10,695 results match your criteria clinically asymptomatic


Delayed hemorrhage after pediatric stereo-electroencephalography: delayed occurrence or delayed diagnosis?

Childs Nerv Syst 2021 Jul 28. Epub 2021 Jul 28.

Department of Pediatric Neurosurgery, Sant Joan de Déu Barcelona Children's Hospital, Universitat de Barcelona, Barcelona, Spain.

Background: Stereo-electroencephalography (SEEG) is a well-known invasive diagnostic method for drug-resistant epilepsy (DRE). Its rate of complications is relatively low, being the intracranial hemorrhage (ICH) the most relevant. Most centers perform immediate imaging studies after SEEG to rule out complications. Read More

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Incidental Diagnosis After a Car Accident: A Rare Case of Asymptomatic Uncorrected Tetralogy of Fallot.

JACC Case Rep 2020 Dec 16;2(15):2289-2294. Epub 2020 Dec 16.

Division of Cardiology, Ospedale degli Infermi, ASL Biella, Italy.

Tetralogy of Fallot (TOF) is a heterogeneous congenital heart disease that is occasionally diagnosed during adulthood. However, although they are often asymptomatic, adult patients with uncorrected TOF often have a poor prognosis. Poor outcomes indicate the importance of the identification and management of these patients, especially in the context of intercurrent disease or noncardiac surgery. Read More

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December 2020

Upper Gastrointestinal Tract Involvement in Inflammatory Bowel Diseases: Histologic Clues and Pitfalls.

Adv Anat Pathol 2021 Jul 26. Epub 2021 Jul 26.

Department of Pathology, Henry Lee Moffitt Cancer Center and Research Institute, Tampa, FL Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ Department of Pathology, University of Szeged and Albert Szent-Györgyi Health Center, Szeged, Hungary.

The upper gastrointestinal (UGI) manifestations of inflammatory bowel diseases (IBDs) are frequently obscured by classic ileal and colonic symptoms and are reported to involve only 0.5% to 4% of adult patients. However, because of the improvement of endoscopic techniques and the growing use of esophagogastroduodenososcopy with biopsy, both asymptomatic and clinically significant esophageal, gastric, and duodenal manifestations are increasingly recognized. Read More

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Miliarial type perifollicular B cell pseudolymphoma: an easily overlooked rare subtype of pseudolymphoma cutis manifesting as a centrofacial acneiform eruption.

J Eur Acad Dermatol Venereol 2021 Jul 26. Epub 2021 Jul 26.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Miliarial type perifollicular B cell pseudolymphoma (MTPBCP) is an uncommon subtype of pseudolymphoma cutis clinically defined by multiple asymptomatic, translucent, firm pinhead sized skin-colored or brownish-red papules with symmetric distribution. Predilection sites are the centrofacial area and the neck. This exceedingly rare type of pseudolymphoma may pose a diagnostic challenge both clinically and histologically. Read More

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Acute Cholecystitis in a Patient With Situs Inversus Totalis: An Unexpected Finding.

Cureus 2021 Jun 21;13(6):e15799. Epub 2021 Jun 21.

Surgery, Universidad Nacional, Bogotá D.C., COL.

Situs inversus totalis (SIT) has an incidence in the general population of 1/10,000, with a female-male ratio of 1:1.5 without racial predilection. Clinically, SIT by itself tends to be asymptomatic; however, when it is associated with other conditions such as cholecystitis or appendicitis, the diagnosis may represent a challenge due to the reversed anatomical location of symptoms. Read More

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Is vaginal laxity an early symptom of pelvic organ prolapse?

Int Urogynecol J 2021 Jul 24. Epub 2021 Jul 24.

Sydney Medical School Nepean, University of Sydney, Penrith, NSW, Australia.

Introduction And Hypothesis: We aimed to determine whether vaginal laxity (VL) may be an early symptom of pelvic organ prolapse (POP).

Methods: This was a retrospective observational study including patients referred to a urogynecological clinic owing to symptoms of pelvic floor dysfunction. The interview included inquiry about VL and POP symptoms. Read More

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Clinicopathologic Features of Gynecologic Malignancies Presenting Clinically as Colonic Malignancies.

