184 results match your criteria combined ilm


Macular Morphology in Patients With Diabetic Retinopathy Treated by ILM Peeling: A Propensity Score-Matched Analysis.

Ophthalmic Surg Lasers Imaging Retina 2021 Aug 1;52(8):420-425. Epub 2021 Aug 1.

Background And Objective: To analyze the effects of vitrectomy combined with internal limiting membrane (ILM) peeling in patients with diabetic retinopathy (DR) by propensity score-matched analysis.

Patients And Methods: Patients with proliferative DR that underwent pars plana vitrectomy were divided into two groups: without or with additional ILM peeling. Propensity score-matched analyses of variables were carried out. Read More

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Functional and anatomic changes between early postoperative recovery and long-term follow-up after combined epiretinal and internal limiting membrane peeling.

Can J Ophthalmol 2021 Jul 31. Epub 2021 Jul 31.

Eye Clinic, Department of Biomedical and Clinical Sciences, "Luigi Sacco" Hospital, University of Milan, Milan, Italy.

Objective: To evaluate short- and long-term changes in best-corrected visual acuity (BCVA) and retinal layer thicknesses after combined epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling for macular holes and symptomatic ERMs.

Design: Retrospective observational case series.

Participants: Patients with ERMs or with macular holes and ERMs treated with combined ERM and ILM peeling. Read More

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Efficiency comparison with fovea-sparing internal limiting membrane peeling and complete internal limiting membrane peeling for treating myopic traction maculopathy.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Ophthalmology, Military Ophthalmological Center, General Hospital of Xinjiang Military Region, No. 754 Beijing Middle Road, Urumqi, 830054, Xinjiang, China.

Purpose: To explore whether the efficacy of fovea-sparing internal limiting membrane peeling (FS-ILMP) is better than that of complete internal limiting membrane peeling (ILMP).

Methods: This retrospective clinical study included 34 cases (34 eyes) with myopic traction maculopathy collected from June 2017 to February 2019. Twenty-three-gauge (23-G) pars plana vitrectomy (23G PPV) was performed on all patients. Read More

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[25-Gauge macular surgery: comparison with and without combined phacoemulsification and artificial lens implantation].

Ophthalmologe 2021 Jul 23. Epub 2021 Jul 23.

Augenklinik, Städtisches Klinikum Dessau, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Brandenburg - Theodor Fontane, Auenweg 38, 06847, Dessau-Roßlau, Deutschland.

Background: With the surgical methods continuously developed in recent years, macular surgery has become an increasingly less traumatic procedure for the eye. For patients with additional lens opacification, a 1-stage procedure with combined cataract surgery is recommended.

Objective: The aim of this retrospective study was to record the functional results and complications after elective macular surgery with and without combined phacoemulsification and artificial lens implantation. Read More

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Management of optic disc pit-associated maculopathy: A case series from a tertiary referral center.

Eur J Ophthalmol 2021 Jun 16:11206721211023727. Epub 2021 Jun 16.

Kocaeli University School of Medicine, Department of Ophthalmology, Kocaeli, Turkey.

Purpose: To report outcomes of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) stuffing technique in patients with optic disc pit associated maculopathy (ODP-M).

Methods: Data including best-corrected visual acuity (BCVA), central macular thickness (CMT), foveal center point thickness (FCP), and maximum height of fluid (max_fluid) (intraretinal or subretinal) were collected from the medical records of the patients.

Results: Six eyes of six patients with a mean age of 28. Read More

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Comparative study of vitrectomy combined with internal limiting membrane peeling and vitrectomy combined with internal limiting membrane flap covering in idiopathic macular hole treatment: a meta-analysis and systematic review.

Ann Palliat Med 2021 May;10(5):5474-5482

The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China; Department of Ophthalmology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: To compare the therapeutic effects of vitrectomy (PPV) combined with the internal limiting membrane (ILM) flap coverage and PPV in combination with ILM peeling on the idiopathic large macular hole (MH), in order to better guide the treatment of large MH.

Methods: Searching was conducted within PubMed, Web of Science, Embase, CNKI, and Wanfang databases, and relevant pieces of literature between 2010 and 2020 published in English or Chinese were included.

