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Advanced multichannel submersible probe for autonomous high-resolution in situ monitoring of the cycling of the potentially bioavailable fraction of a range of trace metals.

Chemosphere 2021 May 29;282:131014. Epub 2021 May 29.

University of Bordeaux, UMR CNRS 5805 EPOC, 33615 Pessac, France.

We report here on the development and application of a submersible, compact, low power consumption, integrated multichannel trace metal sensing probe (TracMetal). This probe is unique in that it allows high-resolution, simultaneous in-situ measurements of the potentially bioavailable (so-called dynamic) fraction of Hg(II), As(III), Cd(II), Pb(II), Cu(II), Zn(II). The TracMetal incorporates nanostructured Au-plated and Hg-plated gel-integrated microelectrode arrays. Read More

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Managing Defects Density and Interfacial Strain via Underlayer Engineering for Inverted CsPbI Br Perovskite Solar Cells with All-Layer Dopant-Free.

Small 2021 Jun 12:e2101902. Epub 2021 Jun 12.

Soochow Institute for Energy and Materials Innovation (SIEMIS), School of Energy, Soochow University, Suzhou, 215006, China.

Inorganic perovskite CsPbI Br has advantages of excellent thermal stability and reasonable bandgap, which make it suitable for top layer of tandem solar cells. Nevertheless, solution-processed all-inorganic perovskites generally suffer from high-density defects as well as significant tensile strain near underlayer/perovskite interface, both leading to compromised device efficiency and stability. In this work, the defect density as well as interfacial tensile strain in inverted CsPbI Br perovskite solar cells (PeSCs) is remarkably reduced by using a bilayer underlayer composed of dopant-free 2,2',7,7'-tetrakis(N,N-dip-methoxyphenylamine)-9,9'-spirobifluorene (Spiro-OMeTAD) and copper phthalocyanine 3,4',4″,4'″-tetrasulfonated acid tetrasodium salt (TS-CuPc) nanoparticles. Read More

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Recurrent neural network-based acute concussion classifier using raw resting state EEG data.

Sci Rep 2021 Jun 11;11(1):12353. Epub 2021 Jun 11.

Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Concussion is a global health concern. Despite its high prevalence, a sound understanding of the mechanisms underlying this type of diffuse brain injury remains elusive. It is, however, well established that concussions cause significant functional deficits; that children and youths are disproportionately affected and have longer recovery time than adults; and that individuals suffering from a concussion are more prone to experience additional concussions, with each successive injury increasing the risk of long term neurological and mental health complications. Read More

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Safety and Efficacy of the Woven EndoBridge Device for Treatment of Ruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis.

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Neurosurgery (M.A.E., G.L., W.B.), Mayo Clinic, Rochester, Minnesota.

Background: The Woven EndoBridge device has been increasingly used to treat wide-neck aneurysms, particularly ruptured ones.

Purpose: Our aim was to investigate the safety and efficacy of the Woven EndoBridge device in the treatment of ruptured intracranial aneurysms.

Data Sources: All studies evaluating the outcomes of Woven EndoBridge device use in the treatment of ruptured intracranial aneurysms from inception through 2020 were searched on Ovid Evidence-Based Medicine Reviews, EMBASE, MEDLINE, Scopus, and the Web of Science Core Collection. Read More

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Philadelphia chromosome-positive B-lymphoblastic lymphoma successfully treated with chemotherapy regimen containing imatinib: A rare case report and literature review.

Medicine (Baltimore) 2021 Jun;100(23):e26323

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Rationale: B-lymphoblastic lymphoma (B-LBL) with BCR/ABL mutation (Ph+ B-LBL) is a rare type of cancer in both childhood and adults. Its clinical manifestations are similar to those of other types lymphoma. However, the targeted therapy can substantially improve the outcome of Ph+ B-LBL. Read More

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Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out.

Lab Chip 2021 Jun 11. Epub 2021 Jun 11.

KTH Royal Institute of Technology, Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, Solna, Sweden. and AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet and, KTH Royal Institute of Technology, Stockholm, Sweden.

