14,644 results match your criteria colorectal adenoma


Cumulative tea consumption is inversely associated with colorectal adenomas in adults: A cross-sectional study in a Taiwanese population.

Cancer Epidemiol 2021 May 5;73:101945. Epub 2021 May 5.

Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Family Medicine, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan; Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Purpose: This study examined the association between cumulative tea consumption over time and various colorectal adenomas as well as their pathology, number, and size.

Methods: 7355 eligible subjects who underwent health check-ups with colonoscopies were recruited. They were classified into three groups: polyp-free, having low-risk colorectal adenomas, and having high-risk colorectal adenomas. Read More

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Incidence and Management of Rectal Cuff and Anal Transitional Zone Neoplasia in Patients with Familial Adenomatous Polyposis.

Dis Colon Rectum 2021 Apr 29. Epub 2021 Apr 29.

Cleveland Clinic, Cleveland, Ohio.

Background: Rectal cuff and anal transitional zone neoplasia is an increasing challenge in patients with familial adenomatous polyposis who have undergone restorative proctocolectomy. Its real incidence, range of severity, and treatment efficacy are poorly documented.

Objective: We sought to document the evolution of rectal cuff and anal transitional zone neoplasia and describe its management. Read More

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SDC2 and TFPI2 Methylation in Stool Samples as an Integrated Biomarker for Early Detection of Colorectal Cancer.

Cancer Manag Res 2021 30;13:3601-3617. Epub 2021 Apr 30.

Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan, 430071, People's Republic of China.

Background: Detection of aberrant methylated DNA in the stool is an effective early screening method for colorectal cancer (CRC). Previously, reporters identified that syndecan-2 (SDC2) and tissue factor pathway inhibitor 2 (TFPI2) were aberrantly methylated in most CRC tissues. However, the combined diagnostic role of them remains undefined. Read More

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Calcium and dairy products in the chemoprevention of colorectal adenomas: a systematic review and meta-analysis.

Crit Rev Food Sci Nutr 2021 May 6:1-25. Epub 2021 May 6.

Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

The risk of transition to colorectal cancer (CRC) in advanced colorectal adenomas (ACAs) is about 2.5 times higher than the non-advanced ones. This systematic review and meta-analysis was performed to determine the effect of calcium and dairy products on the incidence of CAs and ACAs. Read More

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A novel 1-L PEG + ascorbate versus high-volume PEG regimen for colonoscopy cleansing: a multicenter, randomized, phase IV study.

Gastrointest Endosc 2021 Apr 30. Epub 2021 Apr 30.

Digestive Endoscopy Unit, Carpi-Mirandola Hospitals, Azienda USL Modena.

Background And Aims: An adequate bowel cleansing is critical to assure quality and safety of colonoscopy. A novel 1L-PEG plus ascorbate(PEG+ASC) regimen was previously validated against low-volume regimens, but it was never compared with high-volume regimens.

Methods: In a Phase IV study, patients undergoing colonoscopy were randomized 1:1 to receive split-dose 1L PEG+ASC or a split-dose 4L PEG-based regimen in 5 Italian centers. Read More

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MLH1 Epimutation Is a Rare Mechanism for Lynch Syndrome: A Case Report and Review of the Literature.

Genes Chromosomes Cancer 2021 May 2. Epub 2021 May 2.

Department of Pathology and Laboratory Medicine, Sinai Health System and University of Toronto, Toronto, ON, Canada.

Endometrial carcinoma is one of the prototypical malignancies associated with Lynch syndrome, an inherited cancer syndrome most commonly caused by germline mutations in DNA mismatch repair (MMR) genes, although rare alternative mechanisms also exist. In this report, we describe a patient first diagnosed with colorectal cancer at age 33, then vulvar squamous cell carcinoma, facial sebaceous adenoma/sebaceoma and finally endometrial carcinoma at age 52. All tumors were MLH1/PMS2-deficient by immunohistochemistry, and MLH1 promoter methylation was identified in the endometrial cancer. Read More

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Artificial intelligence (AI) real-time detection vs. routine colonoscopy for colorectal neoplasia: a meta-analysis and trial sequential analysis.

Int J Colorectal Dis 2021 May 1. Epub 2021 May 1.

Department of Internal Medicine - Division of Gastroenterology, Emory University, Atlanta, GA, USA.

Goals And Background: Studies analyzing artificial intelligence (AI) in colonoscopies have reported improvements in detecting colorectal cancer (CRC) lesions, however its utility in the realworld remains limited. In this systematic review and meta-analysis, we evaluate the efficacy of AI-assisted colonoscopies against routine colonoscopy (RC).

