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Evaluation of ozone therapy in endodontic treatment of teeth with necrotic pulp and apical periodontitis: A randomized clinical trial.

J Endod 2021 Sep 22. Epub 2021 Sep 22.

Department of Prosthodontics, Pacific Dental college and hospital, Udaipur, Rajasthan, India.

Aim: To compare the effect of different application techniques of ozone on the prevalence of post endodontic pain in patients undergoing single-visit root canal treatment.

Materials And Methods: A hundred and eight patients with necrotic pulp in single-rooted teeth and apical periodontitis participated in the trial. Standard single visit endodontics (SVE) protocol was followed with 5. Read More

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September 2021

Are adjunctive therapies effective in reducing gingivitis and plaque?

Evid Based Dent 2021 Jan;22(3):98-99

CT3 Restorative Dentistry, Glasgow Dental Hospital and School, UK.

Data sources PubMed, CENTRAL, Scopus and Cochrane electronic databases were used as the data sources for the systematic review. All randomised control trials that reviewed antiseptics published up to and including 26 February 2019 were included. A manual search of reference lists of the selected studies was conducted, including information from previous systematic reviews conducted by the same authors. Read More

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January 2021

Does an interim dressing with calcium hydroxide reduce endotoxins between endodontic appointments?

Evid Based Dent 2021 Jan;22(3):96-97

School of Dental Sciences, Newcastle University, Framlington Place, Newcastle, NE2 4BW, UK.

Data sources PubMed, Cochrane Library, LILACS/Biblioteca Brasileira de Odontologica, Web of Science, Embase, Scopus, grey literature.Study selection Randomised and non-randomised clinical studies, experimental studies. Population: human studies with permanent dentition; Intervention: evaluation of lipopolysaccharide (LPS) after dressing with calcium hydroxide (CH); Comparison: evaluation of LPS before dressing with CH; Outcome: antimicrobial efficacy against LPS. Read More

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January 2021

Short-acting β-agonist prescriptions are associated with poor clinical outcomes of asthma: the multi-country, cross-sectional SABINA III study.

Eur Respir J 2021 Sep 24. Epub 2021 Sep 24.

AstraZeneca, The Hague, The Netherlands.

Background: To gain a global perspective on short-acting β-agonist (SABA) prescriptions and associated asthma-related clinical outcomes in patients with asthma, we assessed primary health data across 24 countries in 5 continents.

Methods: SABINA III was a cross-sectional study that employed electronic case report forms at a study visit (in primary or specialist care) to record prescribed medication(s), over-the-counter (OTC) SABA purchase, and clinical outcomes in asthma patients (≥12 years old) during the past 12 months. In patients with ≥1 SABA prescription, associations of SABA with asthma symptom control and severe exacerbations were analysed using multivariable regression models. Read More

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September 2021

Symptom and clinical recovery outcomes for pediatric concussion following early physical activity.

J Neurosurg Pediatr 2021 Sep 24:1-8. Epub 2021 Sep 24.

3Sports Medicine Center, Children's Hospital Colorado, Aurora.

Objective: Recent research supports initiating physical activity as soon as 24 to 48 hours after concussion to reduce persistent postconcussive symptoms. However, this practice has not been widely adopted. The objective of this study was to evaluate the association of early physical activity with patient-reported and functional outcomes for pediatric patients following a concussion. Read More

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September 2021

Pediatric COVID-19 infection in Sulaimaniyah Governorate, Iraq.

Am J Otolaryngol 2021 Sep 3;43(1):103199. Epub 2021 Sep 3.

Doctor Jamal Ahmed Rashid Pediatric Teaching Hospital, Sulaimaniyah, Iraq.

Background: COVID-19 is a severe acute respiratory syndrome caused by SARS-CoV-2.

Objective: To study the demographic and clinical presentations of COVID-19 with their types including MIS-C and Kawasaki among children who were admitted to Doctor Jamal Ahmad Rashid Pediatric Teaching Hospital (DJARPTH) at Sulaimaniyah city, Iraq.

Patients And Methods: A prospective cohort study was conducted from June to December 2020 in which 50 cases suspected of COVID-19 were enrolled in the study that was admitted at the first visit to the emergency department of DJARPTH and their age ranged between 3 months to 14 years. Read More

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September 2021

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study.

BJOG 2021 Sep 24. Epub 2021 Sep 24.

Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, 14049-900, Brazil.

Objective: To assess the risk of spontaneous preterm birth (sPTB) associated with genital mycoplasma infection asymptomatic women.

Design: Prospective cohort.

