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Greater psychological readiness to return to sport, as well as greater present and future knee-related self-efficacy can increase the risk for an ACL re-rupture: a matched cohort study.

Arthroscopy 2021 Sep 24. Epub 2021 Sep 24.

Sportrehab Sports Medicine Clinic, Stampgatan 14, SE-411 01 Gothenburg, Sweden; Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 455, SE-405 30 Gothenburg, Sweden; Sahlgrenska Sports Medicine Center, Gothenburg, Sweden. Electronic address:

Purpose: The purpose of this study was to determine the psychological characteristics and strength outcomes of patients who sustained an early ACL re-rupture after their primary ACL reconstruction and cross-sectionally compare them with a matched cohort of patients who did not sustain a re-injury during the first 2 years after primary ACL reconstruction.

Methods: In this matched cohort study, data for quadriceps and hamstring strength and three hop tests and answers to standardized patient-reported outcomes (the Anterior Cruciate Ligament Return to Sport after Injury scale (ACL-RSI) and a short version of the Knee Self-Efficacy Scale (K-SES)) were extracted from a rehabilitation outcome- registry. Data for patients suffering a re-rupture were extracted and patients were matched in terms of sex, age and activity level with patients not suffering an ACL re-rupture within 2 years of primary reconstruction. Read More

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September 2021

Postoperative Alpha Angle is Predictive of Return to Sport in Athletes Undergoing Hip Arthroscopy for Femoroacetabular Impingement.

Arthroscopy 2021 Sep 24. Epub 2021 Sep 24.

American Hip Institute Research Foundation, Chicago, IL 60018; American Hip Institute, Chicago, IL 60018; AMITA Health St. Alexius Medical Center, Hoffman Estates, IL 60169. Electronic address:

Purpose: To identify clinical and radiographic factors that predict return to sport in athletes undergoing hip arthroscopy and to determine thresholds for significant predictors.

Methods: Data were reviewed on all patients who underwent primary hip arthroscopy between November 2008 and August 2018. Patients were included if they played professional, college, or high school sports within 1 year before surgery and had preoperative, 3-month, 1-year, and 2-year postoperative patient reported outcome (PRO) scores for modified Harris Hip Score (mHHS), Hip Outcome Score-Sport Specific-Subscale (HOS-SSS), and Non-Arthritic Hip Score (NAHS). Read More

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September 2021

No Difference in Neck Pain or Health-Related Quality Measures Between Patients With or Without Degenerative Cervical Spondylolisthesis.

Global Spine J 2021 Sep 27:21925682211046906. Epub 2021 Sep 27.

Rothman Institute Orthopaedics, 387400Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Study Design: This study is a retrospective case control.

Objectives: This study aims to determine whether cervical degenerative spondylolisthesis (DS) is associated with increased baseline neck/arm pain and inferior health quality states compared to a similar population without DS.

Methods: Patient demographics, pre-operative radiographs, and baseline PROMs were reviewed for 315 patients undergoing anterior cervical decompression and fusion (ACDF) with at least 1 year of follow-up. Read More

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September 2021

Claims-based algorithms for common chronic conditions were efficiently constructed using machine learning methods.

PLoS One 2021 27;16(9):e0254394. Epub 2021 Sep 27.

Precision Health, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Identification of medical conditions using claims data is generally conducted with algorithms based on subject-matter knowledge. However, these claims-based algorithms (CBAs) are highly dependent on the knowledge level and not necessarily optimized for target conditions. We investigated whether machine learning methods can supplement researchers' knowledge of target conditions in building CBAs. Read More

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September 2021

A Comparison of Acute Complications and Mortality Between Geriatric Knee and Hip Fractures: A Matched Cohort Study.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Granovsky Gluskin Division of Orthopaedics, Sinai Health System (Wolfstadt, Backstein), Institute of Medical Science, Faculty of Medicine (Nowak), the Division of Orthopaedics, St. Michael's Hospital (Atrey, Melo, Nauth, Khoshbin), University of Toronto, Toronto, Ontario, Canada, the Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA (Stavrakis), and the Division of Orthopaedics, Department of Surgery, University of Western Ontario, London, Ontario, Canada (Schemitsch).

Introduction: To compare acute complication and mortality rates for operatively treated, closed, isolated, low-energy geriatric knee fractures (distal femur [DFF] or tibial plateau [TPF]) with hip fractures (HFs).

