301,354 results match your criteria clinical vascular


Hyperspectral imaging and indocyanine green fluorescence angiography in acute mesenteric ischemia: A case report on how to visualize intestinal perfusion.

Int J Surg Case Rep 2021 Apr 1;82:105853. Epub 2021 Apr 1.

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.

Introduction And Importance: Acute mesenteric ischemia is a challenging acute condition which is often caused by occlusion of an intestinal vessel. Therapeutic algorithms include revascularization of the occluded vessel and a surgical procedure to remove necrotic intestine. Sometimes necrotic intestine is hard to identify visually. Read More

View Article and Full-Text PDF

Necrotising fasciitis of the posterior neck crossing the midline: A case report.

Int J Surg Case Rep 2021 Apr 1;82:105851. Epub 2021 Apr 1.

Northwick Park Hospital, London Northwest University Healthcare NHS Trust, Watford Road, Harrow, HA1 3UJ, United Kingdom. Electronic address:

Introduction And Importance: Craniofacial necrotising fasciitis is a complex condition, with high mortality given its propensity to descend via the deep neck spaces into the chest and mediastinum. Management requires optimal antimicrobial therapy with associated aggressive surgical debridement.

Presentation Of Case: A 64-year-old man presented to ENT with a posterior neck swelling. Read More

View Article and Full-Text PDF

Two different patients with pulmonary pleomorphic carcinoma response to PD-1 inhibitor plus anlotinib.

Lung Cancer 2021 Mar 26;155:170-174. Epub 2021 Mar 26.

Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China; Jiangxi Key Laboratory of Clinical Translational Cancer Research, Nanchang, Jiangxi Province, China. Electronic address:

Pulmonary pleomorphic carcinoma (PPC) is a rare and highly malignant subtype of non-small-cell lung cancer (NSCLC), and chemotherapy and radiotherapy are insensitive. Some clinical trials have shown that targetable driver gene mutations, such as EGFR, ALK or BRAF, have rarely been detected in PPC patients, but the incidence of MET exon 14 mutations is more frequent. For these patients with driver gene mutations, corresponding molecular targeted therapy may be valid. Read More

View Article and Full-Text PDF

Papillary thyroid microcarcinomas that metastasize to lymph nodes.

Am J Otolaryngol 2021 Mar 31;42(5):103023. Epub 2021 Mar 31.

Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Purpose: We aimed to determine clinicopathological features that can predict lymph node metastasis (LNM) in papillary thyroid microcarcinomas (PTMC).

Methods: Medical records of 872 patients with papillary thyroid cancer >1 cm (PTC > 1 cm) and 1184 patients with papillary thyroid microcancer (PTMC) (≤1 cm) were reviewed retrospectively. Demographical, clinical and histopathological features of (PTC > 1 cm) and PTMC were compared. Read More

View Article and Full-Text PDF

IMAGING OF VASCULAR MALFORMATIONS WITH A HIGH-INTENSITY FOCUSED ULTRASOUND PROBE FOR TREATMENT PLANNING.

J Vasc Surg Venous Lymphat Disord 2021 Apr 7. Epub 2021 Apr 7.

Division of Vascular and Endovascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT; Vascular Malformations Program, Yale New Haven Hospital, New Haven, CT. Electronic address:

Objective: We aimed to investigate whether a current commercially available High-Intensity Focused Ultrasound (HIFU) probe can adequately image targeted vascular malformations in anticipation of HIFU treatment planning and delivery.

Methods: We enrolled 10 consecutive patients scheduled to undergo treatment of their symptomatic peripheral vascular malformations (VM) confirmed on routine preoperative contrast enhanced magnetic resonance imaging (MRI) and soft tissue duplex ultrasound (DUS). Lesions were situated no more than 6 cm from the skin. Read More

View Article and Full-Text PDF

Stent Graft Oversizing is Associated with an Increased Risk of Long-Term Left Ventricular Wall Thickening in Young Patients Following Thoracic Endovascular Aortic Repair.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Emory University School of Medicine, Atlanta, GA.