With its origin estimated around December 2019 in Wuhan, China, the ongoing SARS-CoV-2 pandemic is a major global health challenge. The demand for scalable, rapid and sensitive viral diagnostics is thus particularly pressing at present to help contain the rapid spread of infection and prevent overwhelming the capacity of health systems. While high-income countries have managed to rapidly expand diagnostic capacities, such is not the case in resource-limited settings of low- to medium-income countries. Read More

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Semi-automatic stitching of filamentous structures in image stacks from serial-section electron tomography.

J Microsc 2021 Jun 10. Epub 2021 Jun 10.

Zuse Institute Berlin, Takustraße 7, Berlin, 14195, Germany.

We present a software-assisted workflow for the alignment and matching of filamentous structures across a three-dimensional (3D) stack of serial images. This is achieved by combining automatic methods, visual validation, and interactive correction. After the computation of an initial automatic matching, the user can continuously improve the result by interactively correcting landmarks or matches of filaments. Read More

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An Evidence-Based Theory About PRO Use in Kidney Care: A Realist Synthesis.

Patient 2021 Jun 10. Epub 2021 Jun 10.

Sociology and Social Policy, University of Leeds, Leeds, UK.

Background: There is international interest on the use of patient-reported outcomes (PROs) in nephrology.

Objectives: Our objectives were to develop a kidney-specific program theory about use of PROs in nephrology that may enhance person-centered care, both at individual and aggregated levels of care, and to test and refine this theory through a systematic review of the empirical literature. Together, these objectives articulate what works or does not work, for whom, and why. Read More

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High-resolution time-of-flight PET detector with 100 ps coincidence time resolution using a side-coupled phoswich configuration.

Phys Med Biol 2021 Jun 9;66(12). Epub 2021 Jun 9.

Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Stanford University, CA, United States of America.

Photon time-of-flight (TOF) capability in positron emission tomography (PET) enables reconstructed image signal-to-noise ratio (SNR) improvement. With the coincidence time resolution (CTR) of 100 picosecond (ps), a five-fold SNR improvement can be achieved with a 40 cm diameter imaging subject, relative to a system without TOF capability. This 100 ps CTR can be achieved for adetector design (crystal element length ≥20 mm with reasonably high crystal packing fraction) using a side-readout PET detector configuration that enables 511 keV photon interaction depth-independent light collection efficiency and lower variance in scintillation photon transit time to the silicon photomultiplier (SiPM). Read More

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Bio-inspired fractal textile device for rapid sweat collection and monitoring.

Lab Chip 2021 Jun 8. Epub 2021 Jun 8.

Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan. and Advanced Research Center for Green Materials Science and Technology, National Taiwan University, Taipei, Taiwan.

In this study, a new design concept in sweat collection was developed to achieve rapid and intact sweat sampling for analytical purposes. Textiles with fast water wicking properties were first selected and laser engraved into tree-like bifurcating channels for sweat collection. The fractal framework of the bifurcating textile channels was theoretically derived to minimize the flow resistance for fast sweat absorption. Read More

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Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: a systematic review.

Addict Sci Clin Pract 2021 Jun 8;16(1):36. Epub 2021 Jun 8.

University of Connecticut School of Pharmacy, 69 N Eagleville Rd Unit 3092, Storrs, CT, 06269, USA.

Background: Opioid withdrawal symptoms prior to buprenorphine initiation may be intolerable and as a result, alternative strategies have emerged. We aim to systematically review the efficacy and safety of buprenorphine initiation that aims to omit prerequisite withdrawal.

Methods: We conducted a systematic literature search of MEDLINE and CENTRAL from 1996 through April 10, 2020, augmented with searches in Google Scholar and www. Read More

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Efficacy of phloroglucinol in shortening the first stage of labor: systematic review and meta-analysis of randomized controlled trials.

J Matern Fetal Neonatal Med 2021 Jun 8:1-7. Epub 2021 Jun 8.

Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.

Background: Protracted labor is associated with an elevated risk of maternal and fetal complications. Results of randomized controlled trials on the efficacy in labor of phloroglucinol (PHL), a pure antispasmodic drug, are uncertain.

Objectives: To evaluate whether PHL is effective in shortening the first stage of labor. Read More

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The Case for Onlay Biologic Mesh in Abdominal Wall Reconstruction Using Progressive Tension Suture Fixation.

