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Fetoscopic laser ablation therapy in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome treated at a single centre over 10 years: a retrospective study.

J Perinat Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Obstetrics and Gynecology, Spedali Civili, Brescia, Italy.

Objectives: To review experience with fetoscopic laser ablation of placental anastomoses to treat monochorionic diamniotic (MCDA) twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) in a single centre over a ten-year period.

Methods: A retrospective study on 142 MCDA twin pregnancies complicates by TTTS treated with equatorial laser ablation of placental anastomoses (2008-2018). Solomon technique was also applied after 2013. Read More

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September 2021

Demographic characteristics, treatment, and outcome of patients with Kaposi sarcoma: Ten-year follow-up results of a single center.

J Cosmet Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Department of Dermatology and Venereology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Background: Clinical features, types of Kaposi sarcoma, and treatment outcomes have not been well-defined in Turkey. In this study, we reviewed records of the patients who had been diagnosed with Kaposi sarcoma in the last decade in a single center and evaluated treatment results.

Methods: Medical records of the Kaposi sarcoma patients seen in the last decade in a single tertiary center were evaluated in detail. Read More

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September 2021

Clinical analysis of uterine intravenous leiomyomatosis: A retrospective study of 260 cases.

J Obstet Gynaecol Res 2021 Sep 15. Epub 2021 Sep 15.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Methods: We collected the clinical data of 260 patients admitted to the hospital from April 2003 to September 2019 with pathologically confirmed intravenous leiomyomatosis (IVL) and followed up with these patients regularly. Univariate and multivariate logistic regression analyses were carried out on the relevant recurrence factors.

Results: A total of 166 patients were regularly followed up, the median follow-up time was 36 (range 2-168) months, 14 (5. Read More

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September 2021

[Automatic detection of epileptiform potentials and seizures in the EEG].

Fortschr Neurol Psychiatr 2021 Sep 15;89(9):445-458. Epub 2021 Sep 15.

Automatic computer-based algorithms for the detection of epileptiform potentials and seizure patterns on EEG facilitate a time-saving, objective method of quantitative EEG interpretation which is available 7/24. For the automatic detection of interictal epileptiform potentials sensitivities range from 65 to 99% with false positive detections of 0,09 to 13,4 per minute. Recent studies documented equal or even better performance of automatic spike detection programs compared with experienced human EEG readers. Read More

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September 2021

The Orthopaedic Match: Defining the Academic Profile of Successful Candidates.

J Am Acad Orthop Surg 2020 Nov 18. Epub 2020 Nov 18.

From the Division of Plastic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD (Ngaage, Xue, Benzel, Rawes, Rasko), the Medical College of Georgia, Augusta, GA (Xue), the Department of Orthopaedic Surgery, Howard University, Washington, DC (Andrews, Wilson), the Yorkshire and Humber Foundation School, Leeds, UK (Rawes), and the Department of Orthopaedic Surgery, University of Maryland School of Medicine, Baltimore, MD (Ludwig).

Background: Research productivity forms a vital part of the resident selection process and can markedly affect the chance of a successful match. Current reports regarding the publication record among prospective orthopaedic surgery residents are likely inaccurate. Potential applicants have a poor understanding of the strength of their research credentials in comparison to other candidates. Read More

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November 2020

Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

Respiration 2021 Sep 15:1-11. Epub 2021 Sep 15.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.

Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Read More

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September 2021

Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland.

Dermatology 2021 Sep 15:1-8. Epub 2021 Sep 15.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Primary localized cutaneous amyloidosis (PLCA) is defined by the deposition of amyloid protein in the skin without systemic involvement. There are four subtypes of PLCA: lichen amyloidosis (LA), macular amyloidosis (MA), biphasic amyloidosis (BA), and nodular amyloidosis (NA). PLCA occurs most frequently in Latin Americans and Asians. Read More

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September 2021

A highly transparent tri-polymer complexhydrogel of HA, Collagen and 4-arm-PEG as potential vitreous substitute.

Biomed Mater 2021 Sep 15. Epub 2021 Sep 15.

Polymer and Process Engineering , Indian Institute of Technology Roorkee, Saharanpur campus, Roorkee, 247667, INDIA.

There is a requirement of removal and replacement of vitreous for various ophthalmic diseases, e.g., retinopathy and retinal detachment. Read More

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September 2021

Potential risks of cardiovascular and cerebrovascular disease and cancer from cumulative doses received from diagnostic CT scans.

J Radiol Prot 2021 Sep 15. Epub 2021 Sep 15.

Department of Radiation Physics, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Potential risks from radiation exposure on the development of cardiovascular and cerebrovascular disease are indicated by epidemiological studies. Medical exposures give the largest dose to the population from artificial sources, with cumulative doses from multiple CT scans being significant. Data on doses from scans performed on 12 CT scanners in three hospitals over a period of 5½ y, derived using RadimetricsTM software, have been reviewed for 105,757 patients. Read More

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September 2021

Medical management of heavily exposed victims: An experience at the Tokaimura criticality accident.

J Radiol Prot 2021 Sep 15. Epub 2021 Sep 15.

Harada Hospital, Irima, Saitama, JAPAN.

A criticality accident occurred at the uranium conversion plant in Tokaimura, Ibaraki Prefecture, Japan on September 30, 1999. When uranyl nitrate was overloaded to a critical mass level, uncontrolled fission reaction occurred. A procedure was carried out according to the JCO manual, although not an officially approved manual. Read More

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September 2021

Utility of a Postural Stability/Perceptual Inhibition Dual Task for Identifying Concussion in Adolescents.

J Sport Rehabil 2021 Sep 15:1-6. Epub 2021 Sep 15.

Context: Research in the area of dual-task paradigms to assess sport-related concussion (SRC) status is growing, but additional assessment of this paradigm in adolescents is warranted.

Design: This case-control study compared 49 adolescent athletes aged 12-20 years with diagnosed SRC to 49 age- and sex-matched controls on visual-spatial discrimination and perceptual inhibition (PIT) reaction time tasks performed while balancing on floor/foam pad conditions.

Methods: The SRC group completed measures at a single time point between 1 and 10 days postinjury. Read More

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September 2021

Psychological Interventions Can Reduce Injury Risk in Athletes: A Critically Appraised Topic.

J Sport Rehabil 2021 Sep 15:1-6. Epub 2021 Sep 15.

Clinical Scenario: Injury prevention programs are becoming standard practice for reducing sports-related injuries, but most programs focus on musculoskeletal elements. Psychological factors can be strong predictors of sports-related injuries and there is recent evidence that suggests psychological interventions can be effective at reducing injury risk. It is unclear if injury prevention programs that focus on psychological factors are an important inclusion for athletic trainers/therapists. Read More

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September 2021

Neonatal respiratory distress due to a third or fourth branchial pouch sinus: A systematic review.

Int J Pediatr Otorhinolaryngol 2021 Sep 9;151:110922. Epub 2021 Sep 9.

Department of Otorhinolaryngology, Amsterdam UMC Location AMC, University of Amsterdam, Amsterdam, the Netherlands.

Objectives: Third and fourth branchial pouch sinuses can be rare causes of respiratory distress in neonates. An overview of this distinct clinical entity is missing in literature. To aid clinicians in recognizing and adequately treating this unique entity, we conducted a systematic review to discuss patient characteristics, diagnostic considerations and treatment strategy. Read More

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September 2021

Predicting length of stay and mortality among hospitalized patients with type 2 diabetes mellitus and hypertension.

Int J Med Inform 2021 Sep 4;154:104569. Epub 2021 Sep 4.

International Center for Health Information Technology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Electronic address:

Background: Type 2 diabetes mellitus (T2DM) and hypertension (HTN), both non-communicable diseases, are leading causes of death globally, with more imbalances in lower middle-income countries. Furthermore, poor treatment and management are known to lead to intensified healthcare utilization and increased medical care costs and impose a significant societal burden, in these countries, including Indonesia. Predicting future clinical outcomes can determine the line of treatment and value of healthcare costs, while ensuring effective patient care. Read More

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September 2021

Multivariate pattern analysis links drug use severity to distributed cortical hypoactivity during emotional inhibitory control in opioid use disorder.

Neuroimage Clin 2021 Aug 29;32:102806. Epub 2021 Aug 29.

Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market St Ste 500, Philadelphia, PA 19104, USA.

Opioid use disorder (OUD) is characterized by emotional and cognitive impairements that are associated with poor treatment outcomes. The present study investigated the neural mechanism underlying emotion evaluation and inhibitory control using an affective go/no-go (AGN) task and its association with drug use severity and craving in patients with OUD. Twenty-six recently detoxified patients with OUD underwent functional magnetic resonance imaging (fMRI) while performing the AGN task that required response to frequently presented appetitive stimuli ("go") and inhibition of response to infrequently presented aversive stimuli ("no-go"). Read More

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Seizure-induced reversible MRI abnormalities in status epilepticus: A systematic review.

Seizure 2021 Sep 7;92:166-173. Epub 2021 Sep 7.

School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Neurology, Monash Medical Centre, Clayton, Melbourne, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

In the context of status epilepticus (SE), seizure-induced reversible MRI abnormalities (SRMA) can be difficult to differentiate from epileptogenic pathologies. To identify patterns and characteristics of SRMA, we conducted a systematic review in accordance with the Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included publications describing patients (a) presenting with status epilepticus, (b) exhibiting seizure-induced MRI abnormalities, (c) who demonstrated complete resolution of MRI abnormality at follow-up, and (d) who had availability of descriptive MRI results. Read More

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September 2021

No association between children's febrile seizures and S100B protein levels: A meta-analysis.

Seizure 2021 Aug 31;92:158-165. Epub 2021 Aug 31.

The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address:

Background: In recent years, studies have examined the relationship between febrile seizures in children and S100B protein with contradictory results. We systematically evaluated the relationship between children's febrile seizures and S100B protein levels.

Methods: We used Stata 11. Read More

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Adoptive T-cell immunotherapy in digestive tract malignancies: Current challenges and future perspectives.

Cancer Treat Rev 2021 Sep 4;100:102288. Epub 2021 Sep 4.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70124 Bari, Italy.

Multiple systemic treatments are currently available for advanced cancers of the digestive tract, but none of them is curative. Adoptive T-cell immunotherapy refers to the extraction, modification and re-infusion of autologous or allogenic T lymphocytes for therapeutic purposes. A number of clinical trials have investigated either non-engineered T cells (i. Read More

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September 2021

Time to care - An ethnographic study of how temporal structuring affects caring relationships in clinical nursing.

Soc Sci Med 2021 Aug 27;287:114349. Epub 2021 Aug 27.

Centre for the Study of Professions, OsloMet - Oslo Metropolitan University, P.O. Box 4, St. Olavs Plass, N-0130, Oslo, Norway; Faculty of Health and Welfare Sciences, Østfold University College, P.O. Box 700, NO-1757, Halden, Norway. Electronic address:

This article explores how temporal structuring of clinical activities affects nurses' establishment of caring relationships with patients, based on an ethnographic study in a Norwegian cancer ward in January-June 2017. By drawing on practice-based perspectives on time and care, the article shows how 'medical time', 'patient time' and 'hospital time' represent three distinct but interconnected clinical rhythms affecting caring relationships. In this way, the article provides insights into how caring relationships are established in nurses' intermediate role as temporal agents, accommodation various temporal structures associated with the biomedical and person-centred care models. Read More

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Applying interpretable deep learning models to identify chronic cough patients using EHR data.

Comput Methods Programs Biomed 2021 Sep 4;210:106395. Epub 2021 Sep 4.

Indiana University School of Medicine, 340W 10th St #6200, Indianapolis, IN 46202, United States; Regenstrief Institute, 1101W 10th Street, Indianapolis, IN, 46202, United States. Electronic address:

Background And Objective: Chronic cough (CC) affects approximately 10% of adults. Many disease states are associated with chronic cough, such as asthma, upper airway cough syndrome, bronchitis, and gastroesophageal reflux disease. The lack of an ICD code specific for chronic cough makes it challenging to identify such patients from electronic health records (EHRs). Read More

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September 2021

A deep learning approach for synthetic MRI based on two routine sequences and training with synthetic data.

Comput Methods Programs Biomed 2021 Aug 31;210:106371. Epub 2021 Aug 31.

Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain.

Background And Objective: Synthetic magnetic resonance imaging (MRI) is a low cost procedure that serves as a bridge between qualitative and quantitative MRI. However, the proposed methods require very specific sequences or private protocols which have scarcely found integration in clinical scanners. We propose a learning-based approach to compute T1, T2, and PD parametric maps from only a pair of T1- and T2-weighted images customarily acquired in the clinical routine. Read More

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Reporting Transparency and Completeness in Trials: Paper 4 - Reporting of randomised controlled trials conducted using routinely collected electronic records - room for improvement.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Nottingham Clinical Trials Unit, University of Nottingham, Building 42, University Park, Nottingham, United Kingdom. Electronic address:

Objective: To describe characteristics of randomised controlled trials (RCTs) conducted using electronic health records (EHRs), including completeness and transparency of reporting assessed against the 2021 CONSORT Extension for RCTs Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE) criteria.

Study Design: MEDLINE and Cochrane Methodology Register were searched for a sample of RCTs published from 2011-2018. Completeness of reporting was assessed in a random sample using a pre-defined coding form. Read More

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September 2021

Reporting Transparency and Completeness in Trials: Paper 2 - Reporting of randomised trials using registries was often inadequate and hindered the interpretation of results.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland; Meta-Research Innovation Center Berlin (METRIC-B), Berlin Institute of Health, Berlin, Germany; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, USA.

Objective: Registries are important data sources for randomised controlled trials (RCTs), but reporting of how they are used may be inadequate. The objective was to describe the current adequacy of reporting of RCTs using registries.

Study Design And Setting: We used a database of trials using registries from a scoping review supporting the development of the 2021 CONSORT extension for Trials Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE). Read More

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September 2021

Reporting Transparency and Completeness in Trials: Paper 1: Introduction - Better reporting for disruptive clinical trials using routinely collected data.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Departments of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Psychology, McGill University, Montreal, Quebec, Canada; Department of Educational and Counselling Psychology, McGill University, Montreal, Quebec, Canada; Biomedical Ethics Unit, McGill University, Montreal, Quebec, Canada.

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September 2021

Methodological challenges for living systematic reviews conducted during the COVID-19 pandemic: a concept paper.

J Clin Epidemiol 2021 Sep 12. Epub 2021 Sep 12.

Evidence-based Oncology, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.

Background: A living systematic review (LSR) is an emerging review type that makes use of continual updating. In the COVID-19 pandemic, we were confronted with a shifting epidemiological landscape, clinical uncertainties and evolving evidence. These unexpected challenges compelled us to amend standard LSR methodology. Read More

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September 2021