2,348,087 results match your criteria cohort study


The Influence of Sitting, Standing, and Stepping Bouts on Cardiometabolic Health Markers in Older Adults.

J Aging Phys Act 2021 May 13:1-9. Epub 2021 May 13.

Aside from total time spent in physical activity behaviors, how time is accumulated is important for health. This study examined associations between sitting, standing, and stepping bouts, with cardiometabolic health markers in older adults. Participants from the Mitchelstown Cohort Rescreen Study (N = 221) provided cross-sectional data on activity behaviors (assessed via an activPAL3 Micro) and cardiometabolic health. Read More

View Article and Full-Text PDF

Investigating the validity of the Strengths and Difficulties Questionnaire to assess ADHD in young adulthood.

Psychiatry Res 2021 May 4;301:113984. Epub 2021 May 4.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Wales, United Kingdom. Electronic address:

Attention Deficit Hyperactivity Disorder (ADHD) symptoms typically onset early and persist into adulthood for many. Robust investigation of symptom continuity and discontinuity requires repeated assessments using the same measure, but research is lacking into whether measures used to assess ADHD symptoms in childhood are also valid in adulthood. The Strengths and Difficulties Questionnaire (SDQ) is widely used to assess ADHD symptoms in children, but little is known about its utility in adulthood. Read More

View Article and Full-Text PDF

Multimorbidity patterns and their related characteristics in European older adults: A longitudinal perspective.

Arch Gerontol Geriatr 2021 May 4;95:104428. Epub 2021 May 4.

Research Group on Aging, Disability and Health, Girona Biomedical Research Institute (IDIBGI), Catalonia, Spain; Institut d'Assistència Sanitària, Catalonia, Spain; Department of Medical Sciences, School of Medicine, University of Girona, Catalonia, Spain.

Background: The concurrence of several chronic conditions is a rising concern that poses a serious burden on ageing populations. Analysing how these conditions appear together and how they change through time may provide useful information to design successful multimorbidity-management programs.

Objective: To identify multimorbidity patterns and their related characteristics from a longitudinal perspective. Read More

View Article and Full-Text PDF

Associations between malignancy and cardiovascular complications following emergency laparotomy - A retrospective cohort study.

Surg Oncol 2021 May 5;38:101591. Epub 2021 May 5.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background: Systemic inflammation in patients with malignant disease has been associated with increased risk of cardiovascular events. The pro-inflammatory perturbations following surgical trauma may further promote adverse perioperative cardiovascular events and increase the risk of patients with cancer undergoing major surgery. Our objective was to estimate the association between malignant disease and postoperative cardiovascular complications. Read More

View Article and Full-Text PDF

Increasing age and methamphetamine use.

J Forensic Leg Med 2021 May 8;80:102181. Epub 2021 May 8.

Adelaide Medical School, The University of Adelaide, Frome Road, SA, 5000, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5005, Australia. Electronic address:

Analysis: of autopsy files at Forensic Science SA was undertaken over a 20-year period (2000-2019) in five representative time periods to determine the average ages for all adults (≥18 years) where methamphetamine was detected. There were 239 cases with statistically significant increased mean ages over the time of the study ranging from 32.6yrs in 2000 to 42. Read More

View Article and Full-Text PDF

Early trauma and associations with altruistic attitudes and behaviours among young adults.

Child Abuse Negl 2021 May 12;117:105091. Epub 2021 May 12.

The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, Australia. Electronic address:

Background: Childhood and adolescent traumas are exceptionally prevalent worldwide. Despite their high prevalence and substantial impact, little research has investigated the rates and specific types of early trauma by gender. It is also unknown whether the types of early trauma are differentially associated with heightened or hindered prosocial attitudes and behaviours. Read More

View Article and Full-Text PDF

In-vivo kinematic assessment of alloplastic temporomandibular joint replacements by means of helical axis: A cohort study with historical control.

J Biomech 2021 May 5;122:110494. Epub 2021 May 5.

