511 results match your criteria colonization elimination

Adhesion of Candida parapsilosis to Bovine Serum Albumin under Fluid Shear.

J Vis Exp 2021 May 13(171). Epub 2021 May 13.

Women & Infants Hospital of Rhode Island and Warren Alpert Medical School of Brown University.

C. parapsilosis (Cp) is an emerging cause of bloodstream infections in certain populations. The Candida clade, including Cp, is increasingly developing resistance to the first and the second line of antifungals. Read More

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Distinct growth stages controlled by the interplay of deterministic and stochastic processes in functional anammox biofilms.

Water Res 2021 Jul 9;200:117225. Epub 2021 May 9.

Eawag, Swiss Federal Institute for Aquatic Science and Technology, Department of Surface Waters-Research and Management, 6047 Kastanienbaum, Switzerland.

Mainstream anaerobic ammonium oxidation (anammox) represents one of the most promising energy-efficient mechanisms of fixed nitrogen elimination from wastewaters. However, little is known about the exact processes and drivers of microbial community assembly within the complex microbial biofilms that support anammox in engineered ecosystems. Here, we followed anammox biofilm development on fresh carriers in an established 8m mainstream anammox reactor that is exposed to seasonal temperature changes (~25-12°C) and varying NH concentrations (5-25 mg/L). Read More

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: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare Facilities.

Microorganisms 2021 Apr 11;9(4). Epub 2021 Apr 11.

Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait.

a recently recognized, often multidrug-resistant yeast, has become a significant fungal pathogen due to its ability to cause invasive infections and outbreaks in healthcare facilities which have been difficult to control and treat. The extraordinary abilities of to easily contaminate the environment around colonized patients and persist for long periods have recently resulted in major outbreaks in many countries. resists elimination by robust cleaning and other decontamination procedures, likely due to the formation of 'dry' biofilms. Read More

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The immunomodulating role of probiotics in the prevention and treatment of oral diseases.

Cent Eur J Immunol 2021 11;46(1):99-104. Epub 2021 Mar 11.

Department of Oral Hygiene, Medical University of Warsaw, Warsaw, Poland.

Probiotics are defined as non-pathogenic live microorganisms which, when administered in appropriate amounts, are beneficial to the health of the host. Currently, the group of probiotic microorganisms includes bacteria that produce lactic acid of the genera Lactobacillus and Bifidobacterium, belonging to the so-called LAB (lactic acid bacteria) groups, and the yeast Saccharomyces boulardii. Probiotics have a protective role in Candida spp. Read More

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Effects of nasopharyngeal microbiota in respiratory infections and allergies.

Clin Exp Pediatr 2021 Apr 15. Epub 2021 Apr 15.

Division of Pediatric Infectious Diseases, Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The human microbiome, which consists of a collective cluster of commensal, symbiotic, and pathogenic microorganisms living in the human body, plays a key role in host health and immunity. The human nasal cavity harbors commensal bacteria that suppress the colonization of opportunistic pathogens. However, dysbiosis of the nasal microbial community is associated with many diseases, such as acute respiratory infections including otitis media, sinusitis and bronchitis and allergic respiratory diseases including asthma. Read More

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Colonization Dynamics of Multidrug-Resistant Are Dictated by Microbiota-Cluster Group Behavior over Individual Antibiotic Susceptibility: A Metataxonomic Analysis.

Antibiotics (Basel) 2021 Mar 7;10(3). Epub 2021 Mar 7.

Institute of Medical Microbiology, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4., 1089 Budapest, Hungary.

Gastrointestinal carriage of multidrug-resistant (MDR) bacteria is one of the main risk factors for developing serious, difficult-to-treat infections. Given that there is currently no all-round solution to eliminate colonization with MDR bacteria, it is particularly important to understand the dynamic process of colonization to aid the development of novel decolonization strategies. The aim of our present study was to perform metataxonomic analyses of gut microbiota dynamics during colonization with an extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing (ECKP) strain in mice; additionally, to ascertain the effects of antibiotic administration (ampicillin, ceftazidime, and ciprofloxacin) on the establishment and elimination of ECKP intestinal colonization. Read More

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The influence of antibiotics on transitory resistome during gut colonization with CTX-M-15 and OXA-162 producing Klebsiella pneumoniae ST15.

Sci Rep 2021 Mar 18;11(1):6335. Epub 2021 Mar 18.

Institute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4., 1089, Budapest, Hungary.

