190,031 results match your criteria coagulation function

Monomeric C-reactive protein promotes platelets to release mitochondrial DNA in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Mol Immunol 2021 Jul 19;137:228-237. Epub 2021 Jul 19.

Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, 300052, China. Electronic address:

Although high level of circulating C-reactive protein (pCRP) is considered as a biomarker for disease activity, the significance of CRP in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has not been clarified. We once reported in AAV, pentameric CRP (pCRP) could dissociate into monomeric CRP (mCRP) and activate platelets. Recent studies have demonstrated that the activated platelets can release mitochondrial DNA (mtDNA). Read More

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Thrombotic risk in children with COVID-19 infection: A systematic review of the literature.

Thromb Res 2021 Jul 16;205:92-98. Epub 2021 Jul 16.

Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy. Electronic address:

Objective: Coagulation and inflammatory parameters are mildly altered in children with SARS-CoV-2 (COVID-19) infection, and laboratory evidence of a proinflammatory and procoagulant state has been noted in multisystem inflammatory syndrome in children (MIS-C). It is not clear whether this pediatric condition is related to thrombotic events. With this study we reviewed the literature for thrombotic complications in children with COVID-19 infection and MIS-C. Read More

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Herb-drug interactions and toxicity: Underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches.

Food Chem Toxicol 2021 Jul 19:112432. Epub 2021 Jul 19.

Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius. Electronic address:

Herbals in the form of medicine are employed extensively around the world. Herbal and conventional medicine combination is a potentially dangerous practice mainly in comorbid, hepato insufficient and frail patients leading to perilous herb-drug interactions (HDI) and toxicity. This study features potential HDI of 15 globally famous plant species through data mining and computational methods. Read More

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Controlling Coagulation in Blood with Red Light.

Angew Chem Int Ed Engl 2021 Jul 22. Epub 2021 Jul 22.

University of Frankfurt, Cluster of Excellence Macromolecular Complexes, Max-von-Laue-Str. 9, 60438, Frankfurt, GERMANY.

Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalysed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood - restoring the blood's natural coagulation capability. Read More

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Online Search Trends Influencing Anti-Coagulation in COVID-19: An Observational Study.

JMIR Form Res 2021 Apr 11. Epub 2021 Apr 11.

Department of Infectious Diseases, Beaumont Hospital, Beaumont Road, Dublin, IE.

Background: Background: Early evidence of Coronavirus Disease (COVID-19) associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The rapid online spread of case reports was followed by online interim guidelines, discussions and worldwide online searches for further information. The impact of the global online search trends and online discussion on local approach to coagulopathy in COVID-19 patients has not been studied. Read More

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Role of lungs in the hemostasis system (review of literature).

Klin Lab Diagn 2021 Jul;66(7):411-416

Tashkent institute of postgraduate medical education.

The lung tissue contains various hemostatic system elements, which can be released from the lungs, both under physiological and pathological conditions. The COVID-19 pandemic has led to an increase in the number of patients with acute respiratory distress syndrome (ARDS) in intensive care units worldwide. When the lungs are damaged, coagulation disorders are mediated by tissue factor (TF) - factor VIIa (F VIIa), and inhibition of this pathway completely eliminates intrapulmonary fibrin deposition. Read More

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Clinicopathologic Findings in COVID-19-Associated Ischemic Enterocolitis.

Histopathology 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Aims: Coronavirus disease 2019 (COVID-19) has been recognized as a predominantly respiratory tract infection, but some patients manifest severe systemic symptoms/coagulation abnormalities. We evaluated the impact of severe COVID-19 infection on the gastrointestinal tract.

Methods And Results: We examined clinicopathologic findings in 28 resected ischemic bowels from 22 patients with severe COVID-19. Read More

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Causes of an elevated international normalized ratio in the intensive care unit and the implications for plasma transfusion.

Transfusion 2021 Jul 22. Epub 2021 Jul 22.

Department of Coagulation and Transfusion Medicine, The Miriam Hospital, Providence, Rhode Island, USA.

Background: The presence of an elevated international normalized ratio (INR) is common in patients in the intensive care unit (ICU), but the cause rarely determined. These patients are at risk to receive prophylactic plasma prior to invasive procedures.

