501,681 results match your criteria combined therapy


Phase 2 multicenter trial of ofatumumab and prednisone as initial therapy of chronic graft-vs-host disease.

Blood Adv 2021 Oct 14. Epub 2021 Oct 14.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States.

Standard initial therapy of chronic graft vs. host disease (cGVHD) with glucocorticoids results in suboptimal and transient responses in a significant number of patients. Safety and feasibility of anti-CD20 directed B-cell therapy with ofatumumab (1000 mg IV on days 0 and 14) and prednisone (1 mg/kg/day) was previously established in our phase I trial (n=12). Read More

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October 2021

Emerging targets for anticancer vaccination: PD-1.

ESMO Open 2021 Oct 11;6(5):100278. Epub 2021 Oct 11.

Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address:

Among the mechanisms by which tumor cells escape the immune surveillance, one is the interaction between programmed cell death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1). Inhibition of the PD-1/PD-L1 pathway with monoclonal antibodies as immune checkpoint inhibitors targeting PD-1 or its ligand, PD-L1, represents a milestone in cancer therapy. The application of these antibodies, however, suffers from drawbacks including failure to show a response or benefit in a majority of patients following monotherapy or combination therapy, their frequent administration, and cost intensiveness. Read More

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October 2021

68Ga-PSMA-HBED-CC PET/MRI is superior to multiparametric magnetic resonance imaging in men with biochemical recurrent prostate cancer: A prospective single-institutional study.

Transl Oncol 2021 Oct 11;15(1):101242. Epub 2021 Oct 11.

Division of Molecular Imaging and Therapeutics, Department of Radiology, Weill Cornell Medicine, 525 E 68th Street, New York, NY 10065, USA.

Background: The primary objective was to compare the overall diagnostic performance, presented as detection rate of Ga-PSMA-HBED-CC positron emission tomography/magnetic resonance imaging (PSMA PET/MRI) versus conventional, multiparametric MRI (mpMRI) in a population of patients with biochemically recurrent prostate cancer. In conjunction with this analysis, secondary objectives included the evaluation of the detection rate stratified by PSA levels and primary treatment modality.

Methods: A total of 165 PSMA PET MRI were performed from April 2018 to May 2021, of whom 108 were presenting for biochemical recurrent disease. Read More

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October 2021

Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer.

Photodiagnosis Photodyn Ther 2021 Oct 11:102581. Epub 2021 Oct 11.

Department of Stomatology, PLA Strategic Support Force Medical Center, Beijing, 100101, China;; PLA 306 Clinical College of Anhui Medical University, Hefei, 230001, China.. Electronic address:

Background: Rationally designed nanostructured materials can produce ideal drug carriers that plays an increasingly important role in cancer treatment. In comparison with conventional drug combination approaches, using co-delivery systems of multiple drugs achieves sophisticated targeting strategies and multifunctionality.

Methods: First, a nano-co-delivery of chitosan/tripolyphosphate (CS-TPP) was synthesized and characterized combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) shRNA. Read More

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October 2021

Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma.

Gene 2021 Oct 11:145992. Epub 2021 Oct 11.

Department of Urologic Surgery, Ningbo Urology and Nephrology Hospital, Ningbo Yinzhou No 2. Hospital, Ningbo, China. Electronic address:

Renal cell carcinoma (RCC) is a common type of urological cancer and is often diagnosed at an advanced stage. Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), is used as second-line therapy for sorafenib- or sunitinib-refractory metastatic RCC. However, the clinical benefits of Everolimus are often hampered by drug resistance. Read More

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October 2021

Preferences for transitional HIV care among people living with HIV recently released from prison in Zambia: a discrete choice experiment.

J Int AIDS Soc 2021 Oct;24(10):e25805

Implementation Science Unit, Centre for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia.

Introduction: No studies from sub-Saharan Africa have attempted to assess HIV service delivery preferences among incarcerated people living with HIV as they transition from prisons to the community ("releasees"). We conducted a discrete choice experiment (DCE) to characterize releasee preferences for transitional HIV care services in Zambia to inform the development of a differentiated service delivery model to promote HIV care continuity for releasees.

Methods: Between January and October 2019, we enrolled a consecutive sample of 101 releasees from a larger cohort prospectively following 296 releasees from five prisons in Zambia. Read More

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October 2021

Immunotherapy Strategy Targeting Programmed Cell Death Ligand 1 and CD73 with Macrophage-Derived Mimetic Nanovesicles to Treat Bladder Cancer.