Great efforts have been made to limit the transmission of carbapenemase-producing Enterobacteriaceae (CPE), however, the intestinal reservoir of these strains and its modulation by various antibiotics remain largely unexplored. Our aim was to assess the effects of antibiotic administration (ampicillin, ceftazidime, ciprofloxacin) on the establishment and elimination of intestinal colonization with a CTX-M-15 ESBL and OXA-162 carbapenemase producing Klebsiella pneumoniae ST15 (KP5825) in a murine (C57BL/6 male mice) model. Whole genome sequencing of KP5825 strain was performed on an Illumina MiSeq platform. Read More

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Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection.

mBio 2021 03 16;12(2). Epub 2021 Mar 16.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Monoclonal antibody (MAb) 2C7 recognizes a lipooligosaccharide epitope expressed by most clinical isolates and mediates complement-dependent bactericidal activity. We recently showed that a recombinant human IgG1 chimeric variant of MAb 2C7 containing an E430G Fc modification (2C7_E430G), which enhances complement activation, outperformed the parental MAb 2C7 (2C7_WT) Because natural infection with often does not elicit protective immunity and reinfections are common, approaches that prolong bacterial control are of great interest. Advances in DNA-based approaches have demonstrated the combined benefit of genetic engineering, formulation optimizations, and facilitated delivery via CELLECTRA-EP technology, which can induce robust expression of protective DNA-encoded monoclonal antibodies (DMAbs) with durable serum activity relative to traditional recombinant MAb therapies. Read More

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Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of .

Front Immunol 2021 25;12:634923. Epub 2021 Feb 25.

Division of Clinical Vaccinology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Our previous studies showed that a combination of a DNA plasmid encoding Flt3 ligand (pFL) and CpG oligodeoxynucleotides 1826 (CpG ODN) (FL/CpG) as a nasal adjuvant provoked antigen-specific immune responses. In this study, we investigated the efficacy of a nasal vaccine consisting of FimA as the structural subunit of () fimbriae and FL/CpG for the induction of FimA-specific antibody (Ab) responses and their protective roles against nasal and lung infection by , a keystone pathogen in the etiology of periodontal disease. C57BL/6 mice were nasally immunized with recombinant FimA (FimA) plus FL/CpG three times at weekly intervals. Read More

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February 2021

Effects of food matrix and probiotics on the bioavailability of curcumin in different nanoformulations.

J Sci Food Agric 2021 Mar 12. Epub 2021 Mar 12.

Department of Bioengineering, Huainan Normal University, Huainan, China.

Background: Nanoparticles can improve the bioavailability of bioactive compounds. Concomitant intake of food can affect pharmacokinetic profiles by altering dissolution, absorption, metabolism, and elimination behavior. Studies on the effects of food and its supplements on the bioavailability of bioactives in nanoformulations are few. Read More

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Rickets and gross motor delay in a child with atopic dermatitis.

Oxf Med Case Reports 2021 Feb 15;2021(2):omaa143. Epub 2021 Feb 15.

PGY-3, Dayton Children's Hospital, Dayton, OH, USA.

We report a case of a 14-month-old boy with atopic dermatitis (AD) who presented to our hospital with hypocalcemic tetany and gross motor delay. Further laboratory and imaging confirmed the diagnosis of vitamin D deficiency and rickets. He was breastfeeding and on a restricted diet due to presumed multiple food allergies. Read More

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February 2021

Research Progress of Pancreas-Related Microorganisms and Pancreatic Cancer.

Front Oncol 2020 14;10:604531. Epub 2021 Jan 14.

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Pancreatic cancer is one of the most common digestive system cancers. Early diagnosis is difficult owing to the lack of specific symptoms and reliable biomarkers. The cause of pancreatic cancer remains ambiguous. Read More

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January 2021

Recurrent urinary tract infection in women and overactive bladder - Is there a relationship?

Tzu Chi Med J 2021 Jan-Mar;33(1):13-21. Epub 2020 Jun 29.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.

Overactive bladder (OAB) in women has similar symptomatology with other common urologic diseases such as recurrent urinary tract infection (UTI). Recent evidence showed that chronic low-grade bacterial bladder colonization might exacerbate OAB symptoms and could be the etiology of recurrent UTI. The high prevalence of lower urinary tract dysfunction is associated with OAB. Read More

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Towards TB elimination: how are macro-level factors perceived and addressed in policy initiatives in a high burden country?

Global Health 2021 Jan 11;17(1):11. Epub 2021 Jan 11.

School of Population and Public Health, University of British Columbia, 2206 E Mall, Vancouver, BC, V6T 1ZE, Canada.

Background: Notwithstanding extensive general discussion of the effects of upstream forces on health, there has been limited empirical examination, let alone systematic evidence documenting policy responses to such pathways in the area of tuberculosis (TB) management and control. Our study aimed to gain insight into how macro level drivers of TB are perceived by key stakeholders involved in TB management and control in a high-endemic country, and to assess how such concerns are being addressed in policy initiatives in this setting. South Africa was chosen for this case study due to our team's long-standing collaborations there, its very high burden of TB, and its introduction of a strategic plan to combat this disease. Read More

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January 2021

Cholesterol glucosylation-based survival strategy in Helicobacter pylori.