Am J Clin Pathol 2021 Jul 24. Epub 2021 Jul 24.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Objectives: To systematically evaluate gynecologic malignancies (adnexal or uterine) causing gastrointestinal (GI) signs (eg, mass on colonoscopy) or symptoms (eg, bloody stools) clinically mimicking a GI primary malignancy.

Methods: The archives of 2 institutions were retrospectively reviewed for gynecologic malignancies clinically manifesting as colonic lesions. For each case, available radiologic, endoscopic, and histologic findings were recorded. Read More

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Intraindividual Doppler Flow Response to Exercise Differs Between Symptomatic and Asymptomatic Achilles Tendons.

Front Physiol 2021 6;12:617497. Epub 2021 Jul 6.

University Outpatient Clinic, Sports Medicine and Orthopedics, University of Potsdam, Potsdam, Germany.

Objective: This study investigated intraindividual differences of intratendinous blood flow (IBF) in response to running exercise in participants with Achilles tendinopathy.

Design: This is a cross-sectional study.

Setting: The study was conducted at the University Outpatient Clinic. Read More

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Noninvasive exploration of Cardiac Autonomic Neuropathy by heart rate and blood pressure variability analysis in Type 2 Diabetic patients.

Pak J Med Sci 2021 Jul-Aug;37(4):1020-1024

Ambreen Shakir, MBBS. Ex-lecturer Physiology, Bahria Medical, and Dental College, Bahria University, Karachi, Pakistan.

Objectives: To determine the prevalence of asymptomatic cardiac autonomic neuropathy and its association with risk factors among patients with Type-2 diabetes mellitus (T2DM).

Methods: The present case-control study was conducted at Department of Medicine, Civil Hospital, Dow University of Health Sciences (DUHS), Karachi, Pakistan during the period September` 2016 to May` 2017. After taking informed consent, subjects from both genders, 72 healthy controls and 72 clinically diagnosed T2DM diabetic patients, age between 30-65 years were selected by non-probability sampling technique. Read More

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September 2020

Hypokalaemic quadriparesis with respiratory failure due to latent Sjogren syndrome.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

General Medicine, Dr Sampurnanand Medical College, Jodhpur, India.

Sjogren's syndrome (SS) is an autoimmune disease with involvement of multiple organs, including both glandular and extraglandular organs. Usually involvement of glandular organs manifests before the extraglandular ones, but when the sequence is reversed, diagnosis may be missed. Hypokalaemic quadriparesis in SS is not uncommon. Read More

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Serological prevalence of hepatitis B virus (HBV) in Mardan district, Khyber Pakhtunkhwa, Pakistan.

Braz J Biol 2021 14;82:e245813. Epub 2021 Jul 14.

Lanzhou University, School of Life Sciences, MOE Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou, Gansu, China.

Hepatitis B virus infection is perilous among the five types of Hepatitis, as it remains clinically asymptomatic. The present study draws up-to-date prevalence of Hepatitis B virus (HBV) in the general population of Mardan, Khyber Pakhtunkhwa Pakistan. The blood samples from 4803 individuals including 2399 male and 2404 females were investigated. Read More

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Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis.

Ann Rheum Dis 2021 Jul 20. Epub 2021 Jul 20.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: The human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking are the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). However, at which pre-arthritis stage (asymptomatic/symptomatic) they exert their effect is unknown. We aimed to determine whether HLA-SE and smoking are involved in the onset of autoantibody positivity, symptoms (clinically suspect arthralgia (CSA)) and/or progression to clinical arthritis. Read More

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Intact procedural learning and motor intracortical inhibition in adult neurofibromatosis type 1 gene carriers.

Clin Neurophysiol 2021 Jun 21;132(9):2037-2045. Epub 2021 Jun 21.

Experimental Electrophysiology and Neuroimaging (xENi) Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Objective: Neurofibromatosis type 1 (NF1) is known to cause learning deficits in affected individuals. There has been evidence linking altered gamma-aminobutyric acid (GABA) mediated inhibition to learning impairments in rodent models and humans with NF1. Still, evidence on the role of GABA in learning deficits associated with NF1 is inconclusive. Read More

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Burr-Assisted Peripheral Superficial Keratectomy for the Treatment of Persistent Symptomatic Peripheral Corneal Edema.

