127 results match your criteria coexistence graves'

Metastatic Malignant Struma Ovarii and Graves' Disease: A Rare Occurrence.

AACE Clin Case Rep 2021 Jul-Aug;7(4):243-246. Epub 2021 Jan 6.

Tan Tock Seng Hospital, Department of Endocrinology, Novena, Singapore.

Objective: Malignant struma ovarii (SO) is a rare condition. Although there have been a few reported cases of malignant SO with coexisting Graves' disease (GD), the exact incidence of metastasis in these cases is not known. We report a rare case of metastatic malignant SO coexisting with GD. Read More

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January 2021

First case report of papillary thyroid carcinoma arising within a functional teratoma in Graves' disease patient.

Gynecol Endocrinol 2021 Jun 28:1-4. Epub 2021 Jun 28.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei City Hospital, Ren-Ai branch, Taipei, Taiwan.

Aim: Mature cystic teratoma is the most common kind of ovarian germ tumor. However, malignant transformation is uncommon, differentiated thyroid carcinoma is even rare. Hyperthyroidism due to coexistence of Graves' disease (GD) and struma ovarii has been reported. Read More

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Coexistence of diabetic ketoacidosis and thyrotoxicosis: a jeopardy of two endocrine emergencies.

BMJ Case Rep 2021 Jun 15;14(6). Epub 2021 Jun 15.

Internal Medicine, Allama Iqbal Medical College, Lahore, Pakistan.

Simultaneous occurrences of diabetic ketoacidosis (DKA) and thyroid storm have long been known, but only a few cases have been reported to date. Both these endocrine emergencies demand timely diagnosis and management to prevent adverse outcomes. Due to the similarities in their clinical presentation, DKA can mask the diagnosis of thyroid storm and vice versa. Read More

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Unusual Endocrinopathies in 18q Deletion Syndrome: Pseudoparathyroidism and Hyper-/Hypo-Thyroidism.

AACE Clin Case Rep 2021 May-Jun;7(3):192-194. Epub 2020 Dec 24.

Department of Pediatric Endocrinology, University of South Alabama, Mobile, Alabama.

Objective: To describe new and unusual endocrinopathies in children with de novo 18q deletion (18q-) syndrome.

Methods: We describe 2 patients who have atypical thyroid conditions and 1 who also developed symptomatic hypocalcemia.

Results: The first patient developed hyperthyroidism at the age of 3 years, with a free thyroxine level of 3. Read More

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December 2020

A Rare Clinical Manifestation of Graves' Disease: Evans Syndrome and a Review of the Literature.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):518-521

University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital - Endocrinology and Metabolism - Ankara, Turkey.

Evans syndrome is a rare combination of autoimmune hemolytic anemia and immune thrombocytopenia. Evans syndrome in cases of Graves' disease is extremely rare. The coexistence of these autoimmune diseases suggests that they may share a common pathogenic pathway. Read More

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Strong Correlation between HLA and Clinical Course of Subacute Thyroiditis-A Report of the Three Siblings.

Genes (Basel) 2020 10 29;11(11). Epub 2020 Oct 29.

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.

Subacute thyroiditis (SAT) is a thyroid inflammatory disease with susceptibility associated with the presence of human leukocyte antigen (, , and . Previous viral infection is considered as a triggering factor in genetically predisposed individuals. The influence of HLA on the SAT course was previously suggested. Read More

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October 2020

Coexistence of Autoimmune Hyper- and Hypothyroidism in a Kindred with Reduced Sensitivity to Thyroid Hormone.

Eur Thyroid J 2020 Sep 17;9(5):263-268. Epub 2020 Apr 17.

Department of Endocrinology and Nutrition, Ambroise Paré Universitary Hospital, Assistance Publique Hôpitaux de Paris, Boulogne, France.

Introduction: Resistance to thyroid hormone beta (RTHβ) is a rare disease with an autosomal dominant transmission. Diagnosis may be challenging especially in patients with hyper- or hypothyroidism.

Case Presentation: A 31-year-old male patient with suppressed thyroid-stimulating hormone (TSH), elevated free thyroxine and free triiodothyronine, along with high thyroid receptor antibodies was diagnosed with Graves' disease. Read More

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September 2020

A rare case of coexistence of autoimmune polyglandular syndrome type 3 with growth hormone deficiency and hyperthyroidism in a patient with pseudo-Turner's syndrome.

