3,698 results match your criteria combined repetitive


A specific phase of transcranial alternating current stimulation at the β frequency boosts repetitive paired-pulse TMS-induced plasticity.

Sci Rep 2021 Jun 23;11(1):13179. Epub 2021 Jun 23.

Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

Transcranial alternating current stimulation (tACS) at 20 Hz (β) has been shown to modulate motor evoked potentials (MEPs) when paired with transcranial magnetic stimulation (TMS) in a phase-dependent manner. Repetitive paired-pulse TMS (rPPS) with I-wave periodicity (1.5 ms) induced short-lived facilitation of MEPs. Read More

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Detection of Extended-Spectrum β-Lactamases among Isolated from Hospitals of Qazvin, Iran.

Ethiop J Health Sci 2021 Mar;31(2):229-236

Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Acinetobacter baumannii is a major contributor to nosocomial infections. Extended-spectrum β-lactamase (ESBL)-producing A. baumannii is spreading worldwide. Read More

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Cytogenomic analysis unveils mixed molecular evolution and recurrent chromosome rearrangements shaping the multigene families on Schistocerca grasshopper genomes.

Evolution 2021 Jun 21. Epub 2021 Jun 21.

Departamento de Biologia Geral e Aplicada, UNESP - Univ Estadual Paulista, Instituto de Biociências/IB, Rio Claro, São Paulo, Brazil.

Multigene families are essential components of eukaryotic genomes and play key roles either structurally and functionally. Their modes of evolution remain elusive even in the era of genomics, because multiple multigene family sequences coexist in genomes, particularly in large repetitive genomes. Here, we investigate how the multigene families 18S rDNA, U2 snDNA, and H3 histone evolved in ten species of Schistocerca grasshoppers with very large and repeat-enriched genomes. Read More

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Effects of Bihemispheric Transcranial Direct Current Stimulation Combined With Repetitive Peripheral Nerve Stimulation in Acute Stroke Patients.

J Clin Neurophysiol 2021 May 31. Epub 2021 May 31.

Neurophysiology Unit, Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain; Department of Clinical Neurophysiology, Hospital Universitari Dexeus, Barcelona, Spain; Neurology Department, Hospital Universitari de Bellvitge, Barcelona, Spain; Neurology Department, Hospital de Neurorehabilitación, Institut Guttmann, Barcelona, Spain; and EMG Unit, Neurology Department, Hospital Clínic, Department of Medicine, University of Barcelona, August Pi Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.

Purpose: Transcranial direct current stimulation (tDCS) can change the excitability of the central nervous system and contribute to motor recovery of stroke patients. The aim of our study was to examine the short- and long-term effects of real versus sham bihemispheric tDCS combined with repetitive peripheral nerve stimulation in patients with acute stroke and a severe motor impairment.

Methods: The study was prospective, randomized, double blind, and placebo controlled. Read More

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Cold atmospheric plasma improves cutaneous microcirculation in standardized acute wounds: Results of a controlled, prospective cohort study.

Microvasc Res 2021 Jun 16;138:104211. Epub 2021 Jun 16.

Department of Plastic Surgery, Hand Surgery, Burn Unit, University Hospital of Schleswig-Holstein, Campus Lübeck, University of Lübeck, Lübeck, Germany.

Background: Given the high prevalence of wounds and their challenging treatment, the research of therapies to improve wound healing is of great clinical interest. In addition, the general consequences of developing chronic wounds constitute a large health economic aspect, which underscores the interest in the development of efficient treatment strategies. Direct cold atmospheric plasma (di_CAP) has been shown to have beneficial effects on microcirculation of human tissue (Kisch et al. Read More

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Load and Display: Engineering Encapsulin as a Modular Nanoplatform for Protein-Cargo Encapsulation and Protein-Ligand Decoration Using Split Intein and SpyTag/SpyCatcher.

Biomacromolecules 2021 Jun 18. Epub 2021 Jun 18.

Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.