Ophthalmol Ther 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology, Jules-Gonin Eye Hospital, University of Lausanne, Fondation Asile des aveugles, Avenue de France 15, 1002, Lausanne, Switzerland.

Purpose: To describe a simple technique of diamond burr-assisted superficial keratectomy for the treatment of peripheral corneal edema.

Cases Presentation: Two patients with persistent symptomatic peripheral corneal edema underwent superficial keratectomy with the use of a diamond ophthalmic burr. The efficacy of the treatment was evaluated clinically as well as with anterior segment optical coherence tomography. Read More

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Prehospital characteristics of COVID-19 patients in Helsinki - experience of the first wave of the pandemic.

Scand J Trauma Resusc Emerg Med 2021 Jul 19;29(1):95. Epub 2021 Jul 19.

Departments of Emergency Medicine & Services, Anaesthesiology & Intensive Care Medicine, P.O. Box 112, 00099, Helsinki, Finland.

Background: There is a lack of knowledge how patients with COVID-19 disease differ from patients with similar signs or symptoms (but who will have a diagnosis other than COVID-19) in the prehospital setting. The aim of this study was to compare the characteristics of these two patient groups met by the emergency medical services.

Methods: All prehospital patients after the World Health Organisation (WHO) pandemic declaration 11. Read More

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Diagnostic and Management Considerations in a Patient With Primary Pulmonary Meningioma With Associated Micro-Solid Nodules.

Cureus 2021 Jun 16;13(6):e15700. Epub 2021 Jun 16.

Hematology and Medical Oncology, Jersey City Medical Center, Jersey City, USA.

Primary pulmonary meningiomas (PPMs) are rare mesodermal tumors that arise in the lung and are most often incidentally identified as single pulmonary nodules. Most cases of PPM are benign, and surgical resection remains the primary curative treatment. We describe the case of a 65-year-old asymptomatic female who presented with an incidentally identified 2. Read More

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Serum and urine analysis with gold nanoparticle-assisted laser desorption/ionization mass spectrometry for renal cell carcinoma metabolic biomarkers discovery.

Adv Med Sci 2021 Jul 14;66(2):326-335. Epub 2021 Jul 14.

Faculty of Chemistry, Rzeszow University of Technology, Rzeszow, Poland.

Purpose: Renal cell carcinoma (RCC) is a very aggressive and often fatal heterogeneous disease that is usually asymptomatic until late in the disease. There is an urgent need for RCC specific biomarkers that may be exploited clinically for diagnostic and prognostic purposes.

Materials/methods: Serum and urine samples were collected from patients with diagnosed kidney cancer and assessed with gold nanoparticle enhanced target (AuNPET) surface assisted-laser desorption/ionization mass spectrometry (SALDI MS) based metabolomics and statistical analysis. Read More

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Pseudoxanthoma elasticum-like papillary dermal elastolysis: A mimicker of genetic pseudoxanthoma elasticum.

Clin Dermatol 2021 Mar-Apr;39(2):206-210. Epub 2020 Oct 16.

Dermatology Clinic, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Pseudoxanthoma elasticum (PXE)-like papillary dermal elastolysis (PDE) is an acquired, rare, elastic tissue disorder that presents with multiple asymptomatic, nonfollicular yellowish or normochromic papules, coalescing into symmetrical cobblestone plaques, with a predilection for the neck of postmenopausal women. The condition develops slowly, in months to years, and, although clinically similar to PXE, it is devoid of any systemic implication, being only of esthetic concern. The etiology is unknown, but it is speculated that there is a multifactorial pathogenesis, with the contribution of intrinsic aging, exposure to ultraviolet radiation, abnormal elastogenesis, and genetic factors. Read More

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October 2020

Leukemic Variant of Mantle Cell Lymphoma: Clinical Presentation and Management.

Curr Oncol Rep 2021 Jul 16;23(9):102. Epub 2021 Jul 16.