J Int Med Res 2020 Oct;48(10):300060520961684

Department of Emergency, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Autoimmune polyglandular syndrome (APS) is a rare disease that is characterized by autoimmune reactions to multiple endocrine and non-endocrine organs, which can be divided into four main types. The principal manifestations of APS-3 are autoimmune thyroid disease and other autoimmune diseases, such as type 1 diabetes, atrophic gastritis, pernicious anemia, vitiligo, alopecia, and myasthenia gravis, but not Addison's disease or hypoparathyroidism. Here we report a case demonstrating the rare coexistence of growth hormone deficiency and hyperthyroidism with sexual dysgenesis, secondary amenorrhea, cardiomegaly, splenomegaly, hypoproteinemia, pleural effusion, seroperitoneum, pericardial effusion, anasarca, osteoporosis, vitamin D deficiency, iron-deficiency anemia, poor blood coagulation, leucocytopenia, peripheral neuropathy, hyperuricemia, ichthyosis, tinea cruris, and onychomycosis. Read More

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October 2020

A remarkable case of thyrotoxicosis initially caused by graves' disease followed by a probable TSHoma - a case report.

BMC Endocr Disord 2020 Aug 27;20(1):133. Epub 2020 Aug 27.

Department of Diabetes and Endocrinology, Beaumont Hospital and the RCSI, Dublin, Ireland.

Background: Graves' disease is the commonest cause of thyrotoxicosis whilst thyrotropin (TSH)-producing pituitary adenomas (thyrotropinomas, TSHomas) are very rare and account for just 1-2% of all pituitary adenomas. Coexistence of a TSHoma and Graves' disease has been very rarely reported. Here, we report a case of a patient whose initial presentation with primary thyrotoxicosis due to Graves' disease, was subsequently followed by a relapse of thyrotoxicosis due to a probable TSHoma. Read More

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Concurrent Graves' Disease and TSH Secreting Pituitary Adenoma Presenting Suppressed Thyrotropin Levels: A Case Report and Review of the Literature.

Front Endocrinol (Lausanne) 2020 6;11:523. Epub 2020 Aug 6.

Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, China.

Thyroid stimulating hormone (TSH) secreting pituitary adenoma (TSHoma) is a rare cause of hyperthyroidism. To date there have been only thirteen cases reporting the coexistence of TSHoma with Graves' disease (GD). The diagnosis and management for such hyperthyroidism due to both etiologies remain challenging. Read More

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Aspartic acid in the HLA-DRB1 chain and shared epitope alleles partially explain the high prevalence of autoimmunity in Mexicans.

J Transl Autoimmun 2020 15;3:100057. Epub 2020 May 15.

Immunogenetics Division, Transplant Department. Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Mexico.

Introduction: Autoimmune thyroid disease (AITD) is the most common autoimmune disorder worldwide. Remarkably, it is commonly accompanied by other autoimmune diseases, such as rheumatoid arthritis (RA). The immunopathogenic mechanisms behind the coexistence of these disorders are still not completely understood. Read More

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The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report.

BMC Endocr Disord 2020 Jun 30;20(1):97. Epub 2020 Jun 30.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.

Background: Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease.

Case Presentation: A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Read More

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Atypical hemolytic uremic syndrome precipitated by thyrotoxicosis: a case report.

Ling Hou Yue Du

BMC Pediatr 2020 04 17;20(1):169. Epub 2020 Apr 17.

Pediatric Nephrology Department, Shengjing Hospital of China Medical University, No.36 Sanhao Street Heping District, Shenyang City, 110004, Liaoning Province, China.

Background: Autoimmune thyroid disease (AITD) has a complex pathogenesis and is associated with the development of autoimmunity against the thyroid. Graves' disease and Hashimoto's thyroiditis are the two main types of AITD, and they are characterized by thyrotoxicosis and hypothyroidism, respectively. Atypical hemolytic uremic syndrome (aHUS) is a rare disease, presenting with microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Read More

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Familial dysalbuminemic hyperthyroxinemia confounding management of coexistent autoimmune thyroid disease.

Endocrinol Diabetes Metab Case Rep 2020 Feb 26;2020. Epub 2020 Feb 26.

Wellcome-MRC Institute of Metabolic ScienceUniversity of Cambridge, Cambridge, UK.

Summary: Familial dysalbuminemic hyperthyroxinemia (FDH) is a cause of discordant thyroid function tests (TFTs), due to interference in free T4 assays, caused by the mutant albumin. The coexistence of thyroid disease and FDH can further complicate diagnosis and potentially result in inappropriate management. We describe a case of both Hashimoto's thyroiditis and Graves' disease occurring on a background of FDH. Read More

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February 2020

A rare coexistence of Behcet's disease and Graves' thyrotoxicosis in a young man: a case report.

Oxf Med Case Reports 2020 Jan 31;2020(1):omz132. Epub 2020 Jan 31.

Department of Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, UK.

