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Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia.

J Infect Public Health 2021 Apr 24;14(7):832-838. Epub 2021 Apr 24.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients. Read More

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Using Sr-Nd-Pb isotope systems to trace sources of sediment and trace metals to the Weser River system (Germany) and assessment of input to the North Sea.

Sci Total Environ 2021 Jun 3;791:148127. Epub 2021 Jun 3.

Institute of Coastal Research, Helmholtz-Zentrum Geesthacht Center for Materials and Coastal Research, Max-Planck Str.1, 21502 Geethacht, Germany. Electronic address:

In order to trace the sources of sediment materials and trace metals in the Weser River system (Germany), and the riverine input to the North Sea, Sr, Nd and Pb isotopes, together with multi-elemental compositions, were measured for sediments collected over the entire Weser River Basin, from headwaters to the estuary. Mass fractions of metals, including Ag, Cd, and Pb, and of one metalloid, Sb, higher than their crustal abundance, were observed within the entire Weser Basin. Isotope-amount ratio n(Sr)/n(Sr) and ε ranged from 0. Read More

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Short Stay After Shoulder Arthroplasty Does Not Increase 90-Day Readmissions in Medicare Patients Compared to Privately-Insured Patients.

J Shoulder Elbow Surg 2021 Jun 9. Epub 2021 Jun 9.

Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.

Background: As of January 1, 2021 total shoulder arthroplasty was removed from the Medicare inpatient-only list, reflecting a growing belief in the potential merits of same-day discharge regardless of insurance type. It is yet unknown whether Medicare populations, who frequently have more severe comorbidity burdens, would experience higher complication rates relative to privately-insured patients who are often younger with fewer comorbidities. Given the limited number of true outpatient cohorts available to study, discharge at least by postoperative day 1 may serve as a useful proxy for true same-day discharge, and we hypothesized that these Medicare patients would have increased 90-day readmission rates compared to their privately-insured counterparts. Read More

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Identifying counties at risk of high overdose mortality burden during the emerging fentanyl epidemic in the USA: a predictive statistical modelling study.

Lancet Public Health 2021 Jun 9. Epub 2021 Jun 9.

Department of Medicine, University of California, San Diego, CA, USA.

Background: The emergence of fentanyl around 2013 represented a new, deadly stage of the opioid epidemic in the USA. We aimed to develop a statistical regression approach to identify counties at the highest risk of high overdose mortality in the subsequent years by predicting annual county-level overdose death rates across the contiguous USA and to validate our approach against observed overdose mortality data collected between 2013 and 2018.

Methods: We fit mixed-effects negative binomial regression models to predict overdose death rates in the subsequent year for 2013-18 for all contiguous state counties in the USA (ie, excluding Alaska and Hawaii). Read More

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Geochemical characterisation of the thermo-mineral waters of Greece.

Environ Geochem Health 2021 Jun 12. Epub 2021 Jun 12.

Istituto Nazionale Di Geofisica E Vulcanologia, Sezione Di Palermo, via Ugo La Malfa 153, Palermo, Italy.

Geothermal areas of Greece are located in regions affected by recent volcanism and in continental basins characterised by elevated heat flow. Many of them are found along the coast, and thus, water is often saline due to marine intrusion. In the current study, we present about 300 unpublished and literature data from thermal and cold mineral waters collected along Greece. Read More

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Swallowing dysfunction and the onset of fever in older residents with special care needs: a thirteen-month longitudinal prospective study.

Odontology 2021 Jun 12. Epub 2021 Jun 12.

School of Oral Health Sciences, Faculty of Dentistry, Kyushu Dental University, 2-6-1, Manazuru, Kokurakita-ku, Kitakyushu , Fukuoka, 803-8580, Japan.

A decline in swallowing function is frequently observed among older residents in nursing homes. We investigated whether swallowing dysfunction was related to the onset of fever in such individuals. Older residents aged ≥ 65 years from three nursing homes were included in this prospective study conducted from July 2017 to May 2019. Read More

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Combined stoma reversal and liver resection for rectal metastatic cancer: A single center retrospective analysis.

J Visc Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France.

Goal Of The Study: Concomitant liver metastases are discovered at the time of diagnosis in 25% of patients with colorectal cancers. The appropriate time to restore digestive continuity after stoma creation during rectal surgery has not yet been established. The objective of this study is to assess the morbidity of stoma reversal during the secondary hepatectomy procedure. Read More

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia.

BMC Pediatr 2021 Jun 11;21(1):275. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia. Read More

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COVID-19 and gastrointestinal symptoms in Mexico, a systematic review: does location matter?

BMC Infect Dis 2021 Jun 11;21(1):555. Epub 2021 Jun 11.

