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Surgical Management of a Pediatric Cuboid Nutcracker Fracture: A Case Report.

JBJS Case Connect 2021 07 22;11(3). Epub 2021 Jul 22.

Department of Orthopaedic Surgery, Albany Medical Center, Albany, New York.

Case: Cuboid impaction fractures (nutcracker fractures) result from high-energy trauma and are exceedingly rare in children. We present a case of an 8-year-old boy who sustained a comminuted cuboid nutcracker fracture after a fall from height. The patient underwent open reduction and internal fixation with a locking plate. Read More

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Inhibited nanobubble transport in a saturated porous medium: Effects of deposited colloidal particles.

J Contam Hydrol 2021 Jun 29;242:103854. Epub 2021 Jun 29.

Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Nanobubbles have recently attracted much interest for their practical use and potential applications in environmental issues. The pre-existence of deposited colloidal particles in porous media commonly occurs when nanobubbles applied to porous media interact with deposited colloidal particles. However, the current understanding of the effect of the interactions with pre-deposited colloidal particles on nanobubble transport in saturated porous media remains incomplete, and the effects are often overlooked. Read More

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Acetaminophen degradation using bacterial strains isolated from winogradsky column and phytotoxicity analysis of dump site soil.

Chemosphere 2021 Jul 16;286(Pt 1):131570. Epub 2021 Jul 16.

Department of Biotechnology, Stella Maris College (Autonomous), Affiliated to University of Madras, Chennai, 600086, India. Electronic address:

The increase in pollution increased the threat level of living organisms in the environment. Municipal Solid Waste is one of the most important wastes which contribute to polluted sites affecting livelihood. They pollute the water stream, marine environment ecology, soil fertility, and agriculture production. Read More

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DoE-Based Analytical-FMCEA for Enhanced AQbD Approach to MEER-RP-HPLC Method for Synchronous Estimation of Fifteen Antihypertensive Pharmaceutical Dosage Forms.

J AOAC Int 2021 Jul 22. Epub 2021 Jul 22.

Department of Quality Assurance, Maliba Pharmacy College, Uka Tarsadia University, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat-394 350, Gujarat, India.

Background: In the recent scenario of green chemistry, the usage of organic solvent should be minimized in the development of the analytical method for the safety of the environment and analysts.

Objective: Hence, the RP-HPLC method has been developed as an economical and eco-friendly alternative to published RP-HPLC methods for the analysis of FDC of anti-hypertensive drugs to save time, resources, cost and organic solvent.

Method: The method has been developed by the implementation of an enhanced AQbD approach based on DoE-based AFMCEA. Read More

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Nanoscale Solid-Phase Isobaric Labeling for Multiplexed Quantitative Phosphoproteomics.

J Proteome Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Molecular & Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

We established a workflow for highly sensitive multiplexed quantitative phosphoproteomics using a nanoscale solid-phase tandem mass tag (TMT) labeling reactor. Phosphopeptides were first enriched by titanium oxide chromatography and then labeled with isobaric TMT reagents in a StageTip packed with hydrophobic polymer-based sorbents. We found that TMT-labeled singly phosphorylated peptides tend to flow through the titanium oxide column. Read More

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A novel method for the quantification of anlotinib in human plasma using two-dimensional liquid chromatography.

Biomed Chromatogr 2021 Jul 22:e5218. Epub 2021 Jul 22.

Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences.

A simple, efficient and stable detection method of two-dimensional liquid chromatography(2D-LC) was established and validated for the determination of anlotinib in human plasma. The 2D-LC system comprises a first-dimensional column (LC1), an intermediate transfer column and a second-dimensional column (LC2). With simple protein precipitation treatment, the samples were processed directly for detecting. Read More

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Process Engineering Aspects for the Microbial Conversion of C1 Gases.

Adv Biochem Eng Biotechnol 2021 Jul 22. Epub 2021 Jul 22.