Study: We performed an extensive search of major databases (through January 2021) for randomized controlled trials (RCTs) reporting adenoma and polyp detection rates. Read More

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IDH1 and IDH2 Mutations in Colorectal Cancers.

Am J Clin Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: To elucidate clinicopathologic and molecular characteristics of IDH1 and IDH2 (IDH1/2) mutations in colorectal cancers (CRCs).

Methods: We evaluated IDH1/2 mutations in 1,623 CRCs using a next-generation sequencing assay.

Results: IDH1/2 mutations, predominantly IDH1 p. Read More

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External validation of blue light imaging (BLI) criteria for the optical characterization of colorectal polyps by endoscopy experts.

J Gastroenterol Hepatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, Missouri, USA.

Background And Aim: Recently, the BLI Adenoma Serrated International Classification (BASIC) system was developed by European experts to differentiate colorectal polyps. Our aim was to validate the BASIC classification system among the US-based endoscopy experts.

Methods: Participants utilized a web-based interactive learning system where the group was asked to characterize polyps using the BASIC criteria: polyp surface (presence of mucus, regular/irregular and [pseudo]depressed), pit appearance (featureless, round/non-round with/without dark spots; homogeneous/heterogeneous distribution with/without focal loss), and vessels (present/absent, lacy, peri-cryptal, irregular). Read More

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Dietary inflammatory index and risk of colorectal adenoma: effect measure modification by race, nonsteroidal anti-inflammatory drugs, cigarette smoking and body mass index?

Cancer Causes Control 2021 Apr 29. Epub 2021 Apr 29.

Department of Family Medicine, University of Virginia School of Medicine, McKim Hall Rm 3156, Charlottesville, VA, 22908, USA.

Purpose: To investigate if the association between dietary inflammatory potential and colorectal adenoma (CRA) is modified by race and factors known to modulate inflammation.

Methods: We examined effect measure modification of race, nonsteroidal anti-inflammatory drugs (NSAIDs), cigarette smoking and body mass index (BMI) on the diet-CRA association by employing energy-adjusted dietary inflammatory index (E-DII™) to characterize dietary inflammatory potential among 587 cases and 1,313 controls participating in a colonoscopy screening-based cross-sectional study of CRA. Participants completed a food frequency questionnaire from which E-DII score was derived. Read More

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CD36 polymorphisms and the age of disease onset in patients with pathogenic variants within the mutation cluster region of APC.

Hered Cancer Clin Pract 2021 Apr 29;19(1):25. Epub 2021 Apr 29.

School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan Campus, NSW, 2308, Newcastle, Australia.

Background: Familial adenomatous polyposis (FAP) is an autosomal dominant condition that predisposes patients to colorectal cancer. FAP is the result of a loss of APC function due to germline pathogenic variants disrupting gene expression. Genotype-phenotype correlations are described for FAP. Read More

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EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.

Vet Pathol 2021 Apr 30:3009858211009778. Epub 2021 Apr 30.

Konkuk University, Gwangjin-gu, Seoul, Republic of Korea.

Epidermal growth factor receptor (EGFR) is overexpressed in many human colorectal cancers and anti-EGFR agents are employed as immunotherapies. However, , , and gene mutations can influence the activity of the anti-EGFR agents. We evaluated EGFR expression at protein and mRNA levels in canine intestinal adenocarcinomas using immunohistochemistry (IHC) and RNA in situ hybridization (RNA-ISH). Read More

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Identification of colorectal neoplasia by using serum bile acid profile.

Biomarkers 2021 Apr 30:1-6. Epub 2021 Apr 30.

Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: Colonoscopy is the gold standard for detecting earlier stages of CRC, although screening of patients is difficult because of invasiveness, low compliance and procedural health risks. Therefore, the need for new screening methods for CRC is rising. Previous studies have demonstrated the diagnostic ability of serum BAs; however, the results have been inconsistent. Read More

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A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer.

Membranes (Basel) 2021 Apr 24;11(5). Epub 2021 Apr 24.

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.

Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by germline mutations in specific genes. Several factors, such as growth factors, cytokines, and genetic or epigenetic alterations in specific oncogenes or tumor-suppressor genes, play a role during the adenoma-carcinoma sequence. Read More

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Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 Apr 15;18(8). Epub 2021 Apr 15.

School of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy.

PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus were searched in January 2021 in order to retrieve evidence assessing the association between dietary fibre intake and the risk of colorectal adenoma in adults. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the reporting of results. Only primary observational studies were included. Read More

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Unsupervised Monocular Depth Estimation for Colonoscope System Using Feedback Network.

Sensors (Basel) 2021 Apr 11;21(8). Epub 2021 Apr 11.