Clinic of Masticatory Disorders, Center of Dental Medicine, University of Zurich, Switzerland. Electronic address:

Alloplastic total temporomandibular joint replacement (TJR) is a surgical procedure used to restore normal mandibular function when conservative therapies fail. The instantaneous helical axis (HA), is a mathematical model used to visualize globally rigid body kinematics. It can be applied to mandibular motion for quantification of movement patterns and irregularities. Read More

View Article and Full-Text PDF

Associations between sleep and academic performance in US adolescents: a systematic review and meta-analysis.

Sleep Med 2021 Apr 17;83:71-82. Epub 2021 Apr 17.

Department of Population Health Science, John D. Bower School of Population Health, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. Electronic address:

This systematic review and meta-analysis aim to investigate the relationship between sleep and academic performance in students enrolled in secondary education programs in the United States. The study team conducted a literature search of 4 databases-PubMed, Embase, CINAHL, and ERIC-on September 19 and repeated December 17, 2020. Studies were included if they were observational, published in a peer-reviewed, non-predatory journal, available in full-text, written in English, included adolescents enrolled in an organized academic program, took place in the US, and evaluated the effect of sleep duration and/or sleep quality on academic performance. Read More

View Article and Full-Text PDF

Population-based study on the association between autoimmune disease and lymphoma: National Health Insurance Service-National Sample Cohort 2002-2015 in Korea.

J Autoimmun 2021 May 12;121:102647. Epub 2021 May 12.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea. Electronic address:

Background: We aimed to evaluate the association between autoimmune disease (AID) and lymphoma incidence in the Korean population. We also aimed to compare the overall survival (OS) in patients with AID-associated lymphoma (AAL) with that in patients with lymphoma without AID.

Material And Methods: We used National Sample Cohort 2002-2015 provided by National Health Insurance Service. Read More

View Article and Full-Text PDF

The lncRNA RP3-439F8.1 promotes GBM cell proliferation and progression by sponging miR-139-5p to upregulate NR5A2.

Pathol Res Pract 2021 Jan 2;223:153319. Epub 2021 Jan 2.

Department of Neurosurgery, Yunnan Cancer Hospital, Kunming, China. Electronic address:

Background: Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2, LRH-1) is an oncogene in a wide range of cancer types. Bioinformatics analysis on glioblastoma multiforme (GBM) tumors has revealed that the miR-139-5p-NR5A2 axis may be putatively regulated by the long non-coding RNA (lncRNA) RP3-439F8.1. Read More

View Article and Full-Text PDF
January 2021

The impact of sleep quality on the incidence of PTSD: Results from a 7-Year, Nationally Representative, Prospective Cohort of U.S. Military Veterans.

J Anxiety Disord 2021 May 1;81:102413. Epub 2021 May 1.

Veterans Affairs Connecticut Health Care System, 950 Campbell Ave., West Haven, CT, 06516, United States; Department of Psychiatry, Yale School of Medicine, 300 George St., New Haven, CT, 06511, United States; U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, 950 Campbell Ave., West Haven, CT, 06516, United States; Department of Social and Behavioral Sciences, Yale School of Public Health, Laboratory of Epidemiology and Public Health, 60 College St., New Haven, CT, 06510, United States.

Sleep and posttraumatic stress disorder (PTSD) have a complex relationship, with some studies showing that disrupted sleep is associated with subsequent development of PTSD. The purpose of the current study was to examine the relationship between sleep quality and the development of probable PTSD in U.S. Read More

View Article and Full-Text PDF

Navigating the mental health system: Narratives of identity and recovery among people with psychosis across ethnic groups.

Soc Sci Med 2021 May 1;279:113981. Epub 2021 May 1.

Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK. Electronic address:

There is consistent evidence that members of the black Caribbean population in the UK are more likely to have coercive relationships with mental health services, typified by high levels of police involvement and compulsory treatment. This research has relied upon a medical epidemiological framework that has enumerated differences in service use but failed to unravel the complex interplay of individual, social, and cultural factors that inform the pathway to care. The purpose of this study was to explore the journey through mental health services from the perspective of individuals from the black Caribbean and majority white British population to help understand variation in the use of mental health services. Read More

View Article and Full-Text PDF

Relapse protection following early CMV reactivation after HSCT is limited to HLA-C KIR ligand homozygous recipients.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria; Medical Faculty, Johannes Kepler University, Linz, Austria.