Department of Medicine, Department of Pathology and Cancer Center, Department of Biochemistry & Molecular Biology, Howard University College of Medicine, 2041 Georgia Avenue, N.W, Washington, D.C, 20060, USA.

Background: Covid-19 in Mexico is on the rise in different parts of the country. We aimed to study the symptoms and comorbidities that associate with this pandemic in 3 different regions of Mexico.

Methods: We analyzed data from SARS-CoV-2 positive patients evaluated at healthcare centers and hospitals of Mexico (n = 1607) including Northwest Mexico (Sinaloa state), Southeast Mexico (Veracruz state) and West Mexico (Jalisco state) between March 1 and July 30, 2020. Read More

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Comparison of bioelectrical body and visceral fat indices with anthropometric measures and optimal cutoffs in relation to hypertension by age and gender among Chinese adults.

BMC Cardiovasc Disord 2021 Jun 11;21(1):291. Epub 2021 Jun 11.

School of Medicine, Nankai University, 94, Weijin Road, Tianjin, 300071, China.

Background: Few studies have compared bioelectrical body and visceral fat indices with anthropometric measures, or evaluated their optimal cutoffs in relation to hypertension among Asians. We compared the efficiencies of bioelectrical indices (percentage of body fat, PBF; visceral fat area, VFA) with anthropometric measures (body mass index, BMI; waist-hip ratio, WHR) for hypertension and re-evaluated the optimal cutoffs of each index by age and gender.

Methods: We conducted a cross-sectional survey among 8234 adults for health examination. Read More

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Effects of additional load at different heights on gait initiation: A statistical parametric mapping of center of pressure and center of mass behavior.

PLoS One 2021 11;16(6):e0242892. Epub 2021 Jun 11.

Physical Education Department, Federal University of São Carlos, São Carlos, Brazil.

The purpose of this study was to investigate the effects of different vertical positions of an asymmetrical load on the anticipatory postural adjustments phase of gait initiation. Sixty-eight college students (32 males, 36 females; age: 23.65 ± 3. Read More

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Endoscopy Training in Small Animal Internal Medicine: A Survey of Residency Training Programs in North America.

J Vet Med Educ 2021 Jun 11:e20200165. Epub 2021 Jun 11.

Competency in multiple endoscopic techniques is a major goal of small animal internal medicine (SAIM) residency programs. Training relies predominantly on mentored supervision of procedures performed on patients. Supplementation of this apprenticeship model with classroom sessions and hands-on laboratories can be advantageous to trainees and patients. Read More

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Analysis of Repeated Measurements of Serum Carotenoid Levels and All-Cause and Cause-Specific Mortality in Japan.

JAMA Netw Open 2021 Jun 1;4(6):e2113369. Epub 2021 Jun 1.

Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan.

Importance: The associations of levels of diverse serum carotenoids ascertained via repeated measurements with all-cause, cancer, and cardiovascular disease (CVD) mortality risk have not been considered in previous prospective studies.

Objective: To investigate the association between repeated measurement of serum carotenoid levels and all-cause and cause-specific mortality risk.

Design, Setting, And Participants: This cohort study's baseline data were collected using information from physical examinations from 1990 to 1999. Read More

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Smoking History as a Potential Predictor of Immune Checkpoint Inhibitor Efficacy in Metastatic Non-Small Cell Lung Cancer.

J Natl Cancer Inst 2021 Jun 11. Epub 2021 Jun 11.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Ave, Boston, MA, USA.

Background: Despite the therapeutic efficacy of immune checkpoint inhibitors (ICIs) in a subset of patients, consistent and easily obtainable predictors of efficacy remain elusive.

Methods: This study was conducted on 644 advanced non-small cell lung cancer (NSCLC) patients treated with ICI monotherapy between April 2013 and September 2020 at the Dana-Farber Cancer Institute and Brigham and Women's Hospital. Patient smoking history, clinicopathological characteristics, tumor mutation burden (TMB) by clinical targeted next generation sequencing, and PD-L1 tumor proportion score (TPS) by immunohistochemistry were prospectively collected. Read More

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Efficacy of percutaneous pedicle screws for thoracic and lumbar spine fractures compared with open technique.

J Neurosurg Sci 2021 Jun 10. Epub 2021 Jun 10.

Neurosurgery, XII de Octubre University Hospital, Madrid, Spain.

Background: The objective of this study is to compare percutaneous techniques (MIS) with the open technique in terms of angle correction, long-term maintenance and clinical results.

Methods: The authors collected a prospective database of thoraco-lumbar fractures treated with posterior stabilization without fusion from 2013 to 2019. The statistical analysis has been carried out retrospectively. Read More

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The cumulative effects and clinical safety of repeat magnetic resonance imaging on an MRI-conditional pacemaker system at 1.5 tesla.