Behcet's disease is a recurrent systemic vasculitic disorder. It manifests most commonly in the form of skin lesions, oral and genital ulcers and uveitis. Graves' thyrotoxicosis is an autoimmune disorder characterized by excessive production of thyroid hormones. Read More

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January 2020

Assessment of subclinical left ventricular dysfunction with speckle-tracking echocardiography in hyperthyroid and euthyroid Graves' disease and its correlation with serum TIMP-1.

Acta Cardiol 2021 Apr 7;76(2):177-184. Epub 2020 Jan 7.

Department of Cardiology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.

Background: Graves' disease has a multitude of effects on the cardiovascular system. In the detection of subclinical left ventricular dysfunction, speckle-tracking echocardiography is more useful than conventional echocardiography. The aim of the present study was to compare the longitudinal global strain values and venous blood concentration of (tissue inhibitor of metalloproteinase-1) TIMP-1, a regulator of the extracellular matrix, among hyperthyroid patients with Graves' disease, euthyroid patients with Graves' disease and healthy control subjects. Read More

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Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery.

Emin Gurleyik

Cureus 2019 Sep 26;11(9):e5768. Epub 2019 Sep 26.

Surgery, Duzce University Medical Faculty, Duzce, TUR.

Marine-Lenhart syndrome (MLS), a rare form of hyperthyroidism, is the coexistence of Graves' disease (GD) and autonomously functioning thyroid nodule(s). Herein, we report a case of recurrent goiter presented with MLS. A 52-year-old man presented at our department with recurrent goiter, exophthalmia, and symptoms of hyperthyroidism. Read More

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September 2019

2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy.

Eur Thyroid J 2019 Jul 4;8(4):173-185. Epub 2019 Jul 4.

Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.

Thyroid dysfunction (TD) frequently occurs as an autoimmune complication of immune reconstitution therapy (IRT), especially in individuals with multiple sclerosis treated with alemtuzumab, a pan-lymphocyte depleting drug with subsequent recovery of immune cell numbers. Less frequently, TD is triggered by highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV), or patients undergoing bone-marrow/hematopoietic-stem-cell transplantation (BMT/HSCT). In both alemtuzumab-induced TD and HIV/HAART patients, the commonest disorder is Graves' disease (GD), followed by hypothyroidism and thyroiditis; Graves' orbitopathy is observed in some GD patients. Read More

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Phenotypic Expression of Autoimmunity in Children With Autoimmune Thyroid Disorders.

Front Endocrinol (Lausanne) 2019 12;10:476. Epub 2019 Jul 12.

Department of Human Pathology of Adulthood and Childhood, Unit of Pediatrics, University of Messina, Messina, Italy.

Autoimmune thyroid diseases (AITDs), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), tend to aggregate with other non-thyroidal autoimmune diseases (NTADs). Aim of this Mini-review is to report the most recent insights concerning the clustering of NTADs in pediatric patients with either HT or GD, the pathophysiology of AITDs and the metamorphic thyroid autoimmunity. A systematic literature research of the last 15 years, according to EQUATOR statement, was carried out through MEDLINE via PubMed (http://www. Read More

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Rare Co-occurrence of Ocular Myasthenia Gravis and Thyroid-Associated Orbitopathy (Ophthalmopathy) in an Individual With Hypothyroidism.

Front Endocrinol (Lausanne) 2018 12;9:801. Epub 2019 Feb 12.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Ocular myasthenia gravis (Ocular MG, OMG) shares many clinical features with thyroid-associated orbitopathy or thyroid-associated ophthalmopathy (TAO). In the rare instance of their coexistence, clinicians may fail to diagnose ocular MG when TAO is also present. Here we report the case of a patient with both TAO and ocular MG, whose "hyperthyroidism"-most likely the hashitoxicosis variant of Hashimoto's thyroiditis-rapidly transformed to hypothyroidism after radioactive iodine therapy. Read More

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February 2019

A marked goiter involved in Marine-Lenhart syndrome.

J Gen Fam Med 2019 Jan 24;20(1):37-38. Epub 2018 Nov 24.

Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Marine-Lenhart syndrome is rare disease defined as coexistence of Graves' disease and autonomously functioning thyroid nodule. We will introduce a case of Marine-Lenhart with a huge goiter. Read More

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January 2019

A new case of Marine-Lenhart syndrome with a papillary thyroid carcinoma.

Clin Case Rep 2018 Dec 18;6(12):2299-2302. Epub 2018 Oct 18.

Department of Clinical and Experimental Medicine Endocrine Unit University of Pisa Pisa Italy.

We report the case of a patient with the coexistence of Graves' disease and autonomously functioning thyroid nodules. Because of the suspicious ultrasound pattern, he was submitted to fine-needle aspiration of the hot nodule and cytology revealed a papillary thyroid cancer. After total thyroidectomy a papillary thyroid cancer was found. Read More

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December 2018

Marine-Lenhart Syndrome: Case Report, Diagnosis, and Management.

