886,844 results match your criteria collected 24 h


Clinical analysis of uterine intravenous leiomyomatosis: A retrospective study of 260 cases.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Methods: We collected the clinical data of 260 patients admitted to the hospital from April 2003 to September 2019 with pathologically confirmed intravenous leiomyomatosis (IVL) and followed up with these patients regularly. Univariate and multivariate logistic regression analyses were carried out on the relevant recurrence factors.

Results: A total of 166 patients were regularly followed up, the median follow-up time was 36 (range 2-168) months, 14 (5. Read More

View Article and Full-Text PDF
September 2021

The Orthopaedic Match: Defining the Academic Profile of Successful Candidates.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Division of Plastic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD (Ngaage, Xue, Benzel, Rawes, Rasko), the Medical College of Georgia, Augusta, GA (Xue), the Department of Orthopaedic Surgery, Howard University, Washington, DC (Andrews, Wilson), the Yorkshire and Humber Foundation School, Leeds, UK (Rawes), and the Department of Orthopaedic Surgery, University of Maryland School of Medicine, Baltimore, MD (Ludwig).

Background: Research productivity forms a vital part of the resident selection process and can markedly affect the chance of a successful match. Current reports regarding the publication record among prospective orthopaedic surgery residents are likely inaccurate. Potential applicants have a poor understanding of the strength of their research credentials in comparison to other candidates. Read More

View Article and Full-Text PDF
November 2020

Burden of Renal Cysts Imaging: A Survey of Patients among the Greater Plains Collaborative.

Urol Int 2021 Sep 15:1-7. Epub 2021 Sep 15.

Division of Nephrology and Hypertension, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Purpose: Renal cysts are a frequent incidental finding on cross-sectional radiographic imaging. While most cysts are indolent, individuals with such cysts are frequently monitored for interval growth and potential malignant transformation, which is ultimately rare. In this study, we aimed to assess patients' values and preferences (believes and attitudes) about renal cysts. Read More

View Article and Full-Text PDF
September 2021

Reporting Transparency and Completeness in Trials: Paper 4 - Reporting of randomised controlled trials conducted using routinely collected electronic records - room for improvement.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Nottingham Clinical Trials Unit, University of Nottingham, Building 42, University Park, Nottingham, United Kingdom. Electronic address:

Objective: To describe characteristics of randomised controlled trials (RCTs) conducted using electronic health records (EHRs), including completeness and transparency of reporting assessed against the 2021 CONSORT Extension for RCTs Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE) criteria.

Study Design: MEDLINE and Cochrane Methodology Register were searched for a sample of RCTs published from 2011-2018. Completeness of reporting was assessed in a random sample using a pre-defined coding form. Read More

View Article and Full-Text PDF
September 2021

Reporting Transparency and Completeness in Trials: Paper 2 - Reporting of randomised trials using registries was often inadequate and hindered the interpretation of results.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland; Meta-Research Innovation Center Berlin (METRIC-B), Berlin Institute of Health, Berlin, Germany; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, USA.

Objective: Registries are important data sources for randomised controlled trials (RCTs), but reporting of how they are used may be inadequate. The objective was to describe the current adequacy of reporting of RCTs using registries.

Study Design And Setting: We used a database of trials using registries from a scoping review supporting the development of the 2021 CONSORT extension for Trials Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE). Read More

View Article and Full-Text PDF
September 2021

Reporting Transparency and Completeness in Trials: Paper 1: Introduction - Better reporting for disruptive clinical trials using routinely collected data.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Departments of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Department of Educational and Counselling Psychology, McGill University, Montreal, Quebec, Canada; Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada.

View Article and Full-Text PDF
September 2021

Extended spectrum beta-lactamase-producing Escherichia coli from extraintestinal infections in humans and from food-producing animals, in Italy: a "One Health" study.

Int J Antimicrob Agents 2021 Sep 12:106433. Epub 2021 Sep 12.