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S498-S502

From the Division of Plastic Surgery, University of Alabama at Birmingham School of Medicine.

Background: After many years of debate, underlay and sublay placement of mesh slowly emerged as the standard of care in abdominal wall reconstruction because of lower hernia recurrence rates. However, onlay has the advantages of being faster, less invasive, and technically easier compared with underlay and sublay. Therefore, if a similar recurrence could be achieved, then onlay should be a consideration. Read More

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E-Mentoring Female Underrepresented Public Health Student Researchers: Supporting a More Diverse Postpandemic Workforce.

Health Secur 2021 Jun 7. Epub 2021 Jun 7.

Ponn P. Mahayosnand, MPH, and Sheilamae Ablay, PhD, are Research Scholars; both at the Ronin Institute for Independent Scholarship, Montclair, NJ. Lavezza Zanders is a Student, School of Medicine, International University of Health Sciences, St. Kitts, West Indies. Z. M. Sabra and D. M. Sabra are Students, Faculty of Medicine, Islamic University of Gaza, Gaza Strip. Saman Essa is a Student, Department of Psychological, Health, and Learning Sciences, College of Education, University of Houston, Houston, TX. Samiha Ahmed is a Student, Department of Epidemiology and Biostatistics, School of Public Health, University of Maryland, College Park, MD. Diana Mora Bermejo is a Student, Department of Health, Policy, and Management and Department of Global Studies, Providence College, Providence, RI. Maryam Funmilayo, MA, is a Student, Department of Health and Kinesiology, College of Education and Health, Lamar University, Beaumont, TX.

Within higher education, underrepresented students continue to face inequalities and discrimination, with unique challenges surfacing during the COVID-19 pandemic. Mentoring through formal or informal channels is one way to offer assistance to such students. During COVID-19 lockdowns, as classes and work moved online, mentoring also transitioned online. Read More

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Selective Facial Muscle Activation with Acute and Chronic Multichannel Cuff Electrode Implantation in a Feline Model.

Ann Otol Rhinol Laryngol 2021 Jun 6:34894211023218. Epub 2021 Jun 6.

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.

Objectives: Facial paralysis is a debilitating condition with substantial functional and psychological consequences. This feline-model study evaluates whether facial muscles can be selectively activated in acute and chronic implantation of 16-channel multichannel cuff electrodes (MCE).

Methods: Two cats underwent acute terminal MCE implantation experiments, 2 underwent chronic MCE implantation in uninjured facial nerves (FN) and tested for 6 months, and 2 underwent chronic MCE implantation experiments after FN transection injury and tested for 3 months. Read More

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Trade-off mitigation: a conceptual framework for understanding floral adaptation in multispecies interactions.

Biol Rev Camb Philos Soc 2021 Jun 7. Epub 2021 Jun 7.

Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord St., Toronto, ON, M5S 3G5, Canada.

Explanations of floral adaptation to diverse pollinator faunas have often invoked visitor-mediated trade-offs in which no intermediate, generalized floral phenotype is optimal for pollination success, i.e. fitness valleys are created. Read More

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Video Assisted Thoracoscopy as a therapeutic modality in evacuating retained or clotted haemothoraces.

J Pak Med Assoc 2021 May;71(5):1428-1431

Department of Thoracic Surgery, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Objective: To determine the role of video-assisted thoracoscopy for evacuating retained / clotted haemothoraces to minimise the duration of chest tube drainage and length of hospital stay.

Methods: The prospective cohort study was conducted from July 2019 to February 2020 at the Department of Thoracic Surgery, Jinnah Postgraduate Medical Centre, Karachi, and comprised consecutive patients who underwent video-assisted thoracoscopy for retained or clotted haemothoraces. Outcome was measured as evacuation of retained haemothoraces resulting in partial or complete lung expansion and length of hospital stay. Read More

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Successful autologous peripheral blood stem cell collection using large volume leukapheresis in patients with very low or undetectable peripheral blood CD34+ progenitor cells.

Transfus Apher Sci 2021 May 21:103170. Epub 2021 May 21.

