17,122 results match your criteria clostridium difficile


Class-specific relationship between use of immunosuppressants and risk for community-acquired Clostridioides difficile infection.

Clin Infect Dis 2021 Jun 22. Epub 2021 Jun 22.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.

Background: Immunosuppressant exposure is associated with risk for Clostridioides difficile infection (CDI), however it is unknown whether this risk is shared equally across immunosuppressant classes.

Methods: This was a retrospective study. Adults were included if they were tested for community acquired CDI (CA-CDI) by stool PCR within 72 hours of hospital admission from 2010 to 2019. Read More

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Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A.

mSystems 2021 Jun 22:e0034121. Epub 2021 Jun 22.

Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, United Kingdom.

Planobispora rosea is the natural producer of the potent thiopeptide antibiotic GE2270A. Here, we present the results of a metabolomics and transcriptomics analysis of P. rosea during production of GE2270A. Read More

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Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile.

ISME J 2021 Jun 21. Epub 2021 Jun 21.

Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, UMR-CNRS 2001, Université de Paris, Paris, France.

Clostridioides difficile infections are associated with gut microbiome dysbiosis and are the leading cause of hospital-acquired diarrhoea. The infectious process is strongly influenced by the microbiota and successful infection relies on the absence of specific microbiota-produced metabolites. Deoxycholate and short-chain fatty acids are microbiota-produced metabolites that limit the growth of C. Read More

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Microbiota or placebo after antimicrobial therapy for recurrent at home: A clinical trial with novel home-based enrollment.

Clin Trials 2021 Jun 22:17407745211021198. Epub 2021 Jun 22.

Veterans Affairs Cooperative Studies Program Coordinating Center, Veterans Affairs Connecticut Health Care System, West Haven, CT, USA.

Introduction: infection is the leading cause of infectious diarrhea in the United States, with substantial morbidity and mortality. Recurrent infection is especially challenging, with each recurrence increasing the likelihood of a successive recurrence, leading to cycles of prolonged symptoms, frequent antimicrobial use, and decreased quality of life. Fecal microbiota transplantation to prevent recurrent infection is a promising intervention with a large effect size in observational studies, but with conflicting results from randomized controlled trials. Read More

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Risks and Preventive Strategies for Clostridioides difficile Transmission to Household or Community Contacts during Transition in Healthcare Settings.

Emerg Infect Dis 2021 Jul;27(7):1776-1782

The burden of Clostridioides difficile infection (CDI) has greatly increased. We evaluated the risks for CDI transmission to community members after hospitalized patients are discharged. We conducted a systematic literature review in MEDLINE/PubMed, EMBASE, CINAHL plus EBSCO, Web of Science, Cochrane Library, and gray literature during January 2000‒February 2019 and identified 4,798 citations were identified. Read More

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Incidence of Clostridioides difficile infection (CDI) related to antibiotic prescribing by GP surgeries in Wales.

J Antimicrob Chemother 2021 Jun 21. Epub 2021 Jun 21.

Department of Mathematics and Statistics, University of Strathclyde, Glasgow G1 1XH, Scotland.

Background: Clostridioides difficile infection (CDI) is a healthcare-acquired infection (HAI) causing significant morbidity and mortality. Welsh CDI rates are high in comparison with those in England and Scotland.

Objectives: This retrospective ecological study used aggregated disease surveillance data to understand the impact of total and high-risk Welsh GP antibiotic prescribing on total and stratified inpatient/non-inpatient CDI incidence. Read More

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septic arthritis and periprosthetic joint infection in a patient with acute lymphoblastic leukaemia, T-/B-lymphocytopenia and hypogammaglobulinemia - a case report and review of the literature.

Access Microbiol 2021 10;3(5):000233. Epub 2021 May 10.

Department of Orthopaedics, Center for Musculoskeletal Surgery, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.

To the best of our knowledge, we report the first infection in a native hip joint with subsequent prosthetic joint infection in a patient at a state of hypogammaglobulinemia. The infection developed following chemotherapy for B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). After chemotherapy, hip arthroplasty was performed for destructive septic arthritis. Read More

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How to Apply FMT More Effectively, Conveniently and Flexible - A Comparison of FMT Methods.

Front Cell Infect Microbiol 2021 4;11:657320. Epub 2021 Jun 4.

1stDepartment of Internal Medicine - Department of Infectology, University of Pécs Clinical Centre, Pécs, Hungary.

Purpose: Metronidazol and vancomycin were long the two best options against (formerly ) infections (CDI). Now, the cost of new drugs such as fidaxomicin directs us towards alternative treatment options, such as faecal microbiota transplant (FMT). Its effectiveness is similar to fidaxomicin. Read More

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An Immunologic Compatibility Testing Was Not Useful for Donor Selection in Fecal Microbiota Transplantation for Ulcerative Colitis.

Front Immunol 2021 4;12:683387. Epub 2021 Jun 4.

Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.

