154 results match your criteria cll kidney

Mortality among workers at the Los Alamos National Laboratory, 1943-2017.

Int J Radiat Biol 2021 Jun 21:1-28. Epub 2021 Jun 21.

Easterly Scientific, Knoxville, TN, USA.

Background: During World War II (WWII), the Manhattan Engineering District established a secret laboratory in the mountains of northern New Mexico. The mission was to design, construct and test the first atomic weapon, nicknamed 'The Gadget' that was detonated at the TRINITY site in Alamogordo, NM. After WWII, nuclear weapons research continued, and the laboratory became the Los Alamos National Laboratory (LANL). Read More

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Morphological and Molecular Study of Hybrid Oncocytic/Chromophobe Tumor of the Kidney Associated with Sporadic Renal Oncocytosis and Chronic B-Cell Lymphocytic Leukemia: The Possible Contribution of Lymphoma to Renal Oncocytosis.

Pathobiology 2021 Apr 21:1-10. Epub 2021 Apr 21.

Pathology, University Hospital Virgen Macarena, University of Seville, Sevilla, Spain.

Hybrid oncocytic/chromophobe tumor (HOCT) of the kidney arising from a precursor oncocytosis not associated with the Birt-Hogg-Dubé (BHD) syndrome is an unusual and highly interesting neoplasm. Immunohistochemical and molecular findings suggest that HOCT is an entity distinct from both oncocytoma and chromophobe carcinoma. Although uncertainty persists regarding the factors predisposing to the development of HOCT, experimental findings suggest that it may arise due to the effect of toxins or in association with chronic kidney failure. Read More

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Relationship between vasculitis and chronic lymphocytic leukaemia: a correlation without causation.

BMJ Case Rep 2020 Dec 22;13(12). Epub 2020 Dec 22.

Department of Family Medicine, Michigan State University College of Human Medicine, East Lansing, Michigan, USA

We report a novel case of a patient who presented with new diagnoses of both cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCAs) positive vasculitis and chronic lymphocytic leukaemia (CLL). The patient was a 79-year-old man who presented with melena, haemoptysis, acute hypoxia and acute kidney injury. In the current literature, there are rare associations of c-ANCA vasculitis and malignancy, but very few, if any, relating c-ANCA vasculitis and CLL. Read More

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December 2020

Intra-abdominal Hypertension as a Cause of Oliguric Acute Kidney Injury in a Patient with Chronic Lymphocytic Leukemia.

Saudi J Kidney Dis Transpl 2020 Sep-Oct;31(5):1140-1143

Department of Hematology, Venizeleio Hospital, Crete, Greece.

Acute kidney injury (AKI) is a well-known complication in patients with chronic lymphocytic leukemia (CLL). It could occur via diverse mechanisms such as leukemic infiltration, extrarenal obstruction, tumor lysis syndrome, glomerular diseases, and medication side effects. The incidence of kidney disease at the diagnosis of CLL is about 10%. Read More

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November 2020

Global Glomerulosclerosis in Kidney Biopsies With Differing Amounts of Cortex: A Clinical-Pathologic Correlation Study.

Kidney Med 2019 Jul-Aug;1(4):153-161. Epub 2019 Jul 12.

Divisions of Nephrology and Hypertension (RSN, AD) and Biomedical Statistics and Informatics (CLL, WKK), and Departments of Laboratory Medicine and Pathology (SS) and Surgery (MDS), Mayo Clinic, Rochester, MN; Department of Nephrology, Cleveland Clinic, Cleveland, OH (JJA); and Division of Epidemiology, Mayo Clinic, Rochester, MN (ADR).

Rationale & Objective: The number of glomeruli is often used to determine the adequacy of a kidney biopsy (eg, at least 10 glomeruli). It is often assumed that biopsy specimens with limited amounts of cortex are too imprecise for detection of focal pathology.

Study Design: Clinical-pathologic correlation (cross-sectional). Read More

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Crystalglobulin-associated nephropathy presenting as MGRS in a case of monoclonal B-cell lymphocytosis: a case report.

BMC Nephrol 2020 05 18;21(1):184. Epub 2020 May 18.