Methods: This is a retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program. We identified all patients ≥ 70 years from 2011 to 2016 who underwent surgery for DFF, TPF, or HF. Read More

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November 2020

Tranexamic Acid in Patients With Cancer Undergoing Endoprosthetic Reconstruction: A Cost Analysis.

J Am Acad Orthop Surg 2020 Dec 1. Epub 2020 Dec 1.

From the Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS (Haase, Kimbrel, Templeton, Rosenthal, and Sweeney), and University of Kansas School of Medicine (Bombardier).

Introduction: Tranexamic acid (TXA) decreases blood loss, perioperative transfusion rates, and cost in total hip and total knee arthroplasty. In a previous study, topical TXA decreased both perioperative blood loss and transfusions in patients undergoing resection of aggressive bone tumors and endoprosthetic reconstruction. The purpose of this study was to explore the cost effectiveness of TXA in patients undergoing resection of an aggressive bone tumor and endoprosthetic reconstruction, assessing transfusion cost, TXA administration cost, postoperative hospitalization cost, posthospital disposition, and 30-day readmissions. Read More

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December 2020

A Comparison of Acute Complications and Mortality Between Geriatric Knee and Hip Fractures: A Matched Cohort Study.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Granovsky Gluskin Division of Orthopaedics, Sinai Health System (Wolfstadt, Backstein), Institute of Medical Science, Faculty of Medicine (Nowak), the Division of Orthopaedics, St. Michael's Hospital (Atrey, Melo, Nauth, Khoshbin), University of Toronto, Toronto, Ontario, Canada, the Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA (Stavrakis), and the Division of Orthopaedics, Department of Surgery, University of Western Ontario, London, Ontario, Canada (Schemitsch).

Introduction: To compare acute complication and mortality rates for operatively treated, closed, isolated, low-energy geriatric knee fractures (distal femur [DFF] or tibial plateau [TPF]) with hip fractures (HFs).

Methods: This is a retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program. We identified all patients >= 70 years from 2011 to 2016 who underwent surgery for DFF, TPF, or HF. Read More

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November 2020

Hypersensitivity may be involved in severe COVID-19.

Clin Exp Allergy 2021 Sep 27. Epub 2021 Sep 27.

Department of Pulmonary and Critical Care Medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.

Deaths attributed to Coronavirus Disease 2019 (COVID-19) are mainly due to severe hypoxemic respiratory failure. Although the inflammatory storm has been considered main pathogenesis of severe COVID-19, hypersensitivity may be another important mechanism involved in severe cases, which have perfect response to corticosteroids (CS). We detected the presence of anti-SARS-CoV-2-spike S1 protein specific IgE (SP- IgE) and SARS-CoV-2 nucleocapsid protein specific IgE (NP- IgE) in all COVID-19 patients' serum, while it was rarely detected in non-COVID-19 controls. Read More

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September 2021

Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study.

Biol Trace Elem Res 2021 Sep 27. Epub 2021 Sep 27.

Department of Endocrinology, Peking University People's Hospital, Beijing, 100044, China.

Iodine is an essential trace element for humans and the main raw material for thyroid hormone synthesis. However, the association between iodine nutritional status and adverse pregnancy outcomes in different regions remains controversial. This single-center cohort study was focused on the association between iodine nutritional status and adverse pregnancy outcomes in Beijing, China. Read More

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September 2021

Low-Value Care at the Actionable Level of Individual Health Systems.

JAMA Intern Med 2021 Sep 27. Epub 2021 Sep 27.

The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, New Hampshire.

Importance: Low-value health care remains prevalent in the US despite decades of work to measure and reduce such care. Efforts have been only modestly effective in part because the measurement of low-value care has largely been restricted to the national or regional level, limiting actionability.

Objectives: To measure and report low-value care use across and within individual health systems and identify system characteristics associated with higher use using Medicare administrative data. Read More

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September 2021

Sling Exercise in the Management of Chronic Low Back Pain: A Systematic Review and Meta-Analysis.

J Strength Cond Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Physical Therapy, Long Island University, Brooklyn, New York.

Abstract: Drummond, C, Lebedeva, V, Kirker, K, and Masaracchio, M. Sling exercise in the management of chronic low back pain: A systematic review and meta-analysis. J Strength Cond Res XX(X): 000-000, 2021-The purpose of this systematic review is to assess the effectiveness of sling exercise therapy (SET) in individuals with chronic low back pain (LBP). Read More

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September 2021

Pregnancy After Concussion: A Clarion Call for Attention?