Heart Rhythm O2 2021 Feb 18;2(1):73-79. Epub 2020 Dec 18.

Divisions of Cardiovascular Medicine and Mallinckrodt Institute of Radiology, Washington University, Saint Louis, Missouri.

Background: Studies have demonstrated magnetic resonance imaging (MRI) safety in the presence of MRI-conditional permanent pacemakers (PPM). However, since patients' care may require serial MRIs, it is necessary to evaluate device safety and performance after multiple scans.

Objectives: We evaluated safety and performance of MRI-conditional PPMs after serial MRIs over various anatomic regions performed during a multicenter, prospective, single-arm study (ProMRI). Read More

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February 2021

Reliability of Google Trends: Analysis of the Limits and Potential of Web Infoveillance During COVID-19 Pandemic and for Future Research.

Front Res Metr Anal 2021 25;6:670226. Epub 2021 May 25.

Research and Disclosure Division, Mensana srls, Brescia, Italy.

Alongside the COVID-19 pandemic, government authorities around the world have had to face a growing infodemic capable of causing serious damages to public health and economy. In this context, the use of infoveillance tools has become a primary necessity. The aim of this study is to test the reliability of a widely used infoveillance tool which is Google Trends. Read More

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Etiology-Discriminative Multimodal Imaging of Left Ventricular Hypertrophy and Synchrotron-Based Assessment of Microstructural Tissue Remodeling.

Front Cardiovasc Med 2021 25;8:670734. Epub 2021 May 25.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Distinguishing the etiology of left ventricular hypertrophy (LVH) is clinically relevant due to patient outcomes and management. Easily obtained, echocardiography-based myocardial deformation patterns may improve standard non-invasive phenotyping, however, the relationship between deformation phenotypes and etiology-related, microstructural cardiac remodeling has not been reported. Synchrotron radiation-based X-ray phase-contrast imaging (X-PCI) can provide high resolution, three-dimensional (3D) information on myocardial microstructure. Read More

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Patterns of Comorbidities in Psoriasis Patients: A Cross-Sectional Study.

Cureus 2021 May 8;13(5):e14907. Epub 2021 May 8.

Dermatology, King Abdulaziz Medical City, Jeddah, SAU.

Background: Psoriasis is a chronic, inflammatory, and immune-mediated dermatological disease of unknown etiology with predominant involvement of the skin, nails, and joints. This study aimed to assess comorbidities patterns in psoriasis patients.

Methods: This is a cross-sectional study conducted at King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. Read More

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The Value of Susceptibility-Weighted Imaging (SWI) in Evaluating the Ischemic Penumbra of Patients with Acute Cerebral Ischemic Stroke.

Neuropsychiatr Dis Treat 2021 3;17:1745-1750. Epub 2021 Jun 3.

Department of Radiology, Chinese Medical Hospital of Yiwu, Yiwu, 322000, People's Republic of China.

Background: The aim of this study was to discuss the value of susceptibility-weighted imaging (SWI) in evaluating the ischemic penumbra of patients with acute cerebral ischemic stroke.

Methods: Data were collected from 52 patients with acute cerebral ischemic stroke upon clinical diagnosis and routine examinations of magnetic resonance imaging (MRI), including SWI, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) within 72 hours after onset in this retrospective study. The methods also included fusing the DWI and SWI images and calculating the volume of anomaly extension of DWI and PWI-MTT (mean transit time) using semi-automatic analysis software. Read More

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A Bayesian Latent Class Model to Predict Kidney Obstruction in the Absence of Gold Standard.

J Am Stat Assoc 2020 6;115(532):1645-1663. Epub 2020 Jan 6.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania.

Kidney obstruction, if untreated in a timely manner, can lead to irreversible loss of renal function. A widely used technology for evaluations of kidneys with suspected obstruction is diuresis renography. However, it is generally very challenging for radiologists who typically interpret renography data in practice to build high level of competency due to the low volume of renography studies and insufficient training. Read More

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January 2020

Visual mapping of body image disturbance in anorexia nervosa reveals objective markers of illness severity.

Sci Rep 2021 Jun 10;11(1):12262. Epub 2021 Jun 10.

Laureate Institute for Brain Research (LIBR), Tulsa, OK, USA.

Body image disturbance (BID) is a core feature of eating disorders, for which there are few objective markers. We examined the feasibility of a novel digital tool, "Somatomap", to index BID related to anorexia nervosa (AN) severity. Fifty-five AN inpatients and 55 healthy comparisons (HC) outlined their body concerns on a 2-Dimensional avatar. Read More

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Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery.