Background: While the risk for non-relapse mortality (NRM) associated with early cytomegalovirus (CMV) reactivation (CMVR) after allogeneic hematopoietic stem cell transplantation (HSCT) is well established, debate is ongoing on whether CMVR may reduce the risk of primary disease relapse.

Objective: Relapse protection following early CMV reactivation after HSCT in the context of the HLA-C KIR ligands of the recipients.

Study Design: In this retrospective, bi-centric study, 406 matched-related or unrelated transplants for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) were stratified by HLA-C KIRL groups (homozygous versus heterozygous) and were separately analyzed for the impact of early CMVR on the cumulative incidence of relapse, non-relapse mortality (NRM), acute and chronic graft-versus-host-disease (GVHD), using landmark and multi-state analyses. Read More

View Article and Full-Text PDF

Pre-transplant red blood cell and platelet transfusion burden in de novo myelodysplastic syndrome undergoing allogeneic transplantation: Pre-transplant red blood cell and platelet transfusion burden in de novo MDS after allogeneic transplantation.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Most patients of myelodysplastic syndrome (MDS) require red blood cell (RBC) and/or platelet transfusion during their disease courses, which could cause an increased risk of iron overload and alloimmunization. However, it remains less clear whether pre-transplant RBC or platelet transfusion burden affects transplant outcomes in patients with MDS.

Objective: The objective was to examine the significance of pre-transplant RBC and platelet transfusion burden on transplant outcomes after allogeneic HCT for adults with de novo MDS. Read More

View Article and Full-Text PDF

Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

Purpose: Retinal vascular occlusion is a leading cause of profound irreversible visual loss, but the understanding of the disease is insufficient. We systematically investigated the age, gender, and laterality at the onset of retinal artery occlusion (RAO) and retinal vein occlusion (RVO) in the IRIS® Registry (Intelligent Research in Sight).

Design: A retrospective registry cohort. Read More

View Article and Full-Text PDF

Factors Associated with Postpartum Readmission for Hypertensive Disorders of Pregnancy.

Am J Obstet Gynecol MFM 2021 May 12:100397. Epub 2021 May 12.

The Permanente Medical Group, Kaiser Permanente Santa Clara Medical Center, Department of Obstetrics and Gynecology, Division of Obstetric Hospitalists, Santa Clara, CA.

Background: Postpartum readmission (PPR) has negative implications for patients and health systems. Prior studies suggest that up to 5% of women with hypertensive disorders of pregnancy (HDP) experience PPR. Studies examining factors associated with PPR for hypertension have had small sample sizes and conflicting results. Read More

View Article and Full-Text PDF

Perinatal Outcomes in Twin Pregnancies Complicated by Gestational Diabetes.

Am J Obstet Gynecol MFM 2021 May 12:100396. Epub 2021 May 12.

Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Magee-Womens Research Institute, Pittsburgh, Pennsylvania. Electronic address:

Background: Gestational diabetes in singleton pregnancies increases the risk of large for gestational age infants, hypertensive disorders of pregnancy, and neonatal morbidity.[1,2,3,4] Compared to singleton gestations, twin gestations are at increased risk for fetal growth abnormalities, hypertensive disorders and neonatal morbidity.[5] Whether gestational diabetes further increases the risk of these outcomes is unclear. Read More

View Article and Full-Text PDF

Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth.

Am J Obstet Gynecol MFM 2021 May 12:100393. Epub 2021 May 12.

Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC.

Background: There is an increased awareness regarding the association between exposure to environmental contaminants and adverse pregnancy outcomes including preterm birth. Whether an individual's metabolic profile can be utilized during pregnancy to differentiate the subset of patients who are ultimately destined to deliver preterm remains uncertain but could have significant clinical implications.

Objective: We sought to objectively quantify metabolomic profiles of patients at high risk for preterm birth by evaluating mid-trimester maternal plasma, and to measure whether endogenous metabolites and exogenous environmental substances differ among those who ultimately deliver preterm compared to those who deliver at term. Read More

View Article and Full-Text PDF

Use of the angiogenic biomarker profile to risk stratify patients with fetal growth restriction.

