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Real-world experience with botulinum toxin A for the treatment of hemifacial spasm: A study of 1138 injections.

Clin Neurol Neurosurg 2021 Apr 2;205:106632. Epub 2021 Apr 2.

Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Movement Disorders Service and Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Quezon City, Philippines; Department of Neurosciences, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Philippines; Movement Disorders Service and Section of Neurology, Institute for Neurosciences, St. Luke's Medical Center, Global City, Philippines. Electronic address:

Background: Hemifacial spasm (HFS) is a chronic, potentially disabling disorder that often requires long-term management with botulinum toxin (BoNT). In a country where healthcare costs limit compliance to medical follow-up and treatment, the study aims to provide a real-world experience on the use of BoNT for HFS among Filipinos.

Methods: We retrospectively collected data from 162 HFS patients who received 1138 botulinum toxin (BoNT) injections from 2006 to 2019 in our movement disorders center in the Philippines. Read More

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Correlations of typical pain patterns with SPECT/CT findings in unhappy patients after total knee arthroplasty.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 17. Epub 2021 Apr 17.

University of Basel, 4051, Basel, Switzerland.

Purpose: The diagnostic process in patients after painful total knee arthroplasty (TKA) is challenging. The more clinical and radiological information about a patient with pain after TKA is included in the assessment, the more reliable and sustainable the advice regarding TKA revision can be. The primary aim was to investigate the position of TKA components and evaluate bone tracer uptake (BTU) using pre-revision SPECT/CT and correlate these findings with previously published pain patterns in painful patients after TKA. Read More

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Household Food Insecurity, Hair Cortisol, and Adiposity Among Tsimane' Hunter-Forager-Horticulturalists in Bolivia.

Obesity (Silver Spring) 2021 Apr 16. Epub 2021 Apr 16.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, USA.

Objectives: This study examined how household food insecurity (HFI) and chronic stress relate to adiposity among Tsimane' hunter-forager-horticulturalists in remote Bolivia with limited access to energy-dense processed foods that promote weight gain among industrialized populations.

Methods: Retrospective cross-sectional data on HFI (via the Household Food Insecurity Access Scale [HFIAS]), hair cortisol concentration (HCC), adiposity (BMI, body fat percentage [%BF]), and sociodemographics were collected from 171 men, 164 women, and 167 children. Linear mixed-effects models tested linear, quadratic, joint, and interactive relationships between adiposity measures and both the HFIAS score and HCC. Read More

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Rational drug use habits of patients with chronic diseases: a cross-sectional examination focusing on the use of technological devices.

Int J Clin Pract 2021 Apr 16:e14222. Epub 2021 Apr 16.

Istanbul Medical Faculty, Department of Internal Medicine, Division of Hematology, Istanbul University, Istanbul, Turkey.

Objective: The aim of this study was to investigate the factors affecting rational drug use habits and the use of technological devices in patients with chronic diseases.

Methods: Adults who applied to the internal medicine outpatient clinics of a university hospital between March and December 2019, who used medications for chronic disease were included in the study. Using a questionnaire, data on demographic characteristics, technology use, smoking and alcohol use, knowledge, and behavior on rational drug use were collected. Read More

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The effects of booster sessions on self-management interventions for chronic musculoskeletal pain: a systematic review and meta-analysis of randomised controlled trials.

Pain 2021 Apr 9. Epub 2021 Apr 9.

University College London London North West University Healthcare NHS Trust University College London, Royal National Orthopaedic Hospital.

Abstract: Our objective was to investigate the effectiveness of booster sessions after self-management interventions as a means of maintaining self-management behaviours in the treatment of chronic musculoskeletal pain. We searched MEDLINE, EMBASE, Science Citation Index, Cochrane Central Register of Controlled Trials and PsycINFO. Two authors independently identified eligible trials and collected data. Read More

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The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories.

Eur Respir J 2021 Apr 16. Epub 2021 Apr 16.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

Rationale: Patients with concomitant features of asthma and chronic obstructive pulmonary disease (COPD) have a heavy disease burden.

