639 results match your criteria cohort 1495

Development and validation of optimal phenomapping methods to estimate long-term atherosclerotic cardiovascular disease risk in patients with type 2 diabetes.

Diabetologia 2021 Mar 13. Epub 2021 Mar 13.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Aims/hypothesis: Type 2 diabetes is a heterogeneous disease process with variable trajectories of CVD risk. We aimed to evaluate four phenomapping strategies and their ability to stratify CVD risk in individuals with type 2 diabetes and to identify subgroups who may benefit from specific therapies.

Methods: Participants with type 2 diabetes and free of baseline CVD in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial were included in this study (N = 6466). Read More

View Article and Full-Text PDF

Airborne occupational exposures and the risk of developing respiratory symptoms and airway obstruction in the Lifelines Cohort Study.

Thorax 2021 Mar 2. Epub 2021 Mar 2.

University Medical Center Groningen, Department of Epidemiology, University of Groningen, Groningen, Netherlands.

Objectives: To date, only a few studies have investigated the associations between occupational exposures and respiratory outcomes longitudinally in the general population. We investigated the associations between occupational exposures and the development of respiratory symptoms and airway obstruction in the Lifelines Cohort Study.

Methods: We included 35 739 occupationally active subjects with data on chronic cough, chronic phlegm, chronic bronchitis or airway obstruction at baseline and approximately 4. Read More

View Article and Full-Text PDF

One nerve suffices: A clinically guided nerve ultrasound protocol for the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS).

J Neurol 2021 Apr 23;268(4):1495-1507. Epub 2020 Dec 23.

German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 18147, Rostock, Germany.

Objective: To investigate diagnostic accuracy of a nerve ultrasound (US) protocol that is individualized to a patient's clinical deficits for the differentiation of amyotrophic lateral sclerosis with predominant lower motoneuron disease (ALS/LMND) and multifocal motor neuropathy (MMN).

Methods: Single-center, prospective, examiner-blinded, diagnostic study in two cohorts. Cohort I (model development): Convenience sample of subjects with ALS/LMND or MMN according to revised El-Escorial or EFNS guidelines. Read More

View Article and Full-Text PDF

Live-Birth Outcomes and Congenital Malformations After Progestin-Primed Ovarian Stimulation in Maternal Endometriosis.

Drug Des Devel Ther 2020 10;14:5459-5467. Epub 2020 Dec 10.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Purpose: In patients who had advanced endometriosis, we use different protocols including GnRH agonist, GnRH antagonist and progestin-primed ovarian stimulation (PPOS) protocols to assess live-birth congenital malformations delivered after in vitro fertilization (IVF) and vitrified embryo transfer cycles.

Methods: A retrospective cohort study is conducted by us. It includes 1495 live-born infants in maternal endometriosis. Read More

View Article and Full-Text PDF
December 2020

Machine Learning to Predict Contrast-Induced Acute Kidney Injury in Patients With Acute Myocardial Infarction.

Front Med (Lausanne) 2020 13;7:592007. Epub 2020 Nov 13.

Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

To develop predictive models for contrast induced acute kidney injury (CI-AKI) among acute myocardial infarction (AMI) patients treated invasively. Patients with AMI who underwent angiography therapy were enrolled and randomly divided into training cohort (75%) and validation cohort (25%). Machine learning algorithms were used to construct predictive models for CI-AKI. Read More

View Article and Full-Text PDF
November 2020

Plasma adipokines and glycaemic progression among African Americans: Findings from the Jackson Heart Study.

Diabet Med 2020 Nov 25:e14465. Epub 2020 Nov 25.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Aim: To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponectin-to-leptin ratio and high-sensitivity C-reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre-diabetes or diabetes) in a community-based sample of African American (AAs).

Methods: We analysed data from 3223 participants without type 2 diabetes at baseline (2000-2004) who attended ≥1 follow-up visit. Poisson regression was used to generate risk ratios (RRs) for glycaemic progression and incident dysglycaemia. Read More

View Article and Full-Text PDF
November 2020

Mid-term gender-specific differences in periprosthetic bone remodelling after implantation of a curved bone-preserving hip stem.

