489 results match your criteria cmz


Enhanced Photocatalytic Performance of Cu2O/MoS2/ZnO Composites on Cu Mesh Substrate for Nitrogen Reduction.

Nanotechnology 2021 Mar 30. Epub 2021 Mar 30.

Qingdao University of Science and Technology, Qingdao, Shandong, CHINA.

The Cu2O nanopaticles and the MoS2 nanoflowers decorated with ZnO nanospheres were co-deposited on Cu mesh successfully via mild electrodeposition method to build a dual direct Z-scheme heterostructure. The prepared materials can effectively synthesize ammonia with N2 and H2O in the liquid membrane reactor under simulated visible light. The results indicate that three-dimensional nanomaterials exhibit better performance compared with the pure semiconductor due to the synergistic effect of enhanced visible light absorption, longer photogenerated carrier lifetime and the specific charge transfer path of dual direct Z-scheme structure. Read More

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Antithyroid drug use during pregnancy and the risk of birth defects in offspring: systematic review and meta-analysis of observational studies with methodological considerations.

Br J Clin Pharmacol 2021 Mar 30. Epub 2021 Mar 30.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, and PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Aims: Maternal antithyroid drug (ATD) use during pregnancy has been associated with an increased risk of birth defects in offspring. Uncertainty remains on the size of this risk and how it compares to untreated hyperthyroidism due to methodological limitations of previous studies.

Methods: Systematic review of MEDLINE and EMBASE identifying observational studies examining ATD use during pregnancy and risk of birth defects by 28 August 2020. Read More

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Meis homeobox genes control progenitor competence in the retina.

Proc Natl Acad Sci U S A 2021 Mar;118(12)

Laboratory of Transcriptional Regulation, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague 4, Czech Republic;

The vertebrate eye is derived from the neuroepithelium, surface ectoderm, and extracellular mesenchyme. The neuroepithelium forms an optic cup in which the spatial separation of three domains is established, namely, the region of multipotent retinal progenitor cells (RPCs), the ciliary margin zone (CMZ)-which possesses both a neurogenic and nonneurogenic potential-and the optic disk (OD), the interface between the optic stalk and the neuroretina. Here, we show by genetic ablation in the developing optic cup that and homeobox genes function redundantly to maintain the retinal progenitor pool while they simultaneously suppress the expression of genes characteristic of CMZ and OD fates. Read More

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Igf signaling couples retina growth with body growth by modulating progenitor cell division.

Development 2021 Mar 15. Epub 2021 Mar 15.

Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany

How the body and organs balance their relative growth is of key importance for coordinating size and function. This is of particular relevance in organisms, which continue to grow over their entire life span. We addressed this issue in the neuroretina of medaka fish (), a well-studied system to address vertebrate organ growth. Read More

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Agoitrous Graves' Hyperthyroidism with Markedly Elevated Thyroid Stimulating Immunoglobulin Titre displaying Rapid Response to Carbimazole with Discordant Thyroid Function.

J ASEAN Fed Endocr Soc 2020 19;35(2):224-232. Epub 2020 Nov 19.

Department of Epidemiology, Singapore Clinical Research Institute, Singapore.

We characterize the clinical and laboratory characteristics of 5 patients with Graves' thyrotoxicosis whose serum free thyroxine (fT4) concentration decreased unexpectedly to low levels on conventional doses of carbimazole (CMZ) therapy. The initial fT4 mean was 40.0 pM, range 25-69 pM. Read More

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November 2020

Successful de-escalation antibiotic therapy using cephamycins for sepsis caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia: A sequential 25-case series.

Open Med (Wars) 2020 7;15(1):782-786. Epub 2020 Aug 7.

Division of Mathematics, Department of Liberal Arts, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.

Carbapenems are frequently used to treat infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E), but carbapenem-resistant Enterobacteriaceae bacteria are a clinical concern. Although cephamycins (cefmetazole; CMZ) have been shown to be effective against mild cases of ESBL-E infection, data on their use for severe ESBL-E infections with sepsis or septic shock remain scarce. Herein, we discuss a de-escalation therapy to CMZ that could be used after empiric antibiotic therapy in ICU patients with sepsis or septic shock caused by ESBL-E bacteremia. Read More

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Stability of antimicrobial agents in an elastomeric infusion pump used for outpatient parenteral antimicrobial therapy.