Division of Hematology/Oncology, Department of Medicine, University of Virginia Cancer Center, Jefferson Park Avenue, PO 800716, Charlottesville, VA, 22908, USA.

Purpose Of Review: This review summarizes the unique presentation and management of the leukemic variant of mantle cell lymphoma (LV-MCL, also referred to as non-nodal MCL) and highlights the biologic and clinical differentiation from classical mantle cell lymphoma (cMCL) in biomarker expression, clinical features, prognosis, disease course, and treatment.

Recent Findings: Several studies have evaluated the gene expression profile of mantle cell lymphoma, differentiating LV-MCL from cMCL. The typical immunophenotypic profile is CD5-positive, SOX 11-negative, CD23-low, CD200-low, and cyclin D1 overexpressed. Read More

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Diagnostic circulating biomarkers to detect vision-threatening diabetic retinopathy: Potential screening tool of the future?

Acta Ophthalmol 2021 Jul 16. Epub 2021 Jul 16.

Institute of Ophthalmology, University College London, London, UK.

With the increasing prevalence of diabetes in developing and developed countries, the socio-economic burden of diabetic retinopathy (DR), the leading complication of diabetes, is growing. Diabetic retinopathy (DR) is currently one of the leading causes of blindness in working-age adults worldwide. Robust methodologies exist to detect and monitor DR; however, these rely on specialist imaging techniques and qualified practitioners. Read More

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Asymptomatic palatal mass: A case report.

Indian J Dent Res 2021 Jan-Feb;32(1):120-123

Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India.

Accidental detection of asymptomatic clinically suspicious lesions is a common occurrence in routine clinical examination of the oral cavity. In certain cases, these lesions may mimic benign lesions further adding to confusion. In this case report, we have discussed the case of a 51-year-old male patient with an asymptomatic palatal mass which was detected during a routine dental check-up and subsequently confirmed to be an adenoid cystic carcinoma (ACC) arising from the minor salivary glands. Read More

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Changes in vitamin D and calcium metabolism markers in patients undergoing adjuvant chemotherapy for breast cancer.

BMC Cancer 2021 Jul 15;21(1):815. Epub 2021 Jul 15.

Department of Medical Oncology, Institut du Cancer de Montpellier (ICM), University of Montpellier, 208 avenue des Apothicaires, 34090, Montpellier, France.

Background: Changes in calcium metabolism and calcium urinary excretion during chemotherapy have not been thoroughly assessed in patients with early breast cancer (EBC), a population who frequently present vitamin D insufficiency. As hypercalciuria is a classical contra-indication to vitamin D (VD) supplementation, this study evaluated changes in VD and calcium metabolism parameters in patients with EBC undergoing adjuvant chemotherapy (CT).

Methods: In patients with EBC who received six cycles of adjuvant CT, VD and calcium parameters were monitored at inclusion, and then every 3 weeks, at each CT cycle initiation. Read More

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Outcomes With Pembrolizumab Plus Platinum-Based Chemotherapy for Patients With Non-Small-Cell Lung Cancer and Stable Brain Metastases: Pooled Analysis of KEYNOTE-021, 189, and 407.

J Thorac Oncol 2021 Jul 12. Epub 2021 Jul 12.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction: This exploratory analysis retrospectively evaluated outcomes in patients with advanced NSCLC to determine whether baseline brain metastases influenced the efficacy of first-line pembrolizumab plus chemotherapy versus chemotherapy alone.

Patients And Methods: We pooled data for patients with advanced NSCLC in KEYNOTE-021 cohort G (nonsquamous), KEYNOTE-189 (nonsquamous), and KEYNOTE-407 (squamous). Patients were assigned to platinum-doublet chemotherapy with or without the addition of 35 cycles of pembrolizumab 200 mg every 3 weeks. Read More

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Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis.

BMJ Open 2021 Jul 14;11(7):e048409. Epub 2021 Jul 14.

Division of Rheumatology, Geneva University Hospitals (HUG), Geneve, Switzerland.