Institute of Biochemical Engineering, Technical University of Munich, Garching, Germany.

Industrially applied bioprocesses for the reduction of C1 gases (CO and/or CO) are based in particular on (syn)gas fermentation with acetogenic bacteria and on photobioprocesses with microalgae. In each case, process engineering characteristics of the autotrophic microorganisms are specified and process engineering aspects for improving gas and electron supply are summarized before suitable bioreactor configurations are discussed for the production of organic products under given economic constraints. Additionally, requirements for the purity of C1 gases are summarized briefly. Read More

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Hypocupraemia-induced anaemia, sensory ataxia and cognitive impairment secondary to zinc-containing dental adhesive.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK.

A 67-year-old man presented with 5 months of worsening memory impairment and sensory gait ataxia on the background of symptomatic anaemia. He experienced falls, agitation and became socially withdrawn over 3 weeks, resulting in hospital admission. On examination, he had sensory gait ataxia consistent with a dorsal column syndrome. Read More

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A new factor involved during childbirth labor: the importance of having a good dental occlusion.

J Biol Regul Homeost Agents 2021 May-Jun;35(3 Suppl. 1):155-166

Faculty of Medicine and Dental Surgery, University of Rome "Sapienza", Rome, Italy.

It is widely recognized that the physiology of childbirth labor largely depends on the interaction between three factors: a) the force generated by uterine contractions; b) the structure and characteristics of the birth canal and c) the fetus. Harmony between these three variables determines the initiation of maternal dynamic phenomena and the establishment of an optimal maternal-fetal balance in which both warrant for a correct delivery timing. The present study considered the above known factors and assessed if any other factor, still not recognized, could also play a role, and eventually modify the timing of delivery during the expulsive period. Read More

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Acetophenone Azine: The 2021 American Contact Dermatitis Society Allergen of the Year.

Cutis 2021 May;107(5):238-240

Dr. Reeder is from the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison. Dr. Atwater is from the Department of Dermatology, Duke University School of Medicine, Durham, North Carolina.

The American Contact Dermatitis Society chose acetophenone azine (AA) as the 2021 Allergen of the Year. Acetophenone azine is an emerging contact allergen that often is associated with the use of sports equipment and footwear. The pattern of dermatitis initially starts locally at the site of contact but can develop into a generalized dermatitis. Read More

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Development of magnetism-assisted in-tube solid phase microextraction of phenolic acids in fruit juices prior to HPLC quantification.

J Sep Sci 2021 Jul 20. Epub 2021 Jul 20.

Fujian Key Laboratory of Coastal Pollution Prevention and Control, College of the Environment and Ecology, Xiamen University, Xiamen, 361005, P. R. China.

Magnetism-assisted in-tube solid phase microextraction based on porous monolith mingled with Fe O nanoparticles was developed for capture of phenolic acids in fruit juices. First, poly (1-allyl-3-methylimidazolium bis [(trifluoro methyl) sulfonyl] imide-co-ethylene dimethacrylate) monolith embedded with Fe O nanoparticles was facile fabrication in a capillary and employed as microextraction column. Subsequently, a magnetic coil adopted to produce variable magnetic fields during extraction stage was twined on the microextraction column. Read More

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Investigation of the usage potential of calcium alginate beads functionalized with sodium dodecyl sulphate (SDS) for wastewater treatment contaminated with waste motor oil.

Water Environ Res 2021 Jul 20. Epub 2021 Jul 20.

Department of Environmental Engineering, Mersin University, Mersin, Turkey.

In this study, calcium alginate (Ca-Alg) beads, an inexpensive, easily available, biodegradable material, were activated with anionic surfactant and used for the treatment of wastewater contaminated with waste motor oil. First, polyethyleneimine (PEI) was used to bind sodium dodecyl sulfate (SDS) onto the Ca-Alg beads' surface. Three different SDS concentrations (25, 50, 100 mg/L) were prepared and treated with Ca-Alg beads for 1, 2, 4, 6, 24 h. Read More

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Synthesis of ellagic acid glucoside using glucansucrase from Leuconostoc and characterization of this glucoside as a functional neuroprotective agent.