Mol Pharm 2021 Oct 14. Epub 2021 Oct 14.

Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Combination immunotherapy is a promising strategy to remove the inhibitory effect of the tumor microenvironment on immune effector cells, improving the efficacy of immune checkpoint inhibitor treatment in bladder cancer. However, it is challenging to deliver multiple drugs to the tumor tissue effectively and simultaneously to ensure optimal therapeutic effects. Macrophage-derived exosome-mimetic nanovesicles (EMVs) were designed and validated as a nanoplatform for coloading and delivery of the CD73 inhibitor (AB680) and the monoclonal antibody to programmed cell death ligand 1 (aPDL1). Read More

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October 2021

[Digital life in a networked world: opportunities and risks for psychiatry].

Nervenarzt 2021 Oct 14. Epub 2021 Oct 14.

Zentralinstitut für Seelische Gesundheit, Klinik für Psychiatrie und Psychotherapie, J5, Medizinische Fakultät Mannheim, Universität Heidelberg, 68159, Mannheim, Deutschland.

This overview addresses some opportunities and risks of digital transformation in their significance for the diagnostics and therapy of mental illnesses under the aspect of the convergence of new digital technologies. Possibilities of smartphone-based technologies for the recording of the lifeworld context are explained and the application of this approach to the investigation of resilience mechanisms for improving mental well-being is presented on the basis of two current research results. Subsequently, the increasing networking of the environmental context itself is taken into account against the background of the so-called internet of things (IoT). Read More

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October 2021

Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib.

Food Funct 2021 Oct 14. Epub 2021 Oct 14.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

Glioblastoma (GBM), one of the most significant brain neoplasms, is characterized by high metastasis and recurrence. Crossing the blood-brain barrier is one of the main therapeutic obstacles, seriously hampering therapeutic agents entering the brain. This research investigated the co-delivery of erlotinib and curcumin nanomicelles for enhancing anti-GBM treatment . Read More

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October 2021

Randomized controlled trial testing a video-text tobacco cessation intervention among economically disadvantaged African American adults.

Psychol Addict Behav 2021 Oct 14. Epub 2021 Oct 14.

Case School of Engineering.

Objective: This pilot study tested the acceptability and short-term outcomes of a culturally specific mobile health (mHealth) intervention () in a sample of economically disadvantaged African American adults. We hypothesized that would demonstrate greater acceptability, biochemically verified abstinence, and promote nicotine replacement therapy (NRT) use compared with a standard text-messaging program.

Method: In a 2-arm pilot randomized trial, adults who sought to quit smoking ( = 119) received either or the National Cancer Institute's (NCI) SmokefreeTXT, both combined with a brief behavioral counseling session plus 2 weeks of NRT. Read More

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October 2021

Electrospun PCL/MoS Nanofiber Membranes Combined with NIR-Triggered Photothermal Therapy to Accelerate Bone Regeneration.

Small 2021 Oct 13:e2104747. Epub 2021 Oct 13.

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.

Electrospun nanofiber membranes have been widely used for guided bone regeneration (GBR). For assistance in bone healing, photothermal therapy which renders moderate heat stimulation to defect regions by near-infrared (NIR) light irradiation has attracted much attention in recent years. Combined with photothermal therapy, novel electrospun poly(ε-caprolactone)/molybdenum disulfide (PCL/MoS ) nanofiber membranes are innovatively synthesized as GBR for bone therapy, wherein the exfoliated MoS nanosheets served as osteogenic enhancers and NIR photothermal agents. Read More

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October 2021

The efficacy and safety of a combined multipolar radiofrequency with pulsed electromagnetic field technology for the treatment of vaginal laxity: a double-blinded, randomized, sham-controlled trial.

Lasers Med Sci 2021 Oct 14. Epub 2021 Oct 14.

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.

Non-invasive vaginal rejuvenation with radiofrequency (RF) and lasers devices have gained popularity, but well-designed studies confirming their effectiveness are lacking. The aim of this study was to compare the efficacy and safety of a multipolar RF and pulsed electromagnetic field-based device (PEMF) versus sham for vaginal laxity. Thirty-two premenopausal females with ≥ 1 vaginal delivery and self-reported vaginal laxity were randomized into 2 groups: active (RF + PEMF) and sham. Read More

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October 2021

Image-guided combined ablation and resection in thoracic surgery for the treatment of multiple pulmonary metastases: A preliminary case series.

JTCVS Tech 2021 Oct 13;9:156-162. Epub 2021 Mar 13.