Results: A total of 11 studies including 667 patients and 667 affected eyes were included; the effective rate of hole closure between the 2 groups were compared in 11 studies. Read More

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Case of Macular Hole Secondary to Ocular Toxoplasmosis Treated Successfully by Vitrectomy with Inverted Internal Limiting Membrane Flap.

Case Rep Ophthalmol 2021 May-Aug;12(2):363-368. Epub 2021 May 10.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

We report a case of ocular toxoplasmosis that developed a full-thickness macular hole (FTMH) which was successfully treated by pars plana vitrectomy combined with an inverted internal limiting membrane (ILM) flap. A 49-years-old Japanese man was aware of blurred vision in his right eye. Slit-lamp biomicroscopy, ophthalmoscopy, and optical coherence tomography (OCT) of the right eye showed that there was a grayish-white subretinal lesion at the macula accompanied by retinal exudation and mild vitreous flare and iritis. Read More

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Brilliant Blue G toxicity in macular hole surgeries: A report on combined phototoxicity and dye-induced macular damage.

Semin Ophthalmol 2021 May 19:1-6. Epub 2021 May 19.

UPMC Eye Center, University of Pittsburgh, Pittsburgh, USA.

: Vitrectomy with brilliant blue G (BBG) assisted internal limiting membrane (ILM) peeling is the standard operational technique in macular hole surgeries. However, BBG dye, though considered safe and nontoxic, can also occasionally lead to macular toxicity. This study aims to describe the clinical features and characteristics of four eyes who developed macular toxicity after following surgery for macular hole repair. Read More

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Changes in the Ganglion Cell Complex after Inner Limiting Membrane Peeling for Epiretinal Membrane in Glaucoma Patients.

J Nippon Med Sch 2021 ;88(2):97-102

Department of Ophthalmology, Nippon Medical School.

Background: Epiretinal membrane (ERM) is a disease that affects the vitreoretinal interface and causes metamorphopsia, anorthopia, and decreased visual acuity. In this study, ERM patients who underwent internal limiting membrane (ILM) peeling were classified as those with glaucoma (Group G) and a control group (Group C). Changes in ganglion cell complex (GCC) thickness were compared between these groups to investigate whether such changes had an effect on progression of glaucoma from structural change. Read More

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January 2021

Autologous retina transplantation for treatment of refractory double full-thickness macular hole in Alport syndrome.

Retin Cases Brief Rep 2021 Jan 13. Epub 2021 Jan 13.

1Department of Ophthalmology, Centro de Oftalmología Barraquer, Barcelona, Spain; 2Instituto Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain.

Purpose: To report the structural and functional outcomes of autologous neurosensory retinal transplantation for closure of refractory double full-thickness macular hole in a patient diagnosed with Alport syndrome.

Methods: Patient with previous pars plana vitrectomy (PPV) and a failed macular hole surgery (ILM removal) underwent PPV and autologous neurosensory retinal flap transplantation with silicone oil tamponade. Follow-up was performed after one year. Read More

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January 2021

Recurrent macular hole retinal detachment in a patient with pathologic myopia treated by additional intravitreal silicone oil injection: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25465

Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Republic of Korea.

Rationale: Treatment of macular hole retinal detachment (MHRD) in patients with pathologic myopia may require multiple surgeries due to the risk of surgical failures or recurrences. Intravitreal silicone oil injection before an additional surgery may be another option for recurrent MHRD in aphakic eyes, but this procedure is rarely performed.

Patient Concerns: A 69-year-old man visited the hospital with a chief complaint of metamorphopsia in his right eye for 5 days. Read More

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Epiretinal Membrane Surgery Using Intraoperative OCT-Guided Membrane Removal in the DISCOVER Study versus Conventional Membrane Removal.

Ophthalmol Retina 2021 Feb 27. Epub 2021 Feb 27.

The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio; Vitreoretinal Service, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Purpose: To provide a comparative assessment of clinical outcomes between patients undergoing intraoperative OCT (iOCT) and conventional surgery for pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peel.

Design: Case-control retrospective, comparative assessment.