Department of Nephrology, SUNY Upstate Medical University, Syracuse, NY, USA.

Background: Crystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and occasionally monoclonal gammopathy of uncertain significance (MGUS), is characterized by occluding monoclonal pseudothrombi within renal glomerular capillaries and/or interstitial arterioles. Ultrastructurally, these pseudothrombi are unique for having a crystalline substructure. We describe a case of an adult patient with monoclonal B-cell lymphocytosis (MBL) and acute renal failure whose kidney biopsy revealed a rare diagnosis of CAN. Read More

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Risk of second primary papillary thyroid cancer among adult cancer survivors in the United States, 2000-2015.

Cancer Epidemiol 2020 02 26;64:101664. Epub 2019 Dec 26.

Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Institutes of Health, National Cancer Institute, 9609 Medical Center Drive, MSC 9778 Bethesda, MD, 20892-9778, United States.

Background: While radiotherapy is a major risk factor for thyroid cancer after childhood cancer, factors contributing to increased thyroid cancer risk after adulthood cancer remain unclear.

Methods: We evaluated second primary papillary thyroid cancer (PTC) risk among 3,175,216 ≥ 1-year adult survivors of non-thyroid malignancies from US population-based cancer registries (2000-2015), using standardized incidence ratios (SIRs). Because heightened surveillance may increase detection of indolent thyroid tumors and earlier detection of advanced tumors, we examined SIRs by PTC stage and time since first cancer (latency). Read More

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February 2020

Hepatitis C virus and risk of extrahepatic malignancies: a case-control study.

Sci Rep 2019 12 19;9(1):19444. Epub 2019 Dec 19.

Department of Infection Management, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Epidemiological studies have demonstrated an increased risk of non-Hodgkin lymphoma (NHL) in patients with chronic hepatitis C virus (HCV) infection. Therefore, we investigated the risk of extrahepatic malignancies associated with HCV infection. Inpatients diagnosed with lymphoma, breast, thyroid, kidney, or pancreatic cancer (research group, n = 17,925) as well as inpatients with no malignancies (control group, n = 16,580) matched by gender and age were enrolled from The First Affiliated Hospital of Nanjing Medical University between January 2008 and December 2016. Read More

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December 2019

A complex role for Bcl10 in kidney injury.

Cardiovasc Res 2020 04;116(5):882-884

Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Box 103015 DUMC, Durham, NC 27710, USA.

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Possible curative role of curcumin and silymarin against nephrotoxicity induced by gamma-rays in rats.

Exp Mol Pathol 2019 12 20;111:104299. Epub 2019 Aug 20.

Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), P.O. Box 29, Nasr City, Cairo, Egypt. Electronic address:

Curcumin (CUR) and silymarin (SLM) are powerful antioxidant and anti-inflammatory compounds with beneficial protective effects against renal diseases. The purpose of this study was to evaluate the efficacy of CUR and SLM alone or in combination on radiation (IR) induced kidney injury. The results showed that CUR and SLM alone or in combination attenuated the oxidative stress denoted by a reduction in the level of malondialdehyde (MDA), hydrogen peroxide (HO) and advanced oxidation protein products (AOPP) along with a marked increase of glutathione GSH content and total antioxidant capacity (TAC). Read More

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December 2019

Rituximab in kidney disease and transplant.

Animal Model Exp Med 2019 Jun 26;2(2):76-82. Epub 2019 Mar 26.

Department of Pharmacology L. M. College of Pharmacy Ahmedabad Gujarat India.

Rituximab is a chimeric monoclonal antibody that binds to CD20 antigen of B-cells. It depletes the level of mature B-cells by various mechanisms such as mediation of antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and B-cell apoptosis. Rituximab is a USFDA approved drug for clinical use in non-Hodgkin's B-cell lymphoma (NHL), rheumatoid arthritis, chronic lymphocytic leukemia (CLL), granulomatosis with polyangiitis and pemphigus vulgaris. Read More

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B-cell lymphoma/leukaemia 10 and angiotensin II-induced kidney injury.

Cardiovasc Res 2020 04;116(5):1059-1070

Experimental and Clinical Research Center, a cooperation of Charité - Universitätsmedizin Berlin, Berlin, Germany and Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.

