Int J Parasitol 2021 Apr 10. Epub 2021 Apr 10.
Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Institute of Parasitology Biology Centre, CAS v.v.i. Branisovska 31, 370 05 Ceske Budejovice, Czech Republic. Electronic address:
Giardia intestinalis is an enteric pathogen with an extremely modified membrane trafficking system, lacking canonical compartments such as the Golgi, endosomes, and intermediate vesicle carriers. By comparison the fornicate relatives of Giardia possess comparatively greater endomembrane system complexity. In eukaryotes, the ADP ribosylation factor (ARF) GTPase regulatory system proteins, which consist of the small GTPase ARF1, and its guanine exchange nucleotide factors (GEFs) and GTPase activating proteins (GAPs), coordinate temporal and directional trafficking of cargo vesicles by recognizing and interacting with heterotetrameric coat complexes at pre-Golgi and post-Golgi interfaces. Read More