Objectives: Using data collected prospectively in the European Community Respiratory Health Survey, we compared the risk factors, clinical history, and lung function trajectories from early adulthood to the late sixties of middle aged subjects having asthma+COPD (n=179), past (n=263) or current (n=808) asthma alone, COPD alone (n=111), or none of these (n=3477).

Methods: Interview data and prebronchodilator FEV and FVC were obtained during three clinical examinations in 1991-1993, 1999-2002, and 2010-2013. Read More

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Assessing the feasibility and acceptability of a cluster-randomized study of cognitive behavioral therapy for chronic insomnia in a primary care setting.

BMC Fam Pract 2021 Apr 16;22(1):77. Epub 2021 Apr 16.

Primary Care Research Unit, Majorca Department of Primary Care, Baleares Health Service [IbSalut], Escola Graduada 3, 07001, Palma, Spain.

Background: Cognitive behavioral therapy for chronic insomnia (CBT-i) is the treatment of choice for this condition but is underutilized in patients who attend primary care. The purpose of the present feasibility-pilot study was to assess the feasibility and acceptability of a cluster-randomized study of CBT-i in a primary care setting.

Methods: This study, performed at two primary health care centers in Majorca, Spain, was a mixed methods feasibility-pilot study of a parallel cluster-randomized design comparing CBT-i and usual care (UC). Read More

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Exposure of wild boars (Sus scrofa L) to neonicotinoid insecticides.

Chemosphere 2021 Apr 9;279:130519. Epub 2021 Apr 9.

University of Białystok, Faculty of Law, Department of Public International Law and European Law, Mickiewicza 1, 15-213, Białystok, Poland.

The aim was to determine, for the first time, concentrations of 7 neonicotinoids (NEOs) and 5 metabolites in Sus scrofa from hunting areas in north-eastern Poland and assess the risk to consumers eating boar meat. 42 wild boar muscle samples were collected over a one-year period. The concentrations of 12 NEOs were determined by a fully validated LC-ESI-MS/MS protocol based on ultrasonic, freezing and cleanup EMR-lipid sample preparation. Read More

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Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Chronic Health Evaluation-Adjusted Mortality and Length of Stay Than Viral Pneumonia ICU Patients.

Crit Care Med 2021 Apr 2. Epub 2021 Apr 2.

1 Center for Case Management, Natick, MA. 2 Division of Pulmonary and Critical Care Medicine, Baystate Medical Center, Springfield, MA. 3 Department of Anesthesiology, University of Massachusetts Medical School-Baystate, Springfield, MA. 4 Cerner Corporation, Kansas City, MO.

Objectives: To compare Acute Physiology and Chronic Health Evaluation-IV-adjusted mortality and length of stay outcomes of adult ICU patients who tested positive for coronavirus disease 2019 with patients admitted to ICU with other viral pneumonias including a subgroup with viral pneumonia and concurrent acute respiratory distress syndrome (viral pneumonia-acute respiratory distress syndrome).

Design: Retrospective review of Acute Physiology and Chronic Health Evaluation data collected from routine clinical care.

Setting: Forty-three hospitals contributing coronavirus disease 2019 patient data between March 14, and June 17, 2020, and 132 hospitals in the United States contributing data on viral pneumonia patients to the Acute Physiology and Chronic Health Evaluation database between January 1, 2014, and December 31, 2019. Read More

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Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran.

Int J Rheum Dis 2021 Apr 16. Epub 2021 Apr 16.

Cancer & Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Aim: Osteoarthritis (OA) is the most common chronic joint disorder, resulting from the breakdown of joint cartilage. It occurs in the knees, hands, and hips, leading to pain, stiffness, inflammation, and swelling.

Methods: In this study, 100 hand and knee OA patients, meeting the American College of Rheumatology criteria were included in the case group, and 100 healthy individuals were allocated to the control group. Read More

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The association between electrocardiographic data and obesity in children and adolescents.

Minerva Pediatr (Torino) 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatric Endocrinology, Dicle University Hospital, Diyarbakır, Turkey.