Study Design And Methods: Samples from patients with an INR of 1. Read More

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The Diagnostic Value of Coagulation Indicators and Inflammatory Markers in Distinguishing Between Strangulated and Simple Intestinal Obstruction.

Surg Laparosc Endosc Percutan Tech 2021 Jul 21. Epub 2021 Jul 21.

Prenatal Diagnosis Center Departments of Emergency Radiological Clinical Laboratory, Boai Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan, Guangdong, China.

Background: Intestinal obstruction with strangulation can be life-threating, and it is critical to make an accurate and timely diagnosis for emergency surgery.

Objective: This was aimed to investigate the value of coagulation indicators and inflammatory markers in distinguishing between strangulated and simple intestinal obstruction.

Materials And Methods: Fifty-four patients with intestinal obstruction were retrospectively studied. Read More

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L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus.

JCI Insight 2021 07 22;6(14). Epub 2021 Jul 22.

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated with dysfunction of multiple organs, but some infected cells do not express ACE2, the canonical entry receptor for SARS-CoV-2. Here, we report that the C-type lectin receptor L-SIGN interacted in a Ca2+-dependent manner with high-mannose-type N-glycans on the SARS-CoV-2 spike protein. Read More

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The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211026385

Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

Diabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation system. Read More

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The effect of drone transport on the stability of biochemical, coagulation and hematological parameters in healthy individuals.

Clin Chem Lab Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Clinical Chemistry, Isala Hospital, Zwolle, the Netherlands.

Objectives: Transport of blood tubes is mainly by car or pneumatic transport. The transportation of blood tubes by drones is a novel approach for rapid transportation of blood tubes over long distances. However, limited data on the stability of biochemical, coagulation and hematological parameters is available after transport of blood tubes by drone. Read More

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Disseminated intravascular coagulation complicating diagnosis of ROS1-mutant non-small cell lung cancer: A case report and literature review.

Thorac Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, St George Cancer Care Centre, Kogarah, New South Wales, Australia.

Disseminated intravascular coagulation (DIC) is a rare paraneoplastic complication in advanced solid malignancies, with success of treatment and survival dependent on treatment of the underlying malignancy. Best estimates suggest an incidence of 1.6-6. Read More

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Changes in platelet count and coagulation parameters in children with obstructive sleep apnea.

Sleep Breath 2021 Jul 22. Epub 2021 Jul 22.

Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Objective: To investigate the correlation between obstructive sleep apnea (OSA) and coagulation status and to speculate on the underlying mechanism in children with OSA.

Methods: We divided 345 children with OSA (age 2-14 years) into four groups according to the apnea-hypopnea index (AHI). We compared platelet (PLT) and coagulation parameters among groups. Read More

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Posterior Reversible Encephalopathy Syndrome and brain haemorrhage as COVID-19 complication: a review of the available literature.

J Neurol 2021 Jul 21. Epub 2021 Jul 21.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Viale Alvaro del Portillo, 21, 00128, Rome, Italy.

Background: SARS-CoV-2 infection has been associated with various neurological manifestations. Since patients affected by SARS-CoV-2 infection present coagulation and immune system dysregulation, ischemic or haemorragic stroke is not uncommon, irrespective of respiratory distress. However, the occurrence of focal neurological deficits together with other symptoms like headache, cortical blindness, seizure and altered mental status should prompt the diagnosis of Posterior Reversible Encephalopathy Syndrome (PRES). Read More

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Pharmacokinetics and Biologic Activity of Apixaban in Healthy Dogs.

Front Vet Sci 2021 5;8:702821. Epub 2021 Jul 5.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.

Thrombosis is common in critically ill dogs and causes considerable morbidity and mortality. The direct factor Xa inhibitor apixaban is safe, efficacious, and convenient in humans. This study aimed to determine the pharmacokinetics (PK), bioactivity, protein binding, and bioavailability of apixaban following intravenous (IV) and oral (PO) administration to healthy dogs. Read More

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An observational study of a cohort of citizens receiving the AZD1222 vaccine against SARS-CoV-2.

Future Sci OA 2021 Sep 15;7(8):FSO739. Epub 2021 Jun 15.

Centro di Referenza Nazionale per l'Analisi e Studio di Correlazione tra Ambiente, Animale e Uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, 80055, Italy.