Setting: Public and private health services in Ribeirão Preto-SP, Brazil. Read More

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September 2021

Subject satisfaction following treatment with nanofractional radiofrequency for the treatment and reduction of acne scarring and rhytids: A prospective study.

J Cosmet Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Department of Dermatology, Weill Cornell Medical College, New York, New York, USA.

Background: Skin-related changes, such as fine lines, wrinkles, and acne scarring, are a source of distress to both men and women. Nanofractional radiofrequency delivers thermal energy to skin layers leading to dermal remodeling that can address skin conditions related to aging. The objective of this study was to evaluate the subject satisfaction of nanofractional radiofrequency for the treatment of facial wrinkles and acne scarring in both lighter and darker skin tones. Read More

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September 2021

Assessed and perceived oral health of older people who visit the dental practice, an exploratory cross-sectional study.

PLoS One 2021 24;16(9):e0257561. Epub 2021 Sep 24.

Flemish-Netherlands Geriatric Oral Research Group (BENECOMO), Dutch Association for Gerodontology, Bunnik, The Netherlands.

Objectives: To assess the oral health of older people who visit the community dental practice from both the dentists' and the patients' perspective.

Materials And Methods: In this exploratory cross-sectional study the oral health of Dutch community dwelling older people was assessed. A representative sample of general dental practitioners was asked to randomly and prospectively select one older patient and describe this patient using a specially-developed registration form; in addition the patient was requested to complete a questionnaire. Read More

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September 2021

Psychiatric Comorbidity in Bariatric Surgery: A Retrospective Study in a General Hospital.

Psychiatr Danub 2021 Sep;33(Suppl 9):75-79

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132, S. Andrea delle Fratte, Perugia, Italy.

Background: Candidates for bariatric surgery undergo a multidisciplinary evaluation in the pre-operative phase, including a psychiatric visit aimed at the screening for psychiatric comorbidities, including feeding and eating disorders (FEDs), which are shortcomings to the intervention or predictors of worse prognosis. The presence of FEDs, such as Binge Eating Disorder (BED) and Bulimia Nervosa (BN), is associated with higher rates of other psychiatric disorders. Furthermore, there is evidence of the association between obesity and Depressive Disorders, as well as B and C Cluster Personality Disorders. Read More

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September 2021

Utility of a Telephone Triage Hotline in Response to the COVID-19 Pandemic.

J Med Internet Res 2021 Jun 24. Epub 2021 Jun 24.

Department of Anesthesiology, Columbia University Irving Medical Center, 622 West 168th Street, New York, US.

Background: During the initial months of the COVID-19 pandemic, rapidly rising disease prevalence in the United States created a demand for patient-facing information exchanges that addressed questions and concerns about the disease. One approach to managing increased patient volumes during a pandemic involves the implementation of telephone-based triage systems. During a pandemic, telephone triage hotlines can be employed in innovative ways to conserve medical resources and offer useful population-level data about disease symptomatology and risk factor profiles. Read More

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Randomized Prospective Trial Exploring the Impact of Structured Journaling in Patients With Sarcoma on the Management of Treatment-Related Adverse Events.

JCO Oncol Pract 2021 Sep 24:OP2100309. Epub 2021 Sep 24.

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH.

Purpose: Treatment-related adverse events associated with systemic anticancer therapy (SACT) can deter patients with sarcoma from completing treatment. With self-monitoring, patients may be better empowered to self-advocate for improved symptom management. We hypothesized that by incorporating journaling, a structured form of self-monitoring, care team communication, and symptom management would improve. Read More

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September 2021

Discordance in Patient and Physician Global Assessment in Relapsing Polychondritis.

Rheumatology (Oxford) 2021 Sep 24. Epub 2021 Sep 24.

Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, USA.

Objectives: Relapsing polychondritis (RP) is a rare, heterogeneous, systemic inflammatory disease that targets cartilage. Patient-reported outcome measures may differ from physician assessment. This study compared patient global assessment (PtGA) and physician global assessment (PhGA) scores in a prospective cohort of patients with RP. Read More

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September 2021

Pharmacopuncture and joint movement manual therapy for post-traumatic phalangeal osteoarthritis: A case report.

Medicine (Baltimore) 2021 Sep;100(38):e27081

Guideline Center for Korean Medicine, National Institute for Korean Medicine Development, Seoul, Republic of Korea.

Introduction: Post-traumatic osteoarthritis (PTOA) is a type of osteoarthritis that develops after ligament injury, meniscus injury, or fracture. Currently, there is no specific treatment approved for PTOA. This report describes the case of a 38-year-old man who suffered from PTOA of the right second distal interphalangeal (DIP) joint after practicing judo. Read More

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September 2021

Longitudinal Neurocognitive and Pulmonological Profile of Long Covid: the COVIMMUNE-Clin Study Protocol.

