35,533 results match your criteria common bile


Matrix metalloproteinase-9 inhibition or deletion attenuates portal hypertension in rodents.

J Cell Mol Med 2021 Oct 14. Epub 2021 Oct 14.

Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan.

Liver cirrhosis and portal hypertension are accompanied by hyperdynamic circulation, angiogenesis and portosystemic collaterals. Matrix metalloproteinases (MMPs) participate in fibrogenesis and angiogenesis, however, whether they can be targeted in cirrhosis treatment is unclear. Therefore, we performed three series of experiments to investigate this issue. Read More

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October 2021

Prediction of recurrence after surgery based on preoperative MRI features in patients with pancreatic neuroendocrine tumors.

Eur Radiol 2021 Oct 13. Epub 2021 Oct 13.

Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.

Objectives: To investigate useful MRI features in pancreatic neuroendocrine tumor (PNET) patients for predicting recurrence and its timing after surgery.

Methods: A total of 99 patients with PNET who underwent MRI and surgery from 2000 to 2018 were enrolled. Two radiologists independently assessed MRI findings, including size, location, margin, T1 and T2 signal intensity, enhancement patterns, common bile duct (CBD) or main pancreatic duct (MPD) dilatation, vascular invasion, lymph node enlargement, DWI, and ADC value. Read More

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October 2021

Effects of Previous Kasai Surgery on Gut Microbiota and Bile Acid in Biliary Atresia With End-Stage Liver Disease.

Front Med (Lausanne) 2021 27;8:704328. Epub 2021 Sep 27.

Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Biliary atresia (BA) is the most common cholestatic liver disease in neonates. Although the Kasai procedure can improve temporary biliary drainage in some cases, complications and liver fibrosis still develop. Liver transplantation is the ultimate treatment. Read More

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September 2021

Hilar cholangiocarcinoma with extensive immunoglobulin G4 reaction.

Int J Clin Exp Pathol 2021 15;14(9):987-992. Epub 2021 Sep 15.

Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.

Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic fibroinflammatory disorder that can involve multiple organs. It is often challenging to distinguish IgG4-related sclerosing cholangitis (IgG4-SC) from cholangiocarcinoma because of overlap in their clinical findings. A 75-year-old man presented to a hospital for a detailed examination of the elevation of some biliary enzymes. Read More

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September 2021

Laparoscopic management of type VI choledochal cyst with common bile duct stone: report of a case and review of literature.

BMJ Case Rep 2021 Oct 13;14(10). Epub 2021 Oct 13.

Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.

A young adult male presented with biliary colic and intermittent jaundice for 1 year. Abdomen findings were unremarkable. Routine investigations revealed a raised total bilirubin. Read More

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October 2021

Intervention versus surveillance in patients with common bile duct stones detected by intraoperative cholangiography: a population-based registry study.

Br J Surg 2021 Oct 13. Epub 2021 Oct 13.

Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: Each year 13 000 patients undergo cholecystectomy in Sweden, and routine intraoperative cholangiography (IOC) is recommended to minimize bile duct injuries. The risk of requiring endoscopic retrograde cholangiopancreatography (ERCP) following cholecystectomy for common bile duct (CBD) stones where IOC is omitted and in patients with CBD stones left in situ is not well known.

Methods: Data were retrieved from the population-based Swedish Registry of Gallstone Surgery and ERCP between 1 January 2009 and 10 December 2019. Read More

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October 2021

Epstein-Barr Virus Causing Clinical Jaundice and Acute Acalculous Cholecystitis in a Previously Healthy 17-Year-Old Girl.

Am J Case Rep 2021 Oct 13;22:e932285. Epub 2021 Oct 13.

Department of Emergency Medicine, Reading Hospital - Tower Health, West Reading, PA, USA.

BACKGROUND Infectious mononucleosis secondary to Epstein-Barr Virus is a common infection in young adults. Infection usually involves a self-limiting course of fevers, sore throat, malaise, and myalgias. Transaminitis is a relatively common complication; clinical jaundice, however, is rare. Read More

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October 2021

Clinical Impact of Preoperative Relief of Jaundice Following Endoscopic Retrograde Cholangiopancreatography on Determining Optimal Timing of Laparoscopic Cholecystectomy in Patients with Cholangitis.

J Clin Med 2021 Sep 22;10(19). Epub 2021 Sep 22.

Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

Background: About 10% of patients with gallbladder (GB) stones also have concurrent common bile duct (CBD) stones. Laparoscopic cholecystectomy (LC) after removal of CBD stones using endoscopic retrograde cholangiopancreatography (ERCP) is the most widely used method for treating coexisting gallbladder and common bile duct stones. We evaluated the optimal timing of LC after ERCP according to clinical factors, focusing on preoperative relief of jaundice. Read More

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September 2021

Flaxseed Powder Attenuates Non-Alcoholic Steatohepatitis via Modulation of Gut Microbiota and Bile Acid Metabolism through Gut-Liver Axis.