School of Electronics and Information Engineering, Korea Aerospace University, Goyang 10540, Korea.

A colonoscopy is a medical examination used to check disease or abnormalities in the large intestine. If necessary, polyps or adenomas would be removed through the scope during a colonoscopy. Colorectal cancer can be prevented through this. Read More

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Role of the β-Catenin/REG Iα Axis in the Proliferation of Sessile Serrated Adenoma/Polyps Associated with .

Pathogens 2021 Apr 6;10(4). Epub 2021 Apr 6.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine 1-1, Mukogawa, Nishinomiya 663-8501, Japan.

Although sessile serrated adenoma/polyps (SSA/Ps) may arise through a pathway different from the traditional adenoma-carcinoma sequence, details of SSA/P tumorigenesis still remain unclear. () is frequently detected in colorectal cancer (CRC) tissues and may play a pivotal role in colorectal carcinogenesis. Here, we investigated the relationship between and the β-catenin/REG Iα axis in SSA/Ps and their involvement in the proliferation of these lesions. Read More

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Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening.

J Proteomics 2021 Apr 26:104246. Epub 2021 Apr 26.

BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China; BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China; BGI-Guangzhou Medical Laboratory, BGI-Shenzhen, Guangzhou 510006, China. Electronic address:

Colorectal cancer (CRC) is a malignant tumour with high morbidity and mortality worldwide. Efficient screening strategies for CRC and pre-cancerous lesions can promote early medical intervention and treatment, thereby reducing morbidity and mortality. Proteins are generally considered key biomarkers of cancer. Read More

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Helicobacter pylori and colorectal neoplasms: a concise review.

Arq Gastroenterol 2021 Jan-Mar;58(1):114-119

Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.

Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. Read More

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Giant pedunculated rectal polyps in transanal endoscopic surgery: The larger, the more inverted.

Colorectal Dis 2021 Apr 27. Epub 2021 Apr 27.

Department of General and Digestive Surgery, Reina Sofia University Hospital, Cordoba, Spain.

In this video we present a giant pedunculated polyp resected by transanal endoscopic surgery and how its size can be used in our favour by inverting patient´s position and hanging it. The patient is a 82-year-old female with a 5 cm pedunculated polyp on the posterolateral rectal wall, 4 to 9 cm from the anal verge, with a biopsy reporting villous adenoma, that was referred to our unit after an unsuccessful attempt of resection in other hospital with TEO® procedure in the standard position. We proposed inverting the usual position of the patient, in order to have the polyp hanging by its pedicle and so the force of gravity would benefit in exposing the pedicle. Read More

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Real-world cost-effectiveness of stool-based colorectal cancer screening in a Medicare population.

J Med Econ 2021 Apr 26. Epub 2021 Apr 26.

Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.

Aim: Multiple screening strategies are guideline-endorsed for average-risk colorectal cancer (CRC). The impact of real-world adherence rates on the cost-effectiveness of non-invasive stool-based CRC screening strategies remains undefined.

Methods: This cost-effectiveness analysis from the perspective of Medicare as a primary payer used the Colorectal Cancer and Adenoma Incidence and Mortality Microsimulation Model (CRC-AIM) to estimate cost and clinical outcomes for triennial multi-target stool DNA (mt-sDNA), annual fecal immunochemical test (FIT) and annual fecal occult blood test (FOBT) screening strategies in a simulated cohort of U. Read More

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let-7e downregulation characterizes early phase colonic adenoma in APCMin/+ mice and human FAP subjects.

PLoS One 2021 26;16(4):e0249238. Epub 2021 Apr 26.

Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.

The crypt-villus axis represents the essential unit of the small intestine, which integrity and functions are fundamental to assure tissue and whole-body homeostasis. Disruption of pathways regulating the fine balance between proliferation and differentiation results in diseases development. Nowadays, it is well established that microRNAs (miRNAs) play a crucial role in the homeostasis maintenance and perturbation of their levels may promote tumor development. Read More

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Combining the Fecal Immunochemical Test with a Logistic Regression Model for Screening Colorectal Neoplasia.

Front Pharmacol 2021 17;12:635481. Epub 2021 Mar 17.

Department of Health Management, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, China.

The fecal immunochemical test (FIT) is a widely used strategy for colorectal cancer (CRC) screening with moderate sensitivity. To further increase the sensitivity of FIT in identifying colorectal neoplasia, in this study, we established a classifier model by combining FIT result and other demographic and clinical features. A total of 4,477 participants were examined with FIT and those who tested positive (over 100 ng/ml) were followed up by a colonoscopy examination. Read More

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Adenoma and Serrated Lesion Detection by Colonoscopy Indication: The ADR-ESS (ADR Extended to all Screening/Surveillance) Score.