AMB Express 2021 Jul 21;11(1):108. Epub 2021 Jul 21.

Institute of Agricultural Science and Technology, Chonnam National University, Gwangju, 61186, South Korea.

Ellagic acid glucoside was synthesized via transglucosylation using sucrose and glucansucrase derived from Leuconostoc mesenteroides B-512 FMCM. After such enzymatic synthesis, the product was purified by 50% ethyl acetate fraction and C18 column chromatography. Modification of ellagic acid glucoside was verified by LC-MS/MS at m/z 485. Read More

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Development of Second-Tier Liquid Chromatography-Tandem Mass Spectrometry Analysis for Expanded Newborn Screening in Japan.

Int J Neonatal Screen 2021 Jul 14;7(3). Epub 2021 Jul 14.

Division of Neonatal Screening, Research Institute, National Center for Child Health and Development, Tokyo 157-8535, Japan.

To minimize false-positive cases in newborn screening by tandem mass spectrometry in Japan, practical second-tier liquid chromatography-tandem mass spectrometry analyses have been developed using a multimode ODS column with a single set of mobile phases and different gradient elution programs specific to the analysis of acylcarnitines, acylglycines, amino acids, and organic acids. Most analyses were performed using underivatized samples, except for analysis of methylcitric acid, and careful conditioning of the column was necessary for analyses of organic acids. Our second-tier tests enabled us to measure many metabolites useful for detection of target disorders, including allo-isoleucine, homocysteine, methylmalonic acid, and methylcitric acid. Read More

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(Orchidaceae), a new holomycotrophic orchid from China.

PhytoKeys 2021 5;179:91-97. Epub 2021 Jul 5.

Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin, Guangxi, 541006, China Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences Guilin China.

, a new holomycotrophic orchid from Guangxi, southern China is described and illustrated here. This new species is similar to but differs from the latter mainly by the sepals acute at the apex, the hypochile with 2 smaller and semicircular wings, the epichile adaxially smooth, acute, the lateral lobes triangular-ovate and the column clavate. Read More

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Impact of soil organic matter on Pu migration in five Lithuanian surface soils.

J Environ Radioact 2021 Jul 17;237:106702. Epub 2021 Jul 17.

State Research Institute Center for Physical and Technological Sciences, Savanoriu av. 231, LT-02300, Vilnius, Lithuania.

Pu distribution coefficient K variation was experimentally determined and examined in natural soil samples considering the type of soil, particle size, pH, the concentration of macroelements and organic matter content. This research was carried out with sand, silty sand, peat, clayey sand and clayey loam samples by applying Pu tracer in flow-through column tests. Due to relatively short contact time of 0. Read More

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"Biomethanation of syngas by enriched mixed anaerobic consortium in pressurized agitated column".

Bioresour Technol 2021 Jul 14;338:125548. Epub 2021 Jul 14.

Univ Lyon, INSA Lyon, DEEP, EA7429, 69621 Villeurbanne, France. Electronic address:

In a circular economy approach, heterogeneous wastes can be upgraded to energy in the form of syngas via pyrogasification, and then to methane via biomethanation. Working at high pressure is a promising approach to intensify the process and to reduce gas-liquid transfer limitations. However, raising the pressure could lead to reaching the CO inhibition threshold of the microorganisms involved in syngas-biomethanation. Read More

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A comprehensive study on the phenomenon of total breakthrough in liquid chromatography.

J Chromatogr A 2021 Jul 9;1653:462399. Epub 2021 Jul 9.