Int J Infect Dis 2021 Feb 24;103:464-468. Epub 2020 Nov 24.

Division of Pharmacodynamics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Electronic address:

Objectives: The long-term stability of antimicrobials dissolved in infusion solution is necessary to establish and spread the outpatient parenteral antimicrobial therapy (OPAT). In this study, we evaluated the stability of antimicrobial agents dissolved in infusion solutions.

Methods: The antimicrobial agents were dissolved in infusion solutions and kept at 25 °C and 31. Read More

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February 2021

Teratogen update: Antithyroid medications.

Birth Defects Res 2020 09 1;112(15):1150-1170. Epub 2020 Aug 1.

Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Objective: Thyroid disorders including hyperthyroidism are common during pregnancy. Untreated hyperthyroidism can result in adverse outcomes for pregnancy.

Methods: Iodine, propylthiouracil (PTU), carbimazole (CMZ), and methimazole (MMI) are common medications for hyperthyroidism treatment. Read More

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September 2020

Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.

Eur J Cancer 2020 09 17;136:116-129. Epub 2020 Jul 17.

ACCELERATE/ITCC, Belgium; Gustave Roussy Cancer Centre, France.

Purpose: The current standard-of-care for front-line therapy for acute myeloid leukaemia (AML) results in short-term and long-term toxicity, but still approximately 40% of children relapse. Therefore, there is a major need to accelerate the evaluation of innovative medicines, yet drug development continues to be adult-focused. Furthermore, the large number of competing agents in rare patient populations requires coordinated prioritisation, within the global regulatory framework and cooperative group initiatives. Read More

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September 2020

dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye.

Sci Rep 2020 07 9;10(1):11293. Epub 2020 Jul 9.

Department of Ophthalmology, Louis J. Fox Center for Vision Restoration, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

The ciliary marginal zone (CMZ) of the zebrafish retina contains a population of actively proliferating resident stem cells, which generate retinal neurons throughout life. The maintenance methyltransferase, dnmt1, is expressed within the CMZ. Loss of dnmt1 function results in gene misregulation and cell death in a variety of developmental contexts, however, its role in retinal stem cell (RSC) maintenance is currently unknown. Read More

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Ca/calmodulin-dependent regulation of polycystic kidney disease 2-like-1 by binding at C-terminal domain.

Korean J Physiol Pharmacol 2020 May;24(3):277-286

Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.

Polycystic kidney disease 2-like-1 (PKD2L1), also known as polycystin-L or TRPP3, is a non-selective cation channel that regulates intracellular calcium concentration. Calmodulin (CaM) is a calcium binding protein, consisting of N-lobe and C-lobe with two calcium binding EF-hands in each lobe. In previous study, we confirmed that CaM is associated with desensitization of PKD2L1 and that CaM N-lobe and PKD2L1 EF-hand specifically are involved. Read More

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Ca/calmodulin-dependent regulation of polycystic kidney disease 2-like-1 by binding at C-terminal domain.

Korean J Physiol Pharmacol 2020 May;24(3):277-286

Department of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.

Polycystic kidney disease 2-like-1 (PKD2L1), also known as polycystin-L or TRPP3, is a non-selective cation channel that regulates intracellular calcium concentration. Calmodulin (CaM) is a calcium binding protein, consisting of N-lobe and C-lobe with two calcium binding EF-hands in each lobe. In previous study, we confirmed that CaM is associated with desensitization of PKD2L1 and that CaM N-lobe and PKD2L1 EF-hand specifically are involved. Read More

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Distinct roles of calmodulin and Ca/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy.

Biochem Biophys Res Commun 2020 06 15;526(4):960-966. Epub 2020 Apr 15.

Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, 110122, China. Electronic address:

Intracellular calcium is related to cardiac hypertrophy. The Ca1.2 channel and Ca/calmodulin-dependent protein kinase II (CaMKII) and CaM regulate the intracellular calcium content. Read More

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The life cycle of the Central Molecular Zone - II. Distribution of atomic and molecular gas tracers.

Mon Not R Astron Soc 2020 Apr 27;493(4):5273-5289. Epub 2020 Feb 27.

Research School of Astronomy and Astrophysics, The Australian National University, Canberra, ACT 2611, Australia.