Protein cage nanoparticles have a unique spherical hollow structure that provides a modifiable interior space and an exterior surface. For full application, it is desirable to utilize both the interior space and the exterior surface simultaneously with two different functionalities in a well-combined way. Here, we genetically engineered encapsulin protein cage nanoparticles (Encap) as modular nanoplatforms by introducing a split-C-intein (Int) fragment and SpyTag into the interior and exterior surfaces, respectively. Read More

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A Challenging Case of Extraordinary - Long standing Forearm Non-union Treated with Extensive Debridement, Locking Plates, and Bone Grafting. Technical Considerations in Multiple-operated, Neglected Non-unions.

J Orthop Case Rep 2021 ;11(1):63-66

Department of Orthopedics, General University Hospital of Larisa, University of Thessaly, Larisa, Greece.

Introduction: Forearm non-unions pose a significant treatment challenge to orthopedic surgeons. Repetitive treatment failures can lead to a devastating situation for the patient. Forearm function influences both elbow and wrist proper function. Read More

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January 2021

Seizure risk with repetitive TMS: Survey results from over a half-million treatment sessions.

Brain Stimul 2021 Jun 13. Epub 2021 Jun 13.

Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: Seizures are rare during repetitive transcranial magnetic stimulation (rTMS) treatment, but estimating risk is difficult because of study heterogeneity and sampling limitations. Moreover, there are few studies comparing rates between device manufacturers.

Objective: The objective of this study was to calculate rTMS seizure rates across various FDA-cleared devices in naturalistic clinical settings. Read More

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Does a combination treatment of repetitive transcranial magnetic stimulation and occupational therapy improve upper limb muscle paralysis equally in patients with chronic stroke caused by cerebral hemorrhage and infarction?: A retrospective cohort study.

Medicine (Baltimore) 2021 Jun;100(24):e26339

Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo.

Abstract: The clinical presentation of stroke is usually more severe in patients with intracerebral hemorrhage (ICH) than in those with cerebral infarction (CI); recovery of stroke-related muscle paralysis is influenced and limited by the type of stroke. To date, many patients have been treated by neurorehabilitation; however, the changes in the recovery of motor paralysis depending on the type of stroke, ICH or CI, have not been established. This study aimed to determine this difference in improvement of upper extremity paralysis using 2-week in-hospital NovEl intervention Using Repetitive transcranial magnetic stimulation combined with Occupational therapy (NEURO). Read More

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Pharmacy Technicians' Perceptions of Risk Reduction Strategies Implemented in Response to the Repetitive Strain Injury Associated with Sterile Compounding.

Int J Pharm Compd 2021 May-Jun;25(3):182-186

Pharmacy Department, Eastern Health, Melbourne, Victoria, Australia.

Following a 240% increase in the number of compounded sterile preparations between 2012 and 2013, three pharmacy technicians at a metropolitan public hospital suffered hand-related, repetitive strain injuries. This study describes the main safety measures implemented to reduce the risk of repetitive strain injuries associated with sterile compounding at the study hospital, and reports pharmacy technicians' perceptions of their effectiveness. The implemented risk reduction strategies were categorized into five domains of 1) equipment and consumables, 2) training and assessment, 3) Lean waste reduction, 4) roster and shift limits, and 5) workload allocation score. Read More

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Advanced multichannel submersible probe for autonomous high-resolution in situ monitoring of the cycling of the potentially bioavailable fraction of a range of trace metals.

Chemosphere 2021 May 29;282:131014. Epub 2021 May 29.

University of Bordeaux, UMR CNRS 5805 EPOC, 33615 Pessac, France.

We report here on the development and application of a submersible, compact, low power consumption, integrated multichannel trace metal sensing probe (TracMetal). This probe is unique in that it allows high-resolution, simultaneous in-situ measurements of the potentially bioavailable (so-called dynamic) fraction of Hg(II), As(III), Cd(II), Pb(II), Cu(II), Zn(II). The TracMetal incorporates nanostructured Au-plated and Hg-plated gel-integrated microelectrode arrays. Read More

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Paired inhibitory stimulation and gait training modulates supplemental motor area connectivity in freezing of gait.