Department of Thoracic Surgery, University Hospital Southampton, Southampton, United Kingdom.

Objectives: To demonstrate the feasibility and preliminary outcomes of a novel hybrid technique combining percutaneous microwave ablation and wire-assisted wedge resection for patients with multiple pulmonary metastases using intraoperative imaging.

Methods: We describe our technique and present a retrospective case series of 4 patients undergoing iCART at our institution between August 2018 and January 2020. Procedures were performed in a hybrid operating suite using the ARTIS Pheno cone beam computerized tomography scanner (Siemens Healthineers, Erlangen, German). Read More

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October 2021

A Combination of N-Terminal proB-Type Natriuretic Peptide and Myoglobin Can Predict Severe Complications After Major Non-Cardiac Surgery in Elderly Patients: A Prospective Observational Cohort Study.

Front Med (Lausanne) 2021 27;8:679260. Epub 2021 Sep 27.

Departments of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.

Previous studies have demonstrated that serum N-terminal proB-type natriuretic peptide (NT-proBNP) was a predictor of adverse cardiovascular outcomes after surgery. We performed a prospective study to evaluate if NT-proBNP could be a sensitive marker of overall postoperative outcomes in older patients undergoing major elective non-cardiac surgery when combined with myoglobin (MYO). Two hundred and three adults aged ≥65 years were enrolled in the study. Read More

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September 2021

An Advanced Systems Pharmacology Strategy Reveals as Key Genes in the Competing Endogenous RNA Network of Compound Kushen Injection Treating Gastric Carcinoma by Integrated Bioinformatics and Experimental Verification.

Front Cell Dev Biol 2021 27;9:742421. Epub 2021 Sep 27.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Gastric carcinoma (GC) is a severe tumor of the digestive tract with high morbidity and mortality and poor prognosis, for which novel treatment options are urgently needed. Compound Kushen injection (CKI), a classical injection of Chinese medicine, has been widely used to treat various tumors in clinical practice for decades. In recent years, a growing number of studies have confirmed that CKI has a beneficial therapeutic effect on GC, However, there are few reports on the potential molecular mechanism of action. Read More

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September 2021

Case Report: Systemic Treatment and Serial Genomic Sequencing of Metastatic Prostate Adenocarcinoma Progressing to Small Cell Carcinoma.

Front Oncol 2021 27;11:732071. Epub 2021 Sep 27.

Department of Bioinformatics, Center for Translational Medicine, Second Military Medical University, Shanghai, China.

Small cell carcinoma (SCC)/neuroendocrine prostate cancer (NEPC) is a rare and highly aggressive subtype of prostate cancer associated with an AR(androgen receptor)-null phenotype and visceral metastases. This study presents a 44-year-old man originally diagnosed with metastatic hormone-sensitive prostatic adenocarcinoma. After 6-month androgen deprivation therapy (ADT) combined with docetaxel, the patient developed paraplegia. Read More

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September 2021

Constraint-Induced Movement Therapy Combined With Botulinum Toxin for Post-stroke Spasticity: A Systematic Review and Meta-Analysis.

Cureus 2021 Sep 1;13(9):e17645. Epub 2021 Sep 1.

Research, Paolo Procacci Foundation, Roma, ITA.

Stroke is considered one of the main causes of adult disability and the second most serious cause of death worldwide. The combination of botulinum toxin type A (BTX) with rehabilitation techniques such as modified constraint-induced movement therapy (mCIMT) has emerged as a highly efficient intervention for stroke patients to start synchronized motor function along with spasticity reduction. The current systematic review and meta-analysis were conducted in order to evaluate the available literature about the safety and efficacy of constraint-induced movement therapy (CIMT) combined with BTX in stroke patients with upper limb spasticity. Read More

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September 2021

Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI.

Theranostics 2021 13;11(19):9431-9451. Epub 2021 Sep 13.

Department of Intensive Care Unit, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, P.R. China.

The immunosuppressive, inflammatory microenvironment orchestrated by neutrophil extracellular traps (NETs) plays a principal role in pathogenesis of sepsis. Fibroblast growth factor-inducible molecule 14 (Fn14) has been established as a potential target for septic acute kidney injury (AKI), making further therapeutic benefits from combined NETs and Fn14 blockade possible. The concurrence of NETs and Fn14 in mice and patients with septic AKI were assessed by immunofluorescence, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and studies. Read More

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September 2021

Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy.

Theranostics 2021 3;11(19):9234-9242. Epub 2021 Sep 3.

Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.