Aims: B-cell lymphoma/leukaemia 10 (Bcl10) is a member of the CARMA-Bcl10-MALT1 signalosome, linking angiotensin (Ang) II, and antigen-dependent immune-cell activation to nuclear factor kappa-B signalling. We showed earlier that Bcl10 plays a role in Ang II-induced cardiac fibrosis and remodelling, independent of blood pressure. We now investigated the role of Bcl10 in Ang II-induced renal damage. Read More

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Updated mortality analysis of the Mallinckrodt uranium processing workers, 1942-2012.

Int J Radiat Biol 2019 Jan 17:1-21. Epub 2019 Jan 17.

g National Council on Radiation Protection and Measurements , Bethesda , MD , USA.

Purpose: Mallinckrodt Chemical Works (MCW) was the earliest uranium processing facility in the United States, and in 1942 produced the uranium oxide used for the first sustained and controlled nuclear fission chain-reaction at the University of Chicago. A second follow-up through 2012 was conducted of 2514 White male workers employed 1942-1966 at the MCW for dose-response analyses for selected causes of death.

Materials And Methods: Organ/tissue-specific dose reconstruction included both external (12,686 MCW film badge records, 210 other facility film badge records, and 31,297 occupational chest x-rays) and internal sources of uranium and radium (39,451 urine bioassays, 2341 breath radon measurements, and 6846 ambient radon measurements). Read More

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January 2019

Monoclonal B-cell lymphocytosis with renal involvement.

Yao-Ko Wen

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1502-1505

Department of Internal Medicine, Division of Nephrology, Changhua Christian Hospital, Changhua, Taiwan.

We report the case of a 70-year-old man with no relevant past medical history who presented with acute kidney injury. Kidney biopsy showed diffuse interstitial infiltration with typical chronic lymphocytic leukemia (CLL) phenotype B-cells. Subsequent studies revealed a normal lymphocyte count in the peripheral blood, and there was no evidence of lymphadenopathy or hepatosplenomegaly. Read More

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October 2019

An Unusual Case Report: Occurrence of Renal Cell Carcinoma, Basal Cell Carcinoma and Chronic Lymphocytic Leukemia in a Case of Papillary Thyroid Carcinoma Treated with Radioactive Iodine.

Iran J Med Sci 2018 Nov;43(6):659-663

Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.

The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinogen including occupational and therapy related hazard, aging and genetic susceptibility are other causes of second primary cancers. Read More

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November 2018

Renal involvement in chronic lymphocytic leukemia.

Clin Kidney J 2018 Oct 11;11(5):670-680. Epub 2018 Apr 11.

Division of Kidney Diseases and Hypertension, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA.

Chronic lymphocytic leukemia (CLL) is the most commonly diagnosed adult leukemia in the USA and Western Europe. Kidney disease can present in patients with CLL as a manifestation of the disease process such as acute kidney injury with infiltration or with a paraneoplastic glomerular disease or as a manifestation of extra renal obstruction and tumor lysis syndrome. In the current era of novel targeted therapies, kidney disease can also present as a complication of treatment. Read More

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October 2018

Immunophenotypic profile and clinical outcome of monoclonal B-cell lymphocytosis in kidney transplantation.

Clin Transplant 2018 08 26;32(8):e13338. Epub 2018 Aug 26.

Section of Nephrology, Surgical, Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Azienda Ospedaliero - Universitaria Policlinico, Modena, Italy.

Monoclonal B-cell lymphocytosis (MBL) is a lymphoproliferative disorder characterized by clonal expansion of a B-cell population in peripheral blood of otherwise healthy subjects. MBL is divided into CLL (chronic lymphocytic leukemia)-like, atypical CLL-like and non-CLL MBL. The aim of this study was to evaluate immunophenotypic characteristics and clinical outcomes of MBL in kidney transplant (KT) recipients. Read More

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Radiation Therapy Induced Esophageal Ulcer.

S D Med 2018 Feb;71(2):81-84

Vassar Brother Medical Centre, Poughkeepsie, New York.