J Head Trauma Rehabil 2021 Sep 23. Epub 2021 Sep 23.

Departments of Emergency Medicine (Dr Anto-Ocrah), Obstetrics and Gynecology (Drs Anto-Ocrah and Lewis), and Neurology (Dr Anto-Ocrah), School of Medicine and Dentistry, University of Rochester, Rochester, New York; and University of Rochester, Rochester, New York (Ms Cafferky).

Objective: Emerging research shows that women who sustain a mild traumatic brain injury, also termed concussion, have a higher risk of menstrual irregularities and sexual dysfunctions. However, no research exists on how these reproductive disruptions affect women's subsequent pregnancies. The objective of this study was to evaluate pregnancy outcomes after concussion in a cohort of reproductive-aged women (aged 18-45 years), 24 months post-injury. Read More

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September 2021

Estimation of Baseline Serum Creatinine with Machine Learning.

Am J Nephrol 2021 Sep 20:1-10. Epub 2021 Sep 20.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: Comparing current to baseline serum creatinine is important in detecting acute kidney injury. In this study, we report a regression-based machine learning model to predict baseline serum creatinine.

Methods: We developed and internally validated a gradient boosting model on patients admitted in Mayo Clinic intensive care units from 2005 to 2017 to predict baseline creatinine. Read More

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September 2021

Survival of the dysplastic hip after periacetabular osteotomy: a meta-analysis.

Hip Int 2021 Sep 27:11207000211048425. Epub 2021 Sep 27.

Department for Trauma and Reconstructive Surgery, BG Klinik, University of Tübingen, Germany.

Background: Periacetabular osteotomy (PAO) has become a popular procedure for re-orientation of the acetabulum in patients with a developmental pathomorphology. Since its first description by Reinhold Ganz in 1988, many institutions worldwide have adopted the procedure for the treatment of developmental hip dysplasia (DDH) and have subsequently reported their results. The aim of this study was to provide a meta-analysis of the likelihood of long-term survival of a dysplastic hip after PAO. Read More

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September 2021

Health System-Level Evaluation of Tele-Mental Health Services Among Children and Adolescents in Ontario, Canada : Évaluation au niveau du système de santé des services de télésanté mentale chez les enfants et les adolescents de l'Ontario, Canada.

Can J Psychiatry 2021 Sep 27:7067437211043395. Epub 2021 Sep 27.

Department of Psychiatry, Faculty of Medicine, 7938University of Toronto, Toronto, Ontario.

Objective: To describe the characteristics of children and adolescents receiving tele-mental health services in Ontario, Canada and examine access to a psychiatrist, in-person or via tele-mental health services, following a mental health and addictions (MHA)-related emergency department (ED) visit or hospitalization.

Method: Using linked health and administrative data, we described two cohorts: (1) children and adolescents (1-18 years) who used a provincial tele-mental health programme from January 1, 2013 to March 31, 2017, comparing their MHA-related service use (outpatient, ED, hospitalization) in the 1 year prior to and the 1 year following initial consultation; (2) children and adolescents with high mental health service needs, defined as those with an incident MHA-related ED visit or hospitalization between January 1, 2013 and December 31, 2016, examining their 1-year follow-up with telemedicine and other health care utilization.

Results: In the first cohort, 7,216 children and adolescents (mean age 11. Read More

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September 2021

The possibility of short-term hypothalamic-pituitary-adrenal axis suppression with high-volume, high-dose nasal mometasone irrigation in postsurgical patients with chronic rhinosinusitis.

Int Forum Allergy Rhinol 2021 Sep 26. Epub 2021 Sep 26.

Rush Sinus Program, Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.

Background: Medically refractory chronic rhinosinusitis (CRS) is often treated with functional endoscopic sinus surgery (FESS) and high-volume steroid nasal irrigation. While budesonide is the most common steroid irrigation for this indication, mometasone has a superior pharmacokinetic profile, which may allow dose escalation. The safety and efficacy of mometasone at higher concentrations than previously used in treating CRS have not been explored. Read More

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September 2021

Plasma neurofilament light chain level and orthostatic hypotension in early Parkinson's disease.

J Neural Transm (Vienna) 2021 Sep 27. Epub 2021 Sep 27.

Department of Neurology, Parkinson Center, Ajou University School of Medicine, Suwon, Republic of Korea.

