201,763 results match your criteria colorectal


Incidence and Outcomes Associated with 6841 Isolated Distal Deep Vein Thromboses in Patients with 13 Common Cancers.

Thromb Haemost 2022 Jan 17. Epub 2022 Jan 17.

Hematology/Oncology, University of California Davis Health System, Sacramento, United States.

Introduction: The epidemiology of isolated distal deep venous thrombosis (iDDVT) among cancer patients is not well described, particularly the incidence of recurrent venous thromboembolism (rVTE) and effect on mortality by cancer type.

Methods: The cumulative incidence (CI) of iDDVT was determined for patients with 13 common cancers between 2005-2017 using the California Cancer Registry linked to the California Patient Discharge and Emergency Department Utilization datasets. The CI of rVTE was calculated and association of incident CAT location with rVTE was determined using Cox proportional hazards regression models. Read More

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January 2022

Comparison of cold biopsy forceps vs cold snare for diminutive colorectal polyp removal: a multicenter non-inferiority randomized controlled trial.

Clin Res Hepatol Gastroenterol 2022 Jan 14:101867. Epub 2022 Jan 14.

Hepato-gastroenterology and digestive endoscopy department, Georges Pompidou European Hospital, APHP.Centre-Université de Paris, 20 rue Leblanc, 75015 Paris, France. Electronic address:

Background: European guidelines recommends the use of cold snare polypectomy (CSP) for removal of diminutive colorectal polyps (DCP). However, for DCP < 4 mm cold biopsy forceps (CBF) may be optional. We aimed to compare the efficacy of CSP with CBF for removal of DCP in routine colonoscopy. Read More

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January 2022

How to perform an anastomosis following a low anterior resection by taTME surgery: From top to bottom techniques.

Colorectal Dis 2022 Jan 17. Epub 2022 Jan 17.

University Clinic of Navarre, Colorectal Surgery Unit. Madrid & Pamplona, Spain.

Aim: To describe the range of possibilities and our group´s clinical outcomes when performing different types of anastomosis during transanal total mesorectal excision (taTME).

Method: A retrospective analysis was performed based on four taTME series from 2016 to 2021. Inclusion criteria were patients with rectal cancer in whom a sphincter-saving low anterior resection by taTME was performed. Read More

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January 2022

Complete occlusion of lumen after Over-the-scope-clip deployment during ESD. A lesson learned.

Colorectal Dis 2022 Jan 17. Epub 2022 Jan 17.

Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States.

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January 2022

Is it safe to perform an anastomosis for rectal cancer after prostate cancer? A multicenter study of 126 patients from the GRECCAR group.

Colorectal Dis 2022 Jan 17. Epub 2022 Jan 17.

Department of Digestive Surgical Oncology, University Hospital of Besançon, Besançon, France.

Aim: To determine safety of performing an anastomosis after rectal cancer (RC) resection in patients with a previously treated prostate cancer (PC).

Methods: Patients with a previously treated PC who underwent rectal resection from 2008 to 2018 were retrospectively included. Outcomes were compared between patients who underwent rectal resection with anastomosis (restorative surgery, RS+ group) and those with a definitive stoma (RS- group). Read More

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January 2022

Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Ann Intern Med 2022 Jan 18. Epub 2022 Jan 18.

Minneapolis VA Center for Care Delivery and Outcomes Research, Minneapolis, Minnesota (T.J.W.).

Description: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the role of colonoscopy for diagnostic evaluation of colorectal cancer (CRC) after a presumed diagnosis of acute left-sided colonic diverticulitis and on the role of pharmacologic, nonpharmacologic, and elective surgical interventions to prevent recurrence after initial treatment of acute complicated and uncomplicated left-sided colonic diverticulitis. This guideline is based on the current best available evidence about benefits and harms, taken in the context of costs and patient values and preferences.

Methods: The ACP Clinical Guidelines Committee (CGC) based these recommendations on a systematic review on the role of colonoscopy after acute left-sided colonic diverticulitis and pharmacologic, nonpharmacologic, and elective surgical interventions after initial treatment. Read More

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January 2022

Evaluation and Management After Acute Left-Sided Colonic Diverticulitis : A Systematic Review.

Ann Intern Med 2022 Jan 18. Epub 2022 Jan 18.

Warren Alpert Medical School at Brown University, Providence, Rhode Island (N.S.).

Background: The value of interventions used after acute colonic diverticulitis is unclear.

