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: R-Based Software Toolbox for Untargeted Metabolomics with Bladder Cancer Biomarkers Discovery Case Study.

J Proteome Res 2021 Jun 23. Epub 2021 Jun 23.

Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.

Large-scale untargeted LC-MS-based metabolomic profiling is a valuable source for systems biology and biomarker discovery. Data analysis and processing are major tasks due to the high complexity of generated signals and the presence of unwanted variations. In the present study, we introduce an R-based open-source collection of scripts called (), which provides comprehensive data processing. Read More

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Woven EndoBridge device for the treatment of ruptured intracranial aneurysms: A systematic review of clinical and angiographic results.

Interv Neuroradiol 2021 Jun 23:15910199211026712. Epub 2021 Jun 23.

Department of Interventional Radiology and Vascular Surgery, the First Affiliated Hospital of Hunan Normal University, Changsha, China.

Background And Objective: The clinical outcome and angiographic outcome data of Woven EndoBridge (WEB) device for the treatment of ruptured intracranial aneurysms (IAs) are limited. We conducted a meta-analysis of the latest literature on the WEB device in the treatment of ruptured IAs.

Methods: A comprehensive literature search of 4 databases (PubMed, Web of Science, Cochrane library, and Embase) was conducted for studies published from January 1, 2010 to December 31, 2020. Read More

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Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis.

Cochrane Database Syst Rev 2021 Jun 23;6:CD002007. Epub 2021 Jun 23.

Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.

Background: The choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and reduction of drug-related toxicity. Current evidence does not provide a clear answer and the use of intravenous antibiotic therapy in CF requires further evaluation. Read More

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How Nurses Apply Patterns of Knowing in Clinical Practice: A Grounded Theory Study.

Ethiop J Health Sci 2021 Jan;31(1):139-146

Correspondence: PhD of Nursing, Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Nurses require a great deal of knowledge to provide a comprehensive and effective nursing care. A number of patterns have been put into place to help nurses acquire this knowledge. The aim of this study was to describe the core variable in the process of using patterns of knowing by nurses in clinical practice. Read More

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January 2021

Models of care for patients with knee osteoarthritis in primary healthcare: a scoping review protocol.

BMJ Open 2021 Jun 22;11(6):e045358. Epub 2021 Jun 22.

NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisbon, Portugal.

Introduction: Knee osteoarthritis (OA) is a prevalent condition with associated high disability and healthcare costs. Evidence of major gaps in the implementation of evidence-based interventions in people with knee OA led several healthcare systems to implement models of care (MoCs) in order to improve knowledge translation and guaranty their economic sustainability. Nevertheless, there are few studies that analyse the existing body of evidence of MoCs for patients with knee OA in primary healthcare settings. Read More

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Antiviral drugs proposed for COVID-19: action mechanism and pharmacological data.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):4163-4173

Faculty of Life Science and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Objective: As a beta-coronavirus, Coronavirus disease-2019 (COVID-19) has caused one of the most significant historical pandemics, as well as various health and medical challenges. Our purpose in this report is to collect, summarize, and articulate all essential information about antiviral drugs that may or may not be efficient for treating COVID-19. Clinical evidence about these drugs and their possible mechanisms of action are also discussed. Read More

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Cultivating the Bacterial Microbiota of Roots.

mSystems 2021 Jun 22:e0130620. Epub 2021 Jun 22.

Biosciences Division, Oak Ridge National Laboratorygrid.135519.a, Oak Ridge, Tennessee, USA.

The integral role of microbial communities in plant growth and health is now widely recognized, and, increasingly, the constituents of the microbiome are being defined. While phylogenetic surveys have revealed the taxa present in a microbiome and show that this composition can depend on, and respond to, environmental perturbations, the challenge shifts to determining why particular microbes are selected and how they collectively function in concert with their host. In this study, we targeted the isolation of representative bacterial strains from environmental samples of roots using a direct plating approach and compared them to amplicon-based sequencing analysis of root samples. Read More

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Insights into the Cultured Bacterial Fraction of Corals.

mSystems 2021 Jun 22:e0124920. Epub 2021 Jun 22.

Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Bacteria associated with coral hosts are diverse and abundant, with recent studies suggesting involvement of these symbionts in host resilience to anthropogenic stress. Despite their putative importance, the work dedicated to culturing coral-associated bacteria has received little attention. Combining published and unpublished data, here we report a comprehensive overview of the diversity and function of culturable bacteria isolated from corals originating from tropical, temperate, and cold-water habitats. Read More

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THE EFFECT OF COMPREHENSIVE TREATMENT OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH PREDIABETES ON THE LIPID PROFILE.