Université de Lyon, Institut des Sciences Analytiques, UMR 5280, CNRS, 5 rue de la Doua, Villeurbanne 69100, France. Electronic address:

Differences in elution strength between the sample solvent and the mobile phase usually give rise to undesirable effects on the chromatographic separation, which may range from slight broadening to severe peak deformation or even splitting. In the most extreme case, the retention factor of the analyte at the head of the column is so small at the time of injection that part of the analyte goes through the column with very little interaction with the stationary phase and hence elutes very close to the column dead time. This phenomenon is known as breakthrough. Read More

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Flexible Zn-MOF with Rare Underlying Topology for Effective Separation of C6 Alkane Isomers.

ACS Appl Mater Interfaces 2021 Jul 20. Epub 2021 Jul 20.

Department of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.

Adsorptive separation by porous solids provides an energy-efficient alternative for the purification of important chemical species compared to energy-intensive distillations. Particularly, the separation of linear hexane isomers from its branched counterparts is crucial to produce premium grade gasoline with high research octane number (RON). Herein, we report the synthesis of a new, flexible zinc-based metal-organic framework, [Zn(μ-OH)(adtb)(HO)·5 DMA] (Zn-adtb), constructed from a butterfly shaped carboxylate linker with underlying (4,8)-connected topology capable of separating the C6 isomers HEX, 3MP, and 23DMB. Read More

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Signal Separated Quantification of γ-Hydroxybutyrate With Liquid Chromatography-Tandem Mass Spectrometry in Human Urine and Serum as an Improvement of the Analyte Adduct Ion Based Quantification.

J Anal Toxicol 2021 Jul 20. Epub 2021 Jul 20.

Institute of Legal Medicine, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

The aim of the work was the development and validation of an LC-MS/MS γ-hydroxybutyrate (GHB) quantification method in urine and human serum by the use of the analyte adduct ion formation strategy. A combined detection with a conventional precursor ion in the negative electrospray mode and additionally GHB adduct ions with both sodium acetate and lithium acetate was in focus. Therefore GHB quantification based on separated MS/MS signals. Read More

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How to generate graded spinal cord injuries in swine?: Tools and procedures.

Dis Model Mech 2021 Jul 20. Epub 2021 Jul 20.

Department for Immunology, Oslo University Hospital, Norway.

Spinal cord injury (SCI) is a medically, psychologically and socially disabling condition. A large body of our knowledge on the basic mechanisms of SCI has been gathered in rodents. For preclinical validation of promising therapies, the use of animal models that are closer to humans has several advantages. Read More

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Outcome following Open Reduction Internal Fixation (ORIF) of Acetabular Fractures in the Elderly.

J Orthop Trauma 2021 Jul 17. Epub 2021 Jul 17.

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Orthopaedic Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.

Objectives: Assess outcomes of acetabular open-reduction and internal fixation (ORIF) in the elderly; 2) Investigate factors influencing outcome; 3) Compare outcomes following low and high energy mechanisms of injury.

Design: Retrospective case series.

Setting: Level 1 trauma center. Read More

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Dynamics of sediment phosphorus affected by mobile aeration: Pilot-scale simulation study in a hypereutrophic pond.

J Environ Manage 2021 Jul 16;297:113297. Epub 2021 Jul 16.

Chengdu Academy of Agricultural and Forestry Science, Chengdu, 610000, China.

Controlling the release of phosphorus (P) in sediments is important to prevent eutrophication and harmful algal blooms in water bodies. Here we explored the effect of mobile aerators on the control of P release from sediments in a eutrophic pond. The dissolved oxygen in the water body recovered significantly after six months of aeration, becoming 4. Read More

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Accumulation of heavy metals in stormwater biofiltration systems augmented with zeolite and fly ash.

J Environ Manage 2021 Jul 16;297:113298. Epub 2021 Jul 16.

School of Engineering, Deakin University, 75 Pigdons Road, Waurn Ponds, VIC, 3220, Australia.

