Int J Biol Macromol 2021 Jul 29;182:1994-2002. Epub 2021 May 29.
National Engineering Research Center for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China; The Research Center of Biomedicine Engineering of Sichuan University, Chengdu 610065, China.
As a biocompatible and bioactive natural tissue engineering collagen scaffold, porcine acellular dermal matrix (pADM) has limitations for the application in tissue regeneration due to its low strength and rapid biodegradation. Herein, to get a good wound dressing, the epoxy group was added to N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) to synthesize the epoxidized N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (EHTCC), and the porcine acellular dermal matrix was modified with EHTCC at different dosage of 0, 4, 8, 12, 16 and 20%. The properties of the EHTCC-pADM were evaluated. Read More