Participants: Patients undergoing PPV with membrane peel for ERM with eyes pooled from the prospective Determination of Feasibility of Intraoperative Spectral Domain Microscope Combined/Integrated OCT Visualization During En Face Retinal and Ophthalmic Surgery (DISCOVER) iOCT study and eyes undergoing conventional ERM surgery without iOCT. Read More

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February 2021

Vitreous collagen cross-linking and maturation and interactions with internal limiting membrane (ILM) collagen may have a potential role in modulating postnatal growth of the eyeball.

Med Hypotheses 2021 Mar 29;148:110519. Epub 2021 Jan 29.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

At birth, the eye is moderately hypermetropic but achieves emmetropia by the age of 5-6 years in a large majority (Chakraborty et al., 2020; Gwiazda et al., 1993). Read More

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Internal limiting membrane graft as a treatment for the retinal detachment secondary to an optic disc coloboma.

Eur J Ophthalmol 2021 Feb 2:1120672121992686. Epub 2021 Feb 2.

Centro de Oftalmologia Barraquer, Barcelona, Spain.

Purpose: To report our anatomical outcome with the internal limiting membrane (ILM) graft procedure in the management of rhegmatogenous retinal detachment (RRD) secondary to optic disc coloboma (ODC).

Methods: Description of a new surgical procedure in one eye of one patient who underwent pars plana vitrectomy (PPV) combined with ILM graft technique. Subsequent follow-up included optical coherence tomography (OCT) and visual acuity. Read More

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February 2021

Epiretinal membrane vitrectomy: outcomes with or without cataract surgery and a novel prognostic factor for cystoid macular edema.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 25;259(7):1731-1740. Epub 2021 Jan 25.

Department of Ophthalmology, Centro Hospitalar Universitário do Porto, Largo do Prof. Abel Salazar, 4099-001, Porto, Portugal.

Purpose: To assess the outcomes of vitrectomy with or without cataract surgery for the treatment of idiopathic ERM in phakic eyes and evaluate predictors of functional and anatomical outcomes.

Methods: Retrospective cohort of consecutive phakic ERM eyes distributed in three groups: a) combined (phacovitrectomy) group, b) PPV-only group, and c) consecutive group (PPV followed by cataract surgery). Main outcomes were final visual acuity (VA) and cystoid macular edema (CME) occurrence. Read More

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Spontaneous closure of macular hole after vitrectomy for myopic retinoschisis with foveal detachment.

Retin Cases Brief Rep 2021 Jan 18. Epub 2021 Jan 18.

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: To discuss a case of a macular hole formation after vitrectomy for myopic retinoschisis with foveal detachment and spontaneous closure, during long term follow-up.

Methods: Case report.

Results: A 71-year-old man with myopic retinoschisis with foveal detachment had a vitrectomy with internal limiting membrane (ILM) peeling combined with cataract surgery in the left eye. Read More

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January 2021

Does intermeniscal ligament tenodesis affect meniscal allograft extrusion? Retrospective comparative study at a minimum follow-up of 2 years.

Orthop Traumatol Surg Res 2021 04 20;107(2):102815. Epub 2021 Jan 20.

Service de chirurgie orthopédique, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address:

Introduction: Meniscal allograft transplantation (MAT) is indicated for the treatment of post-meniscectomy syndrome in young patients who do not have severe cartilage loss. While its clinical effectiveness is well established in the short- and mid-term, it does not appear to stop the progression of osteoarthritis. Meniscal extrusion often occurs early on and is irreversible. Read More

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The characteristics of optic disc pit maculopathy and the efficacy of vitrectomy: a systematic review and meta-analysis.

Acta Ophthalmol 2021 Jan 9. Epub 2021 Jan 9.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Purpose: To evaluate the basic characteristics of optic disc pit maculopathy (ODPM) and the efficacies of pars plana vitrectomy (PPV) treatment with different adjunctive strategies.

Methods: The databases PubMed, EMBASE and Ovid up to April 2020 were searched to identify relevant studies. Statistical analyses were conducted with R software version 3. Read More

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January 2021

25 vs. 27-gauge micro-incision vitrectomy surgery for visually significant macular membranes and full-thickness macular holes: a retrospective study.