Introduction: Left ventricular (LV) wall thickening occurs in patients following thoracic endovascular aortic repair (TEVAR). Clinical consequences of cardiovascular (CV) remodeling may be more significant younger patients with longer anticipated life spans. Risk factors for CV remodeling following TEVAR are unknown but may be related to graft size. Read More

View Article and Full-Text PDF

Multiple spontaneous visceral arterial dissections in a patient with Tolosa-Hunt syndrome on corticosteroid therapy.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Vascular Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China. Electronic address:

Multiple spontaneous visceral arterial dissections are an infrequent occurrence. The etiology, risk factors and natural history of these dissections have not been elucidated, and the optimal therapeutic strategy has not been established. We report a rare case of multiple spontaneous visceral arterial dissections involving the celiac artery, splenic artery, superior mesenteric artery, and right renal artery in a patient with Tolosa-Hunt syndrome on short-term corticosteroid therapy. Read More

View Article and Full-Text PDF

Feasibility and Acceptability of Virtual Mock Oral Examinations for Senior Vascular Surgery Trainees and Implications for the Certifying Exam.

Ann Vasc Surg 2021 Apr 7. Epub 2021 Apr 7.

Division of Vascular and Endovascular Surgery, Saint Louis University, Saint Louis, MO. Electronic address:

Objectives: The COVID-19 pandemic resulted in the cancellation of in-person testing across the country. We sought to understand the feasibility of conducting virtual oral examinations as well as solicit opinions of vascular surgery program directors regarding the use of virtual platforms to conduct both low stakes mock oral examinations with their trainees and potentially "real" high stakes certifying examinations (CE) moving forward.

Methods: Forty-four senior vascular surgery trainees from 17 institutions took part in a virtual mock oral examination conducted by 38 practicing vascular surgeons via Zoom. Read More

View Article and Full-Text PDF

Novel transcatheter mitral prosthesis designed to preserve physiological ventricular flow dynamics.

Ann Thorac Surg 2021 Apr 7. Epub 2021 Apr 7.

Istituto Auxologico Italiano, IRCCS, Milan, Italy; Department of medicine and surgery, University of Milano-Bicocca, Milan, Italy.

Background: Current mitral bioprostheses are akin to the aortic valve and therefore abolish the left ventricular (LV) physiological vortex. We evaluated the hemodynamic performance and the effects on intraventricular flow dynamics (IFD) of a novel mitral bioprosthesis that presents an innovative design, mimicking the native valve.

Methods: A D-shaped self-expandable stent-bovine pericardium monoleaflet valve was designed to provide physiological asymmetric intraventricular flow. Read More

View Article and Full-Text PDF

Quantitating Mitral Regurgitation in Clinical Trials: The Need for a Uniform Approach.

Ann Thorac Surg 2021 Apr 7. Epub 2021 Apr 7.

Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD.

Background: There is an established relationship between the degree of mitral regurgitation (MR) and prognosis. Quantitation of MR severity guides therapeutic approaches. Inconsistent definitions and categorization of MR severity in clinical studies limit meaningful comparisons between trials and compromise development of an effective evidence base. Read More

View Article and Full-Text PDF

Long-term visual outcome in inferior posterior staphyloma and efficacy of treatment for complicated choroidal neovascularization.

Am J Ophthalmol 2021 Apr 7. Epub 2021 Apr 7.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shogoin Kawahara Cho 54, Sakyo Ku, Kyoto City, Kyoto Prefecture, Japan.

Purpose: To investigate long-term visual outcome in inferior posterior staphyloma (IPS) in each group classified based on macular complications and to examine the treatment effect for eyes with IPS with choroidal neovascularization (CNV) DESIGN: Prospective clinical cohort study PARTICIPANTS: We analyzed 56 eyes of 43 consecutive patients with IPS who were followed for 4 years.

Methods: We classified eligible eyes into three groups based on baseline findings: eyes without CNV or retinal exudate (no-exudate group), eyes without CNV and with retinal exudate (exudate group), and eyes with CNV (CNV group). We investigated the best-corrected visual acuity (BCVA) and associated parameters for 4 years. Read More

View Article and Full-Text PDF

Sleep symptomatology is associated with greater subjective cognitive concerns: Findings from the community-based Healthy Brain Project.

Sleep 2021 Apr 10. Epub 2021 Apr 10.

The Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.

Study Objectives: To examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample.