Am J Obstet Gynecol MFM 2021 May 12:100394. Epub 2021 May 12.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, United States. Electronic address:

Background: Novel angiogenic biomarker profiles have demonstrated emerging evidence for predicting preeclampsia onset, severity, and adverse outcomes. Limited data exists in screening patients with fetal growth restriction for preeclampsia development using angiogenic biomarkers.

Objective: The objective of this study was to risk stratify patients with fetal growth restriction using a soluble fms-like tyrosine kinase-1 (sFlt1) to placental growth factor (PlGF) ratio. Read More

View Article and Full-Text PDF

Total IgE variability is associated with future asthma exacerbations: a one-year prospective cohort study.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Airway Physiology and Imaging Group and the Woolcock Emphysema Centre, The Woolcock Institute of Medical Research, Sydney, NSW, Australia; Discipline of Medical Sciences, School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.

Background: Few prospective studies have investigated the relationship between IgE variability and risk of asthma exacerbations (AEs).

Objective: To explore the relationship between IgE variability and AEs.

Methods: Recruited patients with stable asthma underwent two serum total IgE tests within a month (at screening [baseline IgE] and one-month) to obtain coefficient of variation (CV) of base-10 log-transformed IgE. Read More

View Article and Full-Text PDF

Deep Recurrent Model for Individualized Prediction of Alzheimer's Disease Progression.

Neuroimage 2021 May 12:118143. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea.

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of developing AD in its earliest time. While many of the previous works considered cross-sectional analysis, more recent studies have focused on the diagnosis and prognosis of AD with longitudinal or time series data in a way of disease progression modeling. Read More

View Article and Full-Text PDF

Disparities in Utilization and Outcomes with Continuous Subcutaneous Insulin Infusion in Young Adults with T1D.

Endocr Pract 2021 May 12. Epub 2021 May 12.

Department of Health & Clinical Outcomes Research, Saint Louis University School of Medicine, St. Louis, Missouri, USA; Advanced HEAlth Data (AHEAD) Institute, Saint Louis University, St. Louis, Missouri, USA.

Objective: To evaluate what factors determine utilization patterns and outcomes of continuous subcutaneous insulin infusion (CSII) in young adults with type 1 diabetes (T1D).

Research Design & Methods: Utilizing the Optum® de-identified Electronic Health Record (EHR) dataset between 2008 to 2018 to perform a retrospective, cohort study, we identified 2104 subjects with T1D aged 18-30 years. We evaluated the effect of race on determining CSII utilization, HbA1c (%) and hospital admission for diabetic ketoacidosis (DKA). Read More

View Article and Full-Text PDF

Association between a pre-admission limitation in walking ability and post-discharge adverse outcomes among hospitalized patients with heart failure: Report from a multicenter prospective cohort study.

Int J Cardiol 2021 May 12. Epub 2021 May 12.

Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Background Although limited walking ability at discharge is a known risk factor for adverse outcomes in older patients with heart failure (HF), the association between pre-admission limitations and adverse outcomes is unknown. Therefore, we evaluated the prevalence of a pre-admission limitation in walking ability and its relationship with post-discharge outcomes among patients with HF with reduced, mid-range, and preserved left-ventricular ejection fraction (HFrEF, HFmrEF, and HFpEF). Methods We followed 2042 patients aged ≥65 years (HFrEF, n = 668; HFmrEF, n = 360; HFpEF, n = 1014) from a multicenter cohort study in Japan. Read More

View Article and Full-Text PDF

Invasive Fungal Infections in Immunocompromised Children: Novel Insight Following a National Study.

J Pediatr 2021 May 12. Epub 2021 May 12.

Institute of Pediatric Hematology and Oncology, Hospices Civils de Lyon, University-Lyon1, Lyon, France; Apoptosis, Cancer and Development Laboratory - INSERM U1052-CNRS UMR5286, CRCL, Lyon, France.

Objective: To obtain a national overview of the epidemiology and management of invasive fungal infections (IFIs) in France for severe immunocompromised children who were treated for acute leukemia or had undergone an allogeneic hematopoietic stem cell transplantation (a-HSCT).

Study Design: We performed a national multicenter retrospective study to collect epidemiologic data for proven and probable IFI in children with acute leukemia under first line or relapse treatment or who had undergone an a-HSCT. We also conducted a prospective practice survey to provide a national overview of IFI management in pediatric hematology units. Read More

View Article and Full-Text PDF

Intraductal Carcinoma of the Salivary Gland with NCOA4-RET: Expanding the Morphologic Spectrum and an Algorithmic Diagnostic Approach.

