Ann Surg 2021 Jul 29. Epub 2021 Jul 29.
Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, F-59000 Lille, France Department of General Surgery and Surgical Oncology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France; EMR 3738 Lyon Sud Charles Mérieux Faculty, Claude Bernard University Lyon 1, Oullins, France Department of Surgical Oncology, Cancer Institute Montpellier, University of Montpellier 208 Avenue des Apothicaires, Montpellier, Cedex 05, France IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier, F-34298, France INSERM UMR-S 942, Université de Paris, Paris, France; Department of Anaesthesiology and Critical Care Medicine, Lariboisière University Hospital, DMU PARABOL, AP-HP.Nord, Paris, France Department of Visceral and Oncological Surgery, Gustave Roussy, Cancer Campus, Villejuif Cedex, France Department of Digestive Surgery, Rouen University Hospital, Rouen, France Department of General and Digestive Surgery, Hautepierre Hospital, Strasbourg University, Strasbourg, France Department of Surgical Oncology, ICO René Gauducheau Cancer Center, Saint-Herblain, France Department of Digestive Surgery, Institut de Cancérologie de Lorraine, 54519 Vandoeuvre-les-Nancy Department of General, Digestive and Endocrine Surgery, Robert-Debré Hospital, Université de Reims Champagne-Ardenne, 51100 Reims, France Department of Digestive Surgery, Grenoble-Alpes University Hospital, Grenoble, France Université de Paris; Department of Digestive Surgery, Louis-Mourier Hospital, DMU ESPRIT - GHU AP-HP. Nord - University of Paris; Colombes, France Department of Digestive Surgery, Timône University Hospital, Marseille, France Sorbonne Université, Department of Digestive Surgery, AP-HP, Hôpital Saint Antoine, Paris, France Department of Digestive Surgery, Poitiers University Hospital, Poitiers, France Department of Digestive and Oncologic Surgery, Liver Transplantation Unit, University Hospital of Besançon, Besançon, France Department of Surgical Oncology, Curie Institute, Paris, France Department of Digestive Surgery, CHU Clermont Ferrand, 1 rue Lucie et Raymond Aubrac, Clermont-Ferrand, France Department of Digestive and Oncological Surgery, University Hospital of Amiens, France Department of digestive and oncological Surgery, Oscar Lambret Center, Lille, France Department of Colorectal Surgery, CHU Bordeaux, Haut-Leveque Hospital, University of Bordeaux, Pessac, France Department of Surgical Oncology, François Baclesse Institute, 3 avenue du general Harris, Caen, France Endocrine, General and Digestive Surgery Department, CHU of Limoges, Limoges, France Service de chirurgie digestive hépato-bilio-pancréatique, Hôpital Pitié Salpêtrière, Assistance publique-hôpitaux de Paris, AP-HP, Paris, France. Université de Paris, UMR INSERM 1275 CAP Paris-Tech, F-75010 Paris, France Department of Digestive and Oncological Surgery, Saint-Louis University Hospital, Paris, France UMR-S1277 - CANTHER laboratory "Cancer Heterogeneity, Plasticity and Resistance to Therapies," Lille, France.
Objective: To perform a retrospective root-cause analysis of postoperative death after CRSx and HIPEC procedures.
Background: The combination of CRS and HIPEC is an effective therapeutic strategy to treat peritoneal surface malignancies, however it is associated with significant postoperative mortality.
Methods: All patients treated with a combination of CRS and HIPEC between January 2009 and December 2018 in 22 French centers and died in the hospital, were retrospectively analyzed. Read More