Methods: A total of 1421 middle-aged participants (mean±standard deviation = 57±7; 77% female) from the Healthy Brain Project completed the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), and Epworth Sleepiness Scale (ESS) to measure sleep quality, insomnia symptom severity, and daytime sleepiness, respectively. Participants were classified as having no sleep symptomatology (normal scores on each sleep measure), moderate sleep symptomatology (abnormal scores on one sleep measure), or high sleep symptomatology (abnormal scores on at least two sleep measures), using established cut-off values. Read More

View Article and Full-Text PDF

Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population.

Eur J Prev Cardiol 2021 Apr;28(2):152-158

Department of General and Interventional Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany.

Background: Modifiable lifestyle risk factors (modRF) of coronary artery disease (CAD) are associated with increased inflammation represented by elevated C-reactive protein (CRP) levels. Lifestyle changes may influence the inflammatory burden in patients with CAD, relevantly modifying the target population for emerging anti-inflammatory compounds.

Aims: The aims of this study were to analyse the association of modRF and CRP levels in CAD patients, and to define a potential target population for anti-inflammatory treatment with and without the optimisation of modRF. Read More

View Article and Full-Text PDF

Relationship of physical function with quality of life in older patients with acute heart failure.

J Am Geriatr Soc 2021 Apr 10. Epub 2021 Apr 10.

Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States.

Background: Older patients with acute decompensated heart failure (ADHF) have severely impaired physical function (PF) and quality of life (QOL). However, relationships between impairments in PF and QOL are unknown but are relevant to clinical practice and trial design.

Methods: We assessed 202 consecutive patients hospitalized with ADHF in the multicenter Rehabilitation Therapy in Older Acute HF Patients (REHAB-HF) Trial. Read More

View Article and Full-Text PDF

Inferior mesenteric arteriovenous fistula with colonic ischemia: a case report and review of the literature.

Clin J Gastroenterol 2021 Apr 10. Epub 2021 Apr 10.

Department of Radiology, Saint-Eloi University Hospital, 80 Av. Augustin Fliche, 34000, Montpellier, France.

Inferior mesenteric arteriovenous fistula is a rare abnormal high flow communication with only 40 primary and secondary cases reported in literature. Shunting of arterial flow through the inferior mesenteric vein to the portal system can cause a variety of nonspecific clinical signs and symptoms usually associated with the diagnosis of arteriovenous malformation. Symptom intensities are flow-dependent and can range from minimal abdominal symptoms to severe heart failure due to left to right shunt. Read More

View Article and Full-Text PDF

Schwann-like cell conditioned medium promotes angiogenesis and nerve regeneration.

Cell Tissue Bank 2021 Apr 10. Epub 2021 Apr 10.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang City, 212013, Jiangsu Province, China.

Vascular network reconstruction plays a pivotal role in the axonal regeneration and nerve function recovery after peripheral nerve injury. Increasing evidence indicates that Schwann cells (SCs) can promote nerve function repair, and the beneficial effects attributed to SCs therapy may exert their therapeutic effects through paracrine mechanisms. Recently, the previous research of our group demonstrated the promising neuroregenerative capacity of Schwann-like cells (SCLCs) derived from differentiated human embryonic stem cell-derived neural stem cells (hESC-NSCs) in vitro. Read More

View Article and Full-Text PDF

Clinical characteristics and long-term outcomes of endovascular treatment of renal artery fibromuscular dysplasia with branch lesions.

Pediatr Nephrol 2021 Apr 10. Epub 2021 Apr 10.

Department of Vascular and Endovascular Surgery, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, 7#Weiwu Road, Zhengzhou, Henan, 450003, China.

Background: Renal artery fibromuscular dysplasia (FMD) can cause arterial stenosis, dissection, and aneurysm of renal arteries. This study aimed to analyze the clinical characteristics and evaluate the long-term outcomes of renal branch artery FMD in children and adults.

Methods: Sixty-one patients with renal artery FMD underwent endovascular treatment, including 23 children and 38 adults. Read More

View Article and Full-Text PDF

FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis.

Eur J Nucl Med Mol Imaging 2021 Apr 10. Epub 2021 Apr 10.

Division of Medicine, Research Department of Imaging, University College London (UCL), London, UK.

Purpose: This study assesses the potential for vascular-metabolic imaging with FluoroDeoxyGlucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) perfusion to provide markers of prognosis specific to the site and stage of colorectal cancer.