JMIR Res Protoc 2021 Sep 8. Epub 2021 Sep 8.

Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn Medical Center, Bonn, DE.

Background: There is a dearth of information about "brain fog", concentration, word-finding or memory problems associated with the new World Health Organization provisional classification "U09.9 Post-COVID-19 Condition." Beyond this, the extent to which these symptoms may be associated with neurological, pulmonary or psychiatric difficulties is unclear. Read More

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September 2021

Head-to-head comparison of contemporary heart failure risk scores.

Eur J Heart Fail 2021 Sep 24. Epub 2021 Sep 24.

Heart Failure Clinic and Cardiology Service, University Hospital Germans Trias i Pujol, Badalona, Spain.

Aims: Several heart failure (HF) web-based risk scores are currently used in clinical practice. Currently, we lack head-to-head comparison of the accuracy of risk scores. This study aimed to assess correlation and mortality prediction performance of Meta-Analysis Global Group in Chronic HF (MAGGIC-HF) risk score, which includes clinical variables + medications; Seattle HF Model (SHFM), which includes clinical variables + treatments + analytes; PREDICT-HF and Barcelona Bio-HF Risk Calculator (BCN-Bio-HF) which also include biomarkers, like N- terminal pro B-type natriuretic peptide (NTproBNP). Read More

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September 2021

Doppler Ultrasound to assess the pharmacodynamic effects of splanchnic vasoactive compounds.

Br J Clin Pharmacol 2021 Sep 23. Epub 2021 Sep 23.

Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium.

Aim: In search of non-invasive biomarkers to assess the pharmacodynamic effects of portal pressure-lowering drugs, the reproducibility of flow measurements in the superior mesenteric artery (SMA) was evaluated using Doppler ultrasound.

Methods: A reproducibility study was conducted in 15 healthy male volunteers (18-50 years). Per subject, eight ultrasound measurements were performed: two observers each conducted two measurements during two separate visits. Read More

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September 2021

Lung sound analysis in infants with risk factors for asthma development.

Health Sci Rep 2021 Sep 17;4(3):e379. Epub 2021 Sep 17.

Department of Pediatrics Tokai University School of Medicine Isehara Japan.

Background And Objectives: Using a lung sound analysis, the prognosis of asthma was investigated in infants with risk factors for asthma development by a long-term observation.

Methods: A total of 268 infants were included (median age: 8 months old). The lung sound parameters (the ratio of the third and fourth area to the total area under the curve [A/A and B/A], and the ratio of power and frequency at 50% and 75% of the highest frequency [RPF and RPF]) were evaluated at the first visit. Read More

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September 2021

Development and Validation of a Nomogram to Predict the 180-Day Readmission Risk for Chronic Heart Failure: A Multicenter Prospective Study.

Front Cardiovasc Med 2021 7;8:731730. Epub 2021 Sep 7.

Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College (SUMC), Cardiology, Shantou, China.

The existing prediction models lack the generalized applicability for chronic heart failure (CHF) readmission. We aimed to develop and validate a widely applicable nomogram for the prediction of 180-day readmission to the patients. We prospectively enrolled 2,980 consecutive patients with CHF from two hospitals. Read More

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September 2021

Challenging the Minimum Effective Antipsychotic Dose During Maintenance: Implications From 10-Year Follow-Up of First Episode Psychosis.

Front Psychiatry 2021 7;12:714878. Epub 2021 Sep 7.

Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.

Contradictory messages regarding the necessity of long-term antipsychotic treatment after first episode psychosis arouse deliberations in clinical practice. We explored if there is an alternative beyond the dichotomy of maintenance treatment and discontinuation of medications. We conducted a retrospective observational study by reviewing medical records at the study hospital of a cohort of patients since their participation in an early psychosis study starting from 2006, with special interests in patients able to maintain good functioning under treatment with a low antipsychotic dose. Read More

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September 2021

Preparing a financial incentive program to improve retention in HIV care and viral suppression for scale: using an implementation science framework to evaluate an mHealth system in Tanzania.

Implement Sci Commun 2021 Sep 23;2(1):109. Epub 2021 Sep 23.

School of Public Health, University of California Berkeley, Berkeley, CA, USA.

Background: Viral suppression is key to ending the HIV epidemic, yet only 58% of people living with HIV (PLHIV) in sub-Saharan Africa are suppressed. Cash transfers are an effective strategy to improve retention in care, but little is known about optimization of implementation; for example, designing effective programs that integrate into existing clinic workflows. We studied implementation of an mHealth system to deliver cash transfers to support retention. Read More

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September 2021

Age of puppies at referral to veterinary cardiology specialists for murmur investigation.