Helicobacter 2021 Apr 23;26(2):e12777. Epub 2020 Dec 23.

Pathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, India.

Helicobacter pylori is a major chronic health problem, infecting more than half of the population worldwide. H. pylori infection is linked with various clinical complications ranging from gastritis to gastric cancer. Read More

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Locally delivered adjuvant biofilm-penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection.

J Orthop Res 2021 02 13;39(2):402-414. Epub 2021 Jan 13.

Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut, USA.

Infection is a devastating complication following an open fracture. We investigated whether local rifampin-loaded hydrogel can combat infection and improve healing in a murine model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. A transverse fracture was made at the tibia midshaft of C57BL/6J mice aged 10-12 weeks and stabilized with an intramedullary pin. Read More

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February 2021

Hospital ice, ice machines, and water as sources of nontuberculous mycobacteria: Description of qualitative risk assessment models to determine host-Nontuberculous mycobacteria interplay.

Int J Mycobacteriol 2020 Oct-Dec;9(4):347-362

Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Nightingale (Belfast City) Hospital, Belfast, Northern Ireland, UK.

Over the last 30 years, there have been at least 17 published reports of nontuberculous mycobacteria (NTMs) being isolated from hospital ice or ice-making machines. Of these, 12 were reports of pseudo-outbreaks, i.e. Read More

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December 2020

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children.

J Eur Acad Dermatol Venereol 2020 Dec 17;34(12):2717-2744. Epub 2020 Nov 17.

Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.

Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis is made using evaluated clinical criteria. Disease activity and burden are best measured with a composite score, assessing both objective and subjective symptoms, such as SCORing Atopic Dermatitis (SCORAD). Read More

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December 2020

[Strategies and studies of malaria vector control in Jiangsu Province].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Oct;32(5):459-463

Jiangsu Institute of Parasitic Diseases, WHO Collaborating Center for Research and Training on Malaria Elimination, Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Wuxi 214064, China.

Malaria was one of the major infectious diseases in Jiangsu Province, where and are main vectors for malaria transmission. Following the concerted efforts for decades, the goal of malaria elimination was achieved in Jiangsu Province in 2019, and the vector control strategy has played a vital role during the progress towards malaria elimination in Jiangsu Province. Hereby, we review the historical distribution and ecological features of and and describe vector control strategies at different stages of malaria control in Jiangsu Province. Read More

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October 2020

Oral commensal bacteria differentially modulate epithelial cell death.

Arch Oral Biol 2020 Dec 7;120:104926. Epub 2020 Oct 7.

Division of Periodontics, College of Dentistry, University of Kentucky, 800 Rose St, Lexington, KY, 40536-7001, United States; Center for Oral Health Research, College of Dentistry, University of Kentucky, 1095 VA Drive, HSRB 414, Lexington, KY, 40536-0305, United States. Electronic address:

Objective: Epithelial cell death is an important innate mechanism at mucosal surfaces, which enables the elimination of pathogens and modulates immunoinflammatory responses. Based on the antimicrobial and anti-inflammatory properties of cell death, we hypothesized that oral epithelial cell (OECs) death is differentially modulated by oral bacteria.

Material And Methods: We evaluated the effect of oral commensals Streptococcus gordonii (Sg), Streptococcus sanguinis (Ss), and Veillonella parvula (Vp), and pathogens Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), and Fusobacterium nucleatum (Fn) on OEC death. Read More

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December 2020

Environmental parasitology and its impact on the host nueroimmunoendocrine network.

Front Biosci (Landmark Ed) 2021 01 1;26:431-443. Epub 2021 Jan 1.

Departamento de Immunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, AP 70228, Ciudad de Mexico, 04510, Mexico,

The communication between neuroendocrine and immune system maintains a bidirectional complex network. Both systems jointly act during a parasite infection to maintain homeostasis and to eliminate such pathogens. Parasites interfere with the synthesis, secretion, metabolism, action, and elimination of endogenous hormones, as well as with the immune system in the host. Read More

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January 2021

IgIT-Mediated Signaling Inhibits the Antimicrobial Immune Response in Oyster Hemocytes.

J Immunol 2020 11 28;205(9):2402-2413. Epub 2020 Sep 28.

Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian 116023, China;

The long-term evolutionary interaction between the host and symbiotic microbes determines their cooperative relationship. It is well known that the symbiotic microbes have evolved various mechanisms to either benefit or exploit the mammalian host immune system to maintain homeostasis. However, the strategies employed by the symbiotic microbes to overcome host immune responses in invertebrates are still not clear. Read More

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November 2020

Susceptibility to Bacteriocins in Biofilm-Forming, Variable Staphylococci Isolated from Local Slovak Ewes' Milk Lump Cheeses.

Foods 2020 Sep 22;9(9). Epub 2020 Sep 22.