Dysproteinemia is excessive production of immunoglobulins from clonal proliferation of plasma or B cells. Cryoglobulins are a special group of immunoglobulins that precipitate below 37 degrees C. Type 1 cryoglobulinemia consists mostly of IgM and IgG that infrequently leads to glomerulonephritis. Read More

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February 2018

[Chronic lymphoid leukemia and renal complication: Report on 10 cases from Marseille over 16 years].

Rev Med Interne 2018 Aug 8;39(8):612-617. Epub 2018 Jun 8.

Médecine interne, hôpital de la Timone (AP-HM), Aix-Marseille université, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France. Electronic address:

Introduction: Chronic lymphoid leukemia (CLL) is a hematological malignant disease, associated with a clonal B cell proliferation. The incidence is 4400 new cases per year in France. The prevalence increases with age with a median age at diagnostic of 65 years. Read More

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Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro.

Biomed Pharmacother 2018 Jul 24;103:915-922. Epub 2018 Apr 24.

Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China. Electronic address:

The regulation of renal transporters such as organic anion transporter (OATs) is a new target for treatment of acute renal failure. The purpose of this study was to investigate whether the effect of puerarin (Pur) on renal damage induced by methotrexate (MTX) is related to the expression of renal Oat1/3 in vivo and in vitro, and to explore the related mechanisms. Effect of Pur on the renal damage caused by MTX was evaluated by assessment of the changes of endogenous metabolites, toxins and H&E staining. Read More

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Proteinuria, Hypoalbuminemia, and Chronic Lymphocytic Leukemia: An Unusual Trio.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618764207. Epub 2018 Mar 14.

University of California, Davis, Sacramento, CA, USA.

Chronic lymphocytic leukemia (CLL) is a chronic, progressive lymphoproliferative disorder characterized by a monoclonal population of functionally incompetent lymphocytes. Renal involvement is rare and poorly described. A 57-year-old male with no prior medical history was diagnosed with CLL and followed with a watch and wait approach. Read More

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Forgotten, Encrusted Ureteral Stents: Removal - Multimodal Endourologic Approach.

Mymensingh Med J 2018 Jan;27(1):149-158

Dr Prodyut Kumar Saha, Associate Professor, Department of Urology, Dhaka Medical College, Dhaka, Bangladesh.

Ureteral stent placement is a common procedure in urologic practice. Forgotten, encrusted D/J stents represent a difficult problem for urologists. The major complications are infection, impaired renal function, migration, encrustation, stone formation and multiple fragmentation of stent. Read More

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January 2018

Monoclonal B lymphocytosis and minimal change disease: a new monoclonal B-cell disorder of renal significance?

J Nephrol 2018 04 21;31(2):317-320. Epub 2017 Dec 21.

Service de Néphrologie, Centre Hospitalier de Rouen, 76000, Rouen, France.

Chronic lymphocytic leukemia (CLL) may induce renal complications, which are becoming increasingly common, but in this context the occurrence of minimal change disease (MCD) remains rare. Monoclonal B lymphocytosis (MBL) is a precursor state of CLL and is currently under recognized. Since MBL is seen as a benign disorder that rarely evolves into CLL, screening for MBL is not standardized and does not require any treatment. Read More

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Granulomatous interstitial nephritis due to chronic lymphocytic leukemia: a case report.

BMC Nephrol 2017 Dec 2;18(1):348. Epub 2017 Dec 2.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Renal failure due to the infiltration of chronic lymphocytic leukemia (CLL) cells into the tubulointerstitial area of the kidney is uncommon. Furthermore, granulomatous interstitial nephritis (GIN) is a rare histological diagnosis in patients undergoing a renal biopsy. We herein report a case of GIN due to the diffuse infiltration of CLL cells in a patient who developed progressive renal failure. Read More

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December 2017

Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts.

Int J Mol Med 2017 Dec 17;40(6):1840-1850. Epub 2017 Oct 17.

Centre of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Kidney transplantation is an effective final therapeutic procedure for patients with end-stage kidney failure. Although advanced immunosuppressive therapy is administered following transplantation, certain patients still suffer from acute allograft rejection. MicroRNAs (miRs) have a potential diagnostic and therapeutic value for acute renal allograft rejection; however, their underlying mechanism of action is largely unknown. Read More

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December 2017