Hum Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, Massachusetts General Hospital; Department of Otolaryngology, Massachusetts Eye and Ear; Department of Pathology, Harvard Medical School, Boston, MA, USA. Electronic address:

Following the publication of the 2017 WHO Classification of Head and Neck Tumours, there has been increasing interest in the classification of newly categorized intraductal carcinomas. Intraductal carcinoma (IC) is an indolent tumor, typically arising in the parotid gland, with an intact myoepithelial layer and a cystic, papillary, often cribriform architecture. Early studies of IC identified a heterogeneous group of molecular alterations driving neoplasia, and recent studies have defined three primary morphological/immunohistochemical variants, subsequently linking these morphologic variants with defined molecular signatures. Read More

View Article and Full-Text PDF

Timing of Ocular Hypertension After Pediatric Closed-Globe Traumatic Hyphema: Implications for Surveillance.

Am J Ophthalmol 2021 May 12. Epub 2021 May 12.

Harvard Medical School, Boston, MA; Boston Children's Hospital, Boston, MA; Massachusetts Eye and Ear, Boston, MA. Electronic address:

Purpose: To evaluate the timing of ocular hypertension (OHT) after pediatric closed-globe injury (CGI) and traumatic hyphema. We hypothesize that OHT will occur at different times based on injury characteristics.

Design: Retrospective, cohort study. Read More

View Article and Full-Text PDF

Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial.

Lancet Oncol 2021 May 12. Epub 2021 May 12.

Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.

Background: Locally advanced or metastatic urothelial carcinoma is generally incurable and has scarce treatment options, especially for cisplatin-ineligible patients previously treated with PD-1 or PD-L1 therapy. Enfortumab vedotin is an antibody-drug conjugate directed at Nectin-4, a protein highly expressed in urothelial carcinoma. We aimed to evaluate the efficacy and safety of enfortumab vedotin in the post-immunotherapy setting in cisplatin-ineligible patients. Read More

View Article and Full-Text PDF

Long non-coding RNAs and their targets as potential biomarkers in breast cancer.

IET Syst Biol 2021 May 15. Epub 2021 May 15.

Atta-ur-Rahman School of Applied Biosciences - ASAB, National University of Sciences and Technology (NUST), Islamabad, Pakistan.

Breast cancer is among the lethal types of cancer with a high mortality rate, globally. Its high prevalence can be controlled through improved analysis and identification of disease-specific biomarkers. Recently, long non-coding RNAs (lncRNAs) have been reported as key contributors of carcinogenesis and regulate various cellular pathways through post-transcriptional regulatory mechanisms. Read More

View Article and Full-Text PDF

Multi-biomarker panel prediction model for diagnosis of pancreatic cancer.

J Hepatobiliary Pancreat Sci 2021 May 15. Epub 2021 May 15.

Department of Surgery and Cancer Research Institute, College of Medicine, Seoul National University, Seoul, Korea.

Background/purpose: The current study aimed to develop a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic-ductal-adenocarcinoma.

Methods: Multi-center cohort of 1,991 blood samples were collected from January 2011 to September 2019, of which 609 are normal, 145 are other-cancer (colorectal, thyroid, and breast cancer), 314 are pancreatic-benign-disease, and 923 are pancreatic-ductal-adenocarcinoma. The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed using three potential biomarkers, LRG1, TTR, and CA 19-9. Read More

View Article and Full-Text PDF

Tetracyclines and photosensitive skin reactions: a narrative review.

Dermatol Ther 2021 May 15:e14978. Epub 2021 May 15.

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Italy.

Tetracyclines are a group of broad-spectrum antibiotics largely employed in infectious, dermatological and surgical fields. Some adverse events may occur during treatment, including photosensitivity reactions, which are divided in phototoxic or photoallergic. We performed a systematic search on Pubmed, Cochrane and Embase from database inception to 9 Aug 2020 aim to summarize all available papers on photosensitive reactions related to Tetracyclines in all clinical settings where they are used on human being. Read More

View Article and Full-Text PDF