Int J Retina Vitreous 2020 Nov 16;6(1):56. Epub 2020 Nov 16.

Oregon Eye Consultants LLC, 1550 Oak St, Suite 7, Eugene, OR, 97401, USA.

Background: To evaluate visual and safety outcomes for 25-gauge (25G) and 27-gauge (27G) micro-incision vitrectomy platforms (MIVS) for the treatment of epiretinal membrane and full-thickness macular holes.

Methods: Retrospective analysis of all patients who underwent internal limiting membrane (ILM) peel surgery from January 2017 through December 2018. 207 cases met the eligibility criteria for inclusion. Read More

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November 2020

Vitrectomy With Epiretinal Membrane Peeling Alone Verses Combined With Internal Limiting Membrane Peeling For Idiopathic Epiretinal Membrane.

J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(4):450-453

Al Ibrahim Eye Hospital, Malir, Karachi, Pakistan.

Background: The objective of this study was to determine and compare the structural and functional outcome in eyes who underwent Pars Plana Vitrectomy (PPV) with Epiretinal Membrane (ERM) peeling alone verses combined Epiretinal membrane with Internal Limiting Membrane (ILM) peeling for Idiopathic Epiretinal Membrane along with the rate of recurrence.

Methods: It was an interventional randomized study, conducted at Al-Ibrahaim Eye Hospital, Malir, Karachi, for two-year period from 1st August 2016 to 1st August 2018. A total of forty-four eyes of 44 patients were divided into two groups equally. Read More

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January 2021

Efficacy of internal limiting membrane peeling for diabetic macular edema after preoperative anti-vascular endothelial growth factor injection.

Int J Ophthalmol 2020 18;13(11):1758-1764. Epub 2020 Nov 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300070, China.

Aim: To explore the efficacy of minimally invasive vitrectomy (MIV) with or without internal limiting membrane (ILM) peeling on the treatment of diabetic macular edema (DME) in proliferative diabetic retinopathy (PDR) combining with preoperative anti-vascular endothelial growth factor (anti-VEGF) injection.

Methods: Totally 132 eyes (132 patients) diagnosed PDR with DME were included between June 2015 and June 2018 in Tianjin Eye Hospital. The single MIV treatment group included 68 eyes and the MIV combined with ILM peeling group included 64 eyes. Read More

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November 2020

Inverted internal limiting membrane flap technique in the surgical treatment of macular holes: 8-year experience.

Int Ophthalmol 2021 Feb 14;41(2):499-507. Epub 2020 Oct 14.

Ophthalmology Department, Centro Hospitalar Universitário Do Porto, Largo Do Prof. Abel Salazar, 4099-001, Porto, Portugal.

Purpose: To evaluate the ellipsoid zone (EZ) structural recovery, hole closure rate, and visual acuity improvement after inverted internal limiting membrane (ILM) flap technique.

Methods: Retrospective cohort of eyes affected by idiopathic macular holes (MH) that underwent pars plana vitrectomy combined with inverted ILM flap technique in a tertiary center, over an 8-year period (2011-2019). The main outcomes were the postoperative qualitative analysis of EZ structure on spectral-domain optical coherence tomography, hole closure rate, and best-corrected visual acuity (BCVA) improvement of ≥ 0. Read More

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February 2021

Internal Limiting Membrane Folds as a Presenting Sign in Acute Initial-Onset Vogt-Koyanagi-Harada Disease: A Case Report.

Ocul Immunol Inflamm 2020 Oct 15:1-5. Epub 2020 Oct 15.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purpose: To report a case of initial-onset acute Vogt-Koyanagi-Harada (VKH) presenting with internal limiting membrane (ILM) folds as the initial clinical sign.

Methods: This is a retrospective case review.

Results: A 36-year-old woman with a recent history of periorbital injection of cosmetic filler who presented with sudden blurred vision in the right eye of a few hours duration. Read More

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October 2020

Surgical Treatment of Refractory Medium Macular Hole with Autologous Lens Capsular Flap Transplantation: A Case Report.

Retin Cases Brief Rep 2020 Sep 18. Epub 2020 Sep 18.

