23,623 results match your criteria colon adenocarcinoma

Transforming Type II to Type I c-Met kinase inhibitors via combined scaffold hopping and structure-guided synthesis of new series of 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-one derivatives.

Bioorg Chem 2021 Aug 25;116:105304. Epub 2021 Aug 25.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Novel 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-one derivatives 3a-e, 4a-f and 5a-f were designed as Type I c-Met kinase inhibitors based on scaffold hopping of our previous Type II c-Met kinase lead. Target compounds were then synthesized under the guidance of molecular docking analysis to identify the potential inhibitors that fit the binding pocket of c-Met kinase in the characteristic manner as the reported Type I c-Met kinase inhibitors. All synthesized derivatives were evaluated for their c-Met kinase inhibitory activity at 10 µM concentration, where 3d, 5d and 5f displayed >80% inhibition. Read More

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Prognostic Immunity and Therapeutic Sensitivity Analyses Based on Differential Genomic Instability-Associated LncRNAs in Left- and Right-Sided Colon Adenocarcinoma.

Front Mol Biosci 2021 31;8:668888. Epub 2021 Aug 31.

Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

The purpose of our study was to develop a prognostic risk model based on differential genomic instability-associated (DGIA) long non-coding RNAs (lncRNAs) of left-sided and right-sided colon cancers (LCCs and RCCs); therefore, the prognostic key lncRNAs could be identified. We adopted two independent gene datasets, corresponding somatic mutation and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Identification of differential DGIA lncRNAs from LCCs and RCCs was conducted with the appliance of "Limma" analysis. Read More

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Identification of hub genes and functional modules in colon adenocarcinoma based on public databases by bioinformatics analysis.

J Gastrointest Oncol 2021 Aug;12(4):1613-1624

Department of Geratology Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Colon adenocarcinoma (COAD) is one of the most common cancers in the world. Although an extensive effort has been made to elucidate its pathogenesis, the underlying molecular mechanisms and genetic characteristics remain elusive.

Methods: In this study, protein-coding transcript expression profiles of COAD were downloaded from the Cancer RNA-Seq Nexus (CRN) database. Read More

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The predictive value of RNA binding proteins in colon adenocarcinoma.

J Gastrointest Oncol 2021 Aug;12(4):1543-1557

Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.

Background: RNA binding proteins (RBPs) play an important role in regulating post-transcriptional gene expression and have been reported to be closely associated with the occurrence and development of tumors. However, the effect of RBPs in colon cancer remains unclear.

Methods: We downloaded clinical information and transcriptome data of colon adenocarcinoma (COAD) from The Cancer Genome Atlas database (TCGA) database. Read More

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Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.

Front Immunol 2021 31;12:721030. Epub 2021 Aug 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Poly (ADP-ribose) polymerases-1 (PARP1) alterations are associated with PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in tumor cells, and high PARP1 expression is significantly associated with aggressive behavior and chemotherapeutic resistance in several tumors. However, a comprehensive analysis of the predictive values of PARP1 alteration for immune checkpoint inhibitor (ICI) effectiveness in tumors remains unclear, and the associations between its expression and immunotherapy signatures also needs to be explored further.

Methods: We performed some analyses with the cBioPortal online database (https://www. Read More

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Epidemiology and trends of gastrointestinal cancer in Iran (2004-2008).

J Cancer Res Ther 2021 Jul-Sep;17(4):963-968

Abadan Faculty of Medical Sciences, Abadan, Iran.

Aim: Gastrointestinal (GI) cancer is among the most common cancers in Iran. The main purpose of this study was to evaluate changes in the time trends of stomach, colon and rectum, and esophageal cancer during the past decade in Iran.

Materials And Methods: In this cross-sectional study, the study population was all cases of GI cancers diagnosed in Iran between 2004 and 2008. Read More

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September 2021

Influence of Colonic Mesenteric Area on the Number of Lymph Node Retrieval for Colon Cancer: A Prospective Cohort Study.

Ann Coloproctol 2021 Sep 16. Epub 2021 Sep 16.

Department of General Surgery, Bagcilar Training and Research Hospital, Istanbul, Turkey.

Purpose: The minimum harvested 12 lymph nodes (LNs) is regarded as the limit for accurate staging of nodal status in colorectal cancer patients. Besides the association of the lengths of resected intestinal segments and vascular pedicles, the mesocolic mesenteric area's impact on LN count has not been studied. We aimed to evaluate the associations between metric variables, including the mesocolic mesentery area on the nodal harvest. Read More

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September 2021

Increased Expression of Long Non-coding RNA H19 is Associated With Colon Cancer Recurrence.