Department of Pathology, University of Iowa, Iowa City, IA, USA. Electronic address:

Autologous stem cell transplantation provides some patients with hematolymphoid and solid organ malignancies an opportunity for cure. Management of peripheral hematopoietic stem cell (HSC) collections differs among institutions, especially if a very low pre-procedure peripheral blood CD34+ cell count (PBCD34) is demonstrated. This study retrospectively analyzed results of large-volume peripheral HSC collections in 91 patients over approximately two years. Read More

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Raman spectroscopy for real-time and in situ monitoring of mechanochemical milling reactions.

Nat Protoc 2021 Jun 4. Epub 2021 Jun 4.

Ruđer Bošković Institute, Zagreb, Croatia.

Solid-state milling has emerged as an alternative, sustainable approach for preparing virtually all classes of compounds and materials. In situ reaction monitoring is essential to understanding the kinetics and mechanisms of these reactions, but it has proved difficult to use standard analytical techniques to analyze the contents of the closed, rapidly moving reaction chamber (jar). Monitoring by Raman spectroscopy is an attractive choice, because it allows uninterrupted data collection from the outside of a translucent milling jar. Read More

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Exploring medical ethics' implementation challenges: A qualitative study.

J Educ Health Promot 2021 27;10:66. Epub 2021 Feb 27.

Endocrinology and Metabolism Research Center, Medical Ethics and History of Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Adherence to medical ethics principles by medical professionals is required to improve health-care system's quality. Recognizing medical ethics' challenges and attempting to resolve them are important in the implementation of medical ethics in practice. This study aimed to explore such challenges at Iran's medical sciences universities in 2018. Read More

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February 2021

Cartilage Conduction Hearing Aid Fitting in Clinical Practice.

J Am Acad Audiol 2021 Jun 3. Epub 2021 Jun 3.

Department of Otolaryngology, Kochi Medical School, Kochi University, Oko-cho, Nankoku-shi, Kochi, Japan.

Background:  Cartilage conduction hearing aids (CCHAs) were newly devised and spread fast in Japan since their launch in 2017. However, little knowledge is available for this new device.

Purpose:  The aim of this study was to establish the knowledge of CCHAs and suggest their indication. Read More

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Deep into Laboratory: An Artificial Intelligence Approach to Recommend Laboratory Tests.

Diagnostics (Basel) 2021 May 29;11(6). Epub 2021 May 29.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.

Laboratory tests are performed to make effective clinical decisions. However, inappropriate laboratory test ordering hampers patient care and increases financial burden for healthcare. An automated laboratory test recommendation system can provide rapid and appropriate test selection, potentially improving the workflow to help physicians spend more time treating patients. Read More

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Platinum-Based Interdigitated Micro-Electrode Arrays for Reagent-Free Detection of Copper.

Sensors (Basel) 2021 May 19;21(10). Epub 2021 May 19.

Nanotechnology Group, Tyndall National Institute, T12 R5CP Cork, Ireland.

Water is a precious resource that is under threat from a number of pressures, including, for example, release of toxic compounds, that can have damaging effect on ecology and human health. The current methods of water quality monitoring are based on sample collection and analysis at dedicated laboratories. Recently, electrochemical-based methods have attracted a lot of attention for environmental sensing owing to their versatility, sensitivity and their ease of integration with cost effective, smart and portable readout systems. Read More

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SalivaSTAT: Direct-PCR and Pooling of Saliva Samples Collected in Healthcare and Community Setting for SARS-CoV-2 Mass Surveillance.

Diagnostics (Basel) 2021 May 19;11(5). Epub 2021 May 19.

Department of Pathology, Medical College of Georgia, Augusta University, GA 30901, USA.

Objectives: Limitations of widespread current COVID-19 diagnostic testing exist in both the pre-analytical and analytical stages. To alleviate these limitations, we developed a universal saliva processing protocol (SalivaSTAT) that would enable an extraction-free RT-PCR test using commercially available RT-PCR kits.

Methods: We optimized saliva collection devices, heat-shock treatment, and homogenization. Read More

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Functional and Material Properties in Nanocatalyst Design: A Data Handling and Sharing Problem.

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Institute of Chemistry, Faculty of Science and Technology, University of Silesia, Szkolna 9, 40-006 Katowice, Poland.