Parkinsonism Relat Disord 2021 Jun 1;88:28-33. Epub 2021 Jun 1.

Department of Neurology, Medical University of South Carlina, Charleston, SC, USA. Electronic address:

Introduction: Freezing of gait (FOG) is a debilitating feature of Parkinson's disease (PD). Evidence suggests patients with FOG have increased cortical control of gait. The supplementary motor area (SMA) may be a key structure due to its connectivity with locomotor and cognitive networks. Read More

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Genome-Wide Identification of DNase I Hypersensitive Sites in Plants.

Curr Protoc 2021 Jun;1(6):e148

School of Life Science, Nantong University, Nantong, China.

DNase I hypersensitive site (DHS) mapping combined with high-throughput sequencing (DNase-seq) enables the identification of cis-regulatory DNA elements (CREs) genome wide. However, despite the wide applications of DNase-seq in plants, its application to the highly repetitive genomes of plants has lagged. Here, we describe a modified DNase-seq method, making it more practical for application to plants with genomes enriched with repetitive DNA. Read More

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Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis.

Nat Commun 2021 06 7;12(1):3396. Epub 2021 Jun 7.

German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with overlapping clinical features and the pathological hallmark of cytoplasmic deposits of misfolded proteins. The most frequent cause of familial forms of these diseases is a hexanucleotide repeat expansion in the non-coding region of the C9ORF72 gene that is translated into dipeptide repeat polymers. Here we show that proline/arginine repeat polymers derail protein folding by sequestering molecular chaperones. Read More

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Transposition of the superficial femoral artery combined with ultrasound-guided returning-venous cannulation as a last resort for vascular access in a multi-complicated hemodialysis patient.

J Vasc Access 2021 Jun 6:11297298211023288. Epub 2021 Jun 6.

Department of Surgery, Saiwaicho Memorial Hospital, Okayama, Japan.

A superficialized artery as a blood-drawing route could be an option for vascular access (VA) in hemodialysis patients with cardiac failure, vessel damage, steal syndrome, and venous hypertension, and it could be a secondary VA option in those with repetitive vascular access troubles, routinely requiring a blood-returning venous route. The brachial artery is preferably used for superficialization due to the benefit of its appropriate diameter for cannulation, procedural ease of surgery under local anesthesia, and usable subcutaneous vein for blood-returning route in the upper limb. The superficial femoral artery (SFA) has also been reported as a candidate for arterial transposition; however, its subcutaneous transposition could have difficulties in requiring general anesthesia and securing blood-inflow-venous routes. Read More

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Overcoming reduced antibiotic susceptibility in intracellular Salmonella enterica serovar Typhimurium using AR-12.

FEMS Microbiol Lett 2021 Jun;368(11)

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Host-directed therapies (HDTs) could enhance the activity of traditional antibiotics. AR-12 is a promising HDT against intracellular pathogens including Salmonella enterica serovar Typhimurium, and has been shown to act through modulation of autophagy and the Akt kinase pathway. Since AR-12 does not inhibit the growth of planktonic bacteria but only works in conjunction with the infected host-cell, we hypothesized that AR-12 could enhance the activity of antibiotics in less-susceptible strains in the intracellular host environment. Read More

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Performance Analysis and Applications of Finite-Time ZNN Models With Constant/Fuzzy Parameters for TVQPEI.

IEEE Trans Neural Netw Learn Syst 2021 Jun 3;PP. Epub 2021 Jun 3.

Based on extensive applications of the time-variant quadratic programming with equality and inequality constraints (TVQPEI) problem and the effectiveness of the zeroing neural network (ZNN) to address time-variant problems, this article proposes a novel finite-time ZNN (FT-ZNN) model with a combined activation function, aimed at providing a superior efficient neurodynamic method to solve the TVQPEI problem. The remarkable properties of the FT-ZNN model are faster finite-time convergence and preferable robustness, which are analyzed in detail, where in the case of the robustness discussion, two kinds of noises (i.e. Read More

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An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury.