Istituto Superiore di Sanità, Rome, Italy; Department of Medicine-University of Udine and Clinical Risk Management and Performance Assessment Unit, Udine Healthcare and University Integrated Trust, Udine, Italy.

In recent years, Escherichia coli producing extended spectrum beta-lactamases (ESBL) have become a serious public health problem and food-producing animals (FPA) have been suggested as a potential reservoir/source. In this study, we aimed to compare ESBL-producing E. coli isolates from different sources. Read More

View Article and Full-Text PDF
September 2021

Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar.

Int J Infect Dis 2021 Sep 12. Epub 2021 Sep 12.

Department of Pathology, Sidra Medicine, Doha, Qatar; Pathology and Laboratory Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.

Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves of COVID-19 in Qatar, PCR genotyping, combined with Sanger sequencing of un-typeable samples, was employed to describe the epidemiology of the Alpha, Beta and Delta variants. A total of 9792 nasopharyngeal PCR-positive samples collected between April-June 2021 were successfully genotyped, revealing the importation and transmission dynamics of these three variants in Qatar. Read More

View Article and Full-Text PDF
September 2021

Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Biochim Biophys Acta Gen Subj 2021 Sep 12:130010. Epub 2021 Sep 12.

The Cardiovascular Center, First Hospital of Jilin University, 71 Xinmin Road, Changchun, Jilin 130021, China. Electronic address:

Background: Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).

Methods: A total of 327 subjects were recruited from the inpatient department at First Hospital of Jilin University and divided into 3 groups [control, angina and myocardial infarction (MI)] based on the clinical data and the results of the angiography. Read More

View Article and Full-Text PDF
September 2021

ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers.

Cell Rep 2021 Sep;36(11):109707

School of Life Sciences, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Sciences, Beijing, China. Electronic address:

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before transport to the Golgi apparatus. Decades of research have provided many details of the molecular events underlying ER-Golgi exchanges. Essential questions, however, remain about the organization of the ER-Golgi interface in cells and the type of membrane structures mediating traffic from ERES. Read More

View Article and Full-Text PDF
September 2021

Application of the Challenge Point Framework During Treatment of Speech Sound Disorders.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

School of Communication Sciences and Disorders, McGill University, Montréal, Québec, Canada.

Purpose The purpose of this article is to provide trial-by-trial practice performance data in relation to learning (outcome probe data) as collected from 18 treatment sessions provided to children with severe speech sound disorders. The data illustrate the practice-learning paradox: Specific, perfect practice performance is not required for speech production learning. Method We detailed how nine student speech-language pathologists (SSLPs) implemented and modified the motor learning practice conditions to reach a proposed challenge point during speech practice. Read More

View Article and Full-Text PDF
September 2021

The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomized clinical trial.

Int J Clin Pract 2021 Sep 15:e14872. Epub 2021 Sep 15.

University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, The Department of Anesthesiology and Reanimation, Istanbul, Turkey.

Aims: In this study, we aimed to investigate the anti-inflammatory and antioxidant effects of intravenous ibuprofen by using the C-reactive protein level and thiol/disulfide homeostasis as the oxidative stress marker.

Materials And Methods: This study was conducted on 70 patients aged between 30 and 65 who were scheduled for elective laparoscopic hysterectomy. The patients were divided into two groups to receive either preemptive 800mg of intravenous ibuprofen plus 1000 mg of intravenous paracetamol (Group IP) or only 1000 mg of intravenous paracetamol as a control group (Group P). Read More

View Article and Full-Text PDF
September 2021

Treatment of Palindromic Rheumatism: A systematic review.

Int J Clin Pract 2021 Sep 15:e14868. Epub 2021 Sep 15.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: Palindromic rheumatism (PR) characterized by self-resolving attacks of arthritis and peri-arthritis that may progresses to other autoimmune connective tissue diseases (CTD). The aim of this systematic review was to analyze the effectiveness of different treatments on PR.

Methods: Articles were collected from Cochrane, PubMed, Science Direct, Scopus, ProQuest, Ebsco, Google Scholar, MEDLINE, EMBASE. Read More

View Article and Full-Text PDF
September 2021

COVID-19 among children seeking primary paediatric care with signs of an acute infection.