Methods: This prospective observational study comprised of participants with suspected colorectal cancer categorized as either (a) non-metastatic colon cancer (M0colon), (b) non-metastatic rectal cancer (M0rectum), or (c) metastatic colorectal cancer (M+). Combined FDG-PET/CT perfusion imaging was successfully performed in 286 participants (184 males, 102 females, age: 69. Read More

View Article and Full-Text PDF

Functional and Molecular Adaptations of Quadriceps and Hamstring Muscles to Blood Flow Restricted Training in Patients with ACL Rupture.

Scand J Med Sci Sports 2021 Apr 10. Epub 2021 Apr 10.

Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia, EU.

Effects of low-load blood flow restricted (LL-BFR) training remain unexplored in patients with ACL rupture. Our hypothesis was that LL-BFR training triggers augmented gains in knee muscle strength and size, which are paralleled with transcriptional responses of hypoxia-regulated genes and myokines. Eighteen volunteers (age 37. Read More

View Article and Full-Text PDF

Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study.

Europace 2021 Apr 9. Epub 2021 Apr 9.

Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

Aims: Balloon-based technologies have been developed to simplify catheter ablation of atrial fibrillation (AF), to improve the clinical outcome of the procedure and to achieve durable pulmonary vein isolation (PVI). The objective of this study is to evaluate the safety and efficacy of second-generation laser balloon (LB2) ablation in the treatment of AF using a continuous cardiac rhythm monitoring strategy. Atrial tachyarrhythmias (ATas) recurrences were assessed with implantable cardiac monitors (ICMs) or devices. Read More

View Article and Full-Text PDF

Endovascular repair and open repair surgery of thoraco-abdominal aortic aneurysms cause drastically different types of spinal cord injury.

Sci Rep 2021 Apr 9;11(1):7834. Epub 2021 Apr 9.

Department of Surgery, Division of Vascular and Endovascular Surgery, Eastern Virginia Medical School, 600 Gresham Dr, Norfolk, VA, 23507, USA.

Both endovascular repair (EVR) and open repair (OR) surgery of thoraco-abdominal aortic aneurysms cause spinal cord (SC) injury that can lead to paraparesis or paraplegia. It has been assumed that mechanisms responsible for SC damage after EVR are similar to those after OR. This pilot study compared the pathophysiology of SC injury after EVR versus OR using a newly developed EVR dog model. Read More

View Article and Full-Text PDF

In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.

Neurology 2021 Apr 9. Epub 2021 Apr 9.

Vincenzo Donadio, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Zerui Wang, Departments of Pathology and Neurology, Case Western Reserve University School of Medicine (USA); Alex Incensi, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Giovanni Rizzo, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Enrico Fileccia, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Veria Vacchiano, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Sabina Capellari, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Martina Magnani, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Cesa Scaglione, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Michelangelo Stanzani Maserati, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Patrizia Avoni, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Rocco Liguori, IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy); Wenquan Zou, Departments of Pathology and Neurology, Case Western Reserve University School of Medicine (USA).

Objective: To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in distinguish synucleinopathies (SOPs) from non-synucleinopathies (non-SOPs) in a large cohort of patients.

Methods: We prospectively recruited 90 patients fulfilling clinical and instrumental diagnostic criteria for all SOPs variants and non-SOPs (mainly including Alzheimer disease, tauopathies, and vascular parkinsonism or dementia). Twenty-four patients with mainly peripheral neuropathies were used as controls. Read More

View Article and Full-Text PDF

Systemic conbercept pharmacokinetics and VEGF pharmacodynamics following intravitreal injections of conbercept in patients with retinopathy of prematurity.

Br J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

Department of Ophthalmology, Peking University People's Hospital, Eye diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Clinical Centre of Optometry, College of Optometry, Peking University Health science center, Beijing, China

Background: Data on serum vascular endothelial growth factor (VEGF) and drug levels in patients with retinopathy of prematurity (ROP) following intravitreal injections of conbercept (IVC) are lacking.

Methods: Multicentre, prospective, non-randomised study of patients with aggressive posterior retinopathy of prematurity (APROP) or type 1 ROP who had not received other treatment. All infants received therapy in both eyes plus intravitreal IVC 0. Read More

View Article and Full-Text PDF

Metformin to Limit Abdominal Aortic Aneurysm Expansion: Time for Clinical Trials.

Eur J Vasc Endovasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Université Côte d'Azur, CHU, Inserm U1065, C3M, Nice, France; Clinical Chemistry Laboratory, University Hospital of Nice, France.