Int J Mol Sci 2021 Oct 8;22(19). Epub 2021 Oct 8.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.

Non-alcoholic steatohepatitis (NASH) is gradually becoming one of the most common and health-endangering diseases; therefore, it is very important to prevent the occurrence of NASH and prevent simple non-alcoholic fatty liver (NAFL) from further developing into NASH. We fed mice a high-fat diet (HFD, 60% fat) for 14 weeks to induce NAFL and then fed different doses of flaxseed powder (low (10%), middle (20%), and high (30%)) to the mice for 28 weeks. After the animal experiment, we analyzed fecal bile acid (BA) profiles of the HFD mice, flaxseed-fed (FLA-fed) mice, and control mice with a normal diet (10% fat) using a targeted metabolomics approach, and we analyzed the gut microbiota at the same time. Read More

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October 2021

Challenging diagnostic work-up of a massive fluid-filled structure in the cranial abdomen of a cat.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Oct 12. Epub 2021 Oct 12.

Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation.

A 9-year-old female, neutered European shorthair cat was presented with acute vomiting, obvious jaundice and painful enlargement of the abdomen. Icteric skin and mucous membranes in addition to severe bilirubinaemia (mainly direct bilirubin) and a large increase in liver enzyme activities were the main findings at the initial examination. Radio- and ultrasonographic evaluation revealed a massive fluid-filled structure caudal to the liver displacing abdominal organs, in particular the stomach. Read More

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October 2021

Gallbladder cancer spreading into the aberrant cystic duct: First literature report.

Int J Surg Case Rep 2021 Sep 30;88:106443. Epub 2021 Sep 30.

Department of Surgery, Kobe City Nishi-Kobe Medical Center, Hyogo, Japan. Electronic address:

Introduction And Importance: Although variations from the standard anatomy of the extrahepatic bile ducts are common, duplication of the cystic duct draining a single gallbladder is an extremely rare variant. We herein describe the first report of gallbladder cancer spreading into the aberrant cystic duct.

Case Presentation: A 60-year-old female presented with upper abdominal pain, and she was diagnosed with gallbladder cancer. Read More

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September 2021

Gut Microbiota-Derived Metabolites in Irritable Bowel Syndrome.

Front Cell Infect Microbiol 2021 23;11:729346. Epub 2021 Sep 23.

Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota alterations, and dysfunction of the brain-gut axis; however, its pathophysiology remains poorly understood. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. The aim of our study was to investigate specific types of microbiota-derived metabolites, especially bile acids, short-chain fatty acids, vitamins, amino acids, serotonin and hypoxanthine, which are all implicated in the pathogenesis of IBS. Read More

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September 2021

Features of primary pancreatic lymphoma: A bi-institutional review with an emphasis on typical and atypical imaging features.

World J Clin Oncol 2021 Sep;12(9):823-832

Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.

Background: Primary pancreatic lymphoma (PPL) is a rare neoplasm. Being able to distinguish it from other pancreatic malignancies such as pancreatic ductal adenocarcinoma (PDAC) is important for appropriate management. Unlike PDAC, PPL is highly sensitive to chemotherapy and usually does not require surgery. Read More

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September 2021

Values of Contrast-Enhanced Ultrasound in Classification and Diagnosis of Common Bile Duct and Superficial Organ Lesions under Compression Algorithm.

J Healthc Eng 2021 29;2021:9577440. Epub 2021 Sep 29.

Department of Ultrasound, Minzu Hospital of Guangxi Zhuang Autonomous Region, Affiliated Minzu Hospital of Guangxi Medical University, Nanning 530001, China.

This work aimed to investigate values of contrast-enhanced ultrasound (CEUS) under DEFLATE in the classification and diagnosis of the common bile duct and superficial lymphoid lesions. 88 patients with lower common bile duct lesions and 126 patients with superficial lymphoid lesions were selected as the subjects investigated and examined by CEUS under DEFLATE to compare characteristics and diagnostic efficiency of CEUS in different types of lesions. The time-intensity curve (TIC) was for quantitative analysis on CEUS results. Read More

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September 2021

Evaluation of the protective effect of curcumin on encephalopathy caused by intrahepatic and extrahepatic damage in male rats.

Iran J Basic Med Sci 2021 Jun;24(6):760-766

Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Objectives: Along with increased intracranial pressure (ICP) and brain damage, brain edema is the most common cause of death in patients with hepatic encephalopathy. Curcumin can pass the blood-brain barrier and possesses anti-inflammatory and anti-oxidant properties. This study focuses on the curcumin protective effect on intrahepatic and extrahepatic damage in the brain. Read More

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Gastrointestinal hemorrhage in the setting of gastrointestinal cancer: Anatomical prevalence, predictors, and interventions.

