78,966 results match your criteria cluster region

Clinical profile, antifungal susceptibility, and molecular characterization of Candida auris isolated from patients in a South Indian surgical ICU.

J Mycol Med 2021 Jul 21;31(4):101176. Epub 2021 Jul 21.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 1600012. Electronic address:

Background: Candida auris is an emerging multidrug resistant yeast which causes blood stream infection especially among critically ill patients. This yeast can also colonize patients and are isolated from hospital environment causing outbreaks in hospital settings.

Objective: To describe possible outbreak of C. Read More

View Article and Full-Text PDF

Pollution status, potential sources and health risk assessment of arsenic and trace metals in agricultural soils: A case study in Malatya province, Turkey.

Environ Res 2021 Jul 30:111806. Epub 2021 Jul 30.

East Mediterranean Transitional Zone Agricultural Research of Institute, Kahramanmaraş, Turkey.

We measured the concentrations of arsenic and 11 trace metals in the soils from vegetable fields in Malatya province (Turkey) and assessed health risks for residential adults and children. Also, we assessed their potential sources, contamination status and ecological risks. Median concentrations of only As, Co, Ni and Cr exceeded the world soil average values, while those of Cd, As, Ni and Cu exceeded the upper continental crust contents. Read More

View Article and Full-Text PDF

Ecological risk and source analysis of soil heavy metals pollution in the river irrigation area from Baoji, China.

PLoS One 2021 2;16(8):e0253294. Epub 2021 Aug 2.

Shaanxi Key Laboratory of Disaster Monitoring and Mechanism Simulation, Baoji University of Arts and Sciences, Baoji, China.

Due to various human activities, soil quality under different land use patterns is deteriorating all over the world. This deterioration is very complex in the river irrigation area and is caused by multi-point and non-point source pollution and seasonal variation. Therefore, the characteristics and sources of soil metal pollution in river irrigation area of Baoji city were analyzed. Read More

View Article and Full-Text PDF

Social Stressors, Arboviral Infection, and Immune Dysregulation in the Coastal Lowland Region of Ecuador: A Mixed Methods Approach in Ecological Perspective.

Am J Trop Med Hyg 2021 Aug 2. Epub 2021 Aug 2.

Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York.

Aedes aegypti, the mosquito that transmits arboviral diseases such as dengue (DENV), chikungunya (CHIKV), and Zika viruses (ZIKV), is present in tropical and subtropical regions of the world. Individuals at risk of mosquito-borne disease (MBD) in the urban tropics face daily challenges linked to their socio-environment conditions, such as poor infrastructure, poverty, crowding, and limited access to adequate healthcare. These daily demands induce chronic stress events and dysregulated immune responses. Read More

View Article and Full-Text PDF

Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.

EMBO Rep 2021 Aug 2:e52289. Epub 2021 Aug 2.

Institute of Biochemistry II (IBC2), Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.

Degradation of the endoplasmic reticulum (ER) via selective autophagy (ER-phagy) is vital for cellular homeostasis. We identify FAM134A/RETREG2 and FAM134C/RETREG3 as ER-phagy receptors, which predominantly exist in an inactive state under basal conditions. Upon autophagy induction and ER stress signal, they can induce significant ER fragmentation and subsequent lysosomal degradation. Read More

View Article and Full-Text PDF

Exploring the Origin and Relatedness of Maternal Lineages Through Analysis of Mitochondrial DNA in the Holstein Horse.

Front Genet 2021 15;12:632500. Epub 2021 Jul 15.

Institute of Animal Breeding and Husbandry, Christian-Albrechts-University, Kiel, Germany.

Maternal lineages are important for the breeding decision in the Holstein horse breed. To investigate the genetic diversity of the maternal lineages and the relationships between founder mares, the maternal inherited mitochondrial genome (except the repetitive part of the non-coding region) of 271 mares representing 75 lineages was sequenced. The sequencing predominantly revealed complete homology in the nucleotide sequences between mares from one lineage with exceptions in 13 lineages, where differences in one to three positions are probably caused by mutations or alternate fixation of heteroplasmy. Read More

View Article and Full-Text PDF

Genetic and Flower Volatile Diversity in Natural Populations of subsp. (Link) Ietsw. in Bulgaria: Toward the Development of a Core Collection.