Acta Vet Scand 2021 Sep 23;63(1):37. Epub 2021 Sep 23.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM, Utrecht, the Netherlands.

Background: Cardiac auscultation is an important screening test at the first health examination of puppies because most clinically relevant congenital cardiac anomalies cause a loud murmur from birth. This retrospective study aimed to investigate the age at which dogs with suspected congenital cardiac anomalies were referred to a veterinary cardiology specialist for murmur investigation. A secondary aim was to establish the time interval between the visit to the cardiologist and the first available murmur documentation. Read More

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September 2021

Validity of the ACTS intimate partner violence screen in antenatal care: a cross sectional study.

BMC Public Health 2021 Sep 24;21(1):1733. Epub 2021 Sep 24.

School of Clinical Sciences Auckland, Auckland University of Technology, Auckland, New Zealand.

Background: Intimate partner violence (IPV) is a major public health problem with harmful consequences. In Australia, there is no national standard screening tool and screening practice is variable across states. The objectives of this study were to assess in the antenatal healthcare setting: i) the validity of a new IPV brief screening tool and ii) women's preference for screening response format, screening frequency and comfort level. Read More

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September 2021

Effectiveness of one-visit and two-visit endodontic retreatment of teeth with persistent/secondary endodontic infection: a randomized clinical trial with 18-months of follow-up.

J Endod 2021 Sep 20. Epub 2021 Sep 20.

Full Professor - Department of Operative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University (UNESP), Sao Jose dos Campos, Brazil. Electronic address:

Introduction: This randomized clinical trial aimed to compare the effectiveness of endodontic retreatment of teeth with post-treatment apical periodontitis (PTAP) performed in one-visit versus two visits on the reduction of cultivable bacteria (CFUs), lipopolysaccharides (LPS), lipoteichoic acid (LTA), and the periapical lesion volume (mm) after 18-months of follow-up.

Methods: Forty patients diagnosed with PTAP were selected and randomly divided into 2 groups: 1-visit retreatment, and 2-visit retreatment with the placement of Ca(OH) medication for 14 days. Cone-beam computed tomography (CBCT) scans were performed at two stages: preoperatively and after 18-months of follow-up. Read More

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September 2021

Phase 2 randomized study of oral ibrexafungerp vs fluconazole in vulvovaginal candidiasis.

Clin Infect Dis 2021 Sep 23. Epub 2021 Sep 23.

Wayne State University, Detroit, MI, USA.

Background: Vulvovaginal candidiasis affects approximately 75% of women in their lifetime. Approved treatment options are limited to oral or topical azoles. Ibrexafungerp, a novel, first-in-class oral triterpenoid glucan synthase inhibitor, has demonstrated broad fungicidal Candida activity and a favorable tolerability profile. Read More

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September 2021

Etiologies and 12-month mortality in patients with isolated involuntary weight loss at a rapid diagnostic unit.

PLoS One 2021 23;16(9):e0257752. Epub 2021 Sep 23.

Internal Medicine Service, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Numerous studies on involuntary weight loss (IWL) have been published since the 1980s, although most of them have included small samples of patients with specific symptoms. The aim of the present study was to determine the causes, demographic and clinical characteristics and mortality at 12 months in patients attended at a rapid diagnostic unit (RDU) for isolated IWL.

Methods: A single-center retrospective observational study including all patients presenting to the RDU for isolated IWL between 2005 and 2013. Read More

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September 2021

On Its Own Terms: An ICU Nurse Considers Human Adaptability.

Marcy Phipps

Am J Nurs 2021 Oct;121(10):58

Marcy Phipps is currently a traveling ICU nurse with Cross Country Nurses. Off the Charts is coordinated by Jacob Molyneux, senior editor:

Updated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. Best of the Blog is a regular column to draw the attention of AJN readers to posts we think deserve a wider audience. To read more, please visit: www. Read More

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October 2021

Variability in estimated glomerular filtration rate and patients' outcomes in a real-world heart failure population.

ESC Heart Fail 2021 Sep 23. Epub 2021 Sep 23.

Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Aims: The prognostic significance of renal function variability has not been fully elucidated in heart failure (HF). This multicentre, prospective cohort study aimed to evaluate the usefulness of visit-to-visit variability in estimated glomerular filtration rate (eGFR) for predicting patients' outcomes in a real-world HF population.

Methods: A total of 564 patients who had survived HF hospitalization were randomly assigned with a 2:1 ratio to derivation and validation cohorts, and they were then followed after discharge. Read More

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September 2021