Acta Paediatr 2021 Sep 15. Epub 2021 Sep 15.

Institute of Medical Virology, Goethe University, Frankfurt, Germany.

Aim: It can be challenging to distinguish COVID-19 in children from other common infections. We set out to determine the rate at which children consulting a primary care paediatrician with an acute infection are infected with SARS-CoV-2, and to compare distinct findings.

Method: In seven out-patient clinics, children 0 to 13 years with any new respiratory or gastrointestinal symptoms and presumed infection, were invited to be tested for SARS-CoV-2. Read More

View Article and Full-Text PDF
September 2021

Hepatitis C reinfection by treatment pathway among people who inject drugs in Tayside, Scotland.

J Viral Hepat 2021 Sep 15. Epub 2021 Sep 15.

Gut Group, Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, Scotland.

The efficacy of direct acting antivirals (DAA) provides an excellent opportunity to scale up HCV diagnosis and treatment, achieving the WHO target of HCV elimination by 2030. However, HCV reinfection among people who inject drugs (PWID) remains a concern and may impede elimination efforts. We assessed reinfection rates among PWID across six specialised treatment pathways, following DAA-based and interferon-based therapies in Tayside, Scotland. Read More

View Article and Full-Text PDF
September 2021

Central sympathetic nerve activation in subarachnoid hemorrhage.

J Neurochem 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Kurume University School of Medicine 67, Asahimachi, Kurume, Fukuoka, 830-0011, Japan.

Subarachnoid hemorrhage (SAH) is a life-threatening condition, and although its two main complications-cerebral vasospasm (CVS)/delayed cerebral ischemia (DCI) and early brain injury (EBI)-have been widely studied, prognosis has not improved over time. The sympathetic nerve (SN) system is important for regulating cardiovascular function and is closely associated with cerebral vessels and the regulation of cerebral blood flow and cerebrovascular function; thus, excessive SN activation leads to a rapid breakdown of homeostasis in the brain. In the hyperacute phase, patients with SAH can experience possibly lethal conditions that are thought to be associated with SN activation (catecholamine surge)-related arrhythmia, neurogenic pulmonary edema, and irreversible injury to the hypothalamus and brainstem. Read More

View Article and Full-Text PDF
September 2021

Understanding factors in burn patient follow-up.

J Burn Care Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Surgery, Division of Burn Surgery, University of California, Davis, Sacramento, CA,. Stockton Blvd, Sacramento, CA.

Follow-up rates (FUR) are concerningly low among burn-injured patients. This study investigates the factors associated with low FUR and missed appointments (MA). We hypothesize that patients who are homeless, use illicit substances, and have psychiatric comorbidities will have lower rates of follow-up (FU) and more MAs. Read More

View Article and Full-Text PDF
September 2021

Diversity and antibiotic resistance profiles of Listeria monocytogenes serogroups in different food products from Transylvania Region, Central Romania.

J Food Prot 2021 Sep 15. Epub 2021 Sep 15.

Banat University of Agricultural Sciences and Veterinary Medicine ROMANIA Timasoara.

The aim of this study was to assess the presence and antimicrobial susceptibility profile of the molecularly serogrouped Listeria monocytogenes isolates in different animal origin food products, collected from a county situated in the historical region of Transylvania, Central Romania. A total of 7.7% (17/221) of the screened samples were positive for L. Read More

View Article and Full-Text PDF
September 2021

Addressing the issue of bias in observational studies: Using instrumental variables and a quasi-randomization trial in an ESME research project.

PLoS One 2021 15;16(9):e0255017. Epub 2021 Sep 15.

Department of Biostatistics, DRCI, Centre Leon Berard, Lyon, France.

