Search Our Scientific Publications & Authors

Adv Nutr 2021 Apr 19. Epub 2021 Apr 19.

Deakin University, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Food & Mood Centre, School of Medicine, Barwon Health, Geelong, Victoria, Australia.

Numerous observational studies have investigated the role of the Dietary Inflammatory Index (DII®) in chronic disease risk. The aims of this umbrella review and integrated meta-analyses were to systematically synthesize the observational evidence reporting on the associations between the DII and health outcomes based on meta-analyses, and to assess the quality and strength of the evidence for each associated outcome. This umbrella review with integrated meta-analyses investigated the association between the DII and a range of health outcomes based on meta-analyses of observational data. Read More

J Gynecol Obstet Hum Reprod 2021 Apr 16:102148. Epub 2021 Apr 16.

Centre Hospitalier Régional Universitaire de Lille, Hôpital Jeanne de Flandre, 2 avenue Oscar Lambret 59000 Lille, France; Université Lille CHRU Lille F-59000 Lille, France.

Objective: Post-operative CRP on postoperative day 4 (POD) is used for the early detection of complications after colorectal surgery for cancer, but there is no evidence yet that justifies the use of this marker for bowel resection in case of endometriosis.

Study Design: We retrospectively included 66 consecutive patients who underwent bowel resection for endometriosis (stage 4) in Lille university hospital, France, from August 1, 2015 until January 31, 2017.The composite endpoint of our study included anastomotic leakages, infectious or thrombo-embolic complications, hematomas, bowel stenosis, rectorrhagia, voiding dysfunction, and rehospitalization for related symptoms. Read More

Mitochondrion 2021 Apr 16. Epub 2021 Apr 16.

Oncology Department, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, People's Republic of China. Electronic address:

Colorectal cancer (CRC) affects millions of people worldwide. Chemoresistance seriously impairs the therapeutic effects. Lipid droplets (LDs) abnormally accumulate in CRC supported chemoresistance. Read More

Histopathology 2021 Apr 19. Epub 2021 Apr 19.

Pathology & Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

Aims: Screening all patients newly diagnosed with colorectal cancer (CRC) for possible Lynch syndrome (LS) has been recommended in the UK since the National Institute for Health and Care Excellence (NICE) released new Diagnostics Guidance in February 2017. We sought to validate the NICE screening pathway through a prospective regional programme across a 5.2 million population over a two-year period. Read More

Int J Cancer 2021 Apr 19. Epub 2021 Apr 19.

Cancer Epidemiology Division, Cancer Council Victoria, 615 St Kilda Road, Melbourne, Victoria, Australia.

Alcohol consumption is a known cause of cancer, but its role in the etiology of second primary (metachronous) cancer is uncertain. Associations between alcohol intake up until study enrollment (pre-diagnosis) and risk of metachronous cancer were examined in 9,435 participants in the Melbourne Collaborative Cohort Study who were diagnosed with their first invasive cancer after enrollment (1990-94). Follow-up was from date of first invasive cancer until diagnosis of metachronous cancer, death or censor date (February 2018), whichever came first. Read More

Dis Colon Rectum 2021 Apr 13. Epub 2021 Apr 13.

Rush University Medical Center, Department of Surgery, Division of Colorectal Surgery, Chicago Illinois.

Dis Colon Rectum 2021 Apr 13. Epub 2021 Apr 13.

Sanford R. Weiss M.D. Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio.

Introduction: When patients with familial adenomatous polyposis have a severely affected rectum it is usually assumed that endoscopic control is impossible or unwise. The standard approach is proctectomy with either an end ileostomy, or an ileal pouch anal anastomosis. Here we show that application of aggressive, multistage snare polypectomy to this situation can be effective and allow the patient to avoid surgery, at least in the short term. Read More

JMIR Mhealth Uhealth 2021 Apr 10;9(4):e29325. Epub 2021 Apr 10.

Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.

[This corrects the article DOI: 10.2196/22647.]. Read More

Dig Endosc 2021 Apr 19. Epub 2021 Apr 19.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Background: Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal serrated lesion. It is characterized by distinct clinicopathological and molecular features, including mixed serrated and adenomatous histology and frequent genetic alterations involving KRAS and RSPO. This study aimed to characterize the endoscopic features of isolated and traditional serrated adenoma (TSA)-associated SuSAs. Read More

BioDrugs 2021 Apr 19. Epub 2021 Apr 19.

Dipartimento di Medicina dei Sistemi, Università di Roma "Tor Vergata", Via Montpellier, 1, 00133, Rome, Italy.

Background: A recent phase III trial did not confirm the previous clinical and endoscopic improvements seen in patients with Crohn's disease (CD) receiving Mongersen, an oral Smad7 antisense oligonucleotide. Factors accounting for such a discrepancy are unknown.

Objective: Our objective was to further assess whether Mongersen was effective as induction therapy in active CD and evaluate the in vitro inhibitory effect of various batches of Mongersen used in the previous and present trials on Smad7 expression. Read More

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

Department of Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Background: To evaluate the association between postdiagnostic dairy intake and survival among patients with colorectal cancer (CRC).