Sonodynamic therapy (SDT) triggered by ultrasound (US) can overcome pivotal limitations of photo-therapy owing to its high depth-penetration and low phototoxicity. However, there is still a need to develop more efficient sonosensitizes to enhance the therapy efficiency. In this study, Pt nanoparticles (Pt NPs) are reduced on silicon nanowires (SiNWs) by reduction to prepare Si-Pt nanocomposites (Si-Pt NCs). Read More

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September 2021

Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models.

Evid Based Complement Alternat Med 2021 4;2021:9911935. Epub 2021 Oct 4.

Department of Oncology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Patients with EGFR gene mutation often obtain de novo resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or develop secondary resistance to EGFR-TKIs after taking EGFR-TKI therapy. Traditional Chinese medicine (TCM) with different treatment principles, in combination with EGFR-TKIs, plays an important role in the treatment of cancers including resistant non-small cell lung cancer (NSCLC). However, inappropriate use of TCM herbs may induce resistance to gefitinib. Read More

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October 2021

Evaluation of a Clinically Relevant Drug-Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity.

Front Pharmacol 2021 27;12:715577. Epub 2021 Sep 27.

Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

The combination therapy of rosuvastatin (RSV) and the platelet inhibitor clopidogrel (CP) is widely accepted in the management of cardiovascular diseases. The objective of the present study was to identify the mechanism of RSV-CP DDI and evaluate the risk of hepatotoxicity associated with the concomitant use of CP. We first studied the effect of CP and its major circulating metabolite, carboxylic acid metabolite (CPC), on RSV transport by overexpressing cells and membrane vesicles. Read More

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September 2021

Phase Ib/II study of Cetuximab Plus Pembrolizumab in Patients with Advanced RAS wild-type Colorectal Cancer.

Clin Cancer Res 2021 Oct 13. Epub 2021 Oct 13.

Medical Oncology, Rutgers Cancer Institute of New Jersey.

Purpose: We evaluated the antitumor efficacy of cetuximab in combination with pembrolizumab in patients with wild-type (RASwt), metastatic colorectal adenocarcinoma (mCRC).

Experimental Design: In this phase Ib/II study, cetuximab was combined with pembrolizumab in patients with RASwt mCRC with {greater than or equal to} one prior line of therapy for advanced disease. We analyzed baseline on-treatment tumor tissues for changes in the tumor microenvironment (TME), using flow cytometry and multispectral immunofluorescence. Read More

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October 2021

[Comparative study on prognosis of neoadjuvant chemotherapy followed by hepatic surgery versus upfront surgery in patients with synchronous colorectal liver metastasis].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Mar;24(3):248-255

Department of Hepatopancreatobiliary Surgery Unit I, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China.

To compare the survival outcome in patients with synchronous colorectal cancer liver metastasis receiving neoadjuvant chemotherapy followed by hepatic surgery versus upfront surgery strategies. A retrospective cohort study was carried out. Data of patients undergoing surgery at the Department of Hepatopancreatobiliary Surgery Unit I of Peking University Cancer Hospital from January 2008 to December 2018 for initially resectable synchronous colorectal liver metastasis were retrospectively collected. Read More

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[Safety and short-term efficacy of apatinib combined with oxaliplatin and S-1 in the conversion treatment for gastric cancer with peritoneal metastasis].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Mar;24(3):240-247

Department of Gastrointestinal Surgery, Key Laboratory of Tumor Biological Treatment of Fujian Province, Fujian Cancer Hospital & Affiliated Cancer Hospital, Fujian Medical University, Fuzhou 350014, China.

To investigate the safety and short-term efficacy of apatinib combined with oxaliplatin and S-1 in the conversion treatment for gastric cancer with different types of peritoneal metastasis. A prospective study "one arm exploratory clinical study of conversion therapy of apatinib with S-1 and oxaliplatin in the treatment of advanced gastric cancer" (clinical registration ChiCTR-ONC-17010430) from medical record database was retrospectively analyzed. Patients aged 18-70 years with gastric cancer peritoneal metastasis confirmed by histology and laparoscopic exploration, and had not receive radiotherapy, chemotherapy, targeted therapy or immunotherapy before were enrolled. Read More

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[Research advances on early enteral nutritional therapy in severe burn patients].