J Surg Res 2021 Sep 11;269:59-68. Epub 2021 Sep 11.

Price Institute of Surgical Research, Hiram C. Polk Jr. MD Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky. Electronic address:

Background: Colon cancer is a leading cause of cancer-related death. Long non-coding (Lnc) RNAs are critical mediators of tumor biology. H19 is a well-characterized lncRNA involved in p53 regulation and cancer progression. Read More

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September 2021

Comprehensive Analysis of Gene Expression Profiles Identifies a -Related Gene Panel as a Prognostic Model in Colorectal Cancer Patients.

Cancer Biother Radiopharm 2021 Sep 13. Epub 2021 Sep 13.

Department of Gastroenterology, Chenggong Hospital, Xiamen University, Xiamen, China.

Colorectal cancer (CRC) is the leading cause of mortality worldwide. Growing evidence suggests that current pathological staging system is inadequate for efficient and accurate prognosis. In this study, we aim to build a prognosis model to predict the survival outcome of CRC patients by using gene expression profiles from The Cancer Genome Atlas (TCGA). Read More

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September 2021

Long non-coding RNA VPS9D1-AS1 promotes growth of colon adenocarcinoma by sponging miR-1301-3p and CLDN1.

Wei Liu

Hum Cell 2021 Sep 14. Epub 2021 Sep 14.

Department of Gastroenterology, The First Affiliated Hospital, Zhengzhou University, No.1, Jianshe East Road, Erqi District, Zhengzhou, 450052, Henan, China.

Colon adenocarcinoma is a frequent malignancy among all colon cancer types. Long non-coding RNAs (lncRNAs) are involved in the progression of colon adenocarcinoma. This study aimed to uncover the molecular mechanism of VPS9D1-AS1 in regulating colon adenocarcinoma development. Read More

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September 2021

Neoadjuvant Therapy in Stage II/III Rectal Cancer: A Retrospective Study in a Disparate Population and the Effect on Survival.

Dis Colon Rectum 2021 Oct;64(10):1212-1221

Department of Surgery, Lexington, Kentucky.

Background: Kentucky has one of the highest rectal cancer incidences in the United States. High poverty rates have led to poor insurance coverage and inadequate access to care. The treatment of locally advanced rectal cancer utilizes a multimodal regimen requiring regular access to expert care. Read More

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October 2021

Cardiac Tamponade as the Initial Presentation of Metastatic Esophageal Adenocarcinoma.

Cureus 2021 Aug 3;13(8):e16863. Epub 2021 Aug 3.

Cardiology, Metropolitan Hospital Center, New York Medical College, New York, USA.

Malignancy accounts for approximately 15-20% of moderate to large pericardial effusions. Pulmonary and colon are the most common primary causes. Large pleural effusions tend to present with a less dramatic clinical picture. Read More

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Melanosis Peritonei Associated With Adenocarcinoma of the Sigmoid Colon.

Cureus 2021 Jul 28;13(7):e16693. Epub 2021 Jul 28.

General Surgery, North Manchester General Hospital, Manchester, GBR.

Melanosis peritonei is an unusual and uncommon condition characterized by pigment deposition in the peritoneum. It is usually associated with other conditions. During a right inguinal hernia open repair for an 86-year-old gentleman, widespread black spots were observed on the hernial sac. Read More

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Laparoscopic Synchronous Resection for Descending Colon Cancer and Tailgut Cyst.

Acta Med Okayama 2021 Aug;75(4):529-532

Department of Diagnostic Pathology, Kochi Health Sciences Center.

A 67-year-old woman underwent polypectomy for a tumor at the descending colon. Pathologically, the tumor was diagnosed as adenocarcinoma with an invasion of 2000 μm. Computed tomography showed a swollen paracolic lymph node and a mass lesion in the presacral space. Read More

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Appendectomy is Oncologically Equivalent to Right Hemicolectomy for Well Differentiated T1 Appendiceal Adenocarcinoma.

Dis Colon Rectum 2021 Aug 18. Epub 2021 Aug 18.

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

Background: Right hemicolectomy is recommended for appendiceal adenocarcinoma but may not be needed for early-stage disease.

Objective: This study aimed to determine whether appendectomy offers adequate oncologic outcomes for T1 appendiceal adenocarcinoma from a national cohort of patients.