Fecal microbiota transplantation (FMT) is an effective procedure against infection (CDI), with promising but still suboptimal performance in other diseases, such as ulcerative colitis (UC). The recipient's mucosal immune response against the donor's microbiota could be relevant factor in the effectiveness of FMT. Our aim was to design and validate an individualized immune-based test to optimize the fecal donor selection for FMT. Read More

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Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.

Nat Commun 2021 06 18;12(1):3748. Epub 2021 Jun 18.

Department of Physiology and Biophysics, University of California, Irvine, CA, USA.

C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. Read More

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A systematic review and narrative synthesis of pharmacist-led education-based antimicrobial stewardship interventions and their effect on antimicrobial use in hospital inpatients.

J Hosp Infect 2021 Jun 15. Epub 2021 Jun 15.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

Background: Antimicrobial stewardship (AMS) programmes optimise antimicrobial use and address antimicrobial resistance. Pharmacists are often key agents of these programmes. The effectiveness of hospital-based AMS interventions when they are led by pharmacists, however, has not previously been reported. Read More

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Transition From PCR-Ribotyping to Whole Genome Sequencing Based Typing of .

Front Cell Infect Microbiol 2021 1;11:681518. Epub 2021 Jun 1.

Division of Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.

causes nosocomial outbreaks which can lead to severe and even life-threatening colitis. Rapid molecular diagnostic tests allow the identification of toxin-producing, potentially hypervirulent strains, which is critical for patient management and infection control. PCR-ribotyping has been used for decades as the reference standard to investigate transmission in suspected outbreaks. Read More

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Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target .

ACS Med Chem Lett 2021 Jun 7;12(6):991-995. Epub 2021 May 7.

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.

is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. is difficult to eradicate due to its ability to form spores, which are not susceptible to antibiotics. Read More

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Current Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children.

Am J Gastroenterol 2021 Jun 18. Epub 2021 Jun 18.

Boston Children's Hospital, Boston, Massachusetts, USA.

Introduction: The impact of the 2019 US Food and Drug Administration safety alert involving transmission of multidrug resistant organisms through fecal microbiota transplantation (FMT), and the COVID-19 pandemic on the use of FMT in children, is unknown.

Methods: A survey of pediatric gastroenterologists performing FMT for Clostridioides difficile infection was conducted.

Results: Of 36 respondents, 17 (47%) and 30 (83%) changed their FMT practices related to the US Food and Drug Administration safety alert and COVID-19 pandemic, respectively, with 22 (61%) of programs halted. Read More

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Infection Among Patients Requiring Maintenance Hemodialysis.

Kidney Med 2021 May-Jun;3(3):467-470. Epub 2021 Mar 23.

Division of Infectious Diseases, Brown Medicine, Providence, RI.

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Fecal Microbiota Transplantation Donor Screening Updates and Research Gaps for Solid Organ Transplant Recipients.

J Clin Microbiol 2021 Jun 16:JCM0016121. Epub 2021 Jun 16.

Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA.

In this review, we discuss stool donor screening considerations to mitigate potential risks of pathogen transmission through fecal microbiota transplant (FMT) in solid organ transplant (SOT) recipients. SOT recipients have a higher risk for infection (CDI) and are more likely to have severe CDI. FMT has been shown to be a valuable tool in the treatment of recurrent CDI (RCDI), however guidelines for screening for opportunistic infections transmitted through FMT are underdeveloped. Read More

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Impact of a mobile decision support tool on antimicrobial stewardship indicators in St. John's, Canada.

PLoS One 2021 16;16(6):e0252407. Epub 2021 Jun 16.

Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

Objectives: Inappropriate antibiotic use contributes to antimicrobial resistance. The SpectrumTM app provides antibiotic decision support, based on local antimicrobial resistance rates. We determined the impact of regional implementation of the app on inpatient antimicrobial appropriateness, inpatient antimicrobial usage (AMU), population-based Clostridioides difficile infection (CDI) rates and cost, using a retrospective, before and after quasi-experimental design, including a one-year study period. Read More

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A review of the role of Gastrointestinal Multiplex PCR in the management of Diarrheal illness.

J Gastroenterol Hepatol 2021 Jun 15. Epub 2021 Jun 15.

Division of Gastroenterology and Hepatology, National University Hospital, Singapore.

Acute and chronic diarrheal illness secondary to gastrointestinal infection is a significant cause of morbidity and mortality around the world. A cornerstone of management includes prompt diagnosis and appropriate treatment of culprit pathogens. Timely diagnosis can improve patient care, assist in infection control, and prevent disease outbreaks. Read More

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Intestinal Inflammation and Altered Gut Microbiota Associated with Inflammatory Bowel Disease Render Mice Susceptible to Clostridioides difficile Colonization and Infection.

mBio 2021 Jun 15:e0273320. Epub 2021 Jun 15.

Department of Internal Medicine/Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.

Clostridioides difficile is a noteworthy pathogen in patients with inflammatory bowel disease (IBD). Patients with IBD who develop concurrent C. difficile infection (CDI) experience increased morbidity and mortality. Read More

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Faecal microbiota transplantation influences procarcinogenic Escherichia coli in recipient recurrent Clostridioides difficile patients.