Orthop Traumatol Surg Res 2020 12 31;106(8):1495-1500. Epub 2020 Oct 31.

Department of orthopaedic surgery, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany.

Background: The implant-specific periprosthetic bone remodelling in the proximal femur is considered to be an important factor influencing the long-term survival of cementless hip stems. Particularly data of gender-specific differences regarding bone-preserving stems are very rare in literature and mainly limited to short-term investigations. Therefore, we investigated at mid-term one arm of a prospective randomised study to evaluate if there is an influence of gender on implant-specific stress shielding after implantation of a curved bone preserving hip stem (Fitmore) 5 years postoperatively. Read More

View Article and Full-Text PDF
December 2020

Radiographic features and poor prognostic factors of interstitial lung disease with nivolumab for non-small cell lung cancer.

Cancer Sci 2021 Apr 24;112(4):1495-1505. Epub 2021 Feb 24.

The Jikei University School of Medicine, Tokyo, Japan.

Nivolumab can cause interstitial lung disease (ILD), which may be fatal; however, mortality risk factors have not been identified. This postmarketing study evaluated the poor prognostic factors of ILD in nivolumab-treated patients with non-small cell lung cancer (NSCLC) in Japan. Clinical and chest imaging findings for each ILD case were assessed by an expert central review committee, and prognosis was evaluated by radiographic findings, including the presence/absence of peritumoral ground-glass opacity (peritumoral-GGO). Read More

View Article and Full-Text PDF

Vesicoureteral reflux increases the risk of urinary tract infection prior to corrective surgery in newborn males with anorectal malformation.

Pediatr Surg Int 2020 Dec 16;36(12):1495-1500. Epub 2020 Oct 16.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Purpose: The ideal colostomy type indicated for patients with anorectal malformation (ARM) is disputed. The aim of this study was to analyze the clinical factors associated with urinary tract infection (UTI) prior to corrective surgery in male ARM without perineal fistula having undergone diverting enterostomy.

Methods: A retrospective review of patients diagnosed with ARM and surgically managed at our center from January 2011 to December 2019 was performed. Read More

View Article and Full-Text PDF
December 2020

Asymmetric crypt fission in sessile serrated lesions.

J Clin Pathol 2020 Oct 12. Epub 2020 Oct 12.

Medicine (Solna), Karolinska Institute and Ersta Hospital, Stockholm, Sweden.

Objective: Sessile serrated lesions without dysplasia (SSL-ND) are epitomised by dilated crypts with epithelial serrations and architectural distortions portraying boot-shapes, L-shapes or inverted-T shapes. Recently, crypts in asymmetric fission were detected in SSL-ND. The purpose was to assess the frequency of crypts in asymmetric fission in a cohort of SSL-ND. Read More

View Article and Full-Text PDF
October 2020

Effects of Thrombolytic Therapy in Low-Risk Patients With Pulmonary Embolism.

Am J Cardiol 2021 01 28;139:116-120. Epub 2020 Sep 28.

Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan.

We performed this investigation to determine the effects on mortality of thrombolytic therapy in low-risk patients with pulmonary embolism (PE). This was a retrospective cohort study based on administrative data from the Nationwide Inpatient Sample, 2016 and 2017. Patients with a primary (first-listed) diagnosis of acute PE who were not in shock and not on a ventilator who did not have acute cor pulmonale were defined as low-risk. Read More

View Article and Full-Text PDF
January 2021

In-Hospital Postoperative Pneumonia Following Geriatric Intertrochanteric Fracture Surgery: Incidence and Risk Factors.

Clin Interv Aging 2020 8;15:1599-1609. Epub 2020 Sep 8.

Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, People's Republic of China.

Purpose: The in-hospital death rate in cases of hip fracture ranges from 6% to 10%. Pneumonia is a serious complication for hip fracture patients that contributes to longer hospital stays and higher mortality rates; however, the prevalence and risk factors are not well established. To address this issue, the present study investigated the incidence of and risk factors for in-hospital postoperative pneumonia (IHPOP) following geriatric intertrochanteric fracture surgery. Read More

View Article and Full-Text PDF
January 2021

Etiology and antimicrobial resistance of secondary bacterial infections in patients hospitalized with COVID-19 in Wuhan, China: a retrospective analysis.