Authors:
Y Luo N Li

Zhonghua Shao Shang Za Zhi 2021 Sep;37(9):880-884

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

Severe burns can lead to persistent hypermetabolism. Studies have shown that early enteral nutrition therapy is related to improving the prognosis of severe burn patients, reducing the mortality rate, and reducing gastrointestinal complications and infectious complications. This article introduces the nutritional benefits and non-nutritive benefits of early enteral nutrition therapy for severe burn patients (maintaining the integrity of the intestinal mucosa function and structure and promoting wound healing), the timing and pathways of nutritional intervention, ways of energy evaluation, and nutritional monitoring, etc. Read More

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September 2021

[A prospectively randomized controlled study of the effects of intensive insulin therapy combined with glutamine on nutritional metabolism, inflammatory response, and hemodynamics in severe burn patients].

Zhonghua Shao Shang Za Zhi 2021 Sep;37(9):821-830

Department of Burns and Plastic Surgery, the 71st Group Army Hospital of PLA Army, Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou 221004, China.

To observe the effects of intensive insulin therapy combined with glutamine on nutritional metabolism, inflammatory response, and hemodynamics in severe burn patients. Thirty-two severe burn patients who met the inclusion criteria and hospitalized in the Affiliated Huaihai Hospital of Xuzhou Medical University from June 2017 to January 2019 were recruited into a prospectively randomized controlled study. According to the random number table, the patients were divided into conventional insulin therapy alone group, conventional insulin therapy+glutamine group, intensive insulin therapy alone group, and intensive insulin therapy+glutamine group, with 8 patients in each group, with genders of 5 males and 3 females, 4 males and 4 females, 3 males and 5 females, 4 males and 4 females, and ages of (35±7), (36±9), (33±11), and (38±7) years, respectively. Read More

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September 2021

[Metabolic staging and nutritional treatment strategies of severely burned patients].

Authors:
X Peng

Zhonghua Shao Shang Za Zhi 2021 Sep;37(9):805-810

Clinical Medical Research Center, Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

The complexity of burn metabolism and limitations of its cognition are the core factors leading to dissatisfactory efficacy of nutritional therapy in severe burn patients. Precise understanding of burn metabolic rules is a prerequisite for improving the pertinence and effectiveness of nutritional therapy. The previous division of burn metabolic stages based on energy consumption did not pay enough attention to substance metabolism, so it is difficult to fully comprehend the overall change pattern and stage characteristics of burn metabolism. Read More

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September 2021

Clinical Features and Outcomes of Streptococcus pneumoniae Meningitis in Children: A Retrospective Analysis of 26 Cases in China.

Neuropediatrics 2021 Oct 13. Epub 2021 Oct 13.

Department of Neurology, Children's Hospital of Shanxi, Taiyuan, Shanxi, China.

Background:   is an important cause of pediatric meningitis.

Objective:  The aim of this study was to analyze the clinical features and outcomes of children with pneumococcal meningitis at our hospital in China, so as to provide basis for improving the clinical treatment effect.

Methods:  This retrospective analysis included patients aged <16 years treated for pneumococcal meningitis at the Department of Neurology, Children's Hospital of Shanxi (January 2014-February 2016). Read More

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October 2021

A Systematic Review and Meta-analysis on the Efficacy and Safety of Direct Oral Anticoagulants in Patients with Peripheral Artery Disease.

Ann Vasc Surg 2021 Oct 10. Epub 2021 Oct 10.

Division of Vascular Surgery and Endovascular Therapy, University of Colorado, Anschutz Medical Center, Aurora, CO. Electronic address:

Background-objective: PAD is a significant cause of morbidity and mortality affecting over 200 million people worldwide. Current guidelines recommend at least a single antiplatelet or anticoagulant agent in symptomatic PAD and lifelong antithrombotic treatment after a revascularization procedure. The aim of this systematic review and meta-analysis was to investigate the efficacy and safety of direct oral anticoagulants (DOACs) in patients with peripheral artery disease (PAD). Read More

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October 2021

Cardiometabolic multimorbidity and activity limitation: a cross-sectional study of adults using the Canadian Longitudinal Study on Aging data.

Fam Pract 2021 Oct 13. Epub 2021 Oct 13.

Southern Medical Program, Faculty of Medicine, University of British Columbia, Kelowna, BC, Canada.

Background: Cardiometabolic multimorbidity (CM) is the diagnosis of 2 or more cardiometabolic conditions. Multimorbidity and individual cardiometabolic conditions have been associated with activity limitation, a common form of disability, but few studies have investigated the association between CM and activity limitation.

Objectives: To estimate the prevalence of activity limitation among Canadians with CM and to quantify the association between CM and activity limitation. Read More

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October 2021