Front Plant Sci 2021 15;12:679063. Epub 2021 Jul 15.

Department of Agrobiotechnology, AgroBioInstitute, Agricultural Academy, Sofia, Bulgaria.

We studied the genetic and flower volatile diversity in natural populations of subsp. (Link) Ietsw. in Bulgaria using simple sequence repeat (SSR) and sequence-related amplified polymorphism (SRAP) markers and gas chromatography/mass spectrometry (GC/MS) analysis of flower volatiles from individual plants. Read More

View Article and Full-Text PDF

Structural insights into the allosteric site of Arabidopsis NADP-malic enzyme 2: role of the second sphere residues in the regulatory signal transmission.

Plant Mol Biol 2021 Jul 31. Epub 2021 Jul 31.

Centro de Estudios Fotosintéticos y Bioquímicos, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (CEFOBI-CONICET-UNR), Suipacha 570, Rosario, Argentina.

Key Message: NADP-ME2 from Arabidopsis thaliana exhibits a distinctive and complex regulation by fumarate, acting as an activator or an inhibitor according to substrate and effector concentrations. In this work, we used molecular modeling approach and site-directed mutagenesis to characterized the NADP-ME2 structural determinants necessary for allosteric regulation providing new insights for enzyme optimization. Structure-function studies contribute to deciphering how small modifications in the primary structure could introduce desirable characteristics into enzymes without affecting its overall functioning. Read More

View Article and Full-Text PDF

Reperfusion mediates heme impairment with increased protein cysteine sulfonation of mitochondrial complex III in the post-ischemic heart.

J Mol Cell Cardiol 2021 Jul 28. Epub 2021 Jul 28.

Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, United States of America. Electronic address:

A serious consequence of myocardial ischemia-reperfusion injury (I/R) is oxidative damage, which causes mitochondrial dysfunction. The cascading ROS can propagate and potentially induce heme bleaching and protein cysteine sulfonation (PrSOH) of the mitochondrial electron transport chain. Herein we studied the mechanism of I/R-mediated irreversible oxidative injury of complex III in mitochondria from rat hearts subjected to 30-min of ischemia and 24-h of reperfusion in vivo. Read More

View Article and Full-Text PDF

X-chromosome inactivation and PCDH19-associated epileptic encephalopathy: A novel PCDH19 variant in a Chinese family.

Clin Chim Acta 2021 Jul 28. Epub 2021 Jul 28.

Kowloon West Cluster Laboratory Genetic Service, Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong Special Administrative Region. Electronic address:

Background: Developmental and epileptic encephalopathy 9 (DEE9, MIM #300088) is an early onset seizure disorder associated with cognitive impairment and behavioral disturbances. It is caused by mutation in protocadherin 19 with an unusual X-linked inheritance selectively involving heterozygous females or mosaic hemizygous males, while hemizygous males are unaffected. Cellular interference was the postulated mechanism underlying the unusual inheritance pattern. Read More

View Article and Full-Text PDF

Investigating tinnitus subgroups based on hearing-related difficulties.

Int J Clin Pract 2021 Jul 31:e14684. Epub 2021 Jul 31.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.

Purpose: Meaningfully grouping individuals with tinnitus who share the common characteristics (i.e., subgrouping, phenotyping) may help tailor interventions to certain tinnitus subgroups and hence reduce outcome variability. Read More

View Article and Full-Text PDF

RNA-sequence reveals differentially expressed genes affecting the crested trait of Wumeng crested chicken.

Poult Sci 2021 Jun 26;100(9):101357. Epub 2021 Jun 26.

Agriculture and Rural Bureau of Huaxi District, Guiyang City, Guizhou Province 550025, China.

Wumeng crested chicken has a cluster of slender feathers on its head, and the underlying skull region exhibits an obvious tumor-like protrusion. This is the typical skull structure of crested chickens. The associated regulatory genes are located on autosomes and are incompletely dominant. Read More

View Article and Full-Text PDF

Atomic Cluster Au_{10}^{+} Is a Strong Broadband Midinfrared Chromophore.