We use the hydrodynamical simulation of our inner Galaxy presented in Armillotta et al. to study the gas distribution and kinematics within the Central Molecular Zone (CMZ). We use a resolution high enough to capture the gas emitting in dense molecular tracers such as NH and HCN, and simulate a time window of 50 Myr, long enough to capture phases during which the CMZ experiences both quiescent and intense star formation. Read More

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Safety of antithyroid drugs in pregnancy: update and therapy implications.

Expert Opin Drug Saf 2020 May 1;19(5):565-576. Epub 2020 Apr 1.

Endocrinology and Diabetes Department, Prince Charles Hospital, Cwm Taf University Health Board, Merthyr Tydfil, UK.

: The thionamide antithyroid drugs, methimazole (MMI), its pro-drug derivative carbimazole (CMZ), and propylthiouracil (PTU) are the mainstay of treatment for hyperthyroidism in pregnancy. However, antithyroid drugs carry risks of adverse effects that can affect fetal and maternal well-being.: This review provides an update on the safety of antithyroid drugs in pregnancy, focusing on the most serious concerns of severe liver disease and congenital anomalies. Read More

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Dummy molecularly imprinted microspheres prepared by Pickering emulsion polymerization for matrix solid-phase dispersion extraction of three azole fungicides from fish samples.

J Chromatogr A 2020 Jun 6;1620:461013. Epub 2020 Mar 6.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, China.

Dummy molecularly imprinted microspheres (DMIMs) were synthesized by Pickering emulsion polymerization and used as the matrix solid-phase dispersion extraction (MSPD) sorbent for sample pre-treatment of azole fungicides in fish samples. Alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol (DCE) was used as the fragment dummy template for the imprinting of climbazole (CBZ), clotrimazole (CMZ) and miconazole (MNZ). The morphology of the microspheres were characterized by scanning electron microscopy (SEM) and nitrogen adsorption measurements, narrow diameter distribution (20-50 μm) with regular spherical shape and high surface area (S = 408. Read More

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In Vitro Efficacy of Meropenem-Cefmetazole Combination Therapy against New Delhi Metallo-β-lactamase-producing Enterobacteriaceae.

Int J Antimicrob Agents 2020 Mar 25;55(3):105905. Epub 2020 Jan 25.

Department of Infection Control and Prevention, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address:

Background: Limited treatment options complicate management of infections with New Delhi metallo-β-lactamase (NDM)-producing organisms. The efficacy of combination therapy with meropenem (MEM) and cefmetazole (CMZ) was assessed against NDM-producing Enterobacteriaceae.

Materials And Methods: Twelve Escherichia coli clinical isolates harbouring bla and a positive control E. Read More

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Sodium adsorption by reusable zeolite adsorbents: integrated adsorption cycles for salinised groundwater treatment.

Environ Technol 2020 Feb 5:1-12. Epub 2020 Feb 5.

Department of Civil, Geological and Environmental Engineering, University of Saskatchewan, Saskatoon, Canada.

Using Canadian (CMZ), Bear River (BRZ), and St. Cloud (SCZ) zeolites, this study investigates the application of natural and pre-treated zeolites for Na removal from salinised groundwater. Natural BRZ achieved better Na removal for initial concentrations of 250-10,000 mg Na/L and had the highest maximum adsorption capacity (14. Read More

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February 2020

Photobehavior of the antipsychotic drug cyamemazine in a supramolecular gel protective environment.

J Photochem Photobiol B 2020 Jan 6;202:111686. Epub 2019 Nov 6.

Departamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain. Electronic address:

In this work, a molecular hydrogel made of gelator (S)-4-((3-methyl-1-(nonylamino)-1-oxobutan-2-yl)amino)-4-oxobutanoic acid (SVN) has been employed as soft container to modify the photochemical and photophysical behavior of the antipsychotic drug cyamemazine (CMZ). The interaction of CMZ with the gel network has been evidenced by fluorescence spectroscopy through a hypsochromic shift of the emission band (from λ = 521 nm in solution to λ = 511 nm in the gel) and an increase of the fluorescence lifetime (5.6 ns in PBS vs. Read More

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January 2020

Bactericidal efficacy of meropenem in combination with cefmetazole against IMP-producing carbapenem-resistant Enterobacteriaceae.

BMC Res Notes 2019 Nov 9;12(1):740. Epub 2019 Nov 9.