Design: Patients with T1 appendiceal adenocarcinoma (mucinous and non-mucinous histology) treated with either a right hemicolectomy or appendectomy between 2004-2016 were retrieved. Read More

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Organ Preservation in Rectal Cancer Patients Treated with Total Neoadjuvant Therapy.

Dis Colon Rectum 2021 Aug 18. Epub 2021 Aug 18.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York Department of Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center, New York.

Background: Retrospective studies suggest that watch-and-wait is a safe alternative to total mesorectal excision in selected patients with a clinical complete response after chemoradiotherapy.

Objective: Determine the proportion of rectal cancer patients who may benefit from watch-and-wait.

Design: Retrospective analysis of data from prospectively maintained databases. Read More

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Postoperative bleeding in essential thrombocytosis patients with colorectal cancer: Case report and literature review.

Int J Surg Case Rep 2021 Sep 6;86:106374. Epub 2021 Sep 6.

Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Introduction And Importance: Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by increased platelet count and a high risk of bleeding or thrombotic events due to platelet dysfunction. Patients with ET are treated according to their risk of complications with cytoreductive or anti-aggregant treatment. Neither guidelines for oncologic patients nor perioperative management of patients with ET have been determined. Read More

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September 2021

Tumor to Tumor Metastasis: A Case Report.

JNMA J Nepal Med Assoc 2021 Feb 28;59(234):204-206. Epub 2021 Feb 28.

Department of Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Colon carcinoma spreads locally around the intestine wall and can undergo distant metastasis via the hematogenous or lymphatic spread. It rarely metastasizes to the female genital tract and is not fully reported to involve a uterine leiomyoma. Herein we report such an unusual case of a 27 years female a known case of sigmoid colon adenocarcinoma who presented with abdominal pain with bilateral adnexal mass and per vaginal bleeding. Read More

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February 2021

Prognosis of Different Histological Types in Patients with Stage II and III Colon Cancer.

J Gastrointest Surg 2021 Sep 9. Epub 2021 Sep 9.

Division of General and Gastrointestinal Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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September 2021

Chemopreventive potential of linalool in targeting lung cancer biomarkers: An in silico & in vitro investigation.

Endocr Metab Immune Disord Drug Targets 2021 Sep 9. Epub 2021 Sep 9.

Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, Uttar Pradesh. India.

Background: Phytochemicals are used to treat lung cancer in contemporary and traditional medicine. The limitations of known chemotherapeutic drugs such as non-specificity, resistance, and toxicity restrict their use for lung cancer treatment. Therefore, the search for target-specific novel entities is required continuously. Read More

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September 2021

CBX2 Expression in Colorectal Mucosa-adenoma-adenocarcinoma Sequence.

J Coll Physicians Surg Pak 2021 Sep;31(9):1051-1056

Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Objective: To investigate the expression of chromobox 2 (CBX2) in colorectal adenoma (CRA) and colorectal cancer (CRC), and analyse its correlation with various clinicopathological parameters.

Study Design: Observational study.

Place And Duration Of Study: Pathology Department, Huashan Hospital, Fudan University, from December 2019 to December 2020. Read More

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September 2021

Combined endoscopic robotic surgery for complex colonic polyp resection: case series.

Surg Endosc 2021 Sep 7. Epub 2021 Sep 7.

Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.

Background: The study objective was to evaluate combined endoscopic and robotic surgery, a novel surgical technique modifying traditional combined endoscopic laparoscopic surgery through robotic assistance, and characterize a series of patients who underwent the modified operative technique.

Methods: A retrospective case series was performed. The first thirty-seven consecutive patients who underwent combined endoscopic robotic surgery by a single colorectal surgeon from March 2018 to October 2019 were included. Read More

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September 2021

Long noncoding RNA LINC01703 exacerbates the malignant properties of non-small-cell lung cancer by upregulating MACC1 in a microRNA-605-3p-mediated manner.

Oncol Res 2021 Sep 7. Epub 2021 Sep 7.

Long intergenic nonprotein coding RNA 1703 (LINC01703) has diagnostic significancein lung adenocarcinoma. However, its specific roles in non-small-cell lung cancer(NSCLC) and downstream mechanisms have not been investigated. In the current study,we characterized the role of LINC01703 in NSCLC malignancy and elucidated itsdetailed mechanism of action. Read More

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September 2021

Small bowel hemorrhage from check point inhibitor enteritis: a case report.