The discharge of high levels of heavy metals into the environment is of concern due to its toxicity to aquatic life and potential human health impacts. Biofiltration systems have been used in urban environments to address nutrient contamination, but there is also evidence that such systems can be effective in reducing heavy metals concentration in stormwater. However, the accumulation pattern of heavy metals and lifespan of such systems, which are important in engineering design, have not been thoroughly explored. Read More

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On the identification and quantification of proton-initiated species in the synthesis of poly(2-alkyl-2-oxazoline)s by high resolution liquid chromatography.

J Chromatogr A 2021 Jun 29;1653:462364. Epub 2021 Jun 29.

Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany. Electronic address:

Hydrophilic poly(2-oxazoline)s represent a promising alternative to replace poly(ethylene glycol) in the biomedical field. For that purpose, reliable analytical protocols to confirm identity and quantity of impurities are required. In particular, side products deriving from chain transfer reactions occurring during the cationic ring-opening polymerization and incomplete end-capping processes may be present. Read More

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Removal of Cr (VI) from aqueous solution by activated charcoal derived from Sapindus trifoliate L fruit biomass using continuous fixed bed column studies.

Water Sci Technol 2021 Jul;84(1):55-65

Department of Environmental Science, Fakir Mohan University, Balasore, Odisha 756020, India.

In this study, the removal of hexavalent chromium from aqueous solution were examined using activated charcoal derived from Sapindus trifoliate L fruit biomass in continuous fixed-bed column studies. The activated S. trifoliate L fruit charcoal was prepared by treating the fruit powder using concentrated nitric acid solution. Read More

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Plausible Emergence and Self Assembly of a Primitive Phospholipid from Reduced Phosphorus on the Primordial Earth.

Orig Life Evol Biosph 2021 Jul 19. Epub 2021 Jul 19.

Instituto de Astrobiología de Colombia, Bogotá, Colombia.

How life arose on the primitive Earth is one of the biggest questions in science. Biomolecular emergence scenarios have proliferated in the literature but accounting for the ubiquity of oxidized (+ 5) phosphate (PO) in extant biochemistries has been challenging due to the dearth of phosphate and molecular oxygen on the primordial Earth. A compelling body of work suggests that exogenous schreibersite ((Fe,Ni)P) was delivered to Earth via meteorite impacts during the Heavy Bombardment (ca. Read More

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Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy.

Anal Bioanal Chem 2021 Jul 19. Epub 2021 Jul 19.

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Bioscience 2, Suite 200, 12705 East Montview Blvd, Aurora, CO, 80045, USA.

Neuroactive steroids are potent neuromodulators that play a critical role in both maternal and fetal health during pregnancy. These stress-responsive compounds are reportedly low in women with perinatal depression and may be associated with poor pregnancy outcomes in animal models. Chronic stress is a risk factor for adverse birth outcomes. Read More

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Picometer-Precision Atomic Position Tracking through Electron Microscopy.

J Vis Exp 2021 Jul 3(173). Epub 2021 Jul 3.

Department of Materials Science & Engineering, The Pennsylvania State University;

The modern aberration-corrected scanning transmission electron microscopes (AC-STEM) have successfully achieved direct visualization of atomic columns with sub-angstrom resolution. With this significant progress, advanced image quantification and analysis are still at the early stages. In this work, we present the complete pathway for the metrology of atomic resolution scanning transmission electron microscopy (STEM) images. Read More

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A Rapid Gas-Chromatography/Mass-Spectrometry Technique for Determining Odour Activity Values of Volatile Compounds in Plant Proteins: Soy, and Allergen-Free Pea and Brown Rice Protein.

Molecules 2021 Jul 5;26(13). Epub 2021 Jul 5.

Food, Nutrition and Health, Faculty of Land & Food Systems, 2205 East Mall, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Plant-based protein sources have a characteristic aroma that limits their usage in various meat-alternative formulations. Despite being the most popular plant-based protein, the allergenicity of soy protein severely restricts the potential adoption of soy protein as an animal substitute. Thereby, allergen-free plant-protein sources need to be characterized. Read More

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