Department of Infection Control and Prevention, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Objective: Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to public and clinical health because of their high levels of resistance to various antibiotics. We assessed the efficacy of combination therapy with meropenem (MEM) and cefmetazole (CMZ) against Imipenemase (IMP)-producing CRE, using the checkerboard method and time-killing assay on 13 Enterobacteriaceae isolates harboring bla (4 Enterobacter hormaechei, 5 Escherichia coli, and 4 Klebsiella pneumoniae isolates) and 13 isolates harboring bla (8 E. coli and 5 K. Read More

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November 2019

Are Metal-Free Monolithic Crowns the Present of Prosthesis? Study of Mechanical Behaviour.

Materials (Basel) 2019 Nov 7;12(22). Epub 2019 Nov 7.

Department of Dental Medicine, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.

Purpose: To analyze in vitro the mechanical behavior of five types of complete coverage crowns fabricated from different materials.

Materials And Methods: Seventy-five full coverage crowns were divided into five groups according to material: Group I, metal core with feldspathic ceramic covering (MC- control group); Group II, zirconia core with feldspathic ceramic covering (CZ); Group III, tetragonal monolithic zirconia (TMZ); Group IV, cubic monolithic zirconia (CMZ); Group V, high molecular weight polymethyl methacrylate (PMMAG) doped with graphene nanoparticles. All crowns underwent in vitro fatiguing by dynamic loading in wet conditions to simulate the masticatory forces to which prosthodontic materials are subject in the oral medium. Read More

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November 2019

SIDE EFFECTS OF PTU AND MMI IN THE TREATMENT OF HYPERTHYROIDISM: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Endocr Pract 2020 Feb 25;26(2):207-217. Epub 2019 Oct 25.

The present study aimed to investigate the adverse effects of the antithyroid drugs propylthiouracil (PTU) and methimazole (MMI)/carbimazole (CMZ) in treating hyperthyroidism. Qualitative analysis was performed for studies identified in a literature search up to April 20, 2019, and 30 studies were selected for meta-analysis. The study designs included case-control, randomized controlled, and retrospective cohort. Read More

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February 2020

Rebuilding the Retina: Prospects for Müller Glial-mediated Self-repair.

Curr Eye Res 2020 03 2;45(3):349-360. Epub 2019 Oct 2.

Institute of Ophthalmology, University College London, London, UK.

Retinal degeneration is a leading cause of untreatable blindness in the industrialised world. It is typically irreversible and there are few curative treatments available. The use of stem cells to generate new retinal neurons for transplantation purposes has received significant interest in recent years and is beginning to move towards clinical trials. Read More

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SCF/SCFR signaling plays an important role in the early morphogenesis and neurogenesis of human embryonic neural retina.

Development 2019 10 17;146(20). Epub 2019 Oct 17.

Southwest Hospital/ Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China

The stem cell factor receptor (SCFR) has been demonstrated to be expressed in the neural retina of mice, rat and human for decades. Previous reports indicated that the SCFR correlates with glia differentiation of late retinal progenitor cells (RPCs), retinal vasculogenesis and homeostasis of the blood-retinal barrier. However, the role of SCF/SCFR signaling in the growth and development of the neural retina (NR), especially in the early embryonic stage, remains poorly understood. Read More

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October 2019

Change in the Antimicrobial Resistance Profile of Extended-Spectrum β-Lactamase-Producing .

J Clin Med Res 2019 Sep 1;11(9):635-641. Epub 2019 Sep 1.

Department of Pharmacy, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino-shi, Fukuoka 818-8502, Japan.

Background: This study aimed to investigate the trends and antimicrobial resistance profile of extended-spectrum β-lactamase-producing (ESBL-EC) clinical isolates.

Methods: A total of 1,303 isolates from January 2012 to December 2017 at Fukuoka University Chikushi Hospital, Japan, were analyzed. The rate of resistance to cefmetazole (CMZ), flomoxef (FMOX), imipenem (IPM), meropenem (MEPM), amikacin (AMK), gentamicin (GM), minocycline (MINO), ciprofloxacin (CPFX), and levofloxacin (LVFX) was compared between non-ESBL-producing (non-ESBL-EC) and ESBL-EC. Read More

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September 2019

CYP2E1 and miRNA-378a-3p contribute to acetaminophen- or tripterygium glycosides-induced hepatotoxicity.

Basic Clin Pharmacol Toxicol 2020 Feb 20;126(2):153-165. Epub 2019 Oct 20.

Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan, China.

Increased expression of CYP2E1 may represent the main factor contributing to oxidative stress-mediated liver damage in drug-induced liver injury (DILI). However, the regulation mechanism of CYP2E1 expression is poorly described. The present study was aimed to investigate the role of CYP2E1 in acetaminophen (APAP)- or tripterygium glycosides (TG)-induced hepatotoxicity as well as the regulation of CYP2E1 and miR-378a-3p expression by APAP or TG. Read More

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February 2020

Investigation of pharmaceutical and personal care product interactions of soil and beets (Beta vulgaris L.) under the effect of wastewater reuse.

Chemosphere 2020 Jan 13;238:124553. Epub 2019 Aug 13.

Hellenic Open University, School of Science and Technology, Aristotelous 18 26335, Patras, Greece. Electronic address:

Although, several recent greenhouse studies are beginning to address the uptake of pharmaceuticals and personal care products (PPCPs) by a variety of crops, few studies have assessed the effects of exposure to complex, realistic wastewater effluents on uptake. Hence, in this study, a greenhouse experiment was conducted in order to study the interactions occurring exclusively between PPCPs in soil, and in the edible plant part of beets (Beta vulgaris) after exposure to treated wastewater effluent. According to the findings, the interactions between the pharmaceuticals caffeine (CFN) with bisoprolol (BSP), carbamezapine (CMZ), clarithromycin (CMC), metoprolol (MPL), sulfamethoxazole (SMX), and trimethoprim (TMP) occurring in soil were almost 99% synergistic; it was noted variability in the interactive capacity of the pharmaceuticals; the concentrations of pharmaceuticals which measured did not affect unfavorably beet yield; interactions between the PPCPs via the PPCPs contribution in plant and soil affect the qualitative and quantitative characteristics of the beets. Read More

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January 2020

The motion and distribution of the gas in the central 300 pc of the galaxy as revealed by spectra of H.

Philos Trans A Math Phys Eng Sci 2019 Sep 5;377(2154):20180400. Epub 2019 Aug 5.

Universitäts-Sternwarte München, 81679, Munich, Germany.

Spectroscopy of absorption lines of H in the central molecular zone (CMZ) of the Galaxy show that a previously largely unknown component of the interstellar medium there, warm (T∼200 K) and diffuse (n ≲ 10 cm) gas, makes up a large fraction of the volume of the CMZ, and that this gas is moving radially outward from the centre. These discoveries upend the generally accepted understanding that the interstellar environment of the CMZ comprises almost entirely an ultra-hot plasma and dense molecular clouds. The radial momentum associated with the diffuse gas in the CMZ exceeds that of the ejecta of thousands of core-collapse supernovae and implies some extraordinary past activity in the centre, possibly associated with the supermassive black hole, Sgr A*. Read More

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September 2019

Induction of plasmid-mediated AmpC β-lactamase DHA-1 by piperacillin/tazobactam and other β-lactams in Enterobacteriaceae.

PLoS One 2019 8;14(7):e0218589. Epub 2019 Jul 8.

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki City, Nagasaki, Japan.

Chromosomal AmpC β-lactamase induction by several types of β-lactams has been reported, but not enough data are available on DHA-1 β-lactamase, a plasmid-mediated AmpC β-lactamase. Therefore, we evaluated the DHA-1 β-lactamase induction by various antibiotics including piperacillin/tazobactam (PIP/TZB) in this study. Six strains (Enterobacter cloacae 2 strains, Citrobacter freundii 1 strain, Serratia marcescens 2 strain, and Morganella morganii 1 strain) possessing chromosomal inducible AmpC β-lactamase were used as controls. Read More

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February 2020

In Vivo Assessment of Neural Precursor Cell Cycle Kinetics in the Amphibian Retina.

Cold Spring Harb Protoc 2019 08 1;2019(8). Epub 2019 Aug 1.

Paris-Saclay Institute of Neuroscience, CERTO-Retina France, CNRS, Univ Paris-Sud, University Paris-Saclay, 91405 Orsay, France

Cell cycle progression is intimately linked to cell fate commitment during development. In addition, adult stem cells show specific proliferative behaviors compared to progenitors. Exploring cell cycle dynamics and regulation is therefore of utmost importance, but constitutes a great challenge in vivo. Read More

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