Background: There are not enough studies investigating the relationship between obesity and ECG abnormalities in children and adolescents. This study aims to investigate the relationship between obesity and electrocardiographic data in children and adolescents for early diagnosis to prevent arrhythmia or sudden death in later stages of life.

Patients And Methods: A total of 65 children and adolescents with obesity applied to our pediatric endocrinology outpatient clinic with nonspecific complaints and without any known chronic illnesses; 76 healthy children and adolescents were included in the study. Read More

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Mortality in children with COVID-19: Lessons learned from a tertiary referral hospital in Indonesia.

Int J Infect Dis 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Electronic address:

Background: The incidence of COVID-19 is still rapidly increasing, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aims to describe the characteristics of pediatric COVID-19 cases with fatal outcomes in Indonesia's tertiary referral hospital.

Methods: This is a cross-sectional study with data collected from the medical records of COVID-19 patients admitted to Dr. Read More

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Can predicting COVID-19 mortality in a European cohort using only demographic and comorbidity data surpass age-based prediction: An externally validated study.

PLoS One 2021 15;16(4):e0249920. Epub 2021 Apr 15.

The D-Lab, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, The Netherlands.

Objective: To establish whether one can build a mortality prediction model for COVID-19 patients based solely on demographics and comorbidity data that outperforms age alone. Such a model could be a precursor to implementing smart lockdowns and vaccine distribution strategies.

Methods: The training cohort comprised 2337 COVID-19 inpatients from nine hospitals in The Netherlands. Read More

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Rosuvastatin revert memory impairment and anxiogenic-like effect in mice infected with the chronic ME-49 strain of Toxoplasma gondii.

PLoS One 2021 15;16(4):e0250079. Epub 2021 Apr 15.

Health Sciences Department, State University of Maringá (UEM), Maringá, PR, Brazil.

The aim of this study was to investigate the effect of rosuvastatin treatment on memory impairment, and anxiogenic-like effects in mice chronically infected with Toxoplasma gondii. For this, Balb/c mice were infected orally with chronic ME-49 strain of Toxoplasma gondii. Oral treatment with rosuvastatin (40mg/kg/day) started on the 51st day post-infection and was performed daily for 21 days. Read More

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Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C.

PLoS One 2021 15;16(4):e0249770. Epub 2021 Apr 15.

Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, Egypt.

Background: NS5B polymerase inhibitors represent the cornerstone of the present treatment of Hepatitis C virus infection (HCV). Naturally occurring substitution mutations to NS5B inhibitors have been recorded. The current study intended to demonstrate possible natural direct acting antiviral (DAA)-mutations of the HCV NS5B region in HCV patients in Minia governorate, Egypt. Read More

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Validation of Withings ScanWatch as a Wrist-Worn Reflective Pulse Oximeter: Hypoxia Study.

J Med Internet Res 2021 Apr 11. Epub 2021 Apr 11.

Withings, 2 rue Maurice Hartmann, Issy-Les-Moulineaux, FR.

Background: A decrease in the pulse oxygen saturation (SpO2) level is an indicator of hypoxemia that may occur in various respiratory diseases such as chronic obstructive pulmonary disease (COPD), sleep apnea syndrome (SAS) and COVID-19. There is currently no mass-market wrist-worn SpO2 monitor meeting the medical standards for pulse oximeters.

Objective: The main objective of this monocentric and prospective clinical study with single-blind analysis was to test and validate the accuracy of the Withings ScanWatch's reflective pulse oximeter function to measure SpO2 levels at different stages of hypoxia. Read More

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Cost comparison of osteopathic manipulative treatment for patients with chronic low back pain.

J Osteopath Med 2021 Apr 14. Epub 2021 Apr 14.

Department of Physical Medicine and Rehabilitation, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

Context: Chronic low back pain (cLBP) is the second leading cause of disability in the United States, with significant physical and financial implications. Development of a multifaceted treatment plan that is cost effective and optimizes patients' ability to function on a daily basis is critical. To date, there have been no published prospective studies comparing the cost of osteopathic manipulative treatment to that of standard care for patients with cLBP. Read More

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Real-World Treatment Profiles, Clinical Outcomes, and Healthcare Resource Utilization of Patients with Migraine Prescribed Erenumab: A Multicenter Chart-Review Study of US Headache Centers.