Phys Rev Lett 2021 Jul;127(3):033002

Department of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3QZ, United Kingdom.

We report an intense broadband midinfrared absorption band in the Au_{10}^{+} cluster in a region in which only molecular vibrations would normally be expected. Observed in the infrared multiple photon dissociation spectra of Au_{10}Ar^{+}, Au_{10}(N_{2}O)^{+}, and Au_{10}(OCS)^{+}, the smooth feature stretches 700-3400  cm^{-1} (λ=14-2.9  μm). Read More

View Article and Full-Text PDF


Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Jun;29(Special Issue):694-702

Central Russian Institute of Management - branch, Russian Academy of National Economy and Public Administration under the President of the Russian Federation, 302028, Orel, Russia.

The study substantiates the possibility of the cluster approach for the development of the healthcare system in Russia. The analysis of foreign experience in the functioning of medical clusters made it possible to identify factors that contribute to their successful development. Based on the assessment of the domestic practice of creating clusters in the healthcare sector, their typification was carried out with the identification of groups of high-tech clusters of biomedical technologies and innovations, medical clusters of drug provision and specialized equipment, clusters of medical services, internships and transfer of medical innovations. Read More

View Article and Full-Text PDF

A seroprevalence survey of anti-SARS-CoV-2 antibodies among individuals 18 years of age or older living in a vulnerable region of the city of São Paulo, Brazil.

PLoS One 2021 29;16(7):e0255412. Epub 2021 Jul 29.

Diretoria de Atenção Primária e Rede Assistencial, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brasil.

A second wave of COVID-19 has demonstrated how challenging it will be to achieve sustained control of the disease, even with vaccination underway in many countries. Therefore, it remains relevant to keep improving our understanding of the distribution of COVID-19, especially of asymptomatic individuals, among different populations, and particularly in vulnerable regions. Hence, this population-based serosurvey had the objective of estimating the prevalence of individuals 18 years of age or older infected by SARS-CoV-2, and the proportion of asymptomatic individuals, among a vulnerable population living in an urban setting. Read More

View Article and Full-Text PDF

Rod-Shaped Silver Supercluster Unveiling Strong Electron Coupling between Substituent Icosahedral Units.

J Am Chem Soc 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry, Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Tsinghua University, Beijing 100084, People's Republic of China.

The first linear silver supercluster based on icosahedral Ag units has been constructed via bridging of dpa ligands: Ag(dpa)(SbF) (Hdpa = dipyridylamine) (). Single-crystal X-ray diffraction reveals that this rod-shaped cluster consists of four vertex-sharing Ag icosahedra in a linear arrangement. This cluster represents the longest one-dimensional metal nanocluster with a resolved structure. Read More

View Article and Full-Text PDF

Localised expression of OsIAA29 suggests a key role for auxin in regulating development of the dorsal aleurone of early rice grains.

Planta 2021 Jul 29;254(2):40. Epub 2021 Jul 29.

School of Science and Technology, University of New England, Armidale, NSW, 2351, Australia.

Main Conclusion: Non-canonical AUX/IAA protein, OsIAA29, and ZmMPR-1 homologues, OsMRPLs, are part of an auxin-related signalling cascade operating in the dorsal aleurone during early rice grain development. Endosperm of rice and other cereals accumulates high concentrations of the predominant in planta auxin, indole-3-acetic acid (IAA) during early grain development. However, IAA signalling and function during endosperm development are poorly understood. Read More

View Article and Full-Text PDF

[Method of Identifying Male Lineages Based on Main Haplotype and Analysis of the Distribution of Y-STR Haplotype Mismatch Based on the Bayesian Theory].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):671-678

Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.

Objective: To establish a classification method to identify different male lineages in a large population, to study the distribution patterns of Y-STR loci mismatches among Han Chinese male lineage members and to explore the mismatch probability distribution among the members with different meiosis intervals in the family.