Department II, Quinze-Vingts National Center. 28 Rue de Charenton, 75 571 Paris, France. Tel.: +33 1 40 02 15 20. E-mail:

Purpose: To report the clinical results of lens capsular flap (LCF) transplantation in a patient with refractory medium macular hole (MH).

Methods: Case report.

Results: A 66-year-old female myopic patient with a history of medium macular hole (MH) was previously unsuccessfully treated by vitrectomy surgery, internal limiting membrane (ILM) peeling and air-fluid exchange followed by 12% C2F6 tamponade into the vitreous cavity and face-down positioning. Read More

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September 2020

Hole diameter ratio for prediction of anatomical outcomes in stage III or IV idiopathic macular holes.

BMC Ophthalmol 2020 Aug 28;20(1):351. Epub 2020 Aug 28.

Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab; Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaomminxiang Street, Dongcheng District, Beijing, 100730, China.

Background: To determine whether preoperative hole diameter ratio (HDR) is a predictive factor for postoperative anatomical outcome for stage III or IV idiopathic macular holes (IMHs).

Methods: One-hundred and one eyes with stage III or IV IMH were included in this retrospective case series study. All cases were treated with vitrectomy combined with internal limiting membrane (ILM) peeling and room air tamponade. Read More

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Evaluation of Vision-Related Quality of Life after Autologous Internal Limiting-Membrane Transplantation for Refractory Macular Holes.

Clin Ophthalmol 2020 23;14:2079-2085. Epub 2020 Jul 23.

Department of Ophthalmology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.

Purpose: To evaluate the vision-related quality of life of vitrectomy combined with autologous internal limiting membrane (ILM) transplantation for refractory macular holes (MHs).

Methods: There were 40 eyes with refractory MHs included, and all eyes received 23 G vitrectomy and ILM peeling with autologous ILM transplantation. Preoperative and postoperative basic conditions were recorded. Read More

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Macular pucker formation after macular hole surgery with inverted internal limiting membrane flap technique and silicone oil tamponade.

Am J Ophthalmol Case Rep 2020 Sep 5;19:100847. Epub 2020 Aug 5.

Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, Japan.

Purpose: The inverted internal limiting membrane (ILM) technique was recently introduced for refractory macular hole. Here, we evaluate a case of macular pucker formation after macular hole surgery using the inverted ILM flap technique and silicone oil tamponade. After undergoing vitrectomy combined with ILM removal, the patient had a good visual prognosis. Read More

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September 2020

One-year outcomes of 27G core-pars plana vitrectomy of idiopathic epiretinal membrane.

Exp Ther Med 2020 Sep 13;20(3):2721-2729. Epub 2020 Jul 13.

Department of Ophthalmology, Shanghai 10th People's Hospital affiliated to Tongji University, Shanghai 200072, P.R. China.

The present study aimed to assess the feasibility and safety of 27G core-pars plana vitrectomy (PPV) for idiopathic epiretinal membrane (IERM). A retrospective analysis was performed on 38 eyes from 38 patients with IERM with a mean age of 62.73±5. Read More

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September 2020

Functional evaluation with microperimetry in large idiopathic macular holes treated by a free internal limiting membrane flap tamponade technique.

BMC Ophthalmol 2020 Jul 23;20(1):302. Epub 2020 Jul 23.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, No.100 Hai Ning Road, Shanghai, 200080, China.

Background: Free internal limiting membrane (ILM) flap tamponade technique is an alternative choice for treating large idiopathic macular holes (IMHs). However, the functional recovery related to this surgical approach is not well-characterized. This study aimed to evaluate morphological and microperimetric outcomes 6 months after free ILM flap tamponade technique for large IMHs. Read More

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Electron microscopy study of the central retinal fovea in Pied flycatcher: evidence of a mechanism of light energy transmission through the retina.

Heliyon 2020 Jun 10;6(6):e04146. Epub 2020 Jun 10.

University of Puerto Rico, Rio Piedras Campus, PO Box 23343, San Juan, PR 00931-3343, USA.

We present unique ultrastructural data on avian retinal cells. Presently and earlier (Zueva et al., 2016) we explored distribution of intermediate filaments (IFs) in retinal cells of the Pied flycatcher (, Passeriformes, Aves) in the central foveolar zone. Read More

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