Gastroenterology 2021 Jun 11. Epub 2021 Jun 11.

Experimental Bacteriology, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands; Netherlands Donor Feces Bank, Leiden, Netherlands; Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Background And Aims: Patients suffering from multiple recurrent Clostridioides difficile infections (rCDI) have a disturbed gut microbiota, which can be restored by faecal microbiota transplantation (FMT). Despite extensive screening, healthy faeces donors may carry bacteria in their intestinal tract that could have long-term health effects, such as potentially procarcinogenic pksEscherichia coli. Here, we aim to determine whether the pks abundance and persistence of pksE. Read More

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Is Clostridioides difficile toxins detection necessary when the glutamate dehydrogenase enzyme is detected?

Gac Med Mex 2021 ;157(1):107-109

Microbiology Laboratory, Department of Medicine and Nutrition, Universidad de Guanajuato, Guanajuato.

Introduction: Clostridioides difficile causes diarrhea and pseudomembranous colitis. Its diagnosis is made with glutamate dehydrogenase (GDH) or toxins A and B detection and is confirmed with nucleic acid amplification tests.

Objective: To define if GDH determination is redundant to that of toxins. Read More

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January 2021

Genomic evolution and virulence association of sequence type 37 (ribotype 017) in China.

Emerg Microbes Infect 2021 Jun 14:1-0. Epub 2021 Jun 14.

School of Laboratory Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 310053, China.

sequence type (ST) 37 (ribotype 017) is one of the most prevalent genotypes circulating in China. However, its genomic evolution and virulence determinants were rarely explored. Whole-genome sequencing, phylogeographic and phylogenetic analyses were conducted for ST37 isolates. Read More

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Implementation of fecal microbiota transplantation in a medical center for recurrent or refractory Clostridioides difficile infection and report of preliminary outcome.

Biomed J 2021 Jun 9. Epub 2021 Jun 9.

Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

Background: Fecal microbiota transplantation (FMT) has been shown to highly effective in the treatment of recurrent or refractory Clostridioides difficile infection (rCDI) in many countries of the world. Not until 2018, Ministry of Health and Welfare, Taiwan approved the application of FMT for rCDI under a special law. The study reported the first implementation of the technology in the medical center in Taiwan and the preliminary outcome. Read More

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Fecal microbiota transplant, its usefulness beyond Clostridioides difficile in gastrointestinal diseases.

Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

School of Veterinary Medicine, Faculty of Life Sciences, Universidad Andrés Bello, Chile.

Fecal microbiota transplant (FMT) is currently recommended for recurrent Clostridioides difficile infection. However, it is interesting to acknowledge the potential therapeutic role in other diseases associated with dysbiosis. This review will focus on the current and potential indications of FMT in gastrointestinal diseases, evaluating the available evidence and also exposing the necessary requirements to carry it out. Read More

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Umbrella review of 42 systematic reviews with meta-analyses: the safety of proton pump inhibitors.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.

Background: Proton pump inhibitors (PPIs) are widely used to treat and prevent acid-related disorders. Despite high efficacy, PPI safety has been increasingly scrutinised. However, no comprehensive review summarising investigations of various adverse events is available. Read More

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Major genetic discontinuity and novel toxigenic species in taxonomy.

Elife 2021 Jun 11;10. Epub 2021 Jun 11.

School of Biomedical Sciences, University of Western Australia, Nedlands, Australia.

infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology seen in the last 20 years. We analysed an international collection of over 12,000 genomes spanning the eight currently defined phylogenetic clades. Read More

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Mortality review as a tool to assess the contribution of healthcare-associated infections to death: results of a multicentre validity and reproducibility study, 11 European Union countries, 2017 to 2018.

Euro Surveill 2021 Jun;26(23)

The members of the study group are listed under Investigators.

IntroductionThe contribution of healthcare-associated infections (HAI) to mortality can be estimated using statistical methods, but mortality review (MR) is better suited for routine use in clinical settings. The European Centre for Disease Prevention and Control recently introduced MR into its HAI surveillance.AimWe evaluate validity and reproducibility of three MR measures. Read More

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Detection of Free Toxin B in the Stool of Asymptomatic Carriers by the Cell Cytotoxicity Neutralization Assay.

Open Forum Infect Dis 2021 Jun 25;8(6):ofab209. Epub 2021 Apr 25.

McGill University Faculty of Medicine, Montreal, Québec, Canada.

Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Read More

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Infection and Liver Cirrhosis - A Retrospective, Cohort Study.

Clin Exp Gastroenterol 2021 3;14:229-235. Epub 2021 Jun 3.

Department of Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

Purpose: infection (CDI) is one of the most common health care-associated infections in the United States. Studies revealed a higher mortality when CDI is associated with liver cirrhosis. We aim to present the outcomes of CDI among patients with and without liver cirrhosis and to analyze the association of Model for End-Stage Liver Disease (MELD) and Child-Pugh (CPT) scoring with the severity of CDI. Read More

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