View Article and Full-Text PDF

Exploring patient experiences in the student outpatient clinic - A contribution to learning.

Patient Educ Couns 2021 Mar 24. Epub 2021 Mar 24.

Centre for Educational Development, Aarhus University, Health, Aarhus, Denmark.

Objective: To understand how patients experience participation in student encounters.

Methods: Qualitative semi-structured telephone interviews with ten cardiac surgery patients who had attended voluntary postoperative consultations in a student outpatient clinic. The interview guide included questions about reasons for and experiences of being part of a teaching situation. Read More

View Article and Full-Text PDF

Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography.

BMC Ophthalmol 2021 Apr 9;21(1):170. Epub 2021 Apr 9.

Department of Ophthalmology, Shanghai Tenth People's Hospital affiliated with Tongji University, 301 Middle Yan Chang Road, Shanghai, 200072, People's Republic of China.

Background: Retinal capillary is vulnerable to diabetes, whether gestational diabetes mellitus (GDM) eyes without clinical retinopathy have capillary abnormalities has not been well studied. To observe the microvasculature changes in eyes of GDM women compared with normoglycemic pregnant women and non-pregnant women by optical coherence tomography-angiography (OCT-A).

Methods: GDM women, age-matched normoglycemic pregnant women and non-pregnant women were included in this study. Read More

View Article and Full-Text PDF

The CErebro Placental RAtio as indicator for delivery following perception of reduced fetal movements, protocol for an international cluster randomised clinical trial; the CEPRA study.

BMC Pregnancy Childbirth 2021 Apr 9;21(1):285. Epub 2021 Apr 9.

Department of Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Routine assessment in (near) term pregnancy is often inaccurate for the identification of fetuses who are mild to moderately compromised due to placental insufficiency and are at risk of adverse outcomes, especially when fetal size is seemingly within normal range for gestational age. Although biometric measurements and cardiotocography are frequently used, it is known that these techniques have low sensitivity and specificity. In clinical practice this diagnostic uncertainty results in considerable 'over treatment' of women with healthy fetuses whilst truly compromised fetuses remain unidentified. Read More

View Article and Full-Text PDF

Lidocaine coinfusion alleviates vascular pain induced by hypertonic saline infusion: a randomized, placebo-controlled trial.

BMC Anesthesiol 2021 Apr 10;21(1):109. Epub 2021 Apr 10.

Department of Orthodontics, The Affiliated Stomatological Hospital of Nanchang University, No.49 Fuzhou Road, Nanchang, Jiangxi, 330008, People's Republic of China.

Background: Hypertonic saline solution has been frequently utilized in clinical practice. However, due to the nonphysiological osmolality, hypertonic saline infusion usually induces local vascular pain. We conducted this study to evaluate the effect of lidocaine coinfusion for alleviating vascular pain induced by hypertonic saline. Read More

View Article and Full-Text PDF

Combination Therapy in Pulmonary Arterial Hypertension-Targeting the Nitric Oxide and Prostacyclin Pathways.

J Cardiovasc Pharmacol Ther 2021 Apr 9:10742484211006531. Epub 2021 Apr 9.

Division of Cardiology, 12241Mercer University School of Medicine, Macon, GA, USA.

Pulmonary arterial hypertension (PAH) is a chronic and progressive disorder characterized by vascular remodeling of the small pulmonary arteries, resulting in elevated pulmonary vascular resistance and ultimately, right ventricular failure. Expanded understanding of PAH pathophysiology as it pertains to the nitric oxide (NO), prostacyclin (prostaglandin I) (PGI) and endothelin-1 pathways has led to recent advancements in targeted drug development and substantial improvements in morbidity and mortality. There are currently several classes of drugs available to target these pathways including phosphodiesterase-5 inhibitors (PDE5i), soluble guanylate cyclase (sGC) stimulators, prostacyclin class agents and endothelin receptor antagonists (ERAs). Read More

View Article and Full-Text PDF

Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, 564-8565 Suita, Japan;

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by arteriopathy in the small to medium-sized distal pulmonary arteries, often accompanied by infiltration of inflammatory cells. Aryl hydrocarbon receptor (AHR), a nuclear receptor/transcription factor, detoxifies xenobiotics and regulates the differentiation and function of various immune cells. However, the role of AHR in the pathogenesis of PAH is largely unknown. Read More

View Article and Full-Text PDF