Wiad Lek 2021 ;74(4):957-760

STATE HIGHER EDUCATIONAL ESTABLISHMENT «UZHHOROD NATIONAL UNIVERSITY», UZHHOROD, UKRAINE.

Objective: The aim: To evaluate the efficiency of the proposed therapy, which included recommendations for nutrition, physical activity and treatment with rosuvastatin, omega-3 PUFA and ursodeoxycholic acid, on the indicators of the lipid profile in patients with NAFLD and prediabetes.

Patients And Methods: Materials and methods: 78 patients with impaired glucose tolerance were examined. According to the inclusion and exclusion criteria, 55 patients with prediabetes and concomitant NAFLD were included in the study. Read More

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The household financial burden of non-communicable diseases in low- and middle-income countries: a systematic review.

Health Res Policy Syst 2021 Jun 21;19(1):96. Epub 2021 Jun 21.

Department of Global Public Health, Karolinska Institutet, Solna, Sweden.

Background: The chronic nature of noncommunicable diseases (NCD) and costs associated with long-term care can result in catastrophic health expenditure for the patient and their household pushing them deeper into poverty and entrenching inequality in society. As the full financial burden of NCDs is not known, the objective of this study was to explore existing evidence on the financial burden of NCDs in low- and middle-income countries (LMICs), specifically estimating the cost incurred by patients with NCDs and their households to inform the development of strategies to protect such households from catastrophic expenditure.

Methods: This systematic review followed the PRISMA guidelines, PROSPERO: CRD42019141088. Read More

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Assessment of Preoperative Functional Status Prior to Major Head and Neck Surgery: A Pilot Study.

Otolaryngol Head Neck Surg 2021 Jun 22:1945998211019306. Epub 2021 Jun 22.

Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Objective: To demonstrate feasibility of a recently developed preoperative assessment tool, the Vulnerable Elders Surgical Pathways and Outcomes Analysis (VESPA), to characterize the baseline functional status of patients undergoing major head and neck surgery and to examine the relationship between preoperative functional status and postoperative outcomes.

Study Design: Case series with planned data collection.

Setting: Two tertiary care academic hospitals. Read More

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Development of GBTS and KASP Panels for Genetic Diversity, Population Structure, and Fingerprinting of a Large Collection of Broccoli ( L. var. ) in China.

Front Plant Sci 2021 4;12:655254. Epub 2021 Jun 4.

Institute of Vegetables, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.

Broccoli ( var. ) is one of the most important and nutritious vegetables widely cultivated in China. In the recent four decades, several improved varieties were bred and developed by Chinese breeders. Read More

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The top 100 highly cited articles on anterior cruciate ligament from 2000 to 2019: A bibliometric and visualized analysis.

Orthop Traumatol Surg Res 2021 Jun 16:102988. Epub 2021 Jun 16.

Rehabilitation Medicine Department, The Affiliated Hospital Of Southwest Medical University, Luzhou, Sichuan, People's Republic of China; Department of Rehabilitation Medicine, Southwest Medical University, Luzhou, Sichuan, People's Republic of China. Electronic address:

Introduction: Bibliometrics can trace the overall research trend in a specific field. To our knowledge, there has been no comprehensive bibliometric analysis of all anterior cruciate ligament (ACL) research from 2000-2019. We provided a bibliometric and visualized analysis of the top 100 highly-cited articles on ACL indexed by the Web of Science (WoS) to provide researchers with the present research status and the potential direction of ACL research. Read More

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Indicator displacement assays: from concept to recent developments.

Org Biomol Chem 2021 Jun 18. Epub 2021 Jun 18.

Organic and Supramolecular Functional Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, Okhla, New Delhi 110025, India.

Overcoming the synthetic burden related to covalently connected receptors with appropriate indicators for sensing various analytes via an indicator spacer receptor (ISR) approach, the indicator displacement assay (IDA) seems to be a very sophisticated and versatile supramolecular sensing paradigm, and it has taken the phenomenon of molecular recognition to the next level in the realm of host-guest chemistry. Due to the unavailability of a comprehensive report on what has been done in the last decade in relation to IDAs, we decided to set down this account illustrating diverse indicator displacement assays (IDAs) in detail from the concept stage to recent developments relating to the detection of cationic, anionic, and neutral analytes. The authors conclude this account with future perspectives and highlight the limitations and challenges relating to IDAs which need to be overcome in order to realize the full potential of this popular sensing phenomenon. Read More

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Ecological Morphology of Neotropical Bat Wing Structures.

Zool Stud 2020 20;59:e60. Epub 2020 Nov 20.