Purpose: Observational studies using routinely collected data are faced with a number of potential shortcomings that can bias their results. Many methods rely on controlling for measured and unmeasured confounders. In this work, we investigate the use of instrumental variables (IV) and quasi-trial analysis to control for unmeasured confounders in the context of a study based on the retrospective Epidemiological Strategy and Medical Economics (ESME) database, which compared overall survival (OS) with paclitaxel plus bevacizumab or paclitaxel alone as first-line treatment in patients with HER2-negative metastatic breast cancer (MBC). Read More

View Article and Full-Text PDF
September 2021

Acceptance of COVID-19 vaccine in Pakistan among health care workers.

PLoS One 2021 15;16(9):e0257237. Epub 2021 Sep 15.

Department of Hematology, Foundation University Medical College, Islamabad, Pakistan.

Objective: Acceptance of the COVID-19 vaccine will impart a pivotal role in eradicating the virus. In Pakistan, health care workers (HCWs) are the first group to receive vaccination. This survey aimed at the level of acceptance to the COVID-19 vaccine and predictors of non-acceptance in HCWs. Read More

View Article and Full-Text PDF
September 2021

Exploring barriers for trachomatous trichiasis surgery implementation in gamo zone, Southern Ethiopia.

PLoS Negl Trop Dis 2021 Sep 15;15(9):e0009780. Epub 2021 Sep 15.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Trachomatous trichiasis is the leading infectious cause of blindness worldwide. The World Health Organization recommends eyelid surgery to reduce the risk of visual impairment from trichiasis. Unfortunately, the number of cases operated has grown less than expected. Read More

View Article and Full-Text PDF
September 2021

Seroprevalence of SARS-CoV-2 antibodies among homeless people living rough, in shelters and squats: A large population-based study in France.

PLoS One 2021 15;16(9):e0255498. Epub 2021 Sep 15.

CEReSS: Health Service Research and Quality of Life Center, Aix Marseille University, Marseille, France.

Background: Overcrowded housing, as well as inadequate sanitary conditions, contribute to making homeless people particularly vulnerable to the SARS-CoV-2 infection. We aimed to assess the seroprevalence of the SARS-CoV-2 infection among people experiencing homelessness on a large city-wide scale in Marseille, France, taking into account different types of accommodation.

Methods: A consortium of outreach teams in 48 different locations including streets, slums, squats, emergency or transitional shelters and drop-in centres participated in the inclusion process. Read More

View Article and Full-Text PDF
September 2021

Establishing Benchmarks for Antimicrobial Use in Canadian Children's Hospitals: Results From 2 National Point Prevalence Surveys.

Pediatr Infect Dis J 2021 Oct;40(10):899-905

Division of Infectious Diseases, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

Background: Point prevalence surveys (PPS) are potentially useful to measure antimicrobial use across institutions. The objectives of the study were to describe and compare antimicrobial use between pediatric hospitals in Canada.

Methods: Fifteen pediatric hospitals all with pediatric infectious diseases service participated in 2 single-day PPS in 2018/19. Read More

View Article and Full-Text PDF
October 2021

sp. nov. an aniline blue-decolourizing bacterium isolated from East Pacific sediment.

Int J Syst Evol Microbiol 2021 Sep;71(9)

College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China.

Aniline blue-decolourizing bacterial strain 502str22, isolated from sediment collected in the East Pacific, was subjected to characterization by a polyphasic taxonomic approach. Phylogenetic analyses based on 16S rRNA gene sequences revealed that strain 502str22 belongs to the genus , with closely related type strains '' F72 (97.6%), SM117 (97. Read More

View Article and Full-Text PDF
September 2021

Developing a Psychological Intervention for Decreasing Bedtime Procrastination: The BED-PRO Study.

Behav Sleep Med 2021 Sep 15:1-15. Epub 2021 Sep 15.

Department of Psychology, Sungshin University, Seoul, Republic of Korea.

Introduction: Bedtime Procrastination (BP) is defined as the behavior of going to bed later than intended, without having external reasons for doing so. Previous studies have shown that BP has a negative effect on sleep and health, emphasizing the need to develop interventions to decrease BP. This intervention development study is a proof-of-concept study for a psychological intervention designed for decreasing bedtime procrastination, namely BED-PRO. Read More

View Article and Full-Text PDF
September 2021

Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting.