Methods: Peripheral blood samples of 269 male individuals from 12 lineages in Han Chinese population and 45 unrelated male individuals were collected. Then, Yfiler Plus and ZGWZ FSY or Yfiler Platinum amplification kits were used, obtaining 314 Y-STR haplotypes. Read More

View Article and Full-Text PDF

[Dietary Patterns and Their Association with Diabetes Mellitus in Middle-Aged and Older Rural Population in Xinxiang County, Henan Province].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):662-670

School of Public Health, Xinxiang Medical University/Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, Xinxiang 453003, China.

Objective: To analyze the prevalence of diabetes mellitus among middle-aged and older rural adults of Xinxiang county, Henan Province and its correlation with dietary patterns.

Methods: The study was done based on the data collected from a cross-sectional survey of Xinxiang County, which was part of the Prospective Cohort Study on the Common Chronic Non-Communicable Diseases in Rural areas of Henan Province. Randomized cluster sampling was used to select adult respondents (≥18 years old) from among the residents of 17 villages in Xinxiang county. Read More

View Article and Full-Text PDF

[Study on the Relationship between First-Time Complementary Feeding Practice and the Nutritional Status of Infants and Young Children in the Multi-Ethnic Rural Areas of Sichuan Province].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):655-661

Department of Health Related Social and Behavioral Science, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To evaluate the current status of first food supplement and the nutrition of infants and young children in rural areas inhabited by people of Han, Tibetan, and Yi ethnicities in Sichuan Province, and to explore the relationship between the first ever feeding of food supplement and the nutritional status.

Methods: Using a multi-stage randomized cluster sampling method, we selected 2 Han counties, 2 Tibetan counties and 2 Yi counties in rural areas of Sichuan Province. These counties were previously defined as economically poor counties, but had since been lifted out of poverty. Read More

View Article and Full-Text PDF

The Genome of " Liberibacter asiaticus" Is Highly Transcribed When Infecting the Gut of .

Front Microbiol 2021 12;12:687725. Epub 2021 Jul 12.

Instituto de Química, Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP, Araraquara, Brazil.

The Asian citrus psyllid, , is the vector of the bacterium " Liberibacter asiaticus" (Las), associated with the devastating, worldwide citrus disease huanglongbing. In order to explore the molecular interactions of this bacterium with during the vector acquisition process, cDNA libraries were sequenced on an Illumina platform, obtained from the gut of adult psyllids confined in healthy (H) and in Las-infected young shoots (Las) for different periods of times (I = 1/2 days, II = 3/4 days, and III = 5/6 days). In each sampling time, three biological replicates were collected, containing 100 guts each, totaling 18 libraries depleted in ribosomal RNA. Read More

View Article and Full-Text PDF

Salmonella Paratyphi B; Public Health and Parental Choice: When to Treat Asymptomatic Carriers of Infection?

Pediatr Infect Dis J 2021 Jul 27. Epub 2021 Jul 27.

From the Department of Academic Paediatrics, Royal Alexandra Children's Hospital and Brighton and Sussex Medical School, Brighton Gastrointestinal Bacteria Reference Unit, National Infection Service, Public Health England, London Surrey and Sussex Health Protection Team, Public Health England SE Region, Horsham, West Sussex Division of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, United Kingdom; and Department of Clinical Parasitology, Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London.

Background: Salmonella Paratyphi B (Paratyphoid B) is a rare infection and a notifiable disease in England. Disease is typically mild, and chronic carriage in children has been described in endemic countries. Almost all cases in England are imported, with very few cases of community transmission reported. Read More

View Article and Full-Text PDF

Effects of morbidity on smoking cessation: a national smoking cessation program.

Addict Sci Clin Pract 2021 Jul 28;16(1):47. Epub 2021 Jul 28.

Department of Family Medicine, Research Institute of Medical Science, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Republic of Korea.

Background: In smokers with chronic diseases, we examined the abstinence rates over 6 months and its affecting factors in the context of the Korea National Health Insurance Service (NHIS) smoking cessation program.