PLoS One 2021 2;16(6):e0252023. Epub 2021 Jun 2.

Systems Neuroscience Section, Department of Neuroscience, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.

Repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (MI) is expected to provide a therapeutic impact on spinal cord injury (SCI). On the other hand, treatment with antibody against repulsive guidance molecule-a (RGMa) has been shown to ameliorate motor deficits after SCI in rodents and primates. Facilitating activity of the corticospinal tract (CST) by rTMS following rewiring of CST fibers by anti-RGMa antibody treatment may exert an enhanced effect on motor recovery in a primate model of SCI. Read More

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Measuring the Emergence of Specific Abilities in Young Children with Autism Spectrum Disorders: The Example of Early Hyperlexic Traits.

Brain Sci 2021 May 25;11(6). Epub 2021 May 25.

Department of Psychiatry, Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland.

The presence of a restricted interest in written materials, including an early ability to name and recognize letters and numbers, is regularly reported in preschoolers with autism spectrum disorders (ASDs). There is, however, scarce information on this early ability akin to emerging hyperlexic traits in preschoolers with ASD younger than 3 years old. Here, we defined a measure of early naming and recognition of letters and numbers in 155 preschoolers with ASD using a sliding window approach combined with a 90th percentile threshold criterion, and subsequently compared the profiles of children with ASD with and without early hyperlexic traits. Read More

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Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression.

Int J Mol Sci 2021 May 5;22(9). Epub 2021 May 5.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang-si, Gyeonggi-Do 10326, Korea.

Hypergravity conditions may subject the kidney to intrinsic stress and lead to hemodynamic kidney dysfunction. However, the mechanisms underlying this phenomenon remain unclear. Accumulation of unfolded proteins in the endoplasmic reticulum (i. Read More

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Pan-Mitogenomics Approach Discovers Diversity and Dynamism in the Prominent Brown Rot Fungal Pathogens.

Front Microbiol 2021 12;12:647989. Epub 2021 May 12.

School of Graduate Studies, MSc Program in Biomolecular Sciences, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.

and species are the most destructive and economically devastating fungal plant pathogens causing brown rot disease on stone and pome fruits worldwide. Mitochondrial genomes (mitogenomes) play critical roles influencing the mechanisms and directions of the evolution of fungal pathogens. The pan-mitogenomics approach predicts core and accessory regions of the mitochondrial genomes and explains the gain or loss of variation within and between species. Read More

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The Effect of Teaching Nontechnical Skills in Advanced Life Support: A Systematic Review.

AEM Educ Train 2021 Jul 9;5(3):e10522. Epub 2020 Oct 9.

Department of Emergency Medicine University Hospitals Leuven Leuven Flanders Belgium.

Objectives: The objective of this study was to evaluate the effect of nontechnical skills (NTS) training on performance in advanced life support (ALS) simulation. Furthermore, we aimed to determine the ideal frequency of training sessions for an optimal retention and the value of debriefing.

Methods: A systematic search was performed using PubMed, EMBASE, WoS, ERIC, CINAHL, and the Cochrane Library conducted through August 1, 2018. Read More

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Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Arch Toxicol 2021 May 24. Epub 2021 May 24.

Division of Pulmonology, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 667, Rochester, NY, 14642, USA.

Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or chemical inhalation exposure. Diacetyl (DA; 2,3-butanedione) is a highly reactive alpha-diketone known to cause BO when inhaled, however, the mechanisms of how inhalation exposure leads to BO development remains poorly understood. In the current work, we combined two clinically relevant models for studying the pathogenesis of DA-induced BO: (1) an in vivo rat model of repetitive DA vapor exposures with recovery and (2) an in vitro model of primary human airway epithelial cells exposed to pure DA vapors. Read More

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Re-examination of two diatom reference genomes using long-read sequencing.

BMC Genomics 2021 May 24;22(1):379. Epub 2021 May 24.

Department of Biochemistry and Molecular Biology, Dalhousie University, PO Box 15000, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, B3H 4R2, Canada.