(1) Background: Properties and descriptors are two forms of molecular in silico representations. Properties can be further divided into functional, e.g. Read More

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Thermally Activated Delayed Fluorescence in Commercially Available Materials for Solution-Process Exciplex OLEDs.

Polymers (Basel) 2021 May 20;13(10). Epub 2021 May 20.

Department of Electronic Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan.

Organic light-emitting diodes (OLEDs) have developed rapidly in recent years. Thermally activated delayed fluorescent (TADF) molecules open a path to increase exciton collection efficiency from 25% to 100%, and the solution process provides an alternative technology to achieve lower cost OLEDs more easily. To develop commercial materials as exciplex hosts for high-performance and solution-processed OLEDs, we attempted to use 4,4'-cyclohexylidenebis[N,N-bis(4-methylphenyl)benzenamine (TAPC), poly(9-vinylcarbazole) (PVK), N,N'-Di(1-naphthyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine (NPB), and poly(N,N'-bis-4-butylphenyl-N,N'-bisphenyl)benzidine (Poly-TPD) as the donors and 2,4,6-tris[3-(diphenylphosphinyl)phenyl]-1,3,5-triazine (POT2T) as the acceptor to obtain the TADF effect. Read More

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CT-Guided Drainage of Fluid Collections Following Liver Resection: Technical and Clinical Outcome of 143 Patients during a 14-Year Period.

Diagnostics (Basel) 2021 May 2;11(5). Epub 2021 May 2.

Institute for Diagnostic and Interventional Neuroradiology, University Hospital, LMU Munich, 81377 Munich, Germany.

Purpose: To retrospectively evaluate the technical and clinical outcome of patients with symptomatic postoperative fluid collections following liver resection treated with CT-guided drainage (CTD).

Methods: 143 suitable patients were examined between 2004 and 2017. Technical success was defined as (a) sufficient drainage of the fluid collection and (b) the non-occurrence of peri-interventional complications requiring surgical treatment with minor or prolonged hospitalization. Read More

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Method for Accurate Quantitation of Volatile Organic Compounds in Urine Using Point of Collection Internal Standard Addition.

ACS Omega 2021 May 4;6(19):12684-12690. Epub 2021 May 4.

Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway MS S103-3, Atlanta, Georgia 30341, United States.

A method to achieve accurate measurement of unmetabolized volatile organic compounds (VOCs) in urine was developed and characterized. The method incorporates a novel preanalytical approach of adding isotopically labeled internal standard (ISTD) analogues directly to the collection container at the point of collection to compensate for analyte loss to the headspace and the collection container surfaces. Using this approach, 45 toxic VOCs ranging in water solubility and boiling point were evaluated and analyzed by headspace solid-phase microextraction/gas chromatography-mass spectrometry. Read More

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Renal revascularization by a pedicled intestinal segment wrapping the kidney: a new method for kidney revascularization.

Int Urol Nephrol 2021 May 29. Epub 2021 May 29.

Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Renal artery stenosis is caused by a heterogeneous group of diseases, including atherosclerosis and fibromuscular dysplasia, which can be treated medically, via endovascular techniques, or by open revascularization; however, satisfactory and effective results are not always obtained. We aimed to assess the possibility of renal revascularization by a pedicled intestinal segment wrapping the kidney.

Methods: Five dogs were operated on at three steps. Read More

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Have countries offered the best data to the Pan American Health Organization? Evidence of potential inconsistencies found in a study on alcohol policies in Brazil.

Public Health 2021 May 25;195:39-41. Epub 2021 May 25.

Departamento de Psiquiatria e Psicologia Médica, Universidade Federal de São Paulo, Rua Borges Lagoa, 570, 1º Andar, São Paulo, SP, Brazil; Departamento de Medicina Preventiva, Universidade Federal de São Paulo, Rua Botucatu, 740, 4° Andar, São Paulo, SP, Brazil. Electronic address:

Objective: The objective of this study was to verify the agreement between the alcohol policies score estimated from documental analysis of Brazilian federal regulatory documents (RD), with primary data collection, and the results previously presented by the Pan American Health Organization (PAHO) in its Alcohol Policy Scoring (APS) report.

Study Design: Document identification and content analysis.

Methods: Documental research was carried out in two phases: a document identification and content analysis. Read More

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