Purpose: Rheumatoid arthritis (RA) is an insidious autoimmune disease, with an immunological onset years before diagnosis. Early interventions in preclinical stages could prevent or minimise the progression towards irreversible joint damage. The SCREEN-RA cohort (Evaluation of a SCREENing strategy for Rheumatoid Arthritis) aims to characterise the preclinical stages of the disease, to identify environmental risk factors, and to discover or validate novel biomarkers predictive for RA development. Read More

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The course of thyroid nodules and thyroid volume over a time-period of up to 10 years: a longitudinal analysis of a population-based cohort.

Eur J Endocrinol 2021 Jul 1. Epub 2021 Jul 1.

A Angelow , General Practice , Universitätsmedizin Greifswald Institut für Community Medicine, Greifswald, Germany.

Thyroid disorders are common. Information on long-term progression of morphologic disorders are scarce. The aim of this study was to describe the course of thyroid nodules and volume over a period of up to ten years. Read More

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Unilateral absence of pulmonary artery analysis based on echocardiographic feature.

Rev Cardiovasc Med 2021 Jun;22(2):483-488

Department of Ultrasound, Xijing hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi, China.

The unilateral absence of pulmonary artery (UAPA) is a rare congenital cardiovascular malformation, which is asymptomatic and easy to be ignored in early stage. A large number of complications may occur in the later stage. Therefore, early diagnosis and treatment is of great significance. Read More

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Coronary Artery Calcium Assessed Years Before Was Positively Associated With Subtle White Matter Injury of the Brain in Asymptomatic Middle-Aged Men: The Framingham Heart Study.

Circ Cardiovasc Imaging 2021 Jul 14;14(7):e011753. Epub 2021 Jul 14.

Department of Hygiene, Wakayama Medical University, Japan (H.S., A.F.).

Background: Using magnetic resonance diffusion tensor imaging, we previously showed a cross-sectional association between carotid-femoral pulse wave velocity, a measure of aortic stiffness, and subtle white matter injury in clinically asymptomatic middle-age adults. While coronary artery calcium (CAC) is a robust measure of atherosclerosis, and a predictor of stroke and dementia, whether it predicts diffusion tensor imaging-based subtle white matter injury in the brain remains unknown.

Methods: In FHS (Framingham Heart Study), an observational study, third-generation participants were assessed for CAC (2002-2005) and brain magnetic resonance imaging (2009-2014). Read More

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Satisfaction and usability of an ICT-based system by clinically healthy COVID-19 patients and medical professionals.

JMIR Form Res 2021 Jul 6. Epub 2021 Jul 6.

Office of Hospital Information, Seoul National University Hospital, Seoul, KR.

Background: Digital healthcare is an important strategy in the war against COVID-19. South Korea introduced a Living and Treatment Support Center (LTSC) to control regional outbreaks and care for asymptomatic or mild COVID-19 patients. Seoul National University Hospital (SNUH) introduced information and communications technology (ICT)-based solutions to manage clinically healthy COVID-19 patients. Read More

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Effectiveness of contact tracing apps for SARS-CoV-2: a rapid systematic review.

BMJ Open 2021 07 12;11(7):e050519. Epub 2021 Jul 12.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

Objective: To systematically review evidence on effectiveness of contact tracing apps (CTAs) for SARS-CoV-2 on epidemiological and clinical outcomes.

Design: Rapid systematic review.

Data Sources: EMBASE (OVID), MEDLINE (PubMed), BioRxiv and MedRxiv were searched up to 28 October 2020. Read More

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Clinically actionable findings on surveillance EGD in asymptomatic patients with Lynch syndrome.

Gastrointest Endosc 2021 Jul 9. Epub 2021 Jul 9.

Colorectal Surgery, Cleveland Clinic, Cleveland, OH; Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH; Sanford R. Weiss MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH. Electronic address:

Background And Aims: Lynch syndrome (LS) predisposes to multiple cancers including gastric and small bowel. Data supporting esophagogastroduodenoscopy (EGD) surveillance in LS are limited. Our aim is to describe upper gastrointestinal (UGI) findings in asymptomatic LS patients undergoing EGD surveillance within a hereditary colorectal cancer registry. Read More

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