Parasitological Institute of the Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.

Seventeen staphylococci isolated from 54 Slovak local lump cheeses made from ewes' milk were taxonomically allotted to five species and three clusters/groups involving the following species: (5 strains), (3 strains), (one strain) (5 strains) and (3 strains). Five different species were determined. The aim of the study follows two lines: basic research in connection with staphylococci, and further possible application of the bacteriocins. Read More

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September 2020

Colonization of the Murine Oropharynx by Streptococcus pyogenes Is Governed by the Rgg2/3 Quorum Sensing System.

Infect Immun 2020 09 18;88(10). Epub 2020 Sep 18.

Center for Biomolecular Sciences, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

is a human-restricted pathogen most often found in the human nasopharynx. Multiple bacterial factors are known to contribute to persistent colonization of this niche, and many are important in mucosal immunity and vaccine development. In this work, mice were infected intranasally with transcriptional regulator mutants of the Rgg2/3 quorum sensing (QS) system-a peptide-based signaling system conserved in sequenced isolates of Deletion of the QS system's transcriptional activator (Δ) dramatically diminished the percentage of colonized mice, while deletion of the transcriptional repressor (Δ) increased the percentage of colonized mice compared to that of the wild type (WT). Read More

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September 2020

Complement Evasion Strategies of Human Pathogenic Bacteria.

Indian J Microbiol 2020 Sep 24;60(3):283-296. Epub 2020 Apr 24.

Laboratory of Malaria and Vaccine Research, School of Biotechnology, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, 110067 India.

Human pathogens need to overcome an elaborate network of host defense mechanisms in order to establish their infection, colonization, proliferation and eventual dissemination. The interaction of pathogens with different effector molecules of the immune system results in their neutralization and elimination from the host. The complement system is one such integral component of innate immunity that is critically involved in the early recognition and elimination of the pathogen. Read More

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September 2020

Immune Network Modeling Predicts Specific Nasopharyngeal and Peripheral Immune Dysregulation in Otitis-Prone Children.

Front Immunol 2020 11;11:1168. Epub 2020 Jun 11.

Center for Clinical Systems Biology, Research Institute, Rochester General Hospital, Rochester, NY, United States.

Acute otitis media (AOM) pathogenesis involves nasopharyngeal colonization by potential otopathogens and a viral co-infection. Stringently-defined otitis prone (sOP) children show characteristic patterns of immune dysfunction. We hypothesized that otitis proneness is largely a result of altered signaling between immune components that are otherwise competent, resulting in increased susceptibility to infection by bacterial otopathogens. Read More

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Attenuation of Proteus mirabilis colonization and swarming motility on indwelling urinary catheter by antibiofilm impregnation: An in vitro study.

Colloids Surf B Biointerfaces 2020 Oct 18;194:111207. Epub 2020 Jun 18.

Department of Biotechnology, Alagappa University, Karaikudi, India. Electronic address:

Proteus mirabilis is one of the important etiologic agents of urinary tract infections (UTI), which complicates the long-term urinary catheterization process in clinical settings. Owing to its crystalline biofilm forming ability and flagellar motility, elimination of P. mirabilis from urinary system becomes very difficult. Read More

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October 2020

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

F1000Res 2020 30;9:217. Epub 2020 Mar 30.

Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

The conventional dogma of treating cancer by focusing on the elimination of tumor cells has been recently refined to include consideration of the tumor microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein involved in adhesion and migration, has been shown to be tumor suppressive in the context of the cancer cell. However, its role in the host has not been fully investigated. Read More

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February 2021

IgE sensitivity to Malassezia pachydermatis and mite allergens in dogs with atopic dermatitis.

Vet Immunol Immunopathol 2020 Aug 21;226:110070. Epub 2020 May 21.

Department of Veterinary Microbiology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan. Electronic address:

In this study, dogs with atopic dermatitis were separated into non-food-induced atopic dermatitis (NFIAD) group (n = 15) and food-induced atopic dermatitis (FIAD) group (n = 37) based on an elimination diet test. IgE reactivity for crude Malassezia pachydermatis (M. pachydermatis) and house dust mites (HDM) allergen extracts was investigated in the two groups using fluorometric enzyme-linked immunosorbent assay (ELISA) and intradermal skin test (IDST). Read More

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Deciphering the Role of Colicins during Colonization of the Mammalian Gut by Commensal .

Microorganisms 2020 May 2;8(5). Epub 2020 May 2.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Colicins are specific and potent toxins produced by that result in the rapid elimination of sensitive cells. Colicin production is commonly found throughout microbial populations, suggesting its potential importance for bacterial survival in complex microbial environments. Nonetheless, as colicin biology has been predominately studied using synthetic models, it remains unclear how colicin production contributes to survival and fitness of a colicin-producing commensal strain in a natural environment. Read More

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