Case Rep Endocrinol 2018 24;2018:3268010. Epub 2018 Oct 24.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

The coexistence of thyroid functioning nodules and Graves' disease is called Marine-Lenhart syndrome. This condition is estimated to occur in 0.8-2. Read More

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October 2018

Anti-Saccharomyces Cerevisiae as Unusual Antibody in Autoimmune Polyglandular Syndrome Type III: A Case Report.

Endocr Metab Immune Disord Drug Targets 2019 ;19(1):90-94

Department of Neurology, Gozde Akademi Hospital Malatya, Ankara asfalti 6. Km No:219, 44110 Yesilyurt/ Malatya, Turkey.

Backgraund and Objective: Anti-Saccharomyces Cerevisiae Antibodies (ASCA) that are considered to reflect immune response against increased intestinal permeability due to mucosal damage are among the serological markers of Crohn's Disease.

Methods: This microbial seromarker was recently shown to be elevated in several autoimmune disorders such as celiac disease, autoimmune liver diseases, type 1 diabetes, and Graves' disease. Despite that fact, ASCA seropositivity in Autoimmune Polyglandular Syndrome (APS) has never been reported before. Read More

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Case report of recurrent atrial fibrillation induced by thyrotropin-secreting pituitary adenoma with Graves' disease.

Medicine (Baltimore) 2018 Jun;97(24):e11047

Department of Endocrinology and Metabolism Department of General Practice Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Department of Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

Rationale: Thyrotropin-secreting adenoma (TSHoma) is rare. Even though the thyrotoxicosis is mild in patients with TSHoma, it is still a rare cause of arrhythmia, ignore of mild disfunction of thyroid function of TSHoma can lead to the delayed diagnosis of pituitary tumor or leading to recurring of complications. Graves' disease is an auto-immue endocrinological disorder. Read More

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Coexistence of Primary Hyperaldosteronism and Graves' Disease, a Rare Combination of Endocrine Disorders: Is It beyond a Coincidence-A Case Report and Review of the Literature.

Case Rep Endocrinol 2017 30;2017:4050458. Epub 2017 Oct 30.

Department of Endocrinology, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.

Background: Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays a role in immunomodulation/development of autoimmunity. Recent researches also suggest significant thyroid dysfunction among patients with hyperaldosteronism, but exact causal relationship is not established. Read More

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October 2017

Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature.

Animesh Sharma

J Pediatr Endocrinol Metab 2017 Nov;30(12):1237-1243


Background: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. Read More

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November 2017

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity.

F1000Res 2017 28;6:1776. Epub 2017 Sep 28.

Department of Medical Endocrinology, Section 2132, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen, Denmark.

Autoimmune thyroid disease (AITD) is often observed together with other autoimmune diseases. The coexistence of two or more autoimmune diseases in the same patient is referred to as polyautoimmunity, and AITD is the autoimmune disease most frequently involved. The occurrence of polyautoimmunity has led to the hypothesis that the affected patients suffer from a generalized dysregulation of their immune system. Read More

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September 2017

Periodic Paralysis and Encephalopathy as Initial Manifestations of Graves' Disease: Case Report and Review of the Literature.

Neurologist 2017 Jul;22(4):134-137

*Neurology Department, Papageorgiou General Hospital ‡Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece †Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background: Thyrotoxic periodic paralysis (TPP) is an uncommon complication of Graves' disease, characterized by the triad of acute hypokalemia without total body potassium deficit, episodic muscle paralysis, and thyrotoxicosis. Graves' encephalopathy is an extremely rare form of encephalopathy associated with autoimmune thyroid disease (EAATD), characterized by neuropsychiatric symptoms, increased antithyroid antibodies and cerebrospinal fluid protein concentration, nonspecific electroencephalogram abnormalities, and cortico-responsiveness. Coexistence of both these complications in the same patient has not been reported before. Read More

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Growth hormone and insulin-like growth factor 1 affect the severity of Graves' disease.

Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.

Department of Medical, Oral and Biotechnological Sciences, Dental School, University 'G. d'Annunzio' of Chieti-Pescara, ChietiItaly.

Graves' disease, the most common form of hyperthyroidism in iodine-replete countries, is associated with the presence of immunoglobulins G (IgGs) that are responsible for thyroid growth and hyperfunction. In this article, we report the unusual case of a patient with acromegaly and a severe form of Graves' disease. Here, we address the issue concerning the role of growth hormone (GH) and insulin-like growth factor 1 (IGF1) in influencing thyroid function. Read More

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