Purpose: To evaluate postdiverticulitis colonoscopy and interventions to prevent recurrent diverticulitis.

Data Sources: MEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase, CINAHL, and ClinicalTrials. Read More

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January 2022

A pilot randomized controlled trial on ligation of intersphincteric fistula tract (LIFT) versus modified parks technique and two-stage seton in treatment of complex anal fistula.

Updates Surg 2022 Jan 17. Epub 2022 Jan 17.

Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura University, 60 El-Gomhouria Street, Mansoura, 35516, Dakahlia, Egypt.

Complex anal fistula (CAF) is a challenging condition for surgeons. This randomized trial aimed to compare ligation of the intersphincteric fistula tract (LIFT), modified Parks technique, and two-stage seton in the treatment of complex anal fistula in terms of the success of treatment and complications. This was a pilot randomized trial conducted in the period of January 2019 to December 2019 on adult patients with CAF who were allocated to one of three groups: LIFT, modified Parks technique, and two-stage seton. Read More

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January 2022

Parameters associated with unsuccessful pessary fitting for pelvic organ prolapse up to three months follow-up: a systematic review and meta-analysis.

Int Urogynecol J 2022 Jan 17. Epub 2022 Jan 17.

Multi-Modality Medical Imaging, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Objectives: To clarify which parameters are associated with unsuccessful pessary fitting for pelvic organ prolapse (POP) at up to 3 months follow-up.

Methods: Embase, PubMed and Cochrane CENTRAL library were searched in May 2020. Inclusion criteria were: (1) pessary fitting attempted in women with symptomatic POP; (2) pessary fitting success among the study outcomes with a maximal follow-up of 3 months; (3) baseline parameters compared between successful and unsuccessful group. Read More

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January 2022

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma.

Neoplasma 2022 Jan 18. Epub 2022 Jan 18.

Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Growing evidences have revealed that exosomal miRNAs, lncRNAs, and circRNAs play a pleiotropic role in tumor biology. Cell-cell communication mediated by exosomes has been considered to be a key factor in the malignant progression of colorectal cancer. However, the importance of exosome-derived circRNAs in the biological function and clinical significance of colorectal adenoma remains elusive. Read More

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January 2022

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases.

Neoplasma 2022 Jan 18. Epub 2022 Jan 18.

Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.

This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Read More

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January 2022

Anticancer evaluation of methotrexate and curcumin coencapsulated niosomes against colorectal cancer cell line.

Nanomedicine (Lond) 2022 Jan 17. Epub 2022 Jan 17.

Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

The aim of the present investigation was to develop niosomes containing both curcumin (CUR) and methotrexate (MTX). Also, the combinational effect of CUR and MTX in both free and niosomal forms on growth inhibition potential and induction of apoptosis in the HCT-116 cell line were exploited. Niosomes were prepared by the thin-film hydration method and their physicochemical properties were determined by various techniques. Read More

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January 2022

Colorectal Cancer-Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD-L1 Expression in Tumor-Associated Macrophages.

Adv Sci (Weinh) 2022 Jan 17:e2102620. Epub 2022 Jan 17.

Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, 214062, China.

Tumor-associated macrophages (TAMs) are one of the most abundant cell types in colorectal cancer (CRC) tumor microenvironment (TME). Recent studies observed complicated "cross-talks" between cancer cells and macrophages in TME. However, the underlying mechanisms are still poorly elucidated. Read More

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January 2022

The roles and therapeutic approaches of MSC-derived exosomes in colorectal cancer.

Clin Transl Oncol 2022 Jan 17. Epub 2022 Jan 17.

Anorectal, Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang, 050051, China.

Colorectal cancer (CRC) is the third most common cancer in both men and women, accounting for 8% of all new cancer cases in both. CRC is typically diagnosed at advanced stages, which leads to a higher mortality rate. The 5-year survival rate for CRC is 64% in all cases and just 12% in metastatic cases. Read More

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January 2022

Exploring Why Financial Incentives Fail to Affect At-home Colorectal Cancer Screening: a Mixed Methods Study.

J Gen Intern Med 2022 Jan 17. Epub 2022 Jan 17.

Penn Center for Cancer Care Innovation, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

Background: Despite success in increasing other health behaviors, financial incentives have shown limited to no effect on colorectal cancer (CRC screening. Little is known about the factors shaping why and for whom incentives improve screening.

Objective: To explore the perspective of participants enrolled in a larger, four-arm pragmatic trial at urban family medicine practices which assessed and failed to detect significant effects of financial incentives on at-home CRC screening completion. Read More

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January 2022

Prostate radiotherapy and the risk of secondary rectal cancer-a meta-analysis.