Cleft Palate Craniofac J 2021 Sep 15:10556656211044396. Epub 2021 Sep 15.

159460Peking University School and Hospital of Stomatology, Beijing, P.R. China.

To investigate the longitudinal influence of alveolar bone grafting on the oral microbiota of children with cleft lip and palate (CLP).

Twenty-eight children with nonsyndromic CLP were recruited and underwent secondary alveolar bone grafting at the first time. Unstimulated saliva and plaque samples were collected from the subjects preoperatively and at 2 days, 1 month, and 3 months postoperatively. Read More

View Article and Full-Text PDF
September 2021

Exploring the role of telehealth: A novel approach to group-based smoking cessation treatment for men incarcerated in a rural state prison.

J Telemed Telecare 2021 Sep 15:1357633X211034734. Epub 2021 Sep 15.

364832CUNY Graduate School of Public Health & Health Policy, USA.

Introduction: Tobacco smoking remains an important public health issue in the United States (US), specifically among people who are incarcerated. There is little to no information about smoking behaviors of incarcerated people in rural areas and there is a lack of resources for smoking cessation interventions in rural settings. Telehealth might be efficient for delivering care to incarcerated people in rural areas. Read More

View Article and Full-Text PDF
September 2021

Therapeutic Effects of High Molecular Weight Hyaluronic Acid in Severe Pseudomonas Aeruginosa Pneumonia in Ex Vivo Perfused Human Lungs.

Am J Physiol Lung Cell Mol Physiol 2021 Sep 15. Epub 2021 Sep 15.

Departments of Anesthesiology, Medicine, and Cardiovascular Research Institute, grid.266102.1University of California, San Francisco, San Francisco, CA, United States.

Introduction: We previously reported that extracellular vesicles (EVs) released during Escherichia coli bacterial pneumonia were inflammatory, and administration of high molecular weight hyaluronic acid (HMW HA) suppressed several indices of acute lung injury (ALI) from Escherichia coli pneumonia by binding to these inflammatory EVs. The current study was undertaken to study the therapeutic effects of HMW HA in ex vivo perfused human lungs injured with Pseudomonas aeruginosa (PA)103 bacterial pneumonia.

Methods: For lungs with baseline alveolar fluid clearance (AFC)<10%/h, HMW HA 1 or 2 mg was injected intravenously after 1 h (N = 4-9), and EVs released during PA pneumonia were collected from the perfusate over 6 h. Read More

View Article and Full-Text PDF
September 2021

Essential but Ill-Prepared: How the COVID-19 Pandemic Affects the Mental Health of the Grocery Store Workforce.

Public Health Rep 2021 Sep 15:333549211045817. Epub 2021 Sep 15.

242715 Norton School of Family and Consumer Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ, USA.

Objectives: Frontline essential workers face elevated risks of exposure to COVID-19 because of the interactive nature of their jobs, which require high levels of interaction with the general public and coworkers. The impact of these elevated risks on the mental health of essential workers, especially outside the health care sector, is not well studied. To address this knowledge gap, we examined correlations between perceptions of workplace risks and mental health distress among grocery store workers in Arizona. Read More

View Article and Full-Text PDF
September 2021

Distinct assembly processes and determinants of soil microbial communities between farmland and grassland in arid and semiarid areas.

Appl Environ Microbiol 2021 Sep 15:AEM0101021. Epub 2021 Sep 15.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.

It is critical to identify the assembly processes and determinants of soil microbial communities to better predict soil microbial responses to environmental change in arid and semiarid areas. Here, soils from 16 grassland-only, 9 paired grassland and farmland, and 16 farmland-only sites were collected across the central Inner Mongolia Plateau covering a steep environmental gradient. Through analyzing the paired samples, we discovered that land uses had strong effects on soil microbial communities, but weak effects on their assembly processes. Read More

View Article and Full-Text PDF
September 2021