291 results match your criteria cohesion onset


The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer.

Genes (Basel) 2021 Mar 10;12(3). Epub 2021 Mar 10.

Istituto di Biochimica e Biologia Cellulare-CNR, Via P. Castellino, 111, 80131 Naples, Italy.

DDX11/ChlR1 is a super-family two iron-sulfur cluster containing DNA helicase with roles in DNA replication and sister chromatid cohesion establishment, and general chromosome architecture. Bi-allelic mutations of the DDX11 gene cause a rare hereditary disease, named Warsaw breakage syndrome, characterized by a complex spectrum of clinical manifestations (pre- and post-natal growth defects, microcephaly, intellectual disability, heart anomalies and sister chromatid cohesion loss at cellular level) in accordance with the multifaceted, not yet fully understood, physiological functions of this DNA helicase. In the last few years, a possible role of DDX11 in the onset and progression of many cancers is emerging. Read More

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Adherens junctions are involved in polarized contractile ring formation in dividing epithelial cells of Xenopus laevis embryos.

Exp Cell Res 2021 May 2;402(1):112525. Epub 2021 Mar 2.

Univ Rennes, CNRS, IGDR (Institut de Génétique et Développement de Rennes), UMR 6290, 2 Avenue Du Professeur Leon Bernard, 35000, Rennes, France. Electronic address:

Cells dividing in the plane of epithelial tissues proceed by polarized constriction of the actomyosin contractile ring, leading to asymmetric ingression of the plasma mem brane. Asymmetric cytokinesis results in the apical positioning of the actomyosin contractile ring and ultimately of the midbody. Studies have indicated that the contractile ring is associated with adherens junctions, whose role is to maintain epithelial tissue cohesion. Read More

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Microtubule motors in centrosome homeostasis: A target for cancer therapy?

Biochim Biophys Acta Rev Cancer 2021 Feb 12;1875(2):188524. Epub 2021 Feb 12.

Cellular Dyshomeostasis Laboratory (CDHL), School of Chemical and Bio Technology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India. Electronic address:

Cancer is a grievous concern to human health, owing to a massive heterogeneity in its cause and impact. Dysregulation (numerical, positional and/or structural) of centrosomes is one of the notable factors among those that promote onset and progression of cancers. In a normal dividing cell, a pair of centrosomes forms two poles, thereby governing the formation of a bipolar spindle assembly. Read More

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February 2021

Hamstring muscles rupture under traction, peeling and shear lap tests: A biomechanical study in rabbits.

J Mech Behav Biomed Mater 2021 04 13;116:104324. Epub 2021 Jan 13.

Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023, Saint-Etienne, France.

Lesions of the Musculotendinous Unit (MTU, i.e. tendon, myotendinous junction, muscle, aponeurosis and myoaponeurotic junction) are a common injury and a leading cause of functional impairment, long-term pain, and/or physical disability worldwide. Read More

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Behavioral responses of Japanese macaques to playback-simulated intergroup encounters.

Behav Processes 2021 Jan 12;182:104279. Epub 2020 Nov 12.

School of Human Sciences, Osaka University, Suita, Japan.

Group-living animals gain fitness benefits from intergroup aggression, but also incur costs. Advertisement behaviors, such as long-distance calls and scent marking, help animals avoid disadvantageous, or less rewarding, fights. However, it remains unclear how species that lack advertisement behaviors respond to auditory information from other groups. Read More

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January 2021

Haploinsufficiency of cohesin protease, Separase, promotes regeneration of hematopoietic stem cells in mice.

Stem Cells 2020 Sep 30. Epub 2020 Sep 30.

Texas Childrens Cancer Center, Baylor College of Medicine, Houston, Texas, USA.

Cohesin recently emerged as a new regulator of hematopoiesis and leukemia. In addition to cohesin, whether proteins that regulate cohesin's function have any direct role in hematopoiesis and hematologic diseases have not been fully examined. Separase, encoded by the ESPL1 gene, is an important regulator of cohesin's function. Read More

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September 2020

Introducing the ORIGINS project: a community-based interventional birth cohort.

Rev Environ Health 2020 Sep;35(3):281-293

Telethon Kids Institute, Perth, WA, Australia.