Int J Colorectal Dis 2022 Jan 17. Epub 2022 Jan 17.

Department of Colorectal Surgery, St James's Hospital, Dublin 8, Ireland.

Purpose: Radiotherapy is being used increasingly in the treatment of prostate cancer. However, ionising radiation may confer a small risk of a radiation-induced secondary malignancy. We aim to assess the risk of rectal cancer following pelvic radiotherapy for prostate cancer. Read More

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January 2022

The primary tumor location in colorectal cancer: A focused review on its impact on surgical management.

Glob Health Med 2021 Dec;3(6):386-393

Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.

The primary tumor location (PTL) has attracted increasing attention in recent years for colorectal cancer (CRC) patients. Although the underlying mechanisms for differences caused by PTL remain still unclear, right-sided colon (RCC) and left-sided colon (LCC) are now considered as distinct entities because of their different molecular profile and clinical response to surgery and chemotherapy. In this article, we review the influence of PTL particularly on surgical management of primary and metastatic CRC settings. Read More

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December 2021

Endoscopic resection for gastrointestinal tumors (esophageal, gastric, colorectal tumors): Japanese standard and future prospects.

Glob Health Med 2021 Dec;3(6):365-370

Department of Gastroenterology, National Center for Global Health and Medicine, Tokyo, Japan.

Endoscopic resection (ER) techniques such as polypectomy, endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely accepted as a less invasive treatment for gastrointestinal (GI) tumors. Since there is a limit to the size that can be resected by EMR and it is often divided, it is not possible to accurately evaluate the degree of cancer progression, and the cancer remains or causes recurrence. ESD is a technology that overcomes these weaknesses. Read More

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December 2021

Rectal carcinoma arising in a patient with intestinal and hepatic schistosomiasis due to .

IDCases 2022 6;27:e01383. Epub 2022 Jan 6.

Department of Pathology, Division of Surgical Pathology, Women's and Children's Hospitals, The University of North Carolina at Chapel Hill, 3rd Floor, Room 30149, 101 Manning Drive, Chapel Hill 27514, NC, USA.

Schistosomiasis is a parasitic trematode infection spread by snails with multiple species causing human disease. Infection can cause liver disease, including fibrosis and portal hypertension, and has been linked to malignancies such as bladder and colorectal cancer. We describe a case of a geographically limited form of schistosomiasis, in a Laotian immigrant who presented with both hepatic fibrosis and rectal cancer, with numerous schistosome eggs present in the patient's rectal resection. Read More

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January 2022

Nutritional Complications After Laparoscopic Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass: A Comparative Systematic Review and Meta-Analysis.

Cureus 2022 Jan 11;14(1):e21114. Epub 2022 Jan 11.

General and Laparoscopic Surgery, El Zaitoun Specialized Hospital, Cairo, EGY.

A systematic review and meta-analysis were carried out involving studies that compared the nutritional complications of Roux-en-Y gastric bypass (RYGB) and one-anastomosis gastric bypass (OAGB); these included the incidence of malnutrition as well as deficiencies of other nutritional elements, such as total protein, albumin, calcium and iron. A comprehensive search strategy was implemented in PubMed, Embase, and the Cochrane Library. Effect sizes included the pooled odds ratios (ORs) and 95% confidence intervals (95% CIs), as well as mean differences (MDs) and 95% CIs of the percentage total weight loss (%TWL) and excess weight loss percentage (%EWL). Read More

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January 2022

Percutaneous Cholecystostomy for Acute Cholecystitis: A Three-Year Single-Centre Experience Including During COVID-19.

Cureus 2021 Dec 13;13(12):e20385. Epub 2021 Dec 13.

General Surgery, Mid and South Essex NHS Foundation Trust, Basildon, GBR.

Introduction Percutaneous cholecystostomy is a recognised treatment modality for acute cholecystitis. Traditionally, its use was reserved for patients deemed unfit for surgery. However, the coronavirus disease 2019 (COVID-19) pandemic had a detrimental effect on both elective and emergency surgery. Read More

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December 2021

The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA.

Mol Ther Nucleic Acids 2022 Mar 11;27:363-374. Epub 2021 Dec 11.

Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.

Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality globally. Therefore, a better understanding of the early molecular events of this disease is needed. Long noncoding RNAs (lncRNAs) play a critical role in the regulation of tumorigenesis and cancer progression. Read More

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Multimodal immune activation abilities and characteristics of reovirus.