Antimicrob Resist Infect Control 2020 09 22;9(1):153. Epub 2020 Sep 22.

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: A considerable proportion of patients hospitalized with coronavirus disease 2019 (COVID-19) acquired secondary bacterial infections (SBIs). The etiology and antimicrobial resistance of bacteria were reported and used to provide a theoretical basis for appropriate infection therapy.

Methods: This retrospective study reviewed electronic medical records of all the patients hospitalized with COVID-19 in the Wuhan Union Hospital between January 27 and March 17, 2020. Read More

View Article and Full-Text PDF
September 2020

Computerized tomography scan in pre-diagnostic pancreatic ductal adenocarcinoma: Stages of progression and potential benefits of early intervention: A retrospective study.

Pancreatology 2020 Oct 11;20(7):1495-1501. Epub 2020 Aug 11.

Division of Gastroenterology and Hepatology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: The frequency, nature and timeline of changes on thin-slice (≤3 mm) multi-detector computerized tomography (CT) scans in the pre-diagnostic phase of pancreatic ductal adenocarcinoma (PDAC) are unknown. It is unclear if identifying imaging changes in this phase will improve PDAC survival beyond lead time.

Methods: From a cohort of 128 subjects (Cohort A) with CT scans done 3-36 months before diagnosis of PDAC we developed a CTgram defining CT Stages (CTS) I through IV in the radiological progression of pre-diagnostic PDAC. Read More

View Article and Full-Text PDF
October 2020

Asthma-COPD overlap in World Trade Center Health Registry enrollees, 2015-2016.

J Asthma 2020 Sep 15:1-9. Epub 2020 Sep 15.

Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a newly redefined form of chronic airway disease and has not been well studied among 9/11-exposed populations with increased prevalence of asthma. We assessed the prevalence and risk factors associated with ACO in an exposure cohort of World Trade Center Health Registry (WTCHR) enrollees.

Methods: This is a longitudinal study, including enrollees with complete data on 9/11/01 exposure at enrollment (2003-2004, Wave 1), asthma and COPD diagnoses and at least 25 years of age at the time of the 2015-2016 (Wave 4) WTCHR survey. Read More

View Article and Full-Text PDF
September 2020

Early Comfort Care Following Operative Intervention for Traumatic Injury.

Am Surg 2020 Aug 28;86(8):933-936. Epub 2020 Aug 28.

26520 Department of Surgery, Mountain Area Health Education Center (MAHEC), Asheville, NC, USA.

Background: Several studies have described the population of adult trauma patients who undergo withdrawal of life-sustaining treatments (WLST); however, no study has looked specifically at trauma patients who undergo WLST following surgery.

Methods: This was a retrospective chart review of all trauma patients who underwent surgery at our trauma center between January 1 and December 31, 2017. Demographics were collected along with injury patterns and advance directives. Read More

View Article and Full-Text PDF

Antimicrobial drug use in the first decade of life influences saliva microbiota diversity and composition.

Microbiome 2020 08 21;8(1):121. Epub 2020 Aug 21.

Folkhälsan Research Center, Topeliuksenkatu 20, 00250, Helsinki, Finland.

Background: The human microbiota contributes to health and well-being. Antimicrobials (AM) have an immediate effect on microbial diversity and composition in the gut, but next to nothing is known about their long-term contribution to saliva microbiota. Our objectives were to investigate the long-term impact of AM use on saliva microbiota diversity and composition in preadolescents. Read More

View Article and Full-Text PDF

Lymphocyte predominant cells of nodular lymphocyte predominant Hodgkin lymphoma interact with rosetting T cells in an immunological synapse.

Am J Hematol 2020 12 3;95(12):1495-1502. Epub 2020 Sep 3.

Dr. Senckenberg Institute of Pathology, Goethe University, Frankfurt am Main, Germany.