Neurol Ther 2021 Apr 15. Epub 2021 Apr 15.

Amgen Inc., Thousand Oaks, CA, USA.

Introduction: Erenumab, a first-in-class monoclonal antibody targeting the calcitonin gene-related peptide pathway, was approved by the US Food and Drug Administration in 2018 for the prevention of migraine in adults. There is limited data available on its impact in real-world settings. The study aim was to characterize the real-world treatment profiles, clinical outcomes, and healthcare resource utilization of patients prescribed erenumab from select major US headache centers. Read More

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Can Thermal Imaging Technique be Used to Predict the Healing Status of a Venous Leg Ulcer?

Int J Low Extrem Wounds 2021 Apr 15:15347346211002351. Epub 2021 Apr 15.

5376Royal Melbourne Institute of Technology University, Melbourne, Victoria, Australia.

Venous leg ulcers (VLUs) are the most common chronic wound types in older populations, with many wounds not healing in the normal trajectory. Many older people with wounds are treated in their homes, currently assessed by monitoring the wound area over weeks to ascertain the potential for healing. A noncontact method using thermal imaging has been shown to predict the healing trajectory of diabetes-related foot ulcers, although has not been tested in VLU or the home setting. Read More

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Onychomycosis in patients with multiple sclerosis: prevalence, clinical description, mycological, and dermoscopic study in a Mexican population.

Int J Dermatol 2021 Apr 15. Epub 2021 Apr 15.

Clinical Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.

Background: Multiple sclerosis (MS) is a chronic demyelinating disease related to HLA-DR8. Susceptibility to onychomycosis has been found in Mexican mestizos with HLA-DR8. The frequency of onychomycosis in this neurological disease is unknown. Read More

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Arsenic transfer along the soil-sclerotium-stroma chain in Chinese cordyceps and the related health risk assessment.

PeerJ 2021 9;9:e11023. Epub 2021 Mar 9.

Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, China.

Background: Chinese cordyceps (Lepidoptera: )is a larval-fungus complex. The concentration and distribution of arsenic (As) may vary during the stroma (ST) germination process and between the sclerotium (SC) and the ST. The soil-to-Chinese cordyceps system is an environmental arsenic exposure pathway for humans. Read More

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Premenopausal Women With a Diagnosis of Endometriosis Have a Significantly Higher Prevalence of a Diagnosis or Symptoms Suggestive of Restless Leg Syndrome: A Prospective Cross-Sectional Questionnaire Study.

Front Endocrinol (Lausanne) 2021 29;12:599306. Epub 2021 Mar 29.

Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, United Kingdom.

Background: Endometriosis and restless leg syndrome (RLS) are both chronic conditions that can negatively affect a woman's quality of life. A higher prevalence of RLS is seen in women and particularly in those who are pregnant, suggesting a possible ovarian hormonal influence. Endometriosis is a common (affecting 1 in 10 women) estrogen driven gynecological condition, and the prevalence of RLS in women with symptoms or a diagnosis of endometriosis is unknown. Read More

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Association of Interleukin-1 Functional Polymorphism with Risk of Chronic Periodontitis in Han Chinese Population.

Genet Res (Camb) 2021 27;2021:6614835. Epub 2021 Mar 27.

Hubei College of Chinese Medicine, Jingzhou, Hubei 434020, China.

Chronic periodontitis (CP) is a common inflammatory illness affecting a large proportion of humans. Genetic factors are thought to play important roles in its onset and development. A functional polymorphism (rs1800587) in the promoter of the interleukin-1 gene (-889 C/T) has been found to confer risk of CP primarily in Europeans, but the association between this variant and CP in the Chinese population remains less conclusive. Read More

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Adherence to Treatment Recommendations for Chronic Obstructive Pulmonary Disease - Results from the Swedish National Airway Register.

Int J Chron Obstruct Pulmon Dis 2021 6;16:909-918. Epub 2021 Apr 6.

COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, 413 45, Sweden.