Am J Transl Res 2021 15;13(12):14176-14185. Epub 2021 Dec 15.

Montefiore Medical Center 1695 Eastchester Road, Bronx, New York 10461, USA.

Reovirus is a ubiquitous, non-pathogenic, double stranded RNA virus with anti-tumor properties. The virus's replicative potential is regulated by phosphorylation of protein kinase receptor (PKR). In cancers with pathway activation which leads to dysregulation of PKR, the virus maintains its protein translational potential and induces oncolysis. Read More

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December 2021

The predictive value of the prognostic nutritional index to postoperative prognosis and nursing intervention measures for colorectal cancer.

Am J Transl Res 2021 15;13(12):14096-14101. Epub 2021 Dec 15.

Department of Nursing, Dongying People's Hospital Dongying 257091, Shandong, China.

Objectives: This study discussed and analyzed the predictive value of the prognostic nutritional index (PNI) to postoperative prognosis and nursing intervention measures for colorectal cancer.

Methods: 196 patients with colorectal cancer who underwent radical resection in gastrointestinal surgery were retrospectively analyzed. The patients' data and follow-up results were collected and classified into two groups based on the PNI, i. Read More

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December 2021

Pneumocystis pneumonia in liver transplant recipients.

Am J Transl Res 2021 15;13(12):13981-13992. Epub 2021 Dec 15.

Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University Beijing, China.

The clinical course of Pneumocystis pneumonia in liver transplant recipients has not been well investigated. Therefore, we collected and analyzed the clinical, epidemiological, and molecular data from patients with Pneumocystis pneumonia as well as paired controls (Chinese Clinical Trial Registry, ChiCTR2100046028; www.chictr. Read More

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December 2021

Laparoscopic radical resection combined with neoadjuvant chemotherapy in treatment of colorectal cancer: clinical efficacy and postoperative complications.

Am J Transl Res 2021 15;13(12):13974-13980. Epub 2021 Dec 15.

Department of Anorectal Surgery, Jinan City People's Hospital Jinan, Shandong, China.

Objective: To explore the clinical efficacy of laparoscopic radical resection combined with neoadjuvant chemotherapy (NACT) in the treatment of colorectal cancer and its influence on postoperative complications.

Methods: The clinical data of 90 patients with colorectal cancer admitted to our hospital from June 2019 to June 2021 were retrospectively analyzed. According to different treatment methods, patients were divided into a control group (laparoscopic radical resection) and a study group (combined NACT before radical resection), with 45 cases in each group. Read More

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December 2021

Anti-TNF therapy and immunogenicity in inflammatory bowel diseases: a translational approach.

Am J Transl Res 2021 15;13(12):13916-13930. Epub 2021 Dec 15.

Inflammatory Bowel Disease Research Laboratory, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP) Campinas, Brazil.

Inflammatory bowel diseases are chronic illnesses that involve intestinal inflammation and are usually diagnosed as Crohn's disease or ulcerative colitis. As these diseases do not have a cure, the goal of treatment is to induce and maintain remission. Monoclonal antibodies have been recognized as the most advanced therapy to avoid complications and reduce the need for surgical approaches. Read More

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December 2021

Application and nursing key points of wet dressings on the intestinal stoma after enterostomy.

Am J Transl Res 2021 15;13(12):13741-13749. Epub 2021 Dec 15.

Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital Harbin 150081, Heilongjiang, China.

Patients with severe intestinal injury caused by trauma and malignant intestinal diseases require an artificial anus to be established through enterostomy to replace the original perineal anus for defecation. Although enterostomy has brought a new way of defecation to patients, the nursing requirements for an intestinal stoma after enterostomy are high. If complications arise from improper postoperative wound care, the quality of life of patients will be seriously reduced, and the psychological burden will be aggravated. Read More

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December 2021

RNF128 suppresses the malignancy of colorectal cancer cells via inhibition of Wnt/β-catenin signaling.

Am J Transl Res 2021 15;13(12):13567-13578. Epub 2021 Dec 15.

The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research Nanjing 210009, Jiangsu, China.

Purpose: Colorectal cancer (CRC) is one of the most frequent tumors and causes of mortality worldwide. Ubiquitin ligase was reported to regulate multiple cellular processes, including tumorigenesis. As ubiquitin E3 ligases, RING-finger proteins play a key role in physiological and pathophysiological processes. Read More

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December 2021