J Cardiothorac Vasc Anesth 2021 May 12. Epub 2021 May 12.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA.

Objectives: The objective of this study was to identify novel serum biomarkers specific to postoperative delirium after major cardiac surgery to provide insight into the pathologic processes involved in delirium and its sequelae.

Design: Nested, case-control study.

Setting: Cardiac surgical intensive care unit in a single-site hospital setting. Read More

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Influence of intra-articular tranexamic acid on cost savings and early functional outcomes in total knee arthroplasty.

Rev Esp Cir Ortop Traumatol 2021 Jul-Aug;65(4):285-293

Servicio de Cirugía Ortopédica y Traumatología, Hospital Obispo Polanco, Teruel, Spain.

Background And Aim: Total knee arthroplasty (TKA) is a frequent intervention that can associate significant blood loss. There are several methods to avoid transfusions. One of the most relevant is tranexamic acid (TXA). Read More

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[Influencing factors of weaning outcome of intensive care unit patients with planned extubation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):563-567

Department of Intensive Care Unit, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei, China. Corresponding author: Chen Xiaomin, Email:

Objective: To determine the risk factors of extubation failure and its effect on the prognosis of patients who had successfully passed a spontaneous breathing trial (SBT).

Methods: The clinical data of patients with mechanical ventilation more than 24 hours who passed SBT admitted to department of intensive care unit (ICU) of First Hospital of Qinhuangdao from November 2018 to November 2019 were retrospectively analyzed. According to the outcome of weaning within 48 hours after weaning, patients were divided into weaning success group and weaning failure group. Read More

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Comparison of Acceptance and Knowledge Transfer in Patient Information Before an MRI Exam Administered by Humanoid Robot Versus a Tablet Computer: A Randomized Controlled Study.

Rofo 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiology, Martin Luther University Halle-Wittenberg, Halle, Germany.

Purpose:  To investigate whether a humanoid robot in a clinical radiological setting is accepted as a source of information in conversations before MRI examinations of patients. In addition, the usability and the information transfer were compared with a tablet.

Methods:  Patients were randomly assigned to a robot or tablet group with their consent prior to MRI. Read More

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Disagreement between PCR and serological diagnosis of Trypanosoma cruzi infection in blood donors from a Colombian endemic region.

Biomedica 2021 05 31;41(Supl. 1):47-59. Epub 2021 May 31.

Escuela de Medicina, Universidad Industrial de Santander, Bucaramanga, Colombia.

Introduction: Chagas' disease is the leading cause of infectious myocarditis worldwide. This infection caused by Trypanosoma cruzi is usually life-long and asymptomatic; however, the third part of infected people can develop severe or even fatal cardiomyopathy. As the parasitemia in the chronic phase is both low-grade and intermittent, T. Read More

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Frequency of hearing impairment in children between the ages of 2 and 10 years with middle ear infection.

J Pak Med Assoc 2021 Jun;71(6):1662-1665

Riphah International University, Lahore, Pakistan.

This study was conducted on children between 2 and 10 years age to determine the frequency of hearing impairment in middle ear infection. It was a cross-sectional survey, done at Riphah International University from August 2018 to January 2019. Data was collected from the ENT Department of Children's Hospital Lahore through convenience sampling technique and included 52 patients with middle ear infection. Read More

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Genomic Surveillance for SARS-CoV-2 Variants Circulating in the United States, December 2020-May 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 11;70(23):846-850. Epub 2021 Jun 11.

SARS-CoV-2, the virus that causes COVID-19, is constantly mutating, leading to new variants (1). Variants have the potential to affect transmission, disease severity, diagnostics, therapeutics, and natural and vaccine-induced immunity. In November 2020, CDC established national surveillance for SARS-CoV-2 variants using genomic sequencing. Read More

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'Empowering Our People: ' Impact of a Culturally Adapted Evidence-Based Intervention on STI Risks Among Native Americans with Binge Substance Use.

Sex Transm Dis 2021 Mar 12. Epub 2021 Mar 12.

1Center for American Indian Health. Johns Hopkins University. 415 N. Washington St. Baltimore, MD 21231 2Center for Point-of-Care Technologies Research for Sexually Transmitted Diseases. Johns Hopkins University. 1830 E. Monument Street, Suite 9026 Baltimore, MD 21287.

Background: The objective of this study was to evaluate a culturally adapted evidence-based intervention (EBI) called EMPWR for impacts on sexually transmitted infection (STI) screening and sexual health risk behaviors.

Methods: We enrolled Native American adults with recent binge substance use from a rural, reservation community in the Southwest into a 1:1 randomized controlled trial (RCT) conducted July 2015 to June 2019. All participants were offered non clinic-based self-administered STI screening. Read More

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