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of Hodgkin lymphoma with a preserved B-cell phenotype and follicular T helper (T ) cells rosetting around the tumor cells, the lymphocyte-predominant (LP) cells. As we recently described reactivity of the B-cell receptors of LP cells of some NLPHL cases with Moraxella spp. proteins, we hypothesized that LP cells could present peptides to rosetting T cells in a major histocompatibility complex class II (MHCII)-bound manner. Read More

View Article and Full-Text PDF
December 2020

Anterior circulation large vessel occlusion stroke in Saudi Arabia: Prevalence, predictors, and outcome.

J Stroke Cerebrovasc Dis 2020 Sep 30;29(9):105080. Epub 2020 Jun 30.

King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address:

Objective: Anterior circulation Large Vessel Occlusion (LVO) stroke comes with significant morbidity and mortality. With the advent of endovascular interventions, its management has revolutionized. For health authorities to build systems and allocate resources, its burden, predictors, and outcome must be determined. Read More

View Article and Full-Text PDF
September 2020

A simple four-factor preoperative recipient scoring model for prediction of 90-day mortality after adult liver Transplantation:A retrospective cohort study.

Int J Surg 2020 Sep 29;81:26-31. Epub 2020 Jul 29.

Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address:

Background: Although numerous scoring models are available to predict the prognosis of patients undergoing liver transplantation (LT), the field lacks a simple model for quick prediction of the short-term survival of patients after LT in the event that the donor's information is not available in advance.

Methods: A total of 1495 adult patients underwent LT in the present study. Three-quarters of recipients were randomly selected into the test set (n = 1121), while the remaining 25% formed the validation set (n = 374). Read More

View Article and Full-Text PDF
September 2020

Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study.

AJNR Am J Neuroradiol 2020 08 30;41(8):1495-1502. Epub 2020 Jul 30.

Murdoch Children's Research Institute (S.M., R.L., M.S., J.Y.-M.Y.), Parkville, Australia.

Background And Purpose: Polymicrogyria and lissencephaly may be associated with abnormal organization of the undelying white matter tracts that have been rarely investigated so far. Our aim was to characterize white matter tract organization in polymicrogyria and lissencephaly using constrained spherical deconvolution, a multifiber diffusion MR imaging modeling technique for white matter tractography reconstruction.

Materials And Methods: We retrospectively reviewed 50 patients (mean age, 8. Read More

View Article and Full-Text PDF

Septum resection does not improve reproductive outcomes: truly?

Artur Ludwin

Hum Reprod 2020 07;35(7):1495-1498

Department of Gynecology and Oncology, Jagiellonian University, Krakow 31-501, Poland.

View Article and Full-Text PDF

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study.

Intensive Care Med 2020 Jul 9;46(7):1404-1417. Epub 2020 Jun 9.

Department of Critical Care Medicine, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.

Purpose: The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation.

Methods: Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from October 2016 until May 2018. ADE was defined as (1) discontinuation of an antimicrobial in case of empirical combination therapy or (2) replacement of an antimicrobial with the intention to narrow the antimicrobial spectrum, within the first 3 days of therapy. Read More

View Article and Full-Text PDF

Fluid removal associates with better outcomes in critically ill patients receiving continuous renal replacement therapy: a cohort study.

Crit Care 2020 06 1;24(1):279. Epub 2020 Jun 1.

Department of Critical Care, King's College London, Guy's & St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Fluid overload is associated with morbidity and mortality in patients receiving renal replacement therapy (RRT). We aimed to explore whether fluid overload at initiation of RRT was independently associated with mortality and whether changes in cumulative fluid balance during RRT were associated with outcome.

Methods: We retrospectively analysed the data of patients who were admitted to the multidisciplinary adult intensive care unit (ICU) in a tertiary care centre in the UK between 2012 and 2015 and received continuous RRT (CRRT) for acute kidney injury for at least 24 h. Read More

View Article and Full-Text PDF

Maximal flexion and patient outcomes after TKA, using a bicruciate-stabilizing design.

Arch Orthop Trauma Surg 2020 Oct 28;140(10):1495-1501. Epub 2020 May 28.

Department of Orthopedic Surgery, Sint Maartenskliniek, Nijmegen, The Netherlands.