World J Gastrointest Endosc 2021 Sep;13(9):391-406

Department of Gastroenterology, Medstar Georgetown University Hospital, Washington, DC 20007, United States.

Background: Gastrointestinal hemorrhage (GIH) is a common complication with gastrointestinal cancers (GIC). There is no comprehensive research that examines GIH in different types of GIC.

Aim: To study the prevalence, predictors, and interventions of GIH based on the anatomical location of GIC. Read More

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September 2021

Association of Gut Microbiota and Metabolites With Disease Progression in Children With Biliary Atresia.

Front Immunol 2021 23;12:698900. Epub 2021 Sep 23.

Hangkong Hospital, China Capital University, Beijing, China.

Background And Aims: Biliary atresia is the most common cause of liver disease and liver transplantation in children. The accumulation of bile acids in hepatocytes and the stimulation of the intestinal microbiome can aggravate the disease progression. This study investigated changes in the composition of the gut microbiota and its metabolites in biliary atresia and the possible effects of these changes on disease progression. Read More

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September 2021

Immunotherapy with toripalimab for lung adenocarcinoma in a real-world patient with an Eastern Cooperative Oncology Group performance status (ECOG PS) score of 4: a case report.

Ann Palliat Med 2021 Sep;10(9):10114-10123

Department of Otolaryngology, Second Hospital of Shanxi Medical University, Taiyuan, China.

Multidisciplinary treatment, mainly chemotherapy combined with immunotherapy, is preferred in patients with advanced lung cancer who are negative for driver genes and have an Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0-1; in contrast, patients with an ECOG PS score of 3-4 should be managed with supportive treatment and palliative care rather than chemotherapy or other antitumor treatments. In the real-world settings, however, in the Chinese population, a large proportion of patients and their families are willing to take risks to receive benefit from oncological treatments. We encountered a patient who had definite advanced lung adenocarcinoma with multiple metastases and fusion in abdominal lymph nodes. Read More

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September 2021

Breath-hold 3D magnetic resonance cholangiopancreatography at 1.5 T using a deep learning-based noise-reduction approach: Comparison with the conventional respiratory-triggered technique.

Eur J Radiol 2021 Oct 5;144:109994. Epub 2021 Oct 5.

Department of Radiology, International University of Health and Welfare Narita Hospital, 852 Hatakeda Narita, Chiba 286-0124, Japan. Electronic address:

Objectives: To assess the image quality of conventional respiratory-triggered 3-dimentional (3D) magnetic resonance cholangiopancreatography (Resp-MRCP) and breath-hold 3D MRCP (BH-MRCP) with and without denoising procedure using deep learning-based reconstruction (dDLR) at 1.5 T.

Methods: Forty-two patients underwent MRCP at 1. Read More

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October 2021

Increased post-endoscopic retrograde cholangiopancreatography pancreatitis for choledocholithiasis without acute cholangitis.

J Gastroenterol Hepatol 2021 Oct 9. Epub 2021 Oct 9.

Department of Gastroenterology, Kumamoto City Hospital, Kumamoto, Japan.

Background And Aim: Choledocholithiasis is the most common indication for endoscopic retrograde cholangiopancreatography (ERCP). Identifying risk factors for post-ERCP pancreatitis (PEP) is important for reducing the risk of developing PEP after common bile duct (CBD) stone removal. However, studies examining the risk factors for PEP for CBD stones are scarce. Read More

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October 2021

Gallbladder volvulus:  a case report.

J Med Case Rep 2021 Oct 9;15(1):494. Epub 2021 Oct 9.

Department of General Surgery, Trinity Health System, Trinity West, Steubenville, OH, USA.

Background: Gallbladder volvulus is a rare pathology first reported by Wendel in 1898. Although the main pathological process associated with gallbladder volvulus is not known, there is clinical evidence suggesting that lack of gallbladder adhesions to the liver leads to an eventual twisting around the cystic bile duct (a process that seems to favor older female populations).

Case Presentation: In this report, an 81-year-old Caucasian elderly female presented to the emergency department with acute/severe right upper quadrant pain, which was also accompanied by an elevated leukocyte count. Read More

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October 2021

Common bile duct morphology is associated with recurrence of common bile duct stones in Billroth II anatomy patients.

World J Clin Cases 2021 Sep;9(26):7671-7681

Department of Digestive Endoscopy, General Hospital of Northern Theater Command, Shenyang 110840, Liaoning Province, China.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is the primary choice for removing common bile duct (CBD) stones in Billroth II anatomy patients. The recurrence of CBD stones is still a challenging problem.

Aim: To evaluate CBD morphology and other predictors affecting CBD stone recurrence. Read More

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September 2021

Spontaneous cholangiofibrosis adjacent to a dilated common bile duct with intestinal metaplasia in a Royal College of Surgeons rat.