Methods: To identify 6-month abstinence, we extracted a sample of 15,017 participants using the multi-stage stratified cluster sampling method from the 359,047 individuals enrolled in the 2016 NHIS smoking cessation program and 1500 smokers responded to the telephone survey. From this group, 1245 individuals (48. Read More

View Article and Full-Text PDF

Resiliency Engagement and Care in Health (REaCH): a telephone befriending intervention for upskilled rural youth in the context of COVID-19 pandemic-study protocol for a multi-centre cluster randomised controlled trial.

Trials 2021 Jul 28;22(1):500. Epub 2021 Jul 28.

Rajagiri College of Social Sciences (Autonomous), Rajagiri P.O, Kalamassery, Cochin, Kerala, 683 104, India.

Background: The lockdown associated with the COVID-19 pandemic is likely to impact people's mental health, especially those from economically disadvantaged and vulnerable sections of society. Mental health can be affected by many factors, including fear of disease transmission, from response measures against the pandemic like social distancing, movement restriction, fear of being in quarantine, loneliness, depression due to isolation, fear of losing work and livelihood and avoiding health care due to fear of being infected. Telephonic befriending intervention by non-specialists will be used to provide social and emotional support to the youth from the Deen Dayal Upadhyaya Grameen Kaushalya Yojana (DDUGKY), an initiative of the Government of India. Read More

View Article and Full-Text PDF

Educational films for improving screening and self-management of gestational diabetes in India and Uganda (GUIDES): study protocol for a cluster-randomised controlled trial.

Trials 2021 Jul 28;22(1):501. Epub 2021 Jul 28.

London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: The prevalence of gestational diabetes mellitus (GDM) is rising rapidly in many low- and middle-income countries (LMICs). Most women with GDM in LMICs are undiagnosed and/or inadequately managed due to a lack of knowledge and skills about GDM on the part of both providers and patients. Following contextual analysis, we developed an educational/behavioural intervention for GDM delivered through a package of culturally tailored films. Read More

View Article and Full-Text PDF

Coping with dyspareunia, the importance of inter and intrapersonal context on women's sexual distress: a population-based study.

Reprod Health 2021 Jul 28;18(1):161. Epub 2021 Jul 28.

Department of Reproductive Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Recently known as the genito-pelvic pain/penetration disorder (GPPPD), Dyspareunia is considered a negative factor affecting a couple's sexual health. This paper analyzes pain in Dyspareunia cases and determines protective factors causing lower levels of sexual distress among patients.

Methods: In a population-based cross-sectional study conducted in 2017, the cluster quota sampling technique was adopted to randomly select 590 Iranian married women aged 18-70 years from 30 health centers. Read More

View Article and Full-Text PDF

First Report of Fruit Rot of Grapes (Vitis vinifera) Caused by Cladosporium cladosporioides in Xinjiang, China.

Plant Dis 2021 Jul 28. Epub 2021 Jul 28.

Shihezi University, Plant protection, Shihezi, Xinjiang, China;

Xinjiang Province accounts for nearly 20% of the total grape (Vitis Vinifera L.), proles orientalis) (wine, table and raisin combined) production, being the largest production area in China. Fruit rot is the most common disease that impacts grape quality and yield. Read More

View Article and Full-Text PDF

C-protein α-antigen modulates the lantibiotic thusin resistance in Streptococcus agalactiae.

Antonie Van Leeuwenhoek 2021 Jul 28. Epub 2021 Jul 28.

Laboratory for Molecular Microbiology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444/a, 11042, Belgrade, Serbia.

Screening for producers of potent antimicrobial peptides, resulted in the isolation of Bacillus cereus BGNM1 with strong antimicrobial activity against Listeria monocytogenes. Genome sequence analysis revealed that BGNM1 contains the gene cluster associated with the production of the lantibiotic, thusin, previously identified in B. thuringiensis. Read More

View Article and Full-Text PDF

sp. nov., an epiphytic bacterium isolated from rice root surfaces.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Department of Biology, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Two Gram-stain-negative, non-motile, rod-shaped bacterial strains were isolated from the surfaces of rice roots. They were designated as strains 1303 and 1310. Their colonies were circular, entire, opaque, convex and yellow. Read More

View Article and Full-Text PDF