Objectives Non-communicable diseases (NCDs) pose the greatest threat to human health globally. The dramatic rise in early onset NCDs - such as childhood obesity, the allergy epidemic and an increasing burden of mental ill health in children and youth - reflect the profound early impact of modern environments on developing systems. The ORIGINS Project is a research platform enabling world class investigation of early antecedent pathways to NCDs, and how to curtail these. Read More

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September 2020

Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space.

Essays Biochem 2020 09;64(2):251-261

Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, United States of America.

While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique needs of homolog segregation during meiosis I (MI). CENP-C is a critical component of the centromere for kinetochore assembly in mitosis. Recent work, however, has highlighted the unique features of meiotic CENP-C. Read More

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September 2020

Does community-level social capital mitigate the impact of widowhood & living alone on depressive symptoms?: A prospective, multi-level study.

Soc Sci Med 2020 08 26;259:113140. Epub 2020 Jun 26.

Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.

Widowhood and living alone are linked to increased risk of depression. We examined prospectively whether community-level social capital can mitigate the adverse impact of widowhood and living alone on depressive symptoms. We used data of the Japan Gerontological Evaluation Study of functionally independent adults aged 65 years or older. Read More

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Association between Family Functionality and Depression: A Systematic Review and Meta-Analysis.

Korean J Fam Med 2021 Mar 10;42(2):172-180. Epub 2020 Jun 10.

School of Medicine, Universidad del Valle, Cali, Colombia.

Background: Different scales have attempted to assess various aspects of family dynamics and structures. Good family function seems to allow for better prognoses for basic diseases and appears to be a predictor of depression. The aim of this study was to determine the association between family functionality and depression. Read More

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Language as a biomarker for psychosis: A natural language processing approach.

Schizophr Res 2020 12 1;226:158-166. Epub 2020 Jun 1.

Department of Psychology, Emory University, Atlanta, GA, USA. Electronic address:

Human ratings of conceptual disorganization, poverty of content, referential cohesion and illogical thinking have been shown to predict psychosis onset in prospective clinical high risk (CHR) cohort studies. The potential value of linguistic biomarkers has been significantly magnified, however, by recent advances in natural language processing (NLP) and machine learning (ML). Such methodologies allow for the rapid and objective measurement of language features, many of which are not easily recognized by human raters. Read More

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December 2020

Relationship between Individual Social Capital and Functional Ability among Older People in Anhui Province, China.

Int J Environ Res Public Health 2020 04 17;17(8). Epub 2020 Apr 17.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.

This study aimed to explore the relationship between individual social capital and functional ability, with a focus on whether there is an interactive relationship that exists among social capital related to functional ability among older people in Anhui province, China. We conducted a cross-sectional study with a multi-stage stratified cluster random sampling method from July to September 2017. Data were collected through questionnaire including demographic characteristics, individual social capital status, and functional capability status. Read More

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Psychological Predictors for Depression and Burnout Among German Junior Elite Athletes.

Front Psychol 2020 2;11:601. Epub 2020 Apr 2.

Chair of Sport Psychology, Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany.

There exists a strong need for research in clinical sport psychology which does not merely gather information on prevalence rates for psychological disorders and case studies of affected athletes. Rather, research should also uncover the underlying psychological variables which increase the risk for depression and burnout in elite athletes. Many studies gather general factors (e. Read More

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Postdisaster Changes in Social Capital and Mental Health: A Natural Experiment From the 2016 Kumamoto Earthquake.

Am J Epidemiol 2020 09;189(9):910-921

Levels of social capital can change after a natural disaster; thus far, no study has examined how changes in social capital affect the mental health of disaster victims. In this study, we examined how predisaster social capital and its changes after a disaster were associated with the onset of mental disorders. In October 2013, we mailed a questionnaire to participants in the Japan Gerontological Evaluation Study living in Mifune, a town in Kumamoto Prefecture, Japan, and measured predisaster social capital. Read More

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September 2020

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint.

F1000Res 2020 28;9. Epub 2020 Jan 28.

CEINGE Biotecnologie Avanzate, Naples, 80145, Italy.