J Toxicol Pathol 2021 Oct 17;34(4):339-343. Epub 2021 Jul 17.

Laboratory of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.

A 130-week-old male Royal College of Surgeons rat kept as a non-treated animal in a long-term animal study presented with a mass in the hepatic portal region that adhered to a dilated common bile duct and the duodenum. Histopathologically, the solitary mass showed expansive growth with no apparent compression and continued to dilate the common bile duct, which had a hyperplastic epithelium with intestinal metaplasia. The mass mainly consisted of small to large dilated and/or tortuous ducts with abundant dense connective tissue and many inflammatory cells. Read More

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October 2021

Single Session Endoscopic Ultrasound-Guided Double Bypass (Hepaticogastrostomy and Gastrojejunostomy) for Concomitant Duodenal and Biliary Obstruction: A Case Series.

J Hepatobiliary Pancreat Sci 2021 Oct 7. Epub 2021 Oct 7.

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: Concomitant malignant biliary and gastric outlet obstruction can be difficult to manage endoscopically with traditional ERCP and luminal stenting. Endoscopic ultrasound (EUS)-guided hepaticogastrostomy (HG) and gastrojejunostomy (GJ) are novel techniques that can relieve both obstructions in a single session. This study aims to describe the outcomes of combined, single session EUS-HG and EUS-GJ. Read More

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October 2021

Genomic stability and phenotypic characteristics of industrially-produced GG in a yogurt matrix.

Appl Environ Microbiol 2021 Oct 6:AEM0157521. Epub 2021 Oct 6.

Human Health Research, Chr. Hansen A/S, Kogle Allé 6, 2970 Hørsholm, Denmark.

GG is a widely marketed probiotic with well-documented probiotic properties. Previously, deletion of the mucus-adhesive C1 genes was reported in dairy isolates. Here, we examined the genome preservation of industrially-produced GG (DSM 33156) co-fermented in yogurts. Read More

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October 2021

A novel approach to control severe hemobilia from distal common bile duct by using Surgicel®.

Asian J Surg 2021 Oct 2. Epub 2021 Oct 2.

Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, 100043, China. Electronic address:

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October 2021

Discovery of 1,8-naphthalidine derivatives as potent anti-hepatic fibrosis agents via repressing PI3K/AKT/Smad and JAK2/STAT3 pathways.

Bioorg Med Chem 2021 Sep 27;49:116438. Epub 2021 Sep 27.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address:

Liver fibrosis is one of the most common pathological consequences of chronic liver diseases (CLD). To develop effective antifibrotic strategies, a novel class of 1-(substituted phenyl)-1,8-naphthalidine-3-carboxamide derivatives were designed and synthesized. By means of the collagen type I α 1 (COL1A1)-based screening and cytotoxicity assay in human hepatic stellate cell (HSC) line LX-2, seven compounds were screened out from total 60 derivatives with high inhibitory effect and relatively low cytotoxicity for further COL1A1 mRNA expression analysis. Read More

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September 2021

Healed common bile duct perforation after biliary stent placement.

Gastrointest Endosc 2021 Oct 2. Epub 2021 Oct 2.

Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address:

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October 2021

Impact of single-stage laparoscopic trans-cystic exploration on hospital procedures, admissions and length-of-stay in common bile duct stone clearance.

ANZ J Surg 2021 Oct 5. Epub 2021 Oct 5.

Department of Surgery, (Upper-Gastrointestinal/Hepato-Pancreato-Biliary Unit) Western Health, Melbourne, Australia.

Background: Single-stage approach with bile duct exploration is considered the most efficient and cost-effective method of bile duct clearance. In Australia, apart from centres with subspecialty interests, notably in Brisbane, Queensland, a multi-stage approach with endoscopic retrograde cholangiopancreatography (ERCP) is used more frequently. We aim to evaluate the impact of single stage laparoscopic trans-cystic exploration (LTCE) versus multi-stage approach for choledocholithiasis. Read More

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October 2021

Endoscopic Endoluminal Radiofrequency Ablation and Single-Operator Peroral Cholangioscopy System (SpyGlass) in the Diagnosis and Treatment of Intraductal Papillary Neoplasm of the Bile Duct: A Case Report and Literature Review.

Front Med (Lausanne) 2021 16;8:675720. Epub 2021 Sep 16.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare biliary benign tumor with atypical clinical features and is frequently misdiagnosed. Its treatment is limited and surgical resection is thought to be the only therapeutic option in patients with IPNB. With the aim of increasing the early diagnosis rate of IPNB and providing more therapeutic options for surgeons, we innovatively put forward the concept of combined utilization of SpyGlass and endoscopic endoluminal radiofrequency ablation (ERFA) in the diagnosis and treatment of IPNB. Read More

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September 2021