Introduction: Physiological motion after total knee arthroplasty (TKA) should result in a large range of motion, which would lead to good clinical outcomes. An adjusted design of a bicruciate-stabilizing TKA was developed to reproduce physiological motion. The aim of this study was to (1) investigate the maximal knee flexion of this knee system, 1 year post-operatively; (2) determine the clinical and functional improvement and compare the outcomes between patients with and without high maximal flexion; and (3) evaluate the adverse events. Read More

View Article and Full-Text PDF
October 2020

Sleep apnoea and cardiovascular outcomes after coronary artery bypass grafting.

Heart 2020 Oct 18;106(19):1495-1502. Epub 2020 May 18.

Department of Cardiology, National University Heart Centre, Singapore.

Objective: Patients with advanced coronary artery disease are referred for coronary artery bypass grafting (CABG) and it remains unknown if sleep apnoea is a risk marker. We evaluated the association between sleep apnoea and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing non-emergent CABG.

Methods: This was a prospective cohort study conducted between November 2013 and December 2018. Read More

View Article and Full-Text PDF
October 2020

HIV infection is associated with increased meningococcal carriage acquisition amongst first-year students in two South African universities.

Clin Infect Dis 2020 May 5. Epub 2020 May 5.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Invasive meningococcal disease clusters occur amongst university students and may reflect higher carriage prevalence amongst this population. We aimed to measure meningococcal carriage prevalence, acquisition and risk factors amongst first-year university students in South Africa, a middle-income country.

Methods: In summer to autumn 2017, after consenting to participate, we collected oropharyngeal swabs and questionnaires on carriage risk factors and tested students for HIV infection at two universities, during registration week (survey one) and 6-8 weeks later (survey two). Read More

View Article and Full-Text PDF

Adherence with brand versus generic bisphosphonates among osteoporosis patients: a new-user cohort study in the French National Healthcare Insurance database.

Sci Rep 2020 05 4;10(1):7446. Epub 2020 May 4.

Hospices Civils de Lyon, Pôle de Sante Publique, Lyon, France.

Several studies documented declines in treatment adherence with generic forms of oral bisphosphonates in osteoporosis compared to branded forms, while others did not support this relation. Our aim was to compare medication adherence with brand versus generic forms of oral bisphosphonates. A new-user cohort study was conducted using routinely collected administrative and healthcare data linked at the individual level extracted from a nationwide representative sample of the French National Healthcare Insurance database. Read More

View Article and Full-Text PDF

Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis.

Crit Care 2020 04 20;24(1):161. Epub 2020 Apr 20.

Department of Pharmacy and Health Systems Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, USA.

Background: While delirium prevalence and duration are each associated with increased 30-day, 6-month, and 1-year mortality, the association between incident ICU delirium and mortality remains unclear. We evaluated the association between both incident ICU delirium and days spent with delirium in the 28 days after ICU admission and mortality within 28 and 90 days.

Methods: Secondary cohort analysis of a randomized, double-blind, placebo-controlled trial conducted among 1495 delirium-free, critically ill adults in 14 Dutch ICUs with an expected ICU stay ≥2 days where all delirium assessments were completed. Read More

View Article and Full-Text PDF

Etiologies of apnea of infancy.

Pediatr Pulmonol 2020 06 14;55(6):1495-1502. Epub 2020 Apr 14.

Department of Pediatrics and Adolescents, Homer Stryker MD School of Medicine, Western Michigan University, Kalamazoo, Michigan.

Background: To date there are limited data in the literature to guide the initial evaluation for etiologies of apnea in full-term infants born at greater than or equal to 37 weeks conceptional age (apnea of infancy [AOI]). Pediatricians and pediatric pulmonologists are left to pursue a broad, rather than targeted and a stepwise approach to begin diagnostic evaluation.

Methods: We performed a retrospective chart review of 101 symptomatic full-term infants (age under 12 months) diagnosed with apnea with an inpatient multichannel pneumogram (six channels) or a fully attended overnight pediatric polysomnogram in our outpatient sleep center accredited by American Academy of Sleep Medicine (AASM), scored using the standards set forth by the AASM. Read More

View Article and Full-Text PDF