Sci Rep 2021 Mar 2;11(1):4927. Epub 2021 Mar 2.
BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, Centre for Bioengineering Research and Education (CBRE), Biomedical Engineering Program, University of Calgary, Mechanical Engineering Building, MEB214, 2500 University Dr., N.W., Calgary, AB, T2N 1N4, Canada.
Flow distributor located at the beginning of the micromachined pillar array column (PAC) has significant roles in uniform distribution of flow through separation channels and thus separation efficiency. Chip manufacturing artifacts, contaminated solvents, and complex matrix of samples may contribute to clogging of the microfabricated channels, affect the distribution of the sample, and alter the performance of both natural and engineered systems. An even fluid distribution must be achieved cross-sectionally through careful design of flow distributors and minimizing the sensitivity to clogging in order to reach satisfactory separation efficiency. Read More