Background: The marine diatoms Thalassiosira pseudonana and Phaeodactylum tricornutum are valuable model organisms for exploring the evolution, diversity and ecology of this important algal group. Their reference genomes, published in 2004 and 2008, respectively, were the product of traditional Sanger sequencing. In the case of T. Read More

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Regenerative field effect transistor biosensor for in vivo monitoring of dopamine in fish brains.

Biosens Bioelectron 2021 Sep 17;188:113340. Epub 2021 May 17.

Key Laboratory of Control of Quality and Safety for Aquatic Products, Chinese Academy of Fishery Sciences, Beijing, 100141, China. Electronic address:

The detection of dopamine, one of the neurotransmitters in cerebral physiology, is critical in studying brain activities and understanding brain functions. However, regenerative biosensor for monitoring dopamine in the progress of physiological and pathological events is still challenging, due to lack of the platform for repetitive on-line detection-regeneration cycle. Herein, we have developed a regenerated field effect transistor (FET) combined with in vivo monitoring system. Read More

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September 2021

Effect of repetitive peripheral magnetic stimulation combined with motor imagery on the corticospinal excitability of antagonist muscles.

Neuroreport 2021 Jul;32(10):894-898

Health and Nutrition, Niigata University of Health and Welfare, Niigata, Japan.

Objective: Repetitive peripheral magnetic stimulation (rPMS) combined with motor imagery facilitates the corticospinal excitability of the agonist muscles. However, the effects of rPMS combined with motor imagery on the corticospinal excitability of the antagonist muscles are unclear. This is an important aspect for applying rPMS in neurorehabilitation for sensorimotor dysfunction. Read More

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Comparison of intracervical Foley catheter combined with a single dose of vaginal misoprostol tablet or intracervical dinoprostone gel for cervical ripening: a randomised study.

J Obstet Gynaecol 2021 May 24:1-7. Epub 2021 May 24.

Department of Neonatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We compared two combined methods for cervical ripening before induction of labour (IOL) Women (n = 150) were randomised into Foley's-misoprostol (n = 75) and Foley's-dinoprostone (n = 75) groups. A single dose of vaginal misoprostol tablet (25 µg) or intracervical dinoprostone gel (0.5 mg) were used alongwith intracervical Foley's. Read More

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Handover Control for Human-Robot and Robot-Robot Collaboration.

Front Robot AI 2021 7;8:672995. Epub 2021 May 7.

Dipartimento di Ingegneria, Università degli Studi della Campania Luigi Vanvitelli, Aversa, Italy.

Modern scenarios in robotics involve human-robot collaboration or robot-robot cooperation in unstructured environments. In human-robot collaboration, the objective is to relieve humans from repetitive and wearing tasks. This is the case of a retail store, where the robot could help a clerk to refill a shelf or an elderly customer to pick an item from an uncomfortable location. Read More

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Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing.

Nucleic Acids Res 2021 May 21. Epub 2021 May 21.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

Long-read whole-genome sequencing analysis of DNA methylation would provide useful information on the chromosomal context of gene expression regulation. Here we describe the development of a method that improves the read length generated by using the bisulfite-sequencing-based approach. In this method, we combined recently developed enzymatic base conversion, where an unmethylated cytosine (C) should be converted to thymine (T), with nanopore sequencing. Read More

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Physical training considerations for optimizing performance in essential military tasks.

Eur J Sport Sci 2021 Jun 3:1-15. Epub 2021 Jun 3.

Neuromuscular Research Laboratory/Warrior Human Performance Research Center, University of Pittsburgh, Pittsburgh, PA, USA.

Physically demanding essential military tasks include load carriage, manual material handling and casualty evacuation. This narrative review characterizes the main physical attributes related to performance of these occupational tasks and reviews physical training intervention studies in military settings to improve performance in these military tasks. Load carriage performance requires both aerobic and neuromuscular fitness with greater emphasis on maximal strength and absolute maximal oxygen uptake, especially when carrying heavier loads. Read More

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