Diabetes Metab 2018 Feb 1;44(1):45-54. Epub 2017 Mar 1.
INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, 75006 Paris, France; Sorbonne Université, UPMC, University Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address:
Aim: Alteration of functional beta-cell mass in adults can be programmed by adverse events during fetal life. Previously, it was demonstrated that high glucocorticoid (GC) levels during fetal life participate in this programming by inhibition of beta-cell development. More specifically, GC levels stimulate expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α), a transcriptional co-regulator of the GC receptor (GR), which per se impairs beta-cell mass and function when overexpressed. Read More