Pontificia Universidad Javeriana, Unidad de Ecología y Sistemática (UNESIS), Bogotá 11001000, Colombia. E-mail:

Morphology has a direct influence on animal fitness. Studies addressing the identification of patterns and variations across several guilds are fundamental in ecomorphological research. Wings are the core of ecological morphology in bats; nevertheless, individual bones and structures that support the wing, including metacarpals, phalanges and the length of digits, have rarely been the subject of comprehensive research when studying wing morphology. Read More

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November 2020

Triglycerides and Residual Atherosclerotic Risk.

J Am Coll Cardiol 2021 Jun;77(24):3031-3041

National Center for Cardiovascular Research (CNIC), Madrid, Spain; Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: Even when low-density lipoprotein-cholesterol (LDL-C) levels are lower than guideline thresholds, a residual risk of atherosclerosis remains. It is unknown whether triglyceride (TG) levels are associated with subclinical atherosclerosis and vascular inflammation regardless of LDL-C.

Objectives: This study sought to assess the association between serum TG levels and early atherosclerosis and vascular inflammation in apparently healthy individuals. Read More

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Exploring the Gray Area: Similarities and Differences in Questionable Research Practices (QRPs) Across Main Areas of Research.

Sci Eng Ethics 2021 Jun 16;27(4):40. Epub 2021 Jun 16.

Department of Political Science, The Danish Centre for Studies in Research and Research Policy, Aarhus University, Bartholins Allé 7, 8000, Aarhus C, Denmark.

This paper explores the gray area of questionable research practices (QRPs) between responsible conduct of research and severe research misconduct in the form of fabrication, falsification, and plagiarism (Steneck in SEE 12(1): 53-57, 2006). Up until now, we have had very little knowledge of disciplinary similarities and differences in QRPs. The paper is the first systematic account of variances and similarities. Read More

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Human immunodeficiency virus status disclosure among people living with human immunodeficiency virus receiving care in Enugu, Nigeria: A mixed method study.

Indian J Public Health 2021 Apr-Jun;65(2):172-177

University of Nigeria Teaching Hospital Enugu, Ituku, Nigeria.

Background: Disclosure of human immunodeficiency virus (HIV) status has potential benefits for both the individual and society.

Objectives: This study aimed to determine the disclosure rate and its associated factors in people living with HIV receiving care in Enugu, Nigeria.

Methods: A cross-sectional study using mixed methods was carried out in 5 comprehensive treatment facilities in Enugu, Nigeria during March to August 2019. Read More

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Designing and Implementing an IT Architecture for a Digital Multicenter Dementia Registry: digiDEM Bayern.

Appl Clin Inform 2021 May 16;12(3):551-563. Epub 2021 Jun 16.

Department of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background:  Registries are an essential research tool to investigate the long-term course of diseases and their impact on the affected. The project digiDEM Bayern will set up a prospective dementia registry to collect long-term data of people with dementia and their caregivers in Bavaria (Germany) supported by more than 300 research partners.

Objective:  The objective of this article is to outline an information technology (IT) architecture for the integration of a registry and comprehensive participant management in a dementia study. Read More

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Digitalization of contact tracing: balancing data privacy with public health benefit.

Authors:
Jeremy Wacksman

Ethics Inf Technol 2021 Jun 10:1-7. Epub 2021 Jun 10.

Department of Health Administration, College of Health Professions, Virginia Commonwealth University (VCU), Richmond, VA USA.

The COVID-19 pandemic has brought the long-standing public health practice of contact tracing into the public spotlight. While contact tracing and case investigation have been carefully designed to protect privacy, the huge volume of tracing which is being carried out as part of the pandemic response in the United States is highlighting potential concerns around privacy, legality, and equity. Contact tracing during the pandemic has gained particular attention for the new use of digital technologies-both on the consumer side in the form of Exposure Notification applications, and for public health agencies as digital case management software systems enable massive scaling of operations. Read More

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A global database of plant services for humankind.

PLoS One 2021 15;16(6):e0253069. Epub 2021 Jun 15.

Wadham College, University of Oxford, Oxford, United Kingdom.

Humanity faces the challenge of conserving the attributes of biodiversity that may be essential to secure human wellbeing. Among all the organisms that are beneficial to humans, plants stand out as the most important providers of natural resources. Therefore, identifying plant uses is critical to preserve the beneficial potential of biodiversity and to promote basic and applied research on the relationship between plants and humans. Read More

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Incidence of Complications from Percutaneous Biopsy in Chronic Liver Disease: A Systematic Review and Meta-Analysis.

Dig Dis Sci 2021 Jun 15. Epub 2021 Jun 15.

Global Liver Institute, Washington, USA.

Background: Approaches to liver biopsy have changed over the past decade in patients with chronic liver disease.

Aims: We conducted a systematic review and meta-analysis on the incidence of all complications and technical failure associated with percutaneous liver biopsy.