The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere, have to interact with microtubules of the mitotic spindle so that each chromatid takes connections with microtubules emanating from opposite spindle poles (we will refer to this condition as bipolar attachment). Only once all replicated chromosomes have reached bipolar attachments can sister chromatids lose cohesion with each other, at the onset of anaphase, and move toward opposite spindle poles, being segregated into what will soon become the daughter cell nucleus. Read More

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October 2020

Family functioning among adolescents with narcolepsy.

Paediatr Child Health 2019 Dec 11;24(8):490-494. Epub 2019 Jan 11.

Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario.

Background: Narcolepsy is a sleep disorder with no cure with onset typically during adolescence. Caring for an adolescent with a lifelong medical condition can negatively impact family structure, cohesion, relationships, and overall functioning. The primary objective of this study was to evaluate family functioning in a cohort of adolescents with narcolepsy using the PedsQL Family Impact Module. Read More

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December 2019

Effects of Expressing Writing on organizational variables in Palliative Care health Professionals: an explorative study.

Acta Biomed 2019 11 11;90(11-S):108-116. Epub 2019 Nov 11.

University of Parma.

Background And Aim: Healthcare professionals working in palliative care are exposed to emotionally intense conditions. Scientific literature suggests Expressive Writing as a valid tool for the adjustment to traumatic events. For health workers, EW represents an important support to prevent Compassion Fatigue and Burnout. Read More

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November 2019

Family functioning and satisfaction: A comparative study between hookah users and non-users.

Afr J Prim Health Care Fam Med 2019 Nov 12;11(1):e1-e6. Epub 2019 Nov 12.

Child and Family Studies, Department of Social Work, University of the Western Cape, Bellville.

Background: Although there has been an exponential growth in hookah use on a global scale, research within the context of South Africa is very limited. While hookah use is known internationally to be a health and addiction risk, the focus is on university students and not on families.

Aim: This study aims to compare the family functioning and family satisfaction among hookah users and non-users. Read More

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November 2019

Community social capital and the onset of functional disability among older adults in Japan: a multilevel longitudinal study using Japan Gerontological Evaluation Study (JAGES) data.

BMJ Open 2019 10 8;9(10):e029279. Epub 2019 Oct 8.

Department of Public Health, Nagoya City University, Nagoya, Japan

Objective: The present study examined the association between community social capital and the onset of functional disability among older Japanese people by using validated indicators of social capital and a prospective multilevel design.

Design: Prospective cohort study SETTING: We used data from the Japan Gerontological Evaluation Study, established from August 2010 to January 2012 in 323 districts.

Participants: The target population was restricted to non-institutionalised people aged 65 years or older who were independent in activities of daily living. Read More

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October 2019

[Symptoms of eating disorders in children and adolescents: frequencies and risk factors : Results from KiGGS Wave 2 and trends].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Oct;62(10):1195-1204

Abteilung für Epidemiologie und Gesundheitsmonitoring, Fachgruppe Psychische Gesundheit, Robert Koch-Institut, General-Pape-Str. 62-66, 12101, Berlin, Deutschland.

Eating disorders are of high clinical and societal relevance. They are among the most common chronic mental illnesses in adulthood, but show a high incidence rate and peak of disease onset even in adolescence. Eating disorders are associated with far-reaching costs, such as acute or chronic comorbidities and educational or professional attainment. Read More

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October 2019

Disablement in Context: Neighborhood Characteristics and Their Association With Frailty Onset Among Older Adults.

J Gerontol B Psychol Sci Soc Sci 2019 09;74(7):e40-e49

Department of Sociology, University of Chicago, Illinois.

Objectives: Frailty, an aggregate expression of risk resulting from age- or disease-associated physiologic accumulation, is responsible for large economic and societal costs. Little is known about how the context in which older adult's live may contribute to differences in frailty. This study clarifies the role of neighborhood structural characteristics and social processes for understanding declines in health status. Read More

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September 2019

The expanding phenotypes of cohesinopathies: one ring to rule them all!

Cell Cycle 2019 11 13;18(21):2828-2848. Epub 2019 Sep 13.

Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine , Montréal , QC , Canada.

Preservation and development of life depend on the adequate segregation of sister chromatids during mitosis and meiosis. This process is ensured by the cohesin multi-subunit complex. Mutations in this complex have been associated with an increasing number of diseases, termed cohesinopathies. Read More

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November 2019

The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly.