Methods: This study analyzed data from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Postdiagnostic dairy intake and other dietary and lifestyle factors were obtained from validated questionnaires. Read More

Colorectal Dis 2021 Apr;23(4):774

Gigascience 2021 Apr;10(4)

Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, CA 90064, USA.

Background: Colorectal cancer (CRC) mortality is principally due to metastatic disease, with the most frequent organ of metastasis being the liver. Biochemical and mechanical factors residing in the tumor microenvironment are considered to play a pivotal role in metastatic growth and response to therapy. However, it is difficult to study the tumor microenvironment systematically owing to a lack of fully controlled model systems that can be investigated in rigorous detail. Read More

Asia Pac J Clin Oncol 2021 Apr 18. Epub 2021 Apr 18.

Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The prognosis of patients with multiple liver metastasis of colorectal cancer (CLM) on both lobes accompanied by a portal vein tumor thrombus (PVTT) remains unclear. We report two patients with multiple CLM and PVTT who underwent liver resection. A 73-year-old man had successful extended right hemi-hepatectomy with a thrombectomy for a macroscopic tumor thrombus in the right portal branch and multiple CLM in both lobes. Read More

Asia Pac J Clin Oncol 2021 Apr 18. Epub 2021 Apr 18.

Macarthur Cancer Therapy Centre, Campbelltown, New South Wales, Australia.

Background: Colorectal cancer is the third most common cancer and second leading cause of cancer mortality in Australia, thus carrying a significant disease burden.

Aims: This analysis aims to explore real-world treatment landscape of metastatic colorectal cancer in the third-line setting.

Methods: We retrospectively analysed treatment of recurrent and advanced colorectal cancer (TRACC) registry database from 2009 onwards. Read More

ANZ J Surg 2021 Apr 18. Epub 2021 Apr 18.

Department of General Surgery, Azienda Sanitaria Universitaria Giuliano-Isontina, Trieste University Hospital, Trieste, Italy.

Background: Biomarkers may play a role as predictive and prognostic factors in colorectal cancer patients. The aims of the study were to verify the prognostic role of pre-operative serum carcinoembryonic antigen (CEA) level in predicting overall survival and risk of recurrence in a cohort of colorectal cancer patients and to evaluate optimal cut-off values.

Methods: A retrospective cohort analysis was performed on colorectal cancer patients undergoing elective curative surgery between 2004 and 2019 at an Italian Academic Hospital. Read More

ANZ J Surg 2021 Apr 18. Epub 2021 Apr 18.

Department of Cardiothoracic Surgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Background: Many extrapulmonary neoplasms metastasize to the lungs. We conducted a retrospective review of all patients who underwent pulmonary metastasectomy for oligometastatic disease at two centres in order to determine long-term outcomes.

Methods: The study institutions' thoracic surgery databases were searched for all patients who underwent pulmonary metastasectomy from 2000 to 2017. Read More

ANZ J Surg 2021 Apr 18. Epub 2021 Apr 18.

Department of General and Oncological Surgery - Surgery C, The Chaim Sheba Medical Center, Ramat Gan, Israel.

Background: Although diverting loop ileostomy (DLI) reversal is considered to be a relatively simple procedure, it is not immune from major morbidity. We aimed to compare outcomes of DLI reversal between elderly and non-elderly patients.

Methods: Retrospective review of all patients who underwent DLI reversal at a single tertiary medical centre between 2010 and 2020. Read More

JGH Open 2021 Apr 9;5(4):486-492. Epub 2021 Mar 9.

Cancer Research, Flinders Health and Medical Research, Flinders University Bedford Park South Australia Australia.

Background And Aim: The coronavirus disease 2019 (COVID-19) global pandemic has affected elective procedures, including colonoscopy, worldwide. Delayed colorectal cancer surveillance may increase cancer risk. This study aimed to determine the impact of COVID-19 on the proportion of surveillance colonoscopies booked and completed and the extent to which that surveillance was delayed. Read More

Open Med (Wars) 2021 7;16(1):570-580. Epub 2021 Apr 7.

Department of Anesthesiology, The Affiliated Hospital of Kangda College of Nanjing Medical University (The First People's Hospital of Lianyungang), No. 188 Jianshe East Road, Lianyungang, 222002, Jiangsu, China.

Colorectal cancer (CRC) is responsible for thousands of slow and painful annual deaths. Propofol, an anesthetic, is commonly used in CRC surgery. The role of circularRNA0026344 (circ_0026344) in propofol-treated CRC remains unclear, which was further explored in this study. Read More

Endosc Int Open 2021 Apr 13;9(4):E610-E620. Epub 2021 Apr 13.

Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, Missouri, United States.