BMC Gastroenterol 2021 Sep 7;21(1):345. Epub 2021 Sep 7.

Division of Gastroenterology and Hepatology, Oregon Health and Science University, Portland, OR, USA.

Background: There is rising utilization of immune checkpoint inhibitors (ICI) for a growing number of metastatic malignancies. While gastrointestinal side effects of ICI are common, isolated ICI-induced enteritis leading to small bowel hemorrhage is rare.

Case Presentation: A 71-year-old man with a previously resected right colon adenocarcinoma on atezolizumab and recently treated Clostridioides difficile presented with acute on chronic abdominal pain and non-bloody diarrhea. Read More

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September 2021

Stable Catechol Keto Tautomers in Cytotoxic Heterodimeric Cyclic Diarylheptanoids from the Seagrass .

Org Lett 2021 Sep 7;23(18):7134-7138. Epub 2021 Sep 7.

Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.

Two diarylheptanoid heterodimers, zosterabisphenones A () and B (), were isolated from the seagrass . They feature unprecedented catechol keto tautomers, stable because of steric constraints. Their structure elucidation was based on extensive low-temperature NMR studies and ECD and MS data, with the essential aid of DFT prediction of NMR and ECD spectra. Read More

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September 2021

Aggresome-Autophagy Associated Gene HDAC6 Is a Potential Biomarker in Pan-Cancer, Especially in Colon Adenocarcinoma.

Front Oncol 2021 17;11:718589. Epub 2021 Aug 17.

Department of General Surgery, Medical College of Zhengzhou University, Zhengzhou, China.

Background: Histone deacetylase 6 (HDAC6) regulates cytoplasmic signaling networks through the deacetylation of various cytoplasmic substrates. Recent studies have identified the role of HDAC6 in tumor development and immune metabolism, but its specific function remains unclear.

Methods: The current study determined the role of HDAC6 in tumor metabolism and tumor immunity through a multi-database pan-cancer analysis. Read More

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Immunomodulating Therapy by Picibanil-based Imiquimod and Virotherapy for Advanced Uterine Cancer after Laparoscopic Surgery.

Gynecol Minim Invasive Ther 2021 Jul-Sep;10(3):191-194. Epub 2021 Aug 3.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Linkou Medical Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

This is a case report of a uterine cancer with the International Federation of Gynecology and Obstetrics staging 3c2 with the initial clinical presentation of postmenopausal vaginal bleeding in August 2015. Endometrium biopsy showed invasive nests of poorly differentiated grade 3 endometrioid adenocarcinoma. The patient received robotic surgery including total hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, para-aortic lymph node dissection, and washing cytology. Read More

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A case of appendix adenocarcinoma associated with ulcerative colitis.

Clin Case Rep 2021 Sep 30;9(9):e04768. Epub 2021 Aug 30.

Division of Gastroenterology Kusatsu General Hospital Kusatsu Japan.

Ulcerative colitis (UC) is a chronic relapsing inflammatory disorder of the colon. Patients with UC have an increased risk of developing colorectal cancer. However, appendix adenocarcinoma associated with UC is extremely rare. Read More

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September 2021

Racial Differences in the Phenotype of Colorectal Cancer: A Prospective Comparison Between Nigeria and South Africa.

World J Surg 2021 Sep 5. Epub 2021 Sep 5.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Introduction: There are significant differences in the phenotype of CRC by race in the U.S. A similar CRC phenotype-race relationship also appears to exist in South Africa (SA). Read More

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September 2021

Polystyrene nanoplastics exacerbated the ecotoxicological and potential carcinogenic effects of tetracycline in juvenile grass carp (Ctenopharyngodon idella).

Sci Total Environ 2021 Aug 30;803:150027. Epub 2021 Aug 30.

College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), 528478, China; Institute of Eco-Environmental Research, Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Biophysical and Environmental Science Research Center, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

This study aims to evaluate the ecotoxicity effects of single tetracycline (TC) exposure and mixture exposure in presence of polystyrene nanoplastics (PS-NPs, 80 nm) on juvenile Ctenopharyngodon idella. We carried out single and combined exposure of TC (5000 μg/L) and PS-NPs (20, 200, 2000 μg/L) for 7 days. Compared to TC single exposure, co-exposure to PS-NPs and TC significantly changed the levels of antioxidant entities, including T-AOC, SOD, and CAT in the liver and intestine of C. Read More

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