Nat Cell Biol 2019 09 2;21(9):1138-1151. Epub 2019 Sep 2.

Zentrum für Molekulare Biologie, Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.

One of the first steps in mitotic spindle assembly is the dissolution of the centrosome linker followed by centrosome separation driven by EG5, a tetrameric plus-end-directed member of the kinesin-5 family. However, even in the absence of the centrosome linker, the two centrosomes are kept together by an ill-defined microtubule-dependent mechanism. Here we show that KIFC3, a minus-end-directed kinesin-14, provides microtubule-based centrosome cohesion. Read More

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September 2019

Development of a Healthy Lifestyle Assessment Toolkit for the General Public.

Front Med (Lausanne) 2019 27;6:134. Epub 2019 Jun 27.

Faculty of Medicine, Institute of Pharmacology & Experimental Therapeutics, University of Coimbra, Coimbra, Portugal.

The prevalence of age-related non-communicable chronic diseases has increased worldwide, being the leading causes of morbidity and death in many world regions, including in Europe. Innovative models and strategies focused on preventive care, including early identification of risk factors underlying disease onset and progression, and proper modification of lifestyle habits and behaviors, might contribute to promote quality of life, healthy living and active aging. Healthy Lifestyle Innovative Quarters for Cities and Citizens (HeaLIQs4cities) is an EIT Health-funded project aiming to engage, empower and educate citizens toward healthy lifestyles. Read More

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Social intolerance is a consequence, not a cause, of dispersal in spiders.

PLoS Biol 2019 07 2;17(7):e3000319. Epub 2019 Jul 2.

Centre de Recherches sur la Cognition Animale, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.

From invertebrates to vertebrates, a wealth of species display transient sociality during their life cycle. Investigating the causes of dispersal in temporary associations is important to better understand population dynamics. It is also essential to identify possible mechanisms involved in the evolutionary transition from transient to stable sociality, which has been documented repeatedly across taxa and typically requires the suppression of dispersal. Read More

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SET binding to Sgo1 inhibits Sgo1-cohesin interactions and promotes chromosome segregation.

J Cell Biol 2019 08 21;218(8):2514-2528. Epub 2019 Jun 21.

Department of Biochemistry and Molecular Biology and Tulane Aging Center, Tulane University Health Science Center, New Orleans, LA

At anaphase onset, Sgo1 function of cohesion protection must be disabled to allow timely chromosome segregation, but how this is achieved is not fully understood. Here, we show that SET, a known PP2A inhibitor, directly binds to a domain in Sgo1 in close proximity to the cohesin-binding motif. The Sgo1-cohesin binding can be disrupted by SET in a dose-dependent manner in vitro as well as by SET overexpression in cells, suggesting that SET is also an inhibitor to the Sgo1-cohesin binding. Read More

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SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis.

Nat Commun 2019 04 15;10(1):1755. Epub 2019 Apr 15.

Department of Developmental Biology, University of Hamburg, Hamburg, 22609, Germany.

Mitosis and meiosis both rely on cohesin, which embraces the sister chromatids and plays a crucial role for the faithful distribution of chromosomes to daughter cells. Prior to the cleavage by Separase at anaphase onset, cohesin is largely removed from chromosomes by the non-proteolytic action of WINGS APART-LIKE (WAPL), a mechanism referred to as the prophase pathway. To prevent the premature loss of sister chromatid cohesion, WAPL is inhibited in early mitosis by Sororin. Read More

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Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers.

Psychol Med 2020 04 15;50(5):737-745. Epub 2019 Apr 15.

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

Background: Whereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.

Methods: Data were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Read More

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Meiotic prophase-like pathway for cleavage-independent removal of cohesin for chromosome morphogenesis.

Curr Genet 2019 Aug 28;65(4):817-827. Epub 2019 Mar 28.

Institute for Protein Research, Osaka University, Suita, Osaka, 565-0871, Japan.

Sister chromatid cohesion is essential for chromosome segregation both in mitosis and meiosis. Cohesion between two chromatids is mediated by a protein complex called cohesin. The loading and unloading of the cohesin are tightly regulated during the cell cycle. Read More

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