267,349 results match your criteria clinical progression


Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36.

FEBS Lett 2021 Sep 18. Epub 2021 Sep 18.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.

Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high-fat diet, with and without fructose, significantly upregulated SOX2 in murine liver tissue. Read More

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September 2021

Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy.

Eur J Cancer 2021 Sep 15;157:214-224. Epub 2021 Sep 15.

Melanoma Institute Australia, The University of Sydney, Sydney, New South Wales, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Medical Oncology, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia. Electronic address:

Background: Immune checkpoint inhibitors (ICIs) have activity across many tumor types, but activation of the immune system may also lead to significant, often steroid-refractory immune-related adverse events (irAEs). We sought to determine the activity of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in treatment or prevention of auto-immune irAE in ICI-treated patients.

Methods: Institutional databases from 2 melanoma centers were reviewed for patients treated with ICIs and tocilizumab. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Racial and ethnic disparities in treatment response and tolerability in multiple sclerosis: A comparative study.

Mult Scler Relat Disord 2021 Sep 9;56:103248. Epub 2021 Sep 9.

Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Inter-individual response and tolerability profiles associated with available disease-modifying treatments (DMTs) are an important aspect of the therapeutic decision-making process in multiple sclerosis (MS). In the absence of racially diverse clinical studies, the possible effect of race and ethnicity on treatment outcome remains uncertain. This study aims to compare disease outcome among Hispanic, Black, and White patients with MS, and assess the impact of race/ethnicity on long-term outcome. Read More

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September 2021

Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma.

Biomed Pharmacother 2021 Sep 15;143:112168. Epub 2021 Sep 15.

Department of Histology and Embryology, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.

We investigated the anticancer effect of disulfiram and metformin combination on fibrosarcoma in hamsters. Hamsters of both sexes (~ 70 g) were randomly allocated to control and experimental groups (8 animals per group). In all 10 groups, 2 × 10 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' backs. Read More

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September 2021

Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids.

Biomed Pharmacother 2021 Sep 15;143:112142. Epub 2021 Sep 15.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar; Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar; Department of Dermatology and Venereology, Rumailah Hospital, Hamad Medical Corporation, Doha 3050, Qatar; Laboratory Animal Research Center, Qatar University, Doha 2713, Qatar. Electronic address:

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells. Moreover, cancer cells maintain a delicate balance between ROS and antioxidants to promote pathogenesis and clinical challenges via targeting a battery of signaling pathways converging to cancer hallmarks. Read More

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September 2021

Identification of a novel immune-related prognostic signature associated with tumor microenvironment for breast cancer.

Int Immunopharmacol 2021 Sep 15;100:108122. Epub 2021 Sep 15.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

Background: In the view that immune-related genes play a crucial role in breast cancer progression and long-term patient outcomes, we aimed to identify a novel gene signature based on immune-related genes to improve the prognostic prediction of breast cancer.

Methods: RNA sequencing data and clinical information were obtained from The Cancer Genome Atlas (TCGA). Univariate and multivariate Cox regression analyses were conducted to establish the immune-related prognostic signature (IRPS). Read More

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September 2021

A prospective, phase II trial of monotherapy with low-dose afatinib for patients with EGFR, mutation-positive, non-small cell lung cancer: Thoracic oncology research group 1632.

Lung Cancer 2021 Aug 31;161:49-54. Epub 2021 Aug 31.

Department of Pulmonary Medicine and Oncology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan. Electronic address:

Objectives: Afatinib is an effective treatment for patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). However, the toxicity associated with this agent often leads to dose modifications. The aim of this study was to assess the efficacy, safety and plasma concentrations of low dose afatinib monotherapy in patients with EGFR mutation-positive NSCLC. Read More

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Surgical treatment of terrible triad of the elbow: retrospective continuous 50-patient series at 2 years' follow-up.

Orthop Traumatol Surg Res 2021 Sep 15:103057. Epub 2021 Sep 15.

Service Orthopédie et Traumatologie, CHU Grenoble Alpes, Boulevard de la Chantourne, 38700 La Tronche, France.

Introduction: Terrible triad (TT) of the elbow is an association at high risk of instability. Treatment aims to restore joint stability. Lateral collateral ligament (LCL) repair is systematic, whereas medial collateral ligament (MCL) repair is only exceptionally necessary. Read More

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September 2021

Blood cell respiration rates and mtDNA copy number: a promising tool for the diagnosis of mitochondrial disease.

Mitochondrion 2021 Sep 15. Epub 2021 Sep 15.

Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Uruguay. Electronic address:

Human mitochondrial diseases are a group of heterogeneous diseases caused by defects in oxidative phosphorylation, due to mutations in mitochondrial (mtDNA) or nuclear DNA. The diagnosis of mitochondrial disease is challenging since mutations in multiple genes can affect mitochondrial function, there is considerable clinical variability and a poor correlation between genotype and phenotype. Herein we assessed mitochondrial function in peripheral blood mononuclear cells (PBMCs) and platelets from volunteers without known metabolic pathology and patients with mitochondrial disease. Read More

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September 2021

NLRP3 inflammasome and IL-1β pathway in type 2 diabetes and atherosclerosis: friend or foe?

Pharmacol Res 2021 Sep 15:105885. Epub 2021 Sep 15.

Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), Guangdong Pharmaceutical University, Guangzhou, China; Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangzhou, China. Electronic address:

Type 2 diabetes and atherosclerosis have gradually garnered great attention as inflammatory diseases. Previously, the fact that Interleukin-1β (IL-1β) accelerates the development of type 2 diabetes and atherosclerosis has been proved in animal experiments and clinical trials. However, the continued studies found that the effect of IL-1β on type 2 diabetes and atherosclerosis is much more complicated than the negative impact. Read More

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September 2021

A review of Liquid biopsy as a tool to assess Epigenetic, cfDNA and miRNA variability as Methotrexate response predictors in patients with Rheumatoid Arthritis.

Pharmacol Res 2021 Sep 15:105887. Epub 2021 Sep 15.

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease affecting 0.5-1% of adults worldwide. Achieving long term remission or low disease activity is possible through early diagnosis, rapid initiation of disease modifying anti-rheumatic drugs (DMARDs) and implementation of a treat to target approach. Read More

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September 2021

GPX1-associated prognostic signature predicts poor survival in patients with acute myeloid leukemia and involves in immunosuppression.

Biochim Biophys Acta Mol Basis Dis 2021 Sep 15:166268. Epub 2021 Sep 15.

Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, School of Basic Medical Science, Guizhou Medical University, Guiyang 550004, Guizhou, China. Electronic address:

Objective: Treatment of acute myeloid leukemia (AML) remains a challenge. It is urgent to understand the microenvironment to improve therapy and prognosis.

Methods: Bioinformatics methods were used to analyze transcription expression profile of AML patient samples with complete clinical information from UCSC Xena TCGA-AML datasets and validate with GEO datasets. Read More

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September 2021

OA Foundations - Experimental models of Osteoarthritis.

Osteoarthritis Cartilage 2021 Sep 15. Epub 2021 Sep 15.

Raymond Purves Bone and Joint Research Laboratory. Electronic address:

Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with variable clinical presentation, progression, and response to therapeutic intervention. This same diversity is readily apparent in the many animal models of OA. However, model selection, study design, and interpretation of resultant findings, are not routinely done in the context of the target human (or veterinary) patient OA sub-population or phenotype. Read More

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September 2021

LncRNA SOCS2-AS1 promotes the progression of glioma via regulating ITGB1 expression.

Neurosci Lett 2021 Sep 15:136248. Epub 2021 Sep 15.

Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China.

Background: Accumulating evidence has underscored the important role of long non-coding RNAs (lncRNAs) in the development and progression of glioma. However, the role of lncRNA SOCS2-AS1 in glioma is largely unknown.

Methods: lncRNA SOCS2-AS1 silencing was achieved by specific siRNAs. Read More

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September 2021

Positive Allosteric Modulation of Adenosine A Receptor Alters Immune Cell Responses and Ameliorates Psoriasis-Like Dermatitis in Mice.

J Invest Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Molecular Medicine Research Institute, 428 Oakmead Parkway, Sunnyvale, CA 94085 USA.

Psoriasis is an immune cell-mediated inflammatory disease of the skin with a mixed Th1/Th17 cytokine environment combined with an innate immune response engaging toll-like receptors (TLRs). Inflammatory diseases are characterized by dysregulated immune cell responses and elevated levels of adenosine at disease sites. Adenosine, acting through the AR, regulates inflammation, immune response, T cell homeostasis and tissue repair. Read More

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September 2021

Juvenile-onset Open-angle Glaucoma - A Clinical and Genetic Update.

Surv Ophthalmol 2021 Sep 15. Epub 2021 Sep 15.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying among different populations. Myocilin mutations are the most commonly associated. Read More

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September 2021

Parkinson's disease outside the brain: targeting the autonomic nervous system.

Lancet Neurol 2021 Oct;20(10):868-876

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Patients with Parkinson's disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even precede motor deficits. This dysregulation might reflect early pathology and therefore could be targeted for the development of prodromal or diagnostic biomarkers. Only a few objective clinical tests assess disease progression and are used to evaluate the entire spectrum of autonomic dysregulation in patients with Parkinson's disease. Read More

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October 2021

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet Neurol 2021 Oct;20(10):821-831

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, and Department of Neurology, King's College Hospital, King's College London, London, UK.

Background: There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile function of the human diaphragm. We aimed to evaluate the safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis, with a focus on respiratory function. Read More

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October 2021

Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma: a randomised phase 2 trial by the Nordic Myeloma Study Group.

Eur J Haematol 2021 Sep 18. Epub 2021 Sep 18.

Oslo Myeloma Center, Oslo University Hospital, Oslo, Norway.

Objective: We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and dexamethasone after salvage ASCT in multiple myeloma.

Methods: This randomised, open-label, phase 2 trial included patients with first relapse of multiple myeloma after upfront ASCT who were re-induced with four cycles of carfilzomib, cyclophosphamide and dexamethasone. Two months after salvage ASCT patients were randomised to either observation or maintenance therapy with iv carfilzomib 27 → 56 mg/sqm and p. Read More

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September 2021

A qPCR-based method for molecular subtype classification of urinary bladder cancer - stromal gene expressions show higher prognostic values than intrinsic tumor genes.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Department of Urology, University of Duisburg-Essen, Essen, Germany.

Transcriptome-based molecular subtypes of muscle-invasive bladder cancer (MIBC) have been shown to be both prognostic and predictive, but are not used in routine clinical practice. We aimed to develop a feasible, RT-qPCR-based method for molecular subtyping. First, we defined a 68-gene set covering tumor intrinsic (luminal, basal, squamous, neuronal, epithelial-to-mesenchymal, in situ carcinoma) and stromal (immune, extracellular matrix, p53-like) signatures. Read More

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September 2021

Wnt Pathway Modulators in Cancer Therapeutics- An Update on Completed and Ongoing Clinical Trials.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Health Sciences University, Clovis, California.

Wnt signaling plays an essential role in the initiation and progression of various types of cancer. Besides, the Wnt pathway components have been established as reliable biomarkers and potential targets for cancer therapy. Wnt signaling is categorized into canonical and non-canonical pathways. Read More

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September 2021

Retinoids are not linked to risk of Multiple Sclerosis: a Danish nationwide cohort study.

Eur J Neurol 2021 Sep 18. Epub 2021 Sep 18.

Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Background: Multiple Sclerosis (MS) is a chronic immune-mediated disease of the Central Nervous System with an undetermined etiology. Retinoids may have immunomodulatory effects that favorably influence MS progression. No observational studies have explored the relationship between exposure to retinoids and risk of acquiring MS. Read More

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September 2021

A comprehensive prognostic analysis of osimertinib treatment in advanced non-small cell lung cancer patients with acquired EGFR-T790M mutation: a real-world study.

J Cancer Res Clin Oncol 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Purpose: Osimertinib is the standard treatment for advanced non-small cell lung cancer (NSCLC) patients with T790M mutation after the failure of first-/second-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). We comprehensively analyzed factors that affect the therapeutic efficacy of the osimertinib treatment in NSCLC patients.

Methods: 351 NSCLC patients with T790M mutation receiving osimertinib treatment were included. Read More

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September 2021

The impact of CD4CD28 T lymphocytes on atrial fibrillation: a potential pathophysiological pathway.

Inflamm Res 2021 Sep 18. Epub 2021 Sep 18.

Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Introduction: Atrial fibrillation (AF) represents the most common cardiac arrhythmia in daily clinical practice and substantially impacts affected patients by elevation of both morbidity and mortality. Previous investigations proved that inflammatory processes are closely linked to this multifactorial pathogenesis-especially autoreactive CD4CD28 T cells received in-depth attention.

Purpose: Consequently, a potential pathophysiological pathway of the impact of CD4CD28null T lymphocytes on the development and progression AF can be outlined. Read More

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September 2021

Sleep Disturbance in Individuals at Clinical High Risk for Psychosis.

Schizophr Bull 2021 Sep 18. Epub 2021 Sep 18.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

Introduction: Disturbed sleep is a common feature of psychotic disorders that is also present in the clinical high risk (CHR) state. Evidence suggests a potential role of sleep disturbance in symptom progression, yet the interrelationship between sleep and CHR symptoms remains to be determined. To address this knowledge gap, we examined the association between disturbed sleep and CHR symptoms over time. Read More

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September 2021

Development and validation of a PBRM1-associated immune prognostic model for clear cell renal cell carcinoma.

Cancer Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Anesthesiology, Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Alteration in the polybromo-1 (PBRM1) protein encoding gene PBRM1 is the second most frequent mutation in clear cell renal cell carcinoma (ccRCC). It causes a series of changes in the tumorigenesis, progression, prognosis, and immune response of ccRCC patients. This study explored the PBRM1-associated immunological features and identified the immune-related genes (IRGs) linked to PBRM1 mutation using bioinformatics methods. Read More

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September 2021

The altered functional modular organization in systemic lupus erythematosus: an independent component analysis study.

Brain Imaging Behav 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, Subei People's Hospital of Jiangsu Province, Central South University, No.98 Nantong West Road, Yangzhou, 225001, Jiangsu, China.

The aim of this study was to investigate the abnormities in functional connectivity (FC) within each modular network and between modular networks in patients with systemic lupus erythematosus (SLE). Twelve meaningful modular networks were identified via independent component analysis from 41 patients and 40 volunteers. Parametric tests were used to compare the intra- and intermodular FC between the groups. Read More

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September 2021

Oxidative stress in retinal pigment epithelium impairs stem cells: a vicious cycle in age-related macular degeneration.

Mol Cell Biochem 2021 Sep 17. Epub 2021 Sep 17.

Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, Italy.

Aging, chronic oxidative stress, and inflammation are major pathogenic factors in the development and progression of age-related macular degeneration (AMD) with the loss of retinal pigment epithelium (RPE). The human RPE contains a subpopulation of progenitors (i.e. Read More

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September 2021

Tumor microenvironment is associated with clinical and genetic properties of diffuse gliomas and predicts overall survival.

Cancer Immunol Immunother 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Tumor microenvironment (TME) is a complex and dynamic evolving environment which facilitates tumor proliferation and progression. We aimed at investigating the characteristics of tumor microenvironment and its prognostic value in gliomas. Transcriptome data of 702 glioma samples from The Cancer Genome Atlas were included as training dataset, while 325 samples from Chinese Glioma Genome Atlas database and 268 samples from GSE16011 database were used to validate. Read More

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September 2021