In this retrospective study, a cohort of 67 subjects vaccinated with AZD1222 was retrospectively observed. Consistently with published findings, no serious adverse event was reported, and all adverse events reported (fever, muscle ache and/or pain in the site of injection) had resolved by day 8. Of note, some citizens were prescribed low-dose aspirin and even heparin for thrombosis prevention. Read More

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September 2021

Leukapheresis Does Not Improve Early Survival Outcome of Acute Myeloid Leukemia with Leukostasis Patients - A Dual-Center Retrospective Cohort Study.

J Blood Med 2021 14;12:623-633. Epub 2021 Jul 14.

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Introduction: Leukostasis is a medical emergency with high mortality which often occurs in acute myeloid leukemia patients with hyperleukocytosis. One of the therapies that can be used for leukostasis in acute myeloid leukemia is leukapheresis. However, whether leukapheresis can provide better survival benefit when compared with patients not receiving leukapheresis is still unclear. Read More

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Characterization and visualization of murine coagulation factor VIII-producing cells in vivo.

Sci Rep 2021 Jul 21;11(1):14824. Epub 2021 Jul 21.

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial. Here, we tried to characterize primary FVIII-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein (EGFP) was expressed instead of the F8 gene. EGFP-positive FVIII-producing cells existed only in thin sinusoidal layer of the liver and characterized as CD31, CD146, and lymphatic vascular endothelial hyaluronan receptor 1 (Lyve1). Read More

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Upper-lip laser frenectomy with a diode laser in a pediatric patient: a case report.

J Biol Regul Homeost Agents 2021 May-Jun;35(3 Suppl. 1):29-35

Department of Chemical Science and Technologies, Dentistry, University of Rome "Tor Vergata", Rome, Italy.

The case report aims to describe the parameters of performing upper labial frenectomy with the use of diode laser beams without infiltrated local anaesthesia. A 6-year-old patient was referred by the orthodontist for assessment of the upper anterior labial frenum. The dental treatment plan reported only the presence of caries on deciduous teeth and seals on the first permanent molars. Read More

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[Anatomical observation of the left parietal peritoneum and its clinical significance in left retro-mesocolic space dissection].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Jul;24(7):619-625

Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China.

To investigate the anatomic characteristics of the left parietal peritoneum and its surgical implementation while dissecting in left retro-mesocolic space. A descriptive case series research methods was used. (1) surgical videos of 35 patients who underwent laparoscopic radical resection (complete mobilization of splenic flexure) of colorectal cancer in Union Hospital of Fujian Medical University between January 2018 and December 2018 were reviewed; (2) four specimens after radical resection of rectal cancer performing in June 2020 were prospectively enrolled and reviewed; (3) five specimens of left parietal peritoneum from 5 cadaveric abdomen (3 males and 2 females) were enrolled and reviewed as well; Tissues of 3 unseparated regions, namely the root of the inferior mesenteric artery (IMA), the medial region and the lateral region (including kidney tissue), from above the 5 cadaveric abdominal specimens were selected to perform Masson staining and histopathological examination. Read More

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Increased activity of procoagulant factors in patients with small cell lung cancer.

PLoS One 2021 21;16(7):e0253613. Epub 2021 Jul 21.

Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.

Small cell lung cancer (SCLC) patients have augmented risk of developing venous thromboembolism, but the mechanisms triggering this burden on the coagulation system remain to be understood. Recently, cell-derived microparticles carrying procoagulant phospholipids (PPL) and tissue factor (TF) in their membrane have attracted attention as possible contributors to the thrombogenic processes in cancers. The aims of this study were to assess the coagulation activity of platelet-poor plasma from 38 SCLC patients and to provide a detailed procoagulant profiling of small and large extracellular vesicles (EVs) isolated from these patients at the time of diagnosis, during and after treatment compared to 20 healthy controls. Read More

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Review of coagulation preanalytical variables with update on the effect of direct oral anticoagulants.

Int J Lab Hematol 2021 Jul;43 Suppl 1:109-116

Hemostasis & Thrombosis Center, Davis Health System, University of California, Sacramento, CA, USA.

There are many preanalytical variables (PAV) that are known to affect coagulation testing. The more commonly acknowledged PAV addressed by the clinical laboratory tend to start with their influence on blood collection, but realistically coagulation PAV starts with the patient, where the laboratory has less influence or control. Patient selection and appropriate timing for blood collection may be integral for assuring proper diagnosis and management. Read More

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COVID-19: Thrombosis, thromboinflammation, and anticoagulation considerations.

Int J Lab Hematol 2021 Jul;43 Suppl 1:29-35

Department of Medicine, Hematology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Vascular endothelial injury is a hallmark of acute infection at both the microvascular and macrovascular levels. The hallmark of SARS-CoV-2 infection is the current COVID-19 clinical sequelae of the pathophysiologic responses of hypercoagulability and thromboinflammation associated with acute infection. The acute lung injury that initially occurs in COVID-19 results from vascular and endothelial damage from viral injury and pathophysiologic responses that produce the COVID-19-associated coagulopathy. Read More

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COVID-19-related laboratory coagulation findings.

Int J Lab Hematol 2021 Jul;43 Suppl 1:36-42

Coagulation Laboratory, Department of Laboratory Medicine, Department of Diagnostic Sciences, Ghent University Hospital, Ghent University, Ghent, Belgium.

The alterations in the hemostatic balance in COVID-19 patients are strongly disturbed and contribute to a high prothrombotic status. The high rate of venous thromboembolism in COVID-19 patients goes along with derangements in coagulation laboratory parameters. Hemostasis testing has an important role in diagnosed COVID-19 patients. Read More

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Peripheral blood transcriptome heterogeneity and prognostic potential in lung cancer revealed by RNA-Seq.

J Cell Mol Med 2021 Jul 21. Epub 2021 Jul 21.

State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Understanding of the complex interaction between the peripheral immune system and lung cancer (LC) remains incomplete, limiting patient benefit. Here, we aimed to characterize the host peripheral immune response to LC and investigate its potential prognostic value. Bulk RNA-sequencing data of peripheral blood leucocytes (PBLs) from healthy volunteers and LC patients (n = 142) were analysed for characterization of host systemic immunity in LC. Read More

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Tranexamic acid-loaded hemostatic nanoclay microsphere frameworks.

J Biomed Mater Res B Appl Biomater 2021 Jul 21. Epub 2021 Jul 21.

Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa, USA.

Fast acting topical hemostatic agents play a key role in hemorrhage control. Retarding fibrinolysis is also critical in improving coagulation, thereby expanding chances of survival. The purpose of the present work was to investigate the physical properties, loading capacity and hemostatic efficacy of newly developed nanoclay microsphere frameworks (NMFs) loaded with tranexamic acid (TA), as antifibrinolytic agent. Read More

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Comparison of STA-NeoPTimal (Stago) and STA-Neoplastine CI Plus (Stago) thromboplastin reagents using a STA Satellite Max analyzer to measure prothrombin times in dogs.

Vet Clin Pathol 2021 Jul 20. Epub 2021 Jul 20.

Laboratoire VEBIO, Arcueil, France.

Background: Different thromboplastins are available to measure prothrombin time (PT). Stago coagulation analyzers and reagents are currently used in veterinary laboratories and enable PT measurements to explore the coagulation cascade (extrinsic pathway).

Objectives: The main objective was to compare PT measurements obtained with the STA-NeoPTimal reagent with the commonly used STA-Neoplastine CI Plus reagent. Read More

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"Synthesis of coagulation factors during long-term ex situ liver perfusion".

Artif Organs 2021 Jul 20. Epub 2021 Jul 20.

Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland.

Robust viability assessment of grafts during normothermic liver perfusion is a prerequisite for organ use. Coagulation parameters are used commonly for liver assessment in patients. However, they are not yet included in viability assessment during ex situ perfusion. Read More

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Clinical and histologic evaluation of a fractional radiofrequency treatment of wrinkles and skin texture with novel 1-mm long ultra-thin electrode pins.

Lasers Surg Med 2021 Jul 20. Epub 2021 Jul 20.

Lumenis, Yokneam, Israel.

Background: Fractional radiofrequency (RF) microneedling technologies have shown effectiveness in treating skin laxity and wrinkles. We report the first experience using a novel device with 1-mm long ultrathin electrodes that utilizes a smooth RF-assisted ablation mode.

Objective: To evaluate the safety and effectiveness of treatment with a fractional RF device using 1. Read More

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