 Sessile serrated lesion (SSL) detection rate has been variably reported and unlike adenoma detection rate (ADR) is not currently a quality indicator for screening colonoscopy. Composite detection rates of SSL in patients undergoing average risk screening colonoscopy are not available.  Electronic database search (Medline, Embase and Cochrane) was conducted for studies reporting detection rates of serrated polyps (SSL, Hyperplastic polyp, traditional serrated adenoma) among average risk subjects undergoing screening colonoscopy. Read More

Front Oncol 2021 1;11:648045. Epub 2021 Apr 1.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

NK2 homeobox 5 (Nkx2.5), a homeobox-containing transcription factor, is associated with a spectrum of congenital heart diseases. Recently, Nkx2. Read More

Front Oncol 2021 31;11:643375. Epub 2021 Mar 31.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Hepatopancreatobiliary Surgery Department I, Peking University Cancer Hospital, Beijing, China.

Deficiency of the DNA damage repair (DDR) signaling pathways is potentially responsible for genetic instability and oncogenesis in tumors, including colorectal cancer. However, the correlations of mutated DDR signaling pathways to the prognosis of colorectal cancer liver metastasis (CRLM) after resection and other clinical applications have not been fully investigated. Here, to test the potential correlation of mutated DDR pathways with survival and pre-operative chemotherapy responses, tumor tissues from 146 patients with CRLM were collected for next-generation sequencing with a 620-gene panel, including 68 genes in 7 DDR pathways, and clinical data were collected accordingly. Read More

Front Oncol 2021 25;11:629132. Epub 2021 Mar 25.

Li Ka Shing Faculty of Medicine, School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.

Chemotherapy-induced gastrointestinal (CIGI) toxicity affects the quality of life of patients with colorectal cancer (CRC) and the clinical application of treatment drugs. This review aims to evaluate the efficacy of traditional herbal medicines (HMs) in alleviating symptoms of CIGI toxicity (including nausea and vomiting, anorexia, diarrhea, constipation, oral mucositis, abdominal pain, and abdominal distension), and to explore further individual herb or herbal combinations in alleviating the CIGI toxicity. Nine electronic databases were screened from 2010 to 2020. Read More

PeerJ 2021 5;9:e11219. Epub 2021 Apr 5.

The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.

Colorectal cancer (CRC) is one of the most prevalent and fatal malignancies, and novel biomarkers for the diagnosis and prognosis of CRC must be identified. RNA-binding proteins (RBPs) are essential modulators of transcription and translation. They are frequently dysregulated in various cancers and are related to tumorigenesis and development. Read More

PeerJ 2021 7;9:e10851. Epub 2021 Apr 7.

Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University, Seoul, South Korea.

Immunization with thetumor-associated antigen GA733 glycoprotein, which is highly expressed in colorectal cancer, is considered to be a promising strategy for cancer prevention and treatment. We cloned a fusion gene of GA733 and immunoglobulin Fc fragment (GA733-Fc), and that of GA733-Fc and an endoplasmic reticulum retention motif (GA733-FcK) into the Cowpea mosaic virus (CPMV)-based transient plant expression vector, pEAQ-. (LBA4404) transformed with the vectors pEAQ--GA733-Fc and pEAQ--GA733-FcK was infiltrated into the leaves of plants. Read More

Oncoimmunology 2021 Apr 2;10(1):1905935. Epub 2021 Apr 2.

Laboratory of Integrative Cancer Immunology, INSERM, Paris, France.

Colorectal cancers (CRCs) with microsatellite instability (MSI) are due to a defect in the DNA mismatch repair (MMR) system resulting in an accumulation of frame-shift mutations. They are characterized by a tumor microenvironment richer in cytotoxic CD8 T-cells (CTLs) and a better prognosis compared to microsatellite stable (MSS) CRCs. The mechanisms by which defective MMR system may influence tumor-infiltrating immune cells and their impact on patient survival were still unclear. Read More

J Surg Case Rep 2021 Apr 13;2021(4):rjaa228. Epub 2021 Apr 13.

Capio Sankt Görans Hospital, Stockholm, Sweden.

In this case series report of 10 colorectal cancer patients, a polyethylene glycol-coated collagen-based haemostatic patch was applied after rectal resection to reinforce rectal anastomoses and reduce anastomotic leakage. Patients underwent rectal resection and anastomoses were stapled in place. The patch-Hemopatch®-was applied to 75% of the anastomotic circumference. Read More

Oncol Lett 2021 Jun 7;21(6):448. Epub 2021 Apr 7.

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, D-69120 Heidelberg, Germany.

Up to 50% of patients with colorectal cancer (CRC) have either synchronous or metachronous hepatic metastases in the course of their disease. Patients with metastatic CRC (mCRC) whose tumors express wild-type KRAS benefit from treatment with monoclonal antibodies (such as cetuximab or panitumumab) that target the epidermal growth factor receptor (EGFR). However, the therapeutic response to these antibodies is variable, and further predictive models are required. Read More

Oncol Lett 2021 Jun 30;21(6):430. Epub 2021 Mar 30.

School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China.

Microsatellite instability (MSI) detection is widely used in the diagnosis and prognosis evaluation of colorectal cancer. However, for gastric cancer (GC), there is no standard panel of microsatellites (MSs) used in clinical guidance. The present study aimed to identify useful predictors of the clinical features and for the prognosis of GC, based on an investigation of MSI and loss of heterozygosity (LOH) in tumor-related genes. Read More