Hospital Discharge Outcomes in US Veterans.

Ann Pharmacother 2021 Jul 20:10600280211032072. Epub 2021 Jul 20.

Yale University, New Haven, CT, USA.

Background: Potentially inappropriate medication (PIMs) use is common in older inpatients and it may lead to increased risk of adverse drug events.

Objectives: To examine prevalence of PIMs at hospital discharge and its contribution to health care utilization and mortality within 30-days of hospital discharge.

Methods: This was a prospective cohort of 117 570 veterans aged ≥65 years and hospitalized in 2013. Read More

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Efficacy and safety of Suxiao Jiuxin Pill in the treatment of stable angina (Qi stagnation and blood stasis syndrome): study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial.

Trials 2021 Jul 19;22(1):466. Epub 2021 Jul 19.

Cardiovascular Department, Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, China.

Background: Coronary heart disease (CHD) has become one of the biggest health problems in the world. Stable angina is a common clinical type of CHD with poor prognosis and high mortality. Although there are various interventions for stable angina, none of them can significantly reduce mortality. Read More

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Pushing the Limits of Medical Management in HCM: A Review of Current Pharmacological Therapy Options.

Int J Mol Sci 2021 Jul 5;22(13). Epub 2021 Jul 5.

Cardiology Department, Cardiovascular Diseases Institute "Prof. Dr. George I.M. Georgescu", Carol I Boulevard No. 50, 700503 Iași, Romania.

Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiac disease with a highly variable phenotypic expression, ranging from asymptomatic to drug refractory heart failure (HF) presentation. Pharmacological therapy is the first line of treatment, but options are currently limited to nonspecific medication like betablockers or calcium channel inhibitors, with frequent suboptimal results. While being the gold standard practice for the management of drug refractory HCM patients, septal reduction therapy (SRT) remains an invasive procedure with associated surgical risks and it requires the expertise of the operating centre, thus limiting its accessibility. Read More

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Non-continuous positive airway pressure treatment options in obstructive sleep apnoea: A pathophysiological perspective.

Sleep Med Rev 2021 Jul 1;60:101521. Epub 2021 Jul 1.

Unit of Orthodontics and Sleep Dentistry, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. Electronic address:

The phenotyping of the pathophysiology of obstructive sleep apnoea (OSA) lies at the core of tailored treatments and it is one of the most debated topics in sleep medicine research. Recent sophisticated techniques have broadened the horizon for gaining insight into the variability of the endotypic traits in patients with OSA which account for the heterogeneity in the clinical presentation of the disease and consequently, in the outcome of treatment. However, the implementation of these concepts into clinical practice is still a major challenge for both researchers and clinicians in order to develop tailored therapies targeted to specific endotypic traits that contribute to OSA in each individual patient. Read More

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Management of pediatric atopic dermatitis by primary care providers: A systematic review.

Acad Pediatr 2021 Jul 16. Epub 2021 Jul 16.

Department of Pediatrics, New York University Grossman School of Medicine, New York, NY. 550 First Avenue, New York, NY 10016, USA; The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, 240 East 38th street, 11th floor. New York, NY 10016, USA.

Background: Primary care providers (PCPs), including pediatricians and general practitioners, are often the first to see children with eczema/atopic dermatitis (AD). Little is known about management of pediatric AD by PCPs and adherence to national guidelines.

Objective: To review existing literature examining management components of pediatric AD (topical corticosteroids [TCS], topical calcineurin inhibitors [TCIs], antihistamines, bathing, emollients, and diet) by PCPs. Read More

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Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients.

Cochrane Database Syst Rev 2021 Jul 19;7:CD013307. Epub 2021 Jul 19.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Read More

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Perspectives from the frontline: A pharmacy department's response to the COVID-19 pandemic.

Am J Health Syst Pharm 2020 08;77(17):1409-1416

Department of Pharmacy Services, St. Joseph Mercy Health System, Ann Arbor, MI.

Purpose: The global coronavirus disease 2019 (COVID-19) pandemic has created unprecedented strains on healthcare systems around the world. Challenges surrounding an overwhelming influx of patients with COVID-19 and changes in care dynamics prompt the need for care models and processes that optimize care in this medically complex patient population. The purpose of this report is to describe our institution's strategy to deploy pharmacy resources and standardize pharmacy processes to optimize the management of patients with COVID-19. Read More

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Patients' preferences for treatment with the new direct acting antiviral therapies for chronic hepatitis C virus infection.

Rev Esp Sanid Penit 2021 May-Aug;23(2):67-75

Department of Internal Medicine. Hospital Universitario Infanta Leonor. Madrid.

Objectives: The efficacy of new direct-acting antivirals (DAAs) in treating hepatitis C infection can depend on treatment adherence, which may be influenced by the patient's current lack of awareness of the disease. This study set out to understand the treatment naïve chronic hepatitis C patients' preferences for new DAAs (attributes) and to compile information about the diagnosis process.

Material And Method: Spanish quantitative market research study conducted between November 2018 and January 2019 to assess the posology preferences of treatment-naïve patients with chronic hepatitis C before starting treatment (seen by hepatologists and infectious diseases specialists). Read More

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February 2021

Overcoming the challenges of treating haemophilia in resource-limited nations: a focus on medication access and adherence.

Expert Rev Hematol 2021 Jul 18. Epub 2021 Jul 18.

Clinical Biochemistry, Tata Memorial Hospital, Mumbai, India.

Background: Haemophilia is a high cost low volume disease. Resource limited nations (RLN) usually spend very little on health budget and most of it is spent in dealing with common ailments. Clotting products constitute more than 90 percent of the total cost of haemophilia care. Read More

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