Methods: We systematically searched PubMed and the Cochrane Library for cohort studies reporting on complications resulting from liver biopsy published between 2010 and 2020. Read More

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A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome.

Commun Biol 2021 Jun 14;4(1):730. Epub 2021 Jun 14.

Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in the fate-specification step has been reported, the mechanisms and key regulators underlying the accelerated proliferation of astrocyte precursor cells (APCs) in DS remain elusive. Here, we established a human isogenic cell line panel based on DS-specific induced pluripotent stem cells, the XIST-mediated transcriptional silencing system in trisomic chromosome 21, and genome/chromosome-editing technologies to eliminate phenotypic fluctuations caused by genetic variation. Read More

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Sensitive detection and quantification of SARS-CoV-2 in saliva.

Sci Rep 2021 06 14;11(1):12425. Epub 2021 Jun 14.

Section of Hematology and Oncology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.

Saliva has significant advantages as a test medium for detection of SARS-CoV-2 infection in patients, such as ease of collection, minimal requirement of supplies and trained personnel, and safety. Comprehensive validation in a large cohort of prospectively collected specimens with unknown SARS-CoV-2 status should be performed to evaluate the potential and limitations of saliva-based testing. We developed a saliva-based testing pipeline for detection of SARS-CoV-2 nucleic acids using real-time reverse transcription PCR (RT-PCR) and droplet digital PCR (ddPCR) readouts, and measured samples from 137 outpatients tested at a curbside testing facility and 29 inpatients hospitalized for COVID-19. Read More

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TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood.

EBioMedicine 2021 Jun 10:103429. Epub 2021 Jun 10.

Dipartimento di Medicina Sperimentale e Clinica (DMSC), Laboratory of Neuroimmunology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. Electronic address:

Background: T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the T-cell receptor (TCR) repertoire in cerebrospinal fluid (CSF) of MS patients by high-throughput sequencing (HTS), a deep analysis on repertoire similarities and differences among compartments is still missing.

Methods: We performed comprehensive bioinformatics on high-dimensional TCR Vβ sequencing data from published and unpublished MS and healthy donors (HD) studies. Read More

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Intravesical gemcitabine for non-muscle invasive bladder cancer.

Cochrane Database Syst Rev 2021 Jun 14;6:CD009294. Epub 2021 Jun 14.

Urology Section, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.

Background: It remains unclear whether people with non-muscle invasive bladder cancer (NMIBC) benefit from intravesical gemcitabine compared to other agents in the primary or recurrent setting following transurethral resection of a bladder tumor. This is an update of a Cochrane Review first published in 2012. Since that time, several randomized controlled trials (RCTs) have been reported, making this update relevant. Read More

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Visual or visual-tactile examination to detect and inform the diagnosis of enamel caries.

Cochrane Database Syst Rev 2021 Jun 14;6:CD014546. Epub 2021 Jun 14.

Dundee Dental School, University of Dundee, Dundee, UK.

Background: The detection and diagnosis of caries at the initial (non-cavitated) and moderate (enamel) levels of severity is fundamental to achieving and maintaining good oral health and prevention of oral diseases. An increasing array of methods of early caries detection have been proposed that could potentially support traditional methods of detection and diagnosis. Earlier identification of disease could afford patients the opportunity of less invasive treatment with less destruction of tooth tissue, reduce the need for treatment with aerosol-generating procedures, and potentially result in a reduced cost of care to the patient and to healthcare services. Read More

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The relationship between rheumatoid arthritis and diabetes mellitus: a systematic review and meta-analysis.

Cardiovasc Endocrinol Metab 2021 Jun 19;10(2):125-131. Epub 2021 Feb 19.

Division of Diabetes, Endocrinology and Gastroenterology.

Objective: This systematic review/meta-analysis was conducted to investigate the relationship between rheumatoid arthritis and the incidence of diabetes mellitus.

Methods: A comprehensive search was conducted up to 10 March 2020 in Medline (via Ovid), Embase (via Ovid) and Web of Science core collection to identify cohort studies comparing the risk of diabetes mellitus incidence in people with rheumatoid arthritis with the general population. The I2 statistic was used to test heterogeneity. Read More

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Respectful maternity care in public health care facilities in Gujarat: A direct observation study.

J Family Med Prim Care 2021 Apr 29;10(4):1699-1705. Epub 2021 Apr 29.

Parul Institute of Public Health, Parul University, Waghodia, Gujarat, India.

Introduction: Respectful maternity care (RMC) is not only the marker of quality maternity care but also ensures the protection of basic human rights of every child-bearing woman. This paper discusses the assessment of RMC services during the intrapartum period at public health care facilities in Gujarat state.

Material And Methods: A cross-sectional research design was used for the study. Read More

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