Clin Gastroenterol Hepatol 2021 Apr 22. Epub 2021 Apr 22.

Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.

Background: The adenoma detection rate at screening (ADR) predicts interval colorectal cancer (CRC). Monitoring other lesion detection rates and colonoscopy indications has been proposed. We developed a comprehensive, automated colonoscopy audit program based on standardized clinical documentation, explored detection rates across indications, and developed the "Adenoma Detection Rate - Extended to all Screening / Surveillance" (ADR-ESS) score. Read More

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Sensitive detection of colorectal cancer in peripheral blood by a novel methylation assay.

Clin Epigenetics 2021 Apr 23;13(1):90. Epub 2021 Apr 23.

AnchorDx Medical Co., Ltd, Unit 502, 3rd Luoxuan Road, International Bio-Island, Guangzhou, 510300, China.

Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Early detection of CRC can significantly reduce its mortality rate. Current method of CRC diagnosis relies on the invasive endoscopy. Read More

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Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2.

EMBO Rep 2021 Apr 23:e51913. Epub 2021 Apr 23.

Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

The N-Myc Downstream-Regulated Gene 4 (NDRG4), a prominent biomarker for colorectal cancer (CRC), is specifically expressed by enteric neurons. Considering that nerves are important members of the tumor microenvironment, we here establish different Ndrg4 knockout (Ndrg4 ) CRC models and an indirect co-culture of primary enteric nervous system (ENS) cells and intestinal organoids to identify whether the ENS, via NDRG4, affects intestinal tumorigenesis. Linking immunostainings and gastrointestinal motility (GI) assays, we show that the absence of Ndrg4 does not trigger any functional or morphological GI abnormalities. Read More

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Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed in disparate populations.

World J Clin Cases 2021 Apr;9(11):2433-2445

Department of Medicine, NYC Health and Hospitals/Kings County, Brooklyn, NY 11203, United States.

Background: The Black/African Ancestry (AA) population has a higher prevalence of type 2 diabetes mellitus (T2DM) and a higher incidence and mortality rate for colorectal cancer (CRC) than all other races in the United States. T2DM has been shown to increase adenoma risk in predominantly white/European ancestry (EA) populations, but the effect of T2DM on adenoma risk in Black/AA individuals is less clear. We hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA population. Read More

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Gastroenterology visitation and reminders predict surveillance uptake for patients with adenomas with high-risk features.

Sci Rep 2021 Apr 22;11(1):8764. Epub 2021 Apr 22.

Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Individuals diagnosed with colorectal adenomas with high-risk features during screening colonoscopy have increased risk for the development of subsequent adenomas and colorectal cancer. While US guidelines recommend surveillance colonoscopy at 3 years in this high-risk population, surveillance uptake is suboptimal. To inform future interventions to improve surveillance uptake, we sought to assess surveillance rates and identify facilitators of uptake in a large integrated health system. Read More

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Artificial Intelligence in Colorectal Polyp Detection and Characterization.

Int J Clin Res Trials 2021 20;6. Epub 2021 Mar 20.

Department of Internal Medicine, State University of New York, USA.

Background: Over the past 20 years, the advancement of artificial intelligence (AI) and deep learning (DL) has allowed for fast sorting and analysis of large sets of data. In the field of gastroenterology, colorectal screening procedures produces an abundance of data through video and imaging. With AI and DL, this information can be used to create systems where automatic polyp detection and characterization is possible. Read More

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Fecal microbiota changes with fermented kimchi intake regulated either formation or advancement of colon adenoma.

J Clin Biochem Nutr 2021 Mar 26;68(2):139-148. Epub 2020 Dec 26.

CHA Cancer Preventive Research Center, CHA Bio Complex, 330 Pangyo-dong, Bundang-gu, Seongnam, 13497, Korea.

Gut bacteria might contribute in early stage of colorectal cancer through the development and advancement of colon adenoma, by which exploring either beneficial bacteria, which are decreased in formation or advancement of colon adenoma and harmful bacteria, which are increased in advancement of colon adenoma may result in implementation of dietary interventions or probiotic therapies to functional means for prevention. Korean fermented kimchi is one of representative probiotic food providing beneficiary microbiota and exerting significant inhibitory outcomes in both APC/ polyposis model and colitis-associated cancer. Based on these backgrounds, we performed clinical trial to document the changes of fecal microbiota in 32 volunteers with normal colon, simple adenoma, and advanced colon adenoma with 10 weeks of fermented kimchi intake. Read More

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