Introduction: Swedish guidelines adhere to the international GOLD document regarding management of chronic obstructive pulmonary disease (COPD). Based on data from the Swedish National Airway Register (SNAR) the aim was to evaluate adherence to guidelines of pharmacological treatment of COPD in Swedish primary and secondary care.

Methods: During a period of 18 months, data on symptoms (CAT, mMRC), lung function, exacerbation history and pharmacological treatment from 15,595 COPD patients from 853 primary care and 125 secondary care clinics were collected from SNAR. Read More

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Reduced regulatory T lymphocytes in migraine patients.

Neurol Res 2021 Apr 14:1-6. Epub 2021 Apr 14.

Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

: Migraine is a primary headache disorder with unknown pathophysiology. Recently, many studies have suggested the role of immune dysfunction in the pathophysiology of this disorder. In this study, we investigated the percentage of regulatory T cells (Treg cells) in different migraine categories. Read More

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[Time trend in inequalities in smoking and abusive alcohol consumption in Brazil's state capitals].

Cad Saude Publica 2021 7;37(4):e00050120. Epub 2021 Apr 7.

Programa de Pós-graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, Brasil.

This was a time trend study aimed at assessing inequalities in smoking and abusive alcohol consumption, considering schooling as a proxy for socioeconomic status, according to sex and region of Brazil. The study used data from the Risk and Protective Factors Surveillance System for Chronic Non-Comunicable Diseases Through Telephone Interview (Vigitel) survey collected from 2006 to 2017. The outcomes were abusive alcohol consumption and smoking. Read More

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Improving care for thalassemia patients in line with best practice standards at a tertiary referral cancer care center.

JBI Evid Implement 2021 Apr 12. Epub 2021 Apr 12.

Mater Cancer Care Centre Evidence in Practice Unit and Queensland Centre for Evidence-Based Nursing and Midwifery: A Joanna Briggs Institute Centre of Excellence, Mater Misericordiae Limited, South Brisbane, Queensland, Australia.

Background: Beta-thalassemia major is a chronic hematological disorder that requires life-long management. This project aimed to improve thalassemia patients' care through the implementation of best practice standards at a tertiary referral cancer care center.

Methods: The current project utilized a clinical audit design. Read More

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Structural insights into the cause of human primary ciliary dyskinesia.

Mol Biol Cell 2021 Apr 14:mbcE20120806. Epub 2021 Apr 14.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Cilia and flagella are evolutionarily conserved eukaryotic organelles involved in cell motility and signaling. In humans, mutations in Radial Spoke Head Protein 4 homolog A () can lead to primary ciliary dyskinesia (PCD), a life-shortening disease characterized by chronic respiratory tract infections, abnormal organ positioning, and infertility. Despite its importance for human health, the location of RSPH4A in human cilia has not been resolved, and the structural basis of PCD remains elusive. Read More

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Prevalence of and factors associated with physical restraint use in the intensive care unit: a multicenter prospective observational study in Japan.

Intern Emerg Med 2021 Apr 14. Epub 2021 Apr 14.

Department of Nursing, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan.

Physical restraint is widely used in the intensive care unit (ICU) to ensure patient safety despite its ethical implications. We performed a prospective observational study in six ICUs in Japan to determine the prevalence of and factors associated with physical restraint use in the ICU, a phenomenon that has not yet been reported on in Japan. Data were collected on 10 random days between November 2018 and February 2019. Read More

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A community study of the risk for obstructive sleep apnea and respiratory inflammation in an adult Chinese population.

Postgrad Med 2021 Apr 15:1-10. Epub 2021 Apr 15.

The Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China.

: We aimed to investigate the relationship between obstructive sleep apnea (OSA) risk and respiratory inflammation evaluated by the exhaled breath condensate (EBC) interleukin-6 (IL-6) and plasma surfactant protein-D (SP-D), based on the Berlin questionnaire (BQ) screening values in an adult, urban community in Beijing, China.: Volunteers aged >40 years were recruited from the Shichahai community of central Beijing (Registration number: NCT04832711). Their general information and disease history were recorded. Read More

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