To delineate the impact of non-motor markers (REM sleep behavior disorder (RBD), orthostatic hypotension (OH), cardiac sympathetic denervation, hyposmia) on neuronal injury in early-stage Parkinson's disease (PD), we measured the plasma neurofilament light chain (NFL) level of PD patients and evaluated its relationship with these markers. The study population comprised a cohort of 77 patients with PD and 54 controls. OH was assessed using 5-min head-up tilt-table test. Read More

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September 2021

The relationship between educational attainment and hospitalizations among middle-aged and older adults in the United States.

SSM Popul Health 2021 Sep 14;15:100918. Epub 2021 Sep 14.

Division of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA.

Background: There has been little research on the relationship between education and healthcare utilization, especially for racial/ethnic minorities. This study aimed to examine the association between education and hospitalizations, investigate the mechanisms, and disaggregate the relationship by gender, race/ethnicity, and age groups.

Methods: A retrospective cohort analysis was conducted using data from the 1992-2016 US Health and Retirement Study. Read More

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September 2021

Interrater Reliability of the Prone Apprehension Relocation Test.

Orthop J Sports Med 2021 Sep 20;9(9):23259671211032229. Epub 2021 Sep 20.

Department of Orthopedic Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Background: The Prone Apprehension Relocation Test (PART) augments existing radiographic measures and clinical provocative maneuvers in diagnosing hip instability. One measure of the potential clinical utility of the PART depends on the reproducibility of test results by evaluating providers including physicians, licensed athletic trainers, and physical therapists.

Purpose: To determine the interrater reliability of the PART among health care providers. Read More

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September 2021

Development and Validation of a Simplified Chinese Version and a Face-Scale Version of the Oxford Shoulder Score: A 2-Center Prospective Study.

Orthop J Sports Med 2021 Sep 21;9(9):23259671211023751. Epub 2021 Sep 21.

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, PR China.

Background: There has not yet been a pictorial version of a patient-reported outcome measure for shoulder pain.

Purpose: To translate the English version of the Oxford Shoulder Score (OSS) to a simplified Chinese version (SC-OSS) and to validate a new face-scale version of the OSS (FS-OSS), while investigating cross-cultural adaptation, validation, and reproducibility of both versions in patients with shoulder pain.

Study Design: Cohort study (diagnosis); Level of evidence, 2. Read More

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September 2021

Testosterone and Estradiol as Novel Prognostic Indicators for HBV-Related Acute-on-Chronic Liver Failure.

Front Med (Lausanne) 2021 8;8:729030. Epub 2021 Sep 8.

Department of Infectious Diseases, Southwest Hospital, Third Military Medical University (Amy Medical University), Chongqing, China.

HBV-related acute-on-chronic liver failure (HBV-ACLF) has a high short-term mortality and urgently needs an early warning system with simplicity and high accuracy. Previous studies show that sex hormones play potential roles in the progression of HBV-related liver diseases. To explore the effect of testosterone and estradiol on the occurrence and prognosis of HBV-ACLF. Read More

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September 2021

Design, Implementation, and Evaluation of a Distance Learning Framework to Adapt to the Changing Landscape of Anatomy Instruction in Medical Education During COVID-19 Pandemic: A Proof-of-Concept Study.

Front Public Health 2021 10;9:726814. Epub 2021 Sep 10.

College of Medicine and Health Sciences, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai, United Arab Emirates.

This study presents the design of a DL-framework to deliver anatomy teaching that provides a microfiche of the onsite anatomy learning experience during the mandated COVID-19 lockdown. First, using nominal-group technique, we identified the DL learning theories to be employed in blueprinting the DL-framework. Effectiveness of the designed DL-framework in anatomy teaching was demonstrated using the exemplar of the Head and Neck (H&N) course during COVID-19 lockdown, in the pre-clerkship curriculum at our medical school. Read More

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September 2021

Severe or not so severe? The gravity of geriatric trauma.

J Family Med Prim Care 2021 Jul 30;10(7):2614-2618. Epub 2021 Jul 30.

Non-PG registrar, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Due to associated comorbidities, the elderly population is more vulnerable to injuries with complications. This study was done to assess the severity of trauma and outcome of injuries among these patients presenting to the Emergency Department (ED).

Materials And Methods: This was a retrospective cohort study. Read More

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Exploration of Lipid Metabolism in Gastric Cancer: A Novel Prognostic Genes Expression Profile.

Front Oncol 2021 8;11:712746. Epub 2021 Sep 8.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Alterations in lipid metabolism are increasingly being recognized. However, the application of lipid metabolism in the prognosis of gastric cancer (GC) has not yet been explored.

Methods: A total of 204 lipid metabolism relative genes were analyzed in the GC cohort from The Cancer Genome Atlas (TCGA), and four independent cohorts from Gene Expression Omnibus (GEO) and one cohort from Wuhan Union Hospital were applied for external validation. Read More

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September 2021

Three-Tier Prognostic Index in Young Adults With Advanced Gastric Cancer.

Front Oncol 2021 10;11:667655. Epub 2021 Sep 10.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Purpose: To characterize clinical features and identify baseline prognostic factors for survival in young adults with advanced gastric cancer (YAAGC).

Materials And Methods: A total of 220 young inpatients (age less than or equal to 40 years) with an initial diagnosis of advanced gastric cancer were retrospectively enrolled in this study.

Results: Of a consecutive cohort of 220 patients with YAAGC, the median overall survival (OS) time was 16. Read More

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September 2021

Identification and Evaluation of Autoantibody to a Novel Tumor-Associated Antigen GNA11 as a Biomarker in Esophageal Squamous Cell Carcinoma.

Front Oncol 2021 10;11:661043. Epub 2021 Sep 10.

Henan Institute of Medical and Pharmaceutical Sciences in Academy of Medical Science, Zhengzhou University, Zhengzhou, China.

The study aims to explore the diagnostic value of anti-GNA11 autoantibody in esophageal squamous cell carcinoma (ESCC) from multiple levels. Autoantibody against GNA11 with the highest diagnostic performance was screened out from the customized protein microarray. A total of 486 subjects including ESCC patients and matched normal controls were recruited in the verification and validation phases by using enzyme-linked immunosorbent assay (ELISA). Read More

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September 2021

Association between hyperglycemia treatment and mortality in patients with diabetes and COVID-19 in a Peruvian hospital: A retrospective cohort study.

J Clin Transl Endocrinol 2021 Dec 16;26:100265. Epub 2021 Sep 16.

Department of Medicine, Emory University School of Medicine, Atlanta, USA.

Objective: To evaluate the association between hyperglycemia treatment and mortality in patients with diabetes and COVID-19 in a Peruvian hospital.

Methods: A retrospective cohort study was conducted between March and July 2020. Individual-level data were extracted from an implemented virtual platform. Read More

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December 2021

Determinants of type 2 diabetes remission after bariatric surgery in obese Japanese patients: a retrospective cohort study.

Diabetol Int 2021 Oct 28;12(4):379-388. Epub 2021 Jan 28.

Center for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-0841 Japan.

Objective: Bariatric surgery (BS) improves glycemic control in type 2 diabetes; however, some patients show insufficient improvement. Understanding the pathophysiology of type 2 diabetes in obese patients can facilitate appropriate treatment for type 2 diabetes after BS. The homeostatic model assessment (HOMA) 2 enables the calculation of the values from C-peptide data and evaluation of insulin users. Read More

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October 2021

Vitamin D and Lupus: Are we doing enough?

J Community Hosp Intern Med Perspect 2021 20;11(5):624-628. Epub 2021 Sep 20.

Division of Rheumatology, Loma Linda University Health, Loma Linda, CA, USA.

The aim of this study is to identify rheumatology practice care gaps in evaluating for vitamin D deficiency in systemic lupus erythematosus (SLE), as well as adherence to vitamin D replacement in SLE patients currently on corticosteroid therapy. Data for this study were collected from the Southern California Lupus Registry in addition to data extraction from medical health records. Evaluation of serum vitamin D level within 6 months of patient encounter, current or prior use of systemic corticosteroids, and vitamin D replacement in patients receiving corticosteroid therapy were noted. Read More

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September 2021

Survival analysis of young adults from a Brazilian cohort of non-small cell lung cancer patients.

Ecancermedicalscience 2021 24;15:1279. Epub 2021 Aug 24.

Instituto do Câncer do Estado de São Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, 01246-000, Brazil.

Background: The influence of age at diagnosis in non-small cell lung cancer (NSCLC) prognosis is unclear.

Objectives: To compare in a Brazilian cohort of NSCLC patients of different age groups: 1) The overall survival; 2) Clinical features and treatment options.

Methods: This is a retrospective cohort study using a hospital-based registry, for NSCLC patients registered in years 2000-2009. Read More

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