Colloids Surf B Biointerfaces 2021 Jan 18;197:111423. Epub 2020 Oct 18.
ORDIST, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka, 564-0836, Japan; Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka, 564-0836, Japan. Electronic address:
Low-environmental-impact emulsion systems for transdermal drug delivery in topical treatment have gained increasing interest. However, low stability and adverse systemic side effects severely decrease their efficiency. This study proposed a stable oil-in-water (O/W) emulsion loaded with bifonazole (BFZ) as a lipophilic drug stabilized by poly(2-isopropoxy-2-oxo-1,3,2-dioxaphospholane)-modified cellulose nanocrystals (CNC-g-PIPP) as vehicles for topical delivery of lipophilic drugs. Read More