528,712 results match your criteria clinical practice

Pulse oximetry respiratory monitoring for assessment of acute childhood wheeze.

Arch Dis Child 2022 Aug 8. Epub 2022 Aug 8.

Respiratory Care, Royal Alexandra Children's Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK

Objective: There is a lack of objective measures to assess children with acute wheezing episodes. Increased respiratory rate (RR) and pulsus paradoxus (PP) are recognised markers, but poorly recorded in practice. We examined whether they can be reliably assessed from a pulse oximeter plethysmogram ('pleth') trace and predict clinical outcome. Read More

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Precription Digita Thraputic for atients with nsomnia ( a protocol for a pragmatic randomised controlled trial.

BMJ Open 2022 Aug 8;12(8):e062041. Epub 2022 Aug 8.

Center for Outcomes Research and Evaluation, Yale-New Haven Health, New Haven, Connecticut, USA.

Introduction: Cognitive behavioural therapy for insomnia (CBT-I) is effective at treating chronic insomnia, yet in-person CBT-I can often be challenging to access. Prior studies have used technology to bridge barriers but have been unable to extensively assess the impact of the digital therapeutic on real-world patient experience and multidimensional outcomes. Among patients with insomnia, our aim is to determine the impact of a prescription digital therapeutic (PDT) (PEAR-003b, FDA-authorised as Somryst; herein called PDT) that provides mobile-delivered CBT-I on patient-reported outcomes (PROs) and healthcare utilisation. Read More

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Interventions for and experiences of shared decision-making underpinning reproductive health, family planning options and pregnancy for women with or at high risk of kidney disease: a systematic review and qualitative framework synthesis.

BMJ Open 2022 Aug 8;12(8):e062392. Epub 2022 Aug 8.

School of Medical and Health Sciences, Bangor University, Bangor, UK.

Objective: To determine intervention effects and synthesise qualitative research that explored women with or at high risk of kidney disease experiences of shared decision-making in relation to their reproductive health, family planning options and pregnancy.

Design: A systematic review of interventions and a qualitative evidence synthesis.

Data Sources: We searched Cochrane, CINAHL, MEDLINE, Scopus, ProQuest, Elsevier, PubMed, ScienceDirect and Web of Science. Read More

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Reporting and transparent research practices in sports medicine and orthopaedic clinical trials: a meta-research study.

BMJ Open 2022 Aug 8;12(8):e059347. Epub 2022 Aug 8.

BIH QUEST Center for Responsible Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany

Objectives: Transparent reporting of clinical trials is essential to assess the risk of bias and translate research findings into clinical practice. While existing studies have shown that deficiencies are common, detailed empirical and field-specific data are scarce. Therefore, this study aimed to examine current clinical trial reporting and transparent research practices in sports medicine and orthopaedics. Read More

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Differences in opioid prescription rates between patients with musculoskeletal disorders enrolled in coordinated ambulatory healthcare and patients receiving usual care: a retrospective observational cohort study.

BMJ Open 2022 Aug 8;12(8):e062657. Epub 2022 Aug 8.

Institute of General Practice, Goethe University, Frankfurt am Main, Germany.

Objectives: To compare opioid prescription rates between patients enrolled in coordinated ambulatory care and patients receiving usual care.

Design: In this retrospective cohort study, we analysed claims data for insured patients with non-specific/specific back pain or osteoarthritis of hip or knee from 2014 to 2017.

Setting: The study was based on administrative data provided by the statutory health insurance fund 'Allgemeine Ortskrankenkasse', in the state of Baden-Wurttemberg, Germany. Read More

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Impact of COVID-19 on outpatient appointments in children and young people in England: an observational study.

BMJ Open 2022 Aug 8;12(8):e060961. Epub 2022 Aug 8.

Department of Primary Care and Public Health, Imperial College London, London, UK.

Objectives: To describe the impact of the COVID-19 pandemic on outpatient appointments for children and young people.

Setting: All National Health Service (public) hospitals in England.

Participants: All people in England aged <25 years. Read More

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Detecting Cognitive Impairment and Dementia in the Emergency Department: A Scoping Review.

J Am Med Dir Assoc 2022 Aug;23(8):1314-1315.e55

Department of Emergency Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA; Geriatric Research, Education and Clinical Center, James J. Peters VA Medical Center, Bronx, NY, USA. Electronic address:

Objectives: To identify research and practice gaps to establish future research priorities to advance the detection of cognitive impairment and dementia in the emergency department (ED).

Design: Literature review and consensus-based rankings by a transdisciplinary, stakeholder task force of experts, persons living with dementia, and care partners.

Setting And Participants: Scoping reviews focused on adult ED patients. Read More

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A Care Step Pathway for the Diagnosis and Treatment of COVID-19-Associated Invasive Fungal Infections in the Intensive Care Unit.

Crit Care Nurse 2022 Aug 9:e1-e11. Epub 2022 Aug 9.

Peter G. Pappas is the William E. Dismukes Professor of Medicine in the Division of Infectious Diseases, and Tinsley Harrison Clinical Scholar, Department of Medicine, at the University of Alabama at Birmingham. He is Chair of the Mycoses Study Group Education and Research Consortium Scientific Committee.

Background: In March 2020, the World Health Organization declared COVID-19, caused by the SARS-CoV-2 virus, a pandemic. Patients with severe cases resulting in hospitalization and mechanical ventilation are at risk for COVID-19-associated pulmonary aspergillosis, an invasive fungal infection, and should be screened for aspergillosis if they have persistent hemodynamic instability and fever. Early detection and treatment of this fungal infection can significantly reduce morbidity and mortality in this population. Read More

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Micro-Opening Ridged Waveguide Tumor Hyperthermia Antenna Combined with Microwave-Sensitive MOF Material for Tumor Microwave Hyperthermia Therapy.

ACS Appl Bio Mater 2022 Aug 8. Epub 2022 Aug 8.

Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Microwave hyperthermia is an emerging minimally invasive therapy in which thermal damage and apoptosis of tumor cells are induced by local heating of tissues with microwave radiation. Recently, microwave hyperthermia has been widely used in clinical practice; however, uneven aggregation and dispersion of malignant tumors after microwave hyperthermia are the main problems associated with this method. In this work, a microridged waveguide tumor hyperthermia antenna with an operating frequency of 915 MHz was designed. Read More

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Evaluation of the efficacy and safety of Unani Formulations in Pityriasis Versicolor: A randomized controlled trial.

J Ethnopharmacol 2022 Aug 5:115603. Epub 2022 Aug 5.

Drug Standardization Research Unit, National Research Institute of Unani Medicine for Skin Disorders, Opp. ESI Hospital, Eragadda, Hyderabad, 500032, India. Electronic address:

Ethnopharmacological Relevance: Pityriasis Versicolor (PV) is a commonly encountered infection of the skin caused by Malassezia species. Despite effective conventional antifungal drugs, the prevention and treatment of PV remain a challenge. The Unani pharmacopoeial preparations Itrifal Hakim Ali (IHA) and Habb-e-Kalaf (HK) have been used in the treatment of PV for a long time. Read More

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Pulp Regenerative Cell Therapy for Mature Molars: A Report of 2 Cases.

J Endod 2022 Aug 5. Epub 2022 Aug 5.

Section of Regenerative Dental Medicine, National Center for Geriatrics and Gerontology, Research Institute, Geroscience Research Center, Obu, Aichi 474-8511, Japan.

Introduction: Regenerative cell therapy using autologous dental pulp stem cells (DPSCs) in mature single-rooted teeth is a potential alternative to traditional endodontic treatment. However, there is no evidence supporting the use of DPSCs in multi-rooted teeth. This case report aimed to demonstrate the feasibility and outcomes of pulp regenerative cell therapy in mature multi-rooted molars, which typically have a higher prevalence of apical deltas. Read More

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How Reliable and Valid are Dual-Task Cost Metrics? A Meta-Analysis of Locomotor-Cognitive Dual-Task Paradigms.

Arch Phys Med Rehabil 2022 Aug 5. Epub 2022 Aug 5.

Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Australian Catholic University, Melbourne, Australia.

Objective: To assess the retest reliability, predictive validity, and concurrent validity of locomotor and cognitive dual-task cost (DTC) metrics derived from locomotor-cognitive dual-task paradigms.

Data Sources: A literature search of electronic databases (PubMed, PsycINFO, MEDLINE, CINAHL, and Scopus) was conducted on 29 May 2021 without time restriction.

Study Selection: For 1559 search results, titles and abstracts were screened by a single reviewer and full-text of potentially eligible papers was considered by two independent reviewers. Read More

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Prevalence of Impairment of Visual Acuity and Severity of Retinopathy in Patients with Diabetes Mellitus.

Exp Clin Endocrinol Diabetes 2022 Aug 8. Epub 2022 Aug 8.

Jena University Hospital, Department for Internal Medicine III, Jena, Germany.

Aims: No information exists on the frequency of visual impairment in people with diabetes mellitus (DM) in Germany. In this study, the prevalence of vision impairment in those individuals was investigated.

Methods: We retrospectively analyzed a cohort of 295 people (14221 consultations) at a university outpatient clinic with any type of DM and an available ETDRS-Score and visual acuity. Read More

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Use of Urodynamics by Gynecologists and Urologists in Brazil.

Rev Bras Ginecol Obstet 2022 Jul 8;44(7):654-659. Epub 2022 Aug 8.

Department of Gynecology and Obstetrics of Federal University of Minas Gerais, Belo Horizonte, Brazil.

Objective:  Urodynamic studies (UDSs) are a set of tests that assess the storage and emptying of urine, and they are widely used by gynecologists and urologists in the management of urinary incontinence (UI), despite the discussion about its indications. The objectives of the present study were to verify whether UDSs are routinely used in the conservative and surgical approaches to female UI, their other clinical indications, and to compare the responses of Brazilian gynecologists and urologists.

Methods:  The present is an opinion survey applied from August 2020 to January 2021 through a semistructured questionnaire about the clinical practice sent by e-mail to all participants. Read More

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β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress.

Int Immunopharmacol 2022 Aug 5;111:109101. Epub 2022 Aug 5.

Department of Nephrology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China. Electronic address:

Cisplatin, as a commonly used anticancer drug, can easily lead to acute kidney injury (AKI), and has received more and more attention in clinical practice. β-hydroxybutyric acid (BHB) is a metabolite in the body and acts as an inhibitor of oxidative stress and NLRP3 inflammasome, reducing inflammatory responses and apoptosis. However, the role of BHB in cisplatin-induced AKI is currently not fully elucidated. Read More

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Optimizing the use of patients' individual outcome information - Development and usability tests of a Chronic Kidney Disease dashboard.

Int J Med Inform 2022 Jul 29;166:104838. Epub 2022 Jul 29.

St. Antonius Hospital, Department of Internal Medicine, Nieuwegein, the Netherlands; Leiden University Medical Centre, Department of Internal Medicine, Leiden, the Netherlands.

Background: Reporting individual clinical and patient-reported outcomes to patients during consultations may add to patients' disease knowledge and activation and stimulate Shared Decision Making (SDM). These outcomes can be presented over time in a clear way by the means of dashboarding. We aimed to systematically develop a Chronic Kidney Disease (CKD) dashboard designed to support consultations, test its usability and explore conditions for optimal use in practice. Read More

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Detection of incidental adrenal nodules on computed tomography by radiographers.

Radiography (Lond) 2022 Aug 5;28(4):1025-1031. Epub 2022 Aug 5.

Department of Radiography, Faculty of Health Sciences, University of Malta, Msida, Malta.

Introduction: This research investigated whether radiographers' age, qualifications, shift rotations and years of post-qualification experience as a radiographer affect the detection rate of incidental adrenal nodules, also known as adrenal incidentalomas in Malta. Additionally, local statistics of adrenal incidentaloma findings were evaluated.

Methods: This research consisted of two phases and employed a non-experimental, cross-sectional quantitative approach. Read More

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Transition program: Initial implementation with adults with neuromuscular conditions.

J Pediatr Nurs 2022 Aug 5;67:52-56. Epub 2022 Aug 5.

Hassenfeld Children's Hospital of New York at NYU Langone Health, NYU Langone Orthopedic Hospital, New York, NY, USA.

Purpose: To identify current medical and psychosocial needs and to examine the effectiveness of healthcare transition program for adult-aged patients with neuromuscular conditions transitioning from pediatric to adult services.

Design And Methods: At Neuromuscular Transition Clinic visit, 46 patients were evaluated and referred to adult-based providers, if did not currently have one, from an acquired list of interested clinicians. At mean follow-up of 22 months, 42 were interviewed by phone regarding referrals for Core Services (primary care, physiatry, dental care and gynecology), Medical Specialties and Rehabilitation Services. Read More

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Predictors of pain reduction following a program of manual therapies for patients with temporomandibular disorders: A prospective observational study.

Musculoskelet Sci Pract 2022 Jul 31;62:102634. Epub 2022 Jul 31.

Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham Birmingham, B15 2TT, UK. Electronic address:

Background: Clinical guidelines recommend conservative treatment for the management of temporomandibular disorders (TMD), and manual therapy (MT) is commonly applied to reduce pain and improve function.

Objectives: To identify predictors of pain reduction and functional improvement following a program of manual therapies (MTP) in patients with TMD and develop a first screening tool that could be used in clinical practice to facilitate decision-making.

Design: A cohort of 102 adults with a diagnosis of TMD were treated with four weekly sessions within a MTP applied to craniomandibular structures. Read More

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Association between food insecurity and probable sarcopenia: Data from the 2011-2014 National Health and nutrition examination survey.

Clin Nutr 2022 Jul 8;41(9):1861-1873. Epub 2022 Jul 8.

Division of Geriatric Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Aging alters biological processes resulting in body fat redistribution, loss of lean muscle mass, and reduced muscle strength, termed sarcopenia. Nutrition is an important modifiable risk factor in the development of sarcopenia. Food insecurity refers to limited or uncertain access to enough food for an active, healthy life, and is prevalent among older adults. Read More

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Next-generation sequencing facilitates genetic diagnosis and improves the management of patients with hearing loss in clinical practice.

Int J Pediatr Otorhinolaryngol 2022 Jul 31;161:111258. Epub 2022 Jul 31.

Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, Guangdong, 510010, China; Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, 510010, China. Electronic address:

Background: Hearing loss (HL) is a prevalent sensorineural disorder, and is among the most etiologically heterogeneous disorders. With the advent of next-generation sequencing (NGS) technologies, hundreds of candidate genes can be analyzed simultaneously in a cost-effective manner.

Methods: Ninety-four patients from 87 families diagnosed with non-syndromic or syndromic HL were enrolled. Read More

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[The Management of Endocrine Complications in Patients with Haemoglobinopathies: Good Clinical Practice of the Italian Society of Thalassemia and Haemoglobinopathies (SITE).]

Recenti Prog Med 2022 Sep;113(9):495-554

Centro Emoglobinopatie e Anemie Congenite, Ospedali Galliera, Genova.

Background: The treatment of endocrinopathies in haemoglobinopathies is a continually expanding research area; therefore, recommendations supporting the appropriateness of treatments are a pressing need for the medical community.

Methods: The Management Committee of SITE selected and gathered a multidisciplinary and multiprofessional team including experts in haemoglobinopathies and experts in endocrinopathies, who have been flanked by experts with methodological and organizational expertise, in order to formulate recommendations based on the available scientific evidence integrated by clinical experience. The project followed the systematic approach for the production of clinical practice guidelines according to the methodology suggested by the National Center for Clinical Excellence, Quality and Safety of Care (CNEC). Read More

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September 2022

[Artificial intelligence and dermatology.]

Recenti Prog Med 2022 Sep;113(9):484-486

Medico di Medicina Generale, Massa (MS), Ufficio di Presidenza del Comitato per l'Etica Clinica (ComEC), Azienda USL Toscana Nord-Ovest.

The approach of artificial intelligence (AI) systems can especially support doctors who base their work on the interpretation of digital images. Despite undoubted favorable results, the validation of diagnostic algorithms in clinical practice has not yet been demonstrated. In the dermatological field, a study found the poor performance of AI systems in diagnosing skin lesions that better reflect clinical practice, that is characterized by the presence of "artifacts" such as crusts or ulcerations above the lesion, hair or pen marks, pigmentation. Read More

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September 2022

Relationship Between Feeders and Exclusive Breastfeeding and Mixed Feeding During the First Month of Life.

Adv Neonatal Care 2022 Aug 1. Epub 2022 Aug 1.

Faculty of Nursing, Burapha University, Chon Buri, Thailand (Dr Srisopa); and University of Connecticut, Storrs (Dr Walsh, Henderson, and Lucas and Mss Amoo and Gyamfi).

Background: The critical time to continue or stop breastfeeding is during the first month after hospital discharge. Mothers receive lactation and physical support by fathers and others bottle-feeding human or formula milk to their infants.

Purpose: To describe the effect of feeders (mothers, fathers, and others) and different milk feeding on infants' weekly exclusive breastfeeding rates, from birth to 1 month after discharge. Read More

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An Approach to Solving the Complex Clinicogenomic Data Landscape in Precision Oncology: Learnings From the Design of WAYFIND-R, a Global Precision Oncology Registry.

JCO Precis Oncol 2022 Jul;6:e2200019

Oncoclínicas Grupo, São Paulo, Brazil.

Precision oncology, where patients are given therapies based on their genomic profile and disease trajectory, is rapidly evolving to become a pivotal part of cancer management, supported by regulatory approvals of biomarker-matched targeted therapies and cancer immunotherapies. However, next-generation sequencing (NGS)-based technologies have revealed an increasing number of molecular-based cancer subtypes with rare patient populations, leading to difficulties in executing/recruiting for traditional clinical trials. Therefore, approval of novel therapeutics based on traditional interventional studies may be difficult and time consuming, with delayed access to innovative therapies. Read More

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Patient-centered weaning from venoarterial extracorporeal membrane oxygenation: "A practice-oriented narrative review of literature".

Perfusion 2022 Aug 8:2676591221115938. Epub 2022 Aug 8.

Department of Intensive Care Medicine, 8124University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Venoarterial extracorporeal membrane oxygenation (V-A ECMO) is increasingly used in cardiogenic shock for rapid stabilization and bridging towards recovery, long-term mechanical circulatory support or transplant. Although technological advances have instigated its widespread use, the complex, long-lasting ECMO care creates a significant strain on hospital staff and resources. Therefore, optimal clinical management including timely decisions on ECMO removal and further therapy are pivotal, yet require a well-structured weaning approach. Read More

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Influence of the COVID-19 Pandemic on Clinical Oncology Nursing Care.

Editor Carr

Clin J Oncol Nurs 2022 Jul;26(4):333-334

Exactly where are we in the practice of clinical oncology nursing, now indelibly altered by the COVID-19 pandemic? Depending on the day or hour, experts in clinical oncology care claim that clinical oncology practice has stab. Read More

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The COVID-19 Pandemic and Transition to Digital Health in Clinical Oncology Care.

Clin J Oncol Nurs 2022 Jul;26(4):374-382

Essentia Health Duluth Clinic.

Background: Clinical oncology care is complex, and new technologies can improve efficiency, contribute to safe treatment delivery, and enhance care for the patient. The COVID-19 pandemic prompted a shift to the use of digital health technologies to provide care. Oncology